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UniProtKB - P79102 (CP3AS_BOVIN)
Protein
Cytochrome P450 3A28
Gene
CYP3A28
Organism
Bos taurus (Bovine)
Status
Functioni
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]EC:1.14.14.1
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 442 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- aromatase activity Source: UniProtKB-EC
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- steroid hydroxylase activity Source: GO_Central
- testosterone 6-beta-hydroxylase activity Source: GO_Central
GO - Biological processi
- oxidative demethylation Source: GO_Central
- steroid metabolic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CYP3A28 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051807 | 1 – 507 | Cytochrome P450 3A28Add BLAST | 507 |
Proteomic databases
PaxDbi | P79102 |
PeptideAtlasi | P79102 |
Expressioni
Inductioni
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
InParanoidi | P79102 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
P79102-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELIPSFSME TWVLLATSLV LLYIYGTYSY GLFKKLGIPG PRPVPYFGST
60 70 80 90 100
MAYHKGIPEF DNQCFKKYGK MWGFYEGRQP MLAITDPDII KTVLVKECYS
110 120 130 140 150
VFTNRRIFGP MGIMKYAISL AWDEQWKRIR TLLSPAFTSG KLKEMFPIIG
160 170 180 190 200
QYGDMLVRNL RKEAEKGNPV NMKDMFGAYS MDVITGTAFG VNIDSLNNPH
210 220 230 240 250
DPFVEHSKNL LRFRPFDPFI LSIILFPFLN PVFEILNITL FPKSTVDFFT
260 270 280 290 300
KSVKKIKESR LTDKQMNRVD LLQLMINSQN SKEIDNHKAL SDIELVAQST
310 320 330 340 350
IFIFGGYETT SSTLSFIIYE LTTHPHVQQK LQEEIDATFP NKAPPTYDAL
360 370 380 390 400
VQMEYLDMVV NETLRMFPIA GRLERVCKKD VEIHGVTIPK GTTVLVPLFV
410 420 430 440 450
LHNNPELWPE PEEFRPERFS KNNKDSINPY VYLPFGTGPR NCLGMRFAIM
460 470 480 490 500
NIKLALVRIL QNFSFKPCKE TQIPLKLYTQ GLTQPEQPVI LKVVPRGLGP
QVEPDFL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y10214 mRNA Translation: CAA71266.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y10214 mRNA Translation: CAA71266.1 |
3D structure databases
SMRi | P79102 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000016177 |
Proteomic databases
PaxDbi | P79102 |
PeptideAtlasi | P79102 |
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
InParanoidi | P79102 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP3AS_BOVIN | |
Accessioni | P79102Primary (citable) accession number: P79102 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 1, 1997 | |
Last modified: | September 29, 2021 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families