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Protein

Myosin-7

Gene

MYH7

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.By similarity

Miscellaneous

The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 185ATPSequence analysis8

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SSC-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-7
Alternative name(s):
Myosin heavy chain 7
Myosin heavy chain slow isoform
Short name:
MyHC-slow
Myosin heavy chain, cardiac muscle beta isoform
Short name:
MyHC-beta
Gene namesi
Name:MYH7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234101 – 1935Myosin-7Add BLAST1935

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei129N6,N6,N6-trimethyllysineSequence analysis1
Modified residuei378PhosphothreonineBy similarity1
Modified residuei1137PhosphoserineBy similarity1
Modified residuei1269PhosphoserineBy similarity1
Modified residuei1282PhosphothreonineBy similarity1
Modified residuei1308PhosphotyrosineBy similarity1
Modified residuei1309PhosphothreonineBy similarity1
Modified residuei1510PhosphoserineBy similarity1
Modified residuei1513PhosphothreonineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiP79293
PeptideAtlasiP79293
PRIDEiP79293

Expressioni

Gene expression databases

ExpressionAtlasiP79293 baseline
GenevisibleiP79293 SS

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with ECPAS. Interacts (via C-terminus) with LRRC39.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000002219

Structurei

3D structure databases

ProteinModelPortaliP79293
SMRiP79293
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 81Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST50
Domaini85 – 778Myosin motorPROSITE-ProRule annotationAdd BLAST694
Domaini781 – 810IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni655 – 677Actin-bindingAdd BLAST23
Regioni757 – 771Actin-bindingAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili839 – 1935Sequence analysisAdd BLAST1097

Domaini

Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Four skip residues (Skip1: Thr-1188, Skip2: Glu-1385, Skip3: Glu-1582 and Skip4: Gly-1807) introduce discontinuities in the coiled-coil heptad repeats. The first three skip residues are structurally comparable and induce a unique local relaxation of the coiled-coil superhelical pitch and the fourth skip residue lies within a highly flexible molecular hinge that is necessary for myosin incorporation in the bare zone of sarcomeres.By similarity

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919
HOGENOMiHOG000173959
HOVERGENiHBG004704
InParanoidiP79293
KOiK17751
OrthoDBiEOG091G07UM

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 3 hits
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

P79293-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDAEMAAFG EAAPYLRKSE KERLEAQTRP FDLKKDVYVP DDKEEFVKAK
60 70 80 90 100
ILSREGGKVT AETEHGKTVT VKEDQVLQQN PPKFDKIEDM AMLTFLHEPA
110 120 130 140 150
VLYNLKERYA SWMIYTYSGL FCVTINPYKW LPVYNAEVVA AYRGKKRSEA
160 170 180 190 200
PPHIFSISDN AYQYMLTDRE NQSILITGES GAGKTVNTKR VIQYFAVIAA
210 220 230 240 250
IGDRSKKEQT PGKGTLEDQI IQANPALEAF GNAKTVRNDN SSRFGKFIRI
260 270 280 290 300
HFGATGKLAS ADIETYLLEK SRVIFQLKAE RDYHIFYQIL SNKKPELLDM
310 320 330 340 350
LLITNNPYDY AFISQGETTV ASIDDAEELM ATDNAFDVLG FTSEEKNSMY
360 370 380 390 400
KLTGAIMHFG NMKFKLKQRE EQAEPDGTEE ADKSAYLMGL NSADLLKGLC
410 420 430 440 450
HPRVKVGNEY VTKGQNVQQV MYATGALAKA VYEKMFNWMV TRINTTLETK
460 470 480 490 500
QPRQYFIGVL DIAGFEIFDF NSFEQLCINF TNEKLQQFFN HHMFVLEQEE
510 520 530 540 550
YKKEGIEWEF IDFGMDLQAC IDLIEKPMGI MSILEEECMF PKATDMTFKA
560 570 580 590 600
KLYDNHLGKS NNFQKPRNIK GRPEAHFALI HYAGTVDYNI IGWLQKNKDP
610 620 630 640 650
LNETVVDLYK KSSLKLLSNL FANYAGADTP VEKGKGKAKK GSSFQTVSAL
660 670 680 690 700
HRENLNKLMT NLRSTHPHFV RCIIPNETKS PGVIDNPLVM HQLRCNGVLE
710 720 730 740 750
GIRICRKGFP NRILYGDFRQ RYRILNPAAI PEGQFIDSRK GAEKLLGSLD
760 770 780 790 800
IDHNQYKFGH TKVFFKAGLL GLLEEMRDER LSRIITRIQA QSRGVLSRME
810 820 830 840 850
FKKLLERRDS LLIIQWNIRA FMSVKNWPWM KLYFKIKPLL KSAETEKEMA
860 870 880 890 900
TMKEEFGRLK EALEKSEARR KELEEKMVSL LQEKNDLQLQ VQAEQDNLAD
910 920 930 940 950
AEERCDQLIK NKIQLEAKVK EMTERLEDEE EMNAELTAKK RKLEDECSEL
960 970 980 990 1000
KRDIDDLELT LAKVEKEKHA TENKVKNLTE EMAGLDEIIA KLTKEKKALQ
1010 1020 1030 1040 1050
EAHQQALDDL QAEEDKVNTL TKAKVKLEQH VDDLEGSLEQ EKKVRMDLER
1060 1070 1080 1090 1100
AKRKLEGDLK LTQESIMDLE NDKQQLDERL KKKDFELNAL NARIEDEQAL
1110 1120 1130 1140 1150
GSQLQKKLKE LQARIEELEE ELEAERTARA KVEKLRSDLS RELEEISERL
1160 1170 1180 1190 1200
EEAGGATSVQ IEMNKKREAE FQKMRRDLEE ATLQHEATAA ALRKKHADSV
1210 1220 1230 1240 1250
AELGEQIDNL QRVKQKLEKE KSEFKLELDD VTSNMEQIIK AKANLEKMCR
1260 1270 1280 1290 1300
TLEDQMNEHR SKAEETQRSV NDLTSQRAKL QTENGELSRQ LDEKEALISQ
1310 1320 1330 1340 1350
LTRGKLTYTQ QLEDLKRQLE EEVKAKNALA HALQSARHDC DLLREQYEEE
1360 1370 1380 1390 1400
TEAKAELQRV LSKANSEVAQ WRTKYETDAI QRTEELEEAK KKLAQRLQDA
1410 1420 1430 1440 1450
EEAVEAVNAK CSSLEKTKHR LQNEIEDLMV DVERSNAAAA ALDKKQRNFD
1460 1470 1480 1490 1500
KILAEWKQKY EESQSELESS QKEARSLSTE LFKLKNAYEE SLEHLETFKR
1510 1520 1530 1540 1550
ENKNLQEEIS DLTEQLGSSG KTIHELEKVR KQLEAEKLEL QSALEEAEAS
1560 1570 1580 1590 1600
LEHEEGKILR AQLEFNQIKA EMERKLAEKD EEMEQAKRNH LRVVDSLQTS
1610 1620 1630 1640 1650
LDAETRSRNE ALRVKKKMEG DLNEMEIQLS HANRMAAEAQ KQVKSLQSLL
1660 1670 1680 1690 1700
KDTQIQLDDA VRANDDLKEN IAIVERRNNL LQAELEELRA VVEQTERSRK
1710 1720 1730 1740 1750
LAEQELIETS ERVQLLHSQN TSLINQKKKM EADLSQLQTE VEEAVQECRN
1760 1770 1780 1790 1800
AEEKAKKAIT DAAMMAEELK KEQDTSAHLE RMKKNMEQTI KDLQHRLDEA
1810 1820 1830 1840 1850
EQIALKGGKK QLQKLEARVR ELENELEAEQ KRNAESVKGM RKSERRIKEL
1860 1870 1880 1890 1900
TYQTEEDRKN LLRLQDLVDK LQLKVKAYKR QAEEAEEQAN TNLSKFRKVQ
1910 1920 1930
HELDEAEERA DIAESQVNKL RAKSRDIGTK GLNEE
Length:1,935
Mass (Da):223,298
Last modified:February 6, 2007 - v2
Checksum:i270556D9A3E86C4A
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286ZXE3A0A286ZXE3_PIG
Myosin-7
LOC100736765
1,939Annotation score:
K7GMH0K7GMH0_PIG
Myosin-7
LOC100736765
1,937Annotation score:
A0A286ZPX6A0A286ZPX6_PIG
Myosin-7
LOC100736765
1,892Annotation score:
A0A287AGU3A0A287AGU3_PIG
Myosin-7
LOC100736765
1,937Annotation score:
A0A286ZPQ9A0A286ZPQ9_PIG
Myosin-7
LOC100736765
1,937Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149E → D in AAB37320 (Ref. 1) Curated1
Sequence conflicti841K → E in AAB37320 (Ref. 1) Curated1
Sequence conflicti899 – 901ADA → SDS in AAB37320 (Ref. 1) Curated3
Sequence conflicti942 – 943KL → NV in AAB37320 (Ref. 1) Curated2
Sequence conflicti1035E → A in AAB37320 (Ref. 1) Curated1
Sequence conflicti1339 – 1340DC → AA in AAB37320 (Ref. 1) Curated2
Sequence conflicti1353A → T in AAB37320 (Ref. 1) Curated1
Sequence conflicti1498F → S in AAB37320 (Ref. 1) Curated1
Sequence conflicti1547A → S in AAB37320 (Ref. 1) Curated1
Sequence conflicti1748C → S in AAB37320 (Ref. 1) Curated1
Sequence conflicti1879K → N in AAB37320 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75316 mRNA Translation: AAB37320.1
AB053226 mRNA Translation: BAB20630.1
PIRiA59286
RefSeqiNP_999020.1, NM_213855.1
UniGeneiSsc.1544

Genome annotation databases

EnsembliENSSSCT00000002271; ENSSSCP00000002219; ENSSSCG00000002029
GeneIDi396860
KEGGissc:396860

Similar proteinsi

Entry informationi

Entry nameiMYH7_PIG
AccessioniPrimary (citable) accession number: P79293
Secondary accession number(s): Q9GKR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 6, 2007
Last modified: September 12, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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