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Protein

Krueppel-like factor 9

Gene

KLF9

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri143 – 167C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri173 – 197C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri203 – 225C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 9
Alternative name(s):
Basic transcription element-binding protein 1
Short name:
BTE-binding protein 1
GC-box-binding protein 1
Transcription factor BTEB1
Gene namesi
Name:KLF9
Synonyms:BTEB, BTEB1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471561 – 244Krueppel-like factor 9Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP79288
PRIDEiP79288

Expressioni

Gene expression databases

BgeeiENSSSCG00000021646
GenevisibleiP79288 SS

Interactioni

Protein-protein interaction databases

IntActiP79288, 1 interactor
STRINGi9823.ENSSSCP00000023475

Structurei

3D structure databases

ProteinModelPortaliP79288
SMRiP79288
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi84 – 116Asp/Glu-rich (acidic)Add BLAST33

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri143 – 167C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri173 – 197C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri203 – 225C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000233575
HOVERGENiHBG050746
InParanoidiP79288
KOiK09208
OMAiDAWKDYC
OrthoDBiEOG091G1BN0
TreeFamiTF351003

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

P79288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAAYMDFV AAQCLVSISN RAAVPEHGGA PDAERLRLPE REVTKEHGDP
60 70 80 90 100
GDTWKDYCTL VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDMGSDSDVT
110 120 130 140 150
TESGSSPSHS PEERQDPGSA PSPLSLLHPG VAAKGKHASE KRHKCPYSGC
160 170 180 190 200
GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC LKKFSRSDEL TRHYRTHTGE
210 220 230 240
KQFRCPLCEK RFMRSDHLTK HARRHTEFHP SMIKRSKKAL ANPL
Length:244
Mass (Da):27,219
Last modified:June 12, 2007 - v3
Checksum:i771B4BFAA3C5833C
GO

Sequence cautioni

The sequence AAC48767 differs from that shown. Reason: Frameshift at position 119.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24Missing in AAC48767 (PubMed:9314570).Curated1
Sequence conflicti29G → V in AAC48767 (PubMed:9314570).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY850383 mRNA Translation: AAW34126.1
U57346 mRNA Translation: AAC48767.1 Frameshift.
RefSeqiNP_001011504.1, NM_001011504.1
UniGeneiSsc.16104
Ssc.86968
Ssc.97575

Genome annotation databases

GeneIDi494562
KEGGissc:494562

Similar proteinsi

Entry informationi

Entry nameiKLF9_PIG
AccessioniPrimary (citable) accession number: P79288
Secondary accession number(s): Q5I6A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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