UniProtKB - P79307 (A4_PIG)
Amyloid-beta A4 protein
APP
Functioni
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 147 | Copper 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 151 | Copper 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 168 | Copper 1PROSITE-ProRule annotation | 1 | |
Sitei | 170 | Required for Cu(2+) reductionPROSITE-ProRule annotation | 1 | |
Sitei | 301 – 302 | Reactive bondBy similarity | 2 | |
Metal bindingi | 677 | Copper or zinc 2By similarity | 1 | |
Metal bindingi | 681 | Copper or zinc 2By similarity | 1 | |
Metal bindingi | 684 | Copper or zinc 2By similarity | 1 | |
Metal bindingi | 685 | Copper or zinc 2By similarity | 1 | |
Sitei | 704 | Implicated in free radical propagationBy similarity | 1 | |
Sitei | 706 | Susceptible to oxidationBy similarity | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- heparin binding Source: UniProtKB-KW
- serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
- transition metal ion binding Source: InterPro
GO - Biological processi
- adult locomotory behavior Source: UniProtKB
- apoptotic process Source: UniProtKB-KW
- axo-dendritic transport Source: UniProtKB
- axon midline choice point recognition Source: UniProtKB
- axonogenesis Source: UniProtKB
- cell adhesion Source: UniProtKB-KW
- cellular copper ion homeostasis Source: UniProtKB
- cognition Source: UniProtKB
- collateral sprouting in absence of injury Source: UniProtKB
- dendrite development Source: UniProtKB
- endocytosis Source: UniProtKB
- extracellular matrix organization Source: UniProtKB
- ionotropic glutamate receptor signaling pathway Source: UniProtKB
- locomotory behavior Source: UniProtKB
- mating behavior Source: UniProtKB
- mRNA polyadenylation Source: UniProtKB
- neuron projection development Source: UniProtKB
- neuron remodeling Source: UniProtKB
- Notch signaling pathway Source: UniProtKB-KW
- positive regulation of mitotic cell cycle Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
- regulation of multicellular organism growth Source: UniProtKB
- regulation of synapse structure or activity Source: UniProtKB
- regulation of translation Source: UniProtKB
- visual learning Source: UniProtKB
Keywordsi
Molecular function | Heparin-binding, Protease inhibitor, Serine protease inhibitor |
Biological process | Apoptosis, Cell adhesion, Endocytosis, Notch signaling pathway |
Ligand | Copper, Iron, Metal-binding, Zinc |
Protein family/group databases
MEROPSi | I02.015 |
Names & Taxonomyi
Protein namesi | Recommended name: Amyloid-beta A4 proteinAlternative name(s): ABPP Short name: APP Alzheimer disease amyloid A4 protein homolog Amyloid precursor proteinCurated Amyloid-beta precursor proteinCurated Cleaved into the following 14 chains: Alternative name(s): Beta-secretase C-terminal fragment Short name: Beta-CTF Alternative name(s): Beta-APP42 Alternative name(s): Beta-APP40 Alternative name(s): Alpha-secretase C-terminal fragment Short name: Alpha-CTF Alternative name(s): Gamma-CTF(59) Alternative name(s): Gamma-CTF(57) Alternative name(s): Gamma-CTF(50) |
Gene namesi | Name:APP |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Endosome
- Early endosome By similarity
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- Membrane By similarity; Single-pass type I membrane protein By similarity
- Perikaryon By similarity
- growth cone By similarity
- clathrin-coated pit By similarity
- Cytoplasmic vesicle By similarity
Note: Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proportion is present at the cell membrane; most of the protein is present in intracellular vesicles. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. APP sorts to the basolateral surface in epithelial cells. During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body. Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment. Associates with GPC1 in perinuclear compartments. Colocalizes with SORL1 in a vesicular pattern in cytoplasm and perinuclear regions.By similarity
Extracellular region or secreted
- Secreted By similarity
Other locations
- Cell surface By similarity
Note: Associates with FPR2 at the cell surface and the complex is then rapidly internalized.By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- Nucleus By similarity
Note: Located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65). In dopaminergic neurons, the phosphorylated Thr-743 form is localized to the nucleus (By similarity).By similarity
Endosome
- early endosome Source: UniProtKB
- recycling endosome Source: UniProtKB
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- clathrin-coated pit Source: UniProtKB-SubCell
Other locations
- axon Source: UniProtKB
- cell surface Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- Golgi-associated vesicle Source: UniProtKB
- growth cone Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB
- perikaryon Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 701 | ExtracellularCuratedAdd BLAST | 684 | |
Transmembranei | 702 – 722 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 723 – 770 | CytoplasmicCuratedAdd BLAST | 48 |
Keywords - Cellular componenti
Amyloid, Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane, Nucleus, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | By similarityAdd BLAST | 17 | |
ChainiPRO_0000000140 | 18 – 770 | Amyloid-beta A4 proteinAdd BLAST | 753 | |
ChainiPRO_0000000141 | 18 – 687 | Soluble APP-alphaSequence analysisAdd BLAST | 670 | |
ChainiPRO_0000000142 | 18 – 671 | Soluble APP-betaSequence analysisAdd BLAST | 654 | |
ChainiPRO_0000381970 | 18 – 286 | N-APPBy similarityAdd BLAST | 269 | |
ChainiPRO_0000000143 | 672 – 770 | C99By similarityAdd BLAST | 99 | |
ChainiPRO_0000000144 | 672 – 713 | Amyloid-beta protein 42By similarityAdd BLAST | 42 | |
ChainiPRO_0000000145 | 672 – 711 | amyloid-beta protein 40By similarityAdd BLAST | 40 | |
ChainiPRO_0000000146 | 688 – 770 | C83By similarityAdd BLAST | 83 | |
PeptideiPRO_0000000147 | 688 – 713 | P3(42)By similarityAdd BLAST | 26 | |
PeptideiPRO_0000000148 | 688 – 711 | P3(40)By similarityAdd BLAST | 24 | |
ChainiPRO_0000384578 | 691 – 770 | C80Add BLAST | 80 | |
ChainiPRO_0000000149 | 712 – 770 | Gamma-secretase C-terminal fragment 59Add BLAST | 59 | |
ChainiPRO_0000000150 | 714 – 770 | Gamma-secretase C-terminal fragment 57Add BLAST | 57 | |
ChainiPRO_0000000151 | 721 – 770 | Gamma-secretase C-terminal fragment 50By similarityAdd BLAST | 50 | |
ChainiPRO_0000000152 | 740 – 770 | C31By similarityAdd BLAST | 31 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 38 ↔ 62 | PROSITE-ProRule annotation | ||
Disulfide bondi | 73 ↔ 117 | PROSITE-ProRule annotation | ||
Disulfide bondi | 98 ↔ 105 | PROSITE-ProRule annotation | ||
Disulfide bondi | 133 ↔ 187 | PROSITE-ProRule annotation | ||
Disulfide bondi | 144 ↔ 174 | PROSITE-ProRule annotation | ||
Disulfide bondi | 158 ↔ 186 | PROSITE-ProRule annotation | ||
Modified residuei | 198 | Phosphoserine; by CK2By similarity | 1 | |
Modified residuei | 206 | Phosphoserine; by CK1By similarity | 1 | |
Modified residuei | 217 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 262 | SulfotyrosineSequence analysis | 1 | |
Disulfide bondi | 291 ↔ 341 | PROSITE-ProRule annotation | ||
Disulfide bondi | 300 ↔ 324 | PROSITE-ProRule annotation | ||
Disulfide bondi | 316 ↔ 337 | PROSITE-ProRule annotation | ||
Modified residuei | 336 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 441 | PhosphoserineBy similarity | 1 | |
Modified residuei | 497 | PhosphotyrosineBy similarity | 1 | |
Glycosylationi | 542 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 571 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 729 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 730 | Phosphoserine; by APP-kinase IBy similarity | 1 | |
Modified residuei | 743 | Phosphothreonine; by CDK5 and MAPK10By similarity | 1 | |
Modified residuei | 757 | Phosphotyrosine; by ABL1By similarity | 1 | |
Cross-linki | 763 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 197 – 198 | Cleavage; by caspasesBy similarity | 2 | |
Sitei | 219 – 220 | Cleavage; by caspasesBy similarity | 2 | |
Sitei | 671 – 672 | Cleavage; by beta-secretaseBy similarity | 2 | |
Sitei | 687 – 688 | Cleavage; by alpha-secretaseBy similarity | 2 | |
Sitei | 690 – 691 | Cleavage; by theta-secretaseBy similarity | 2 | |
Sitei | 711 – 712 | Cleavage; by gamma-secretase; site 1By similarity | 2 | |
Sitei | 713 – 714 | Cleavage; by gamma-secretase; site 2By similarity | 2 | |
Sitei | 720 – 721 | Cleavage; by gamma-secretase; site 3By similarity | 2 | |
Sitei | 739 – 740 | Cleavage; by a caspaseBy similarity | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Sulfation, Ubl conjugationProteomic databases
PaxDbi | P79307 |
PeptideAtlasi | P79307 |
PRIDEi | P79307 |
Interactioni
Subunit structurei
Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1 and NUMB and DAB1 (By similarity). Binding to DAB1 inhibits its serine phosphorylation (By similarity).
Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif.
Also interacts with GPCR-like protein BPP, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity).
Interacts, through a C-terminal domain, with GNAO1. Amyloid-beta protein 42 binds CHRNA7 in hippocampal neurons (By similarity). Amyloid-beta associates with HADH2 (By similarity).
Interacts with CPEB1, ANKS1B, TNFRSF21 and AGER (By similarity).
Interacts with ITM2B.
Interacts with ITM2C.
Interacts with IDE. Can form homodimers; dimerization is enhanced in the presence of Cu2+ ions. Can form homodimers; this is promoted by heparin binding (By similarity). Amyloid-beta protein 40 interacts with S100A9 (By similarity). CTF-alpha product of APP interacts with GSAP (By similarity).
Interacts with SORL1 (via N-terminal ectodomain); this interaction retains APP in the trans-Golgi network and reduces processing into soluble APP-alpha and amyloid-beta peptides (By similarity). The C99 fragment also interacts with SORL1 (By similarity).
Interacts with PLD3 (By similarity).
Interacts with VDAC1 (By similarity).
Interacts with NSG1; could regulate APP processing (By similarity). Amyloid-beta protein 42 interacts with FPR2 (By similarity).
Interacts (via transmembrane region) with PSEN1; the interaction is direct (By similarity).
Interacts with LRRK2 (By similarity).
Interacts (via cytoplasmic domain) with KIF5B (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9823.ENSSSCP00000012805 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 189 | E1PROSITE-ProRule annotationAdd BLAST | 162 | |
Domaini | 291 – 341 | BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 374 – 565 | E2PROSITE-ProRule annotationAdd BLAST | 192 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 28 – 123 | GFLD subdomainPROSITE-ProRule annotationAdd BLAST | 96 | |
Regioni | 96 – 110 | Heparin-bindingBy similarityAdd BLAST | 15 | |
Regioni | 131 – 189 | CuBD subdomainPROSITE-ProRule annotationAdd BLAST | 59 | |
Regioni | 135 – 155 | Copper-bindingBy similarityAdd BLAST | 21 | |
Regioni | 181 – 188 | Zinc-bindingBy similarity | 8 | |
Regioni | 391 – 423 | Heparin-bindingBy similarityAdd BLAST | 33 | |
Regioni | 491 – 522 | Heparin-bindingBy similarityAdd BLAST | 32 | |
Regioni | 523 – 540 | Collagen-bindingBy similarityAdd BLAST | 18 | |
Regioni | 695 – 722 | Interaction with PSEN1By similarityAdd BLAST | 28 | |
Regioni | 732 – 751 | Interaction with G(o)-alphaBy similarityAdd BLAST | 20 | |
Regioni | 756 – 770 | Required for the interaction with KIF5B and for anterograde transport in axonsBy similarityAdd BLAST | 15 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 344 – 365 | OX-2By similarityAdd BLAST | 22 | |
Motifi | 724 – 734 | Basolateral sorting signalAdd BLAST | 11 | |
Motifi | 757 – 762 | YENPXY motif; contains endocytosis signalBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 230 – 260 | Asp/Glu-rich (acidic)Add BLAST | 31 | |
Compositional biasi | 274 – 280 | Poly-Thr | 7 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3540, Eukaryota |
InParanoidi | P79307 |
OMAi | WSELEDR |
OrthoDBi | 953529at2759 |
Family and domain databases
CDDi | cd00109, KU, 1 hit |
Gene3Di | 1.20.120.770, 1 hit 2.30.29.30, 1 hit 3.30.1490.140, 1 hit 3.90.570.10, 1 hit 4.10.230.10, 1 hit 4.10.410.10, 1 hit |
InterProi | View protein in InterPro IPR036669, Amyloid_Cu-bd_sf IPR008155, Amyloid_glyco IPR013803, Amyloid_glyco_Abeta IPR037071, Amyloid_glyco_Abeta_sf IPR011178, Amyloid_glyco_Cu-bd IPR024329, Amyloid_glyco_E2_domain IPR008154, Amyloid_glyco_extra IPR015849, Amyloid_glyco_heparin-bd IPR036454, Amyloid_glyco_heparin-bd_sf IPR019745, Amyloid_glyco_intracell_CS IPR028866, APP IPR019543, APP_amyloid_C IPR019744, APP_CUBD_CS IPR036176, E2_sf IPR002223, Kunitz_BPTI IPR036880, Kunitz_BPTI_sf IPR011993, PH-like_dom_sf IPR020901, Prtase_inh_Kunz-CS |
PANTHERi | PTHR23103, PTHR23103, 1 hit PTHR23103:SF7, PTHR23103:SF7, 1 hit |
Pfami | View protein in Pfam PF10515, APP_amyloid, 1 hit PF12924, APP_Cu_bd, 1 hit PF12925, APP_E2, 1 hit PF02177, APP_N, 1 hit PF03494, Beta-APP, 1 hit PF00014, Kunitz_BPTI, 1 hit |
PRINTSi | PR00203, AMYLOIDA4 PR00759, BASICPTASE PR00204, BETAAMYLOID |
SMARTi | View protein in SMART SM00006, A4_EXTRA, 1 hit SM00131, KU, 1 hit |
SUPFAMi | SSF109843, SSF109843, 1 hit SSF56491, SSF56491, 1 hit SSF57362, SSF57362, 1 hit SSF89811, SSF89811, 1 hit |
PROSITEi | View protein in PROSITE PS00319, APP_CUBD, 1 hit PS51869, APP_E1, 1 hit PS51870, APP_E2, 1 hit PS00320, APP_INTRA, 1 hit PS00280, BPTI_KUNITZ_1, 1 hit PS50279, BPTI_KUNITZ_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MLPGLALVLL AAWTARALEV PTDGNAGLLA EPQVAMFCGK LNMHMNVQNG
60 70 80 90 100
KWESDPSGTK TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR
110 120 130 140 150
SRKQCKTHTH IVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW
160 170 180 190 200
HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDNIDSAD
210 220 230 240 250
AEEDDSDVWW GGADTDYADG SEDKVVEVAE EEEVADVEEE EAEDDEDDED
260 270 280 290 300
GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC
310 320 330 340 350
RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSVMSQSLL
360 370 380 390 400
KTTQEHLPQD PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA
410 420 430 440 450
KHRERMSQVM REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER
460 470 480 490 500
QQLVETHMAR VEAMLNDRRR LALENYITAL QAVPPRPRHV FNMLKKYVRA
510 520 530 540 550
EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER MNQSLSLLYN
560 570 580 590 600
VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET
610 620 630 640 650
KTTVELLPVN GEFSLDDLQP WHPFGVDSVP ANTENEVEPV DARPAADRGL
660 670 680 690 700
TTRPGSGLTN IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG
710 720 730 740 750
AIIGLMVGGV VIATVIVITL VMLKKKQYTS IHHGVVEVDA AVTPEERHLS
760 770
KMQQNGYENP TYKFFEQMQN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 134 – 136 | KFL → SSY in CAB06313 (Ref. 2) Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB032550 mRNA Translation: BAA84580.1 Z84022 mRNA Translation: CAB06313.1 X56127 mRNA Translation: CAA39592.1 |
PIRi | F60045 |
RefSeqi | NP_999537.1, NM_214372.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB032550 mRNA Translation: BAA84580.1 Z84022 mRNA Translation: CAB06313.1 X56127 mRNA Translation: CAA39592.1 |
PIRi | F60045 |
RefSeqi | NP_999537.1, NM_214372.1 |
3D structure databases
BMRBi | P79307 |
SMRi | P79307 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000012805 |
Protein family/group databases
MEROPSi | I02.015 |
Proteomic databases
PaxDbi | P79307 |
PeptideAtlasi | P79307 |
PRIDEi | P79307 |
Genome annotation databases
Organism-specific databases
CTDi | 351 |
Phylogenomic databases
eggNOGi | KOG3540, Eukaryota |
InParanoidi | P79307 |
OMAi | WSELEDR |
OrthoDBi | 953529at2759 |
Miscellaneous databases
ChiTaRSi | APP, pig |
Family and domain databases
CDDi | cd00109, KU, 1 hit |
Gene3Di | 1.20.120.770, 1 hit 2.30.29.30, 1 hit 3.30.1490.140, 1 hit 3.90.570.10, 1 hit 4.10.230.10, 1 hit 4.10.410.10, 1 hit |
InterProi | View protein in InterPro IPR036669, Amyloid_Cu-bd_sf IPR008155, Amyloid_glyco IPR013803, Amyloid_glyco_Abeta IPR037071, Amyloid_glyco_Abeta_sf IPR011178, Amyloid_glyco_Cu-bd IPR024329, Amyloid_glyco_E2_domain IPR008154, Amyloid_glyco_extra IPR015849, Amyloid_glyco_heparin-bd IPR036454, Amyloid_glyco_heparin-bd_sf IPR019745, Amyloid_glyco_intracell_CS IPR028866, APP IPR019543, APP_amyloid_C IPR019744, APP_CUBD_CS IPR036176, E2_sf IPR002223, Kunitz_BPTI IPR036880, Kunitz_BPTI_sf IPR011993, PH-like_dom_sf IPR020901, Prtase_inh_Kunz-CS |
PANTHERi | PTHR23103, PTHR23103, 1 hit PTHR23103:SF7, PTHR23103:SF7, 1 hit |
Pfami | View protein in Pfam PF10515, APP_amyloid, 1 hit PF12924, APP_Cu_bd, 1 hit PF12925, APP_E2, 1 hit PF02177, APP_N, 1 hit PF03494, Beta-APP, 1 hit PF00014, Kunitz_BPTI, 1 hit |
PRINTSi | PR00203, AMYLOIDA4 PR00759, BASICPTASE PR00204, BETAAMYLOID |
SMARTi | View protein in SMART SM00006, A4_EXTRA, 1 hit SM00131, KU, 1 hit |
SUPFAMi | SSF109843, SSF109843, 1 hit SSF56491, SSF56491, 1 hit SSF57362, SSF57362, 1 hit SSF89811, SSF89811, 1 hit |
PROSITEi | View protein in PROSITE PS00319, APP_CUBD, 1 hit PS51869, APP_E1, 1 hit PS51870, APP_E2, 1 hit PS00320, APP_INTRA, 1 hit PS00280, BPTI_KUNITZ_1, 1 hit PS50279, BPTI_KUNITZ_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A4_PIG | |
Accessioni | P79307Primary (citable) accession number: P79307 Secondary accession number(s): Q29023, Q9TUI0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | April 23, 2003 | |
Last modified: | February 10, 2021 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families