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Protein

Kit ligand

Gene

KITLG

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Kit ligand
Alternative name(s):
Mast cell growth factor
Short name:
MGF
Stem cell factor
Short name:
SCF
c-Kit ligand
Cleaved into the following chain:
Soluble KIT ligand
Short name:
sKITLG
Gene namesi
Name:KITLG
Synonyms:SCF
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 215ExtracellularSequence analysisAdd BLAST190
Transmembranei216 – 238HelicalSequence analysisAdd BLAST23
Topological domaini239 – 274CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003191126 – 274Kit ligandAdd BLAST249
ChainiPRO_000040338926 – 191Soluble KIT ligandBy similarityAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 114By similarity
Disulfide bondi68 ↔ 164By similarity
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP79169

Interactioni

Subunit structurei

Homodimer, non-covalently linked.Curated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000020444

Structurei

3D structure databases

ProteinModelPortaliP79169
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SCF family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3Y Eukaryota
ENOG410XYQR LUCA
HOVERGENiHBG036146
InParanoidiP79169
KOiK05461

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003452 SCF
PANTHERiPTHR11574 PTHR11574, 1 hit
PfamiView protein in Pfam
PF02404 SCF, 1 hit
PIRSFiPIRSF015599 SCF, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P79169-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKTQTWIVT CIYLQLLLFN PLVKTKGLCR NRVTDDVKDV TKLVANLPKD
60 70 80 90 100
YKIALKYVPG MDVLPSHCWI SVMVEQLSVS LTDLLDKFSN ISEGLSNYSI
110 120 130 140 150
IDKLVKIVDD LVECVEGHSS ENVKKSSKSP EPRLFTPEEF FRIFNRSIDA
160 170 180 190 200
FKDLEMVASK TSECVVSSTL SPEKDSRVSV TKPFMLPPVA ASSLRNDSSS
210 220 230 240 250
SNRKATNPIE DSSIQWAVMA LPACFSLVIG FAFGAFYWKK KQPNLTRTVE
260 270
NIQINEEDNE ISMLQEKERE FQEV
Length:274
Mass (Da):30,988
Last modified:May 1, 1997 - v1
Checksum:iC5B78DB4791237BE
GO
Isoform 2 (identifier: P79169-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-203: DSRVSVTKPFMLPPVAASSLRNDSSSSNR → G

Show »
Length:246
Mass (Da):27,956
Checksum:i1484E5DCB8A7F9A5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006021175 – 203DSRVS…SSSNR → G in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50833 mRNA Translation: BAA09445.1
RefSeqiNP_001009343.1, NM_001009343.1 [P79169-1]

Genome annotation databases

GeneIDi493937
KEGGifca:493937

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSCF_FELCA
AccessioniPrimary (citable) accession number: P79169
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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