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Protein

Lysophospholipase 1

Gene

plb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Required for survival under high osmolarity, for normal osmotic stress-induced gene expression, and for nutrient-mediated repression of sexual differentiation.1 Publication

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

  • cellular response to osmotic stress Source: PomBase
  • conjugation with cellular fusion Source: PomBase
  • phospholipid catabolic process Source: InterPro
  • response to osmotic stress Source: UniProtKB

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 1 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 1
Gene namesi
Name:plb1
ORF Names:SPAC1A6.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1A6.04c
PomBaseiSPAC1A6.04c plb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002464022 – 613Lysophospholipase 1Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi494N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi551N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP78854
PaxDbiP78854
PRIDEiP78854

PTM databases

iPTMnetiP78854

Interactioni

Protein-protein interaction databases

BioGridi278956, 105 interactors
DIPiDIP-59118N
IntActiP78854, 1 interactor
STRINGi4896.SPAC1A6.04c.1

Structurei

3D structure databases

ProteinModelPortaliP78854
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 593PLA2cPROSITE-ProRule annotationAdd BLAST539

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi396 – 399Poly-Ser4

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189547
InParanoidiP78854
KOiK13333
OMAiQTEQCKK
OrthoDBiEOG092C2IZ9
PhylomeDBiP78854

Family and domain databases

InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR002642 LysoPLipase_cat_dom
PfamiView protein in Pfam
PF01735 PLA2_B, 1 hit
SMARTiView protein in SMART
SM00022 PLAc, 1 hit
SUPFAMiSSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS51210 PLA2C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P78854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFRGLSLWM LFLASCLSAL ALPAAEDDGS VKVFKRAKKH STKQEGPSYA
60 70 80 90 100
PYYVDCPSDN IVESLSSNEI PSAESEYLST RSTITNTAMK DFLRNANLPG
110 120 130 140 150
LNADTLSGSE GPSIGIALSG GGLRAMILGS GALSAMDARH DNHTVLTGLL
160 170 180 190 200
QASDYLVGTD GSAWTVGGIA LNNFSTINDF SKLWAFNHPL MYPKSAIVFN
210 220 230 240 250
AHFYSSIMNE VAEKANAGFN ISLSDYWGRV ISRTLGDTTY GFPNVSLSSI
260 270 280 290 300
TSQEWYRNAN FPYPIITFAT QNYGEDISNV NTTFFEASPN VFGTFDHGIN
310 320 330 340 350
SFIPTEYLGT TLNNGASSNG SCVINYDNFG FMMGASSTYF NKIMRNFNDS
360 370 380 390 400
STKNGRIIQQ YLKGNFSENG QQIISIPNPF QGVESANSDA ANNLGSSSSL
410 420 430 440 450
NLVDTFLTGE KIPLWPLLQK GRDVDVIVAV DNGDDSEWLW PNGNSLVQTY
460 470 480 490 500
ERVVAAQAAG NTNVKGFPYV PSQQSFVSLH FNDRPVFFGC DGRNTTAGNH
510 520 530 540 550
TVTRDTPPLV IYLPNVPYNY FTNISTDRTY YTEDMIQQLL TNGLISSTVD
560 570 580 590 600
NDTYFGQCFA CAVVKRTLER NNITASPECQ QCYYNYCWSG LYDDSAANDD
610
IVYNPTCRLG EGI
Length:613
Mass (Da):67,119
Last modified:November 1, 1998 - v2
Checksum:iEE7C8B5D78A8FFFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY235223 mRNA Translation: AAO46159.1
CU329670 Genomic DNA Translation: CAB16354.1
AB005603 mRNA Translation: BAA21498.1
D89204 mRNA Translation: BAA13865.1
PIRiT38007
RefSeqiNP_593196.1, NM_001018592.2

Genome annotation databases

EnsemblFungiiSPAC1A6.04c.1; SPAC1A6.04c.1:pep; SPAC1A6.04c
GeneIDi2542497
KEGGispo:SPAC1A6.04c

Similar proteinsi

Entry informationi

Entry nameiPLB1_SCHPO
AccessioniPrimary (citable) accession number: P78854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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