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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

SPBC660.16

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable glucose-6-phosphate 1-dehydrogenase C7.13c (SPAC3C7.13c), Probable glucose-6-phosphate 1-dehydrogenase C794.01c (SPCC794.01c), Glucose-6-phosphate 1-dehydrogenase (zwf1)
  2. Probable 6-phosphogluconolactonase (SPCC16C4.10)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (SPBC660.16)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106NADPBy similarity1
Binding sitei106SubstrateBy similarity1
Active sitei187Proton acceptorBy similarity1
Active sitei194Proton donorBy similarity1
Binding sitei195SubstrateBy similarity1
Binding sitei264Substrate; via amide nitrogenBy similarity1
Binding sitei291SubstrateBy similarity1
Binding sitei449Substrate; shared with dimeric partnerBy similarity1
Binding sitei455Substrate; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 18NADPBy similarity6
Nucleotide bindingi36 – 38NADPBy similarity3
Nucleotide bindingi78 – 80NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGluconate utilization, Pentose shunt
LigandNADP

Enzyme and pathway databases

ReactomeiR-SPO-71336 Pentose phosphate pathway
UniPathwayi
UPA00115;UER00410

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
ORF Names:SPBC660.16
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC660.16
PomBaseiSPBC660.16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000900741 – 4926-phosphogluconate dehydrogenase, decarboxylatingAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107Phosphoserine1 Publication1
Modified residuei215Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP78812
PaxDbiP78812
PRIDEiP78812

PTM databases

iPTMnetiP78812

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi277661, 4 interactors
STRINGi4896.SPBC660.16.1

Structurei

3D structure databases

ProteinModelPortaliP78812
SMRiP78812
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni132 – 134Substrate bindingBy similarity3
Regioni190 – 191Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000255147
InParanoidiP78812
KOiK00033
OMAiEGEPCVT
OrthoDBiEOG092C1NQM
PhylomeDBiP78812

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR006184 6PGdom_BS
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
PANTHERiPTHR11811 PTHR11811, 1 hit
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000109 6PGD, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit
PROSITEiView protein in PROSITE
PS00461 6PGD, 1 hit

Sequencei

Sequence statusi: Complete.

P78812-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQKEVADFG LIGLAVMGQN LILNGADKGF TVCCYNRTTS RVDEFLANEA
60 70 80 90 100
KGKSIVGAHS LEEFVSKLKK PRVCILLVKA GKPVDYLIEG LAPLLEKGDI
110 120 130 140 150
IVDGGNSHYP DTTRRCEELA KKGILFVGSG VSGGEEGARY GPSLMPGGNP
160 170 180 190 200
AAWPRIKPIF QTLAAKAGNN EPCCDWVGEQ GAGHYVKMVH NGIEYGDMQL
210 220 230 240 250
ICETYDIMKR GLGMSCDEIA DVFEKWNTGK LDSFLIEITR DVLRYKADDG
260 270 280 290 300
KPLVEKILDA AGQKGTGKWT AQNALEMGTP VSLITEAVFA RCLSSLKSER
310 320 330 340 350
VRASKKLTGP NTKFTGDKKQ LIDDLEDALY ASKIISYAQG FMLMREAAKE
360 370 380 390 400
YGWKLNNAGI ALMWRGGCII RSVFLKDITE AFREDPNLES ILFHPFFTNG
410 420 430 440 450
VEKAQAGWRR VVAQAAMLGI PVPATSTGLS FYDGYRSAVL PANLLQAQRD
460 470 480 490
YFGAHTFRVL PEAADKSLPA DKDIHINWTG HGGNISATTY DA
Length:492
Mass (Da):53,680
Last modified:January 11, 2001 - v2
Checksum:iF55F342957A9D3E1
GO

Sequence cautioni

The sequence BAA13823 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219 – 220IA → ST in BAA13823 (PubMed:9501991).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89161 mRNA Translation: BAA13823.1 Different initiation.
CU329671 Genomic DNA Translation: CAA22536.1
PIRiT40628
T42523
RefSeqiNP_595095.1, NM_001021002.2

Genome annotation databases

EnsemblFungiiSPBC660.16.1; SPBC660.16.1:pep; SPBC660.16
GeneIDi2541146
KEGGispo:SPBC660.16

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89161 mRNA Translation: BAA13823.1 Different initiation.
CU329671 Genomic DNA Translation: CAA22536.1
PIRiT40628
T42523
RefSeqiNP_595095.1, NM_001021002.2

3D structure databases

ProteinModelPortaliP78812
SMRiP78812
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277661, 4 interactors
STRINGi4896.SPBC660.16.1

PTM databases

iPTMnetiP78812

Proteomic databases

MaxQBiP78812
PaxDbiP78812
PRIDEiP78812

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC660.16.1; SPBC660.16.1:pep; SPBC660.16
GeneIDi2541146
KEGGispo:SPBC660.16

Organism-specific databases

EuPathDBiFungiDB:SPBC660.16
PomBaseiSPBC660.16

Phylogenomic databases

HOGENOMiHOG000255147
InParanoidiP78812
KOiK00033
OMAiEGEPCVT
OrthoDBiEOG092C1NQM
PhylomeDBiP78812

Enzyme and pathway databases

UniPathwayi
UPA00115;UER00410

ReactomeiR-SPO-71336 Pentose phosphate pathway

Miscellaneous databases

PROiPR:P78812

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR006184 6PGdom_BS
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
PANTHERiPTHR11811 PTHR11811, 1 hit
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000109 6PGD, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit
PROSITEiView protein in PROSITE
PS00461 6PGD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei6PGD_SCHPO
AccessioniPrimary (citable) accession number: P78812
Secondary accession number(s): Q9UQW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 11, 2001
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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