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Entry version 140 (02 Jun 2021)
Sequence version 1 (01 May 1997)
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Protein

Protein transport protein sec61 subunit alpha

Gene

sec61

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to sec62/63 complex, secretory precursor polypeptides may engage sec61 to begin membrane penetration event. A cycle of assembly and disassembly of sec62/63 from sec61 may govern the activity of the translocase (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Translocation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein sec61 subunit alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sec61
ORF Names:SPBC354.02c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC354.02c, sec61

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC354.02c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 76LumenalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 119CytoplasmicSequence analysisAdd BLAST22
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 146LumenalSequence analysis6
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 245CytoplasmicSequence analysisAdd BLAST78
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 354LumenalSequence analysisAdd BLAST88
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 415CytoplasmicSequence analysisAdd BLAST40
Transmembranei416 – 434HelicalSequence analysisAdd BLAST19
Topological domaini435 – 440LumenalSequence analysis6
Transmembranei441 – 458HelicalSequence analysisAdd BLAST18
Topological domaini459 – 479CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001317871 – 479Protein transport protein sec61 subunit alphaAdd BLAST479

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P79088

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P79088

PRoteomics IDEntifications database

More...
PRIDEi
P79088

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P79088

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P79088

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
277552, 3 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC354.02c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P79088

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1373, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_031763_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P79088

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWGIGSG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P79088

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3370.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002208, SecY/SEC61-alpha
IPR030659, SecY_CS
IPR023201, SecY_dom_sf
IPR019561, Translocon_Sec61/SecY_plug_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10906, PTHR10906, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10559, Plug_translocon, 1 hit
PF00344, SecY, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004557, SecY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103491, SSF103491, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00967, 3a0501s007, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00755, SECY_1, 1 hit
PS00756, SECY_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P79088-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDLRFLDLV KPFAPFLPEI AAPERKVPFK QKMLWTGVTL LIFLVMSQVP
60 70 80 90 100
LYGIVSSDSS DPLLWLRMIL AANRGTLMEL GISPIVTSSM LVQLLVGSQL
110 120 130 140 150
IEVNMELKSD REMYQLVQKF LAIIIAFGQA TAYVLTGMYG RPQDLGAGIC
160 170 180 190 200
LLLILQLAAA SLIVLLLDEL LQKGYGLGSG ISLFIATINC ENIFWKAFSP
210 220 230 240 250
TTYHIANGVQ FEGAVINFVY VMFTWDNKAA ALYQAFFRSG LTSSQIQLPN
260 270 280 290 300
LWNFFATLLV FGVVIYLQDF RVEIPIRSQK FRGYRSTFPV KLLYTSNTPI
310 320 330 340 350
MLQSALTSNL FFASRLLFNR FSSNFLVRFL GVWEQTATSG LSYYLSPPAS
360 370 380 390 400
FQDALIDPIH TLVYVFFTMF ACALFSKLWI EVSGASPRDV AKQLKSQQLV
410 420 430 440 450
MAGHREGSMY KELKRIIPTA AWLSGAVVGA LAVASDLLGA LGSGTAVLLC
460 470
TTTIYGYYEQ LQKEIKGDQY GLPVTPMMQ
Length:479
Mass (Da):53,254
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36E3F08E2CFD9868
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y11376 mRNA Translation: CAA72200.1
Y11375 Genomic DNA Translation: CAA72199.1
CU329671 Genomic DNA Translation: CAA17802.1
AB027782 Genomic DNA Translation: BAA87086.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40282

NCBI Reference Sequences

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RefSeqi
NP_595226.1, NM_001021132.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC354.02c.1; SPBC354.02c.1:pep; SPBC354.02c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541037

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC354.02c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11376 mRNA Translation: CAA72200.1
Y11375 Genomic DNA Translation: CAA72199.1
CU329671 Genomic DNA Translation: CAA17802.1
AB027782 Genomic DNA Translation: BAA87086.1
PIRiT40282
RefSeqiNP_595226.1, NM_001021132.2

3D structure databases

SMRiP79088
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi277552, 3 interactors
STRINGi4896.SPBC354.02c.1

PTM databases

iPTMnetiP79088
SwissPalmiP79088

Proteomic databases

MaxQBiP79088
PaxDbiP79088
PRIDEiP79088

Genome annotation databases

EnsemblFungiiSPBC354.02c.1; SPBC354.02c.1:pep; SPBC354.02c
GeneIDi2541037
KEGGispo:SPBC354.02c

Organism-specific databases

PomBaseiSPBC354.02c, sec61
VEuPathDBiFungiDB:SPBC354.02c

Phylogenomic databases

eggNOGiKOG1373, Eukaryota
HOGENOMiCLU_031763_2_1_1
InParanoidiP79088
OMAiKWGIGSG
PhylomeDBiP79088

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P79088

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
InterProiView protein in InterPro
IPR002208, SecY/SEC61-alpha
IPR030659, SecY_CS
IPR023201, SecY_dom_sf
IPR019561, Translocon_Sec61/SecY_plug_dom
PANTHERiPTHR10906, PTHR10906, 1 hit
PfamiView protein in Pfam
PF10559, Plug_translocon, 1 hit
PF00344, SecY, 1 hit
PIRSFiPIRSF004557, SecY, 1 hit
SUPFAMiSSF103491, SSF103491, 1 hit
TIGRFAMsiTIGR00967, 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755, SECY_1, 1 hit
PS00756, SECY_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC61A_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P79088
Secondary accession number(s): Q9UU67
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 2, 2021
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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