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Entry version 125 (29 Sep 2021)
Sequence version 2 (01 May 2000)
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Protein

5'-AMP-activated protein kinase subunit beta

Gene

amk2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Beta subunit of AMP-activated protein kinase (AMPK), which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the AMPK kinase complex.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi250 – 252ADP; shared with subunit gammaCombined sources3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-1632852, Macroautophagy
R-SPO-163680, AMPK inhibits chREBP transcriptional activation activity
R-SPO-200425, Carnitine metabolism
R-SPO-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-SPO-5628897, TP53 Regulates Metabolic Genes

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM48, Carbohydrate-Binding Module Family 48

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-AMP-activated protein kinase subunit beta
Short name:
AMPK subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:amk2
ORF Names:SPCC1919.03cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPCC1919.03c, amk2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPCC1919.03c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003391251 – 2985'-AMP-activated protein kinase subunit betaAdd BLAST298

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P78789

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P78789

PRoteomics IDEntifications database

More...
PRIDEi
P78789

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P78789

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P78789

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

AMPK is a heterotrimer of an alpha catalytic subunit (ssp2), a beta (amk2) and a gamma non-catalytic subunits (cbs2). The beta subunit serves as a bridge between the catalytic and the regulatory subunit.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
275702, 631 interactors

Database of interacting proteins

More...
DIPi
DIP-29521N

Protein interaction database and analysis system

More...
IntActi
P78789, 2 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC1919.03c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P78789

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P78789

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 98DisorderedSequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 36Polar residuesSequence analysisAdd BLAST36
Compositional biasi55 – 81Polar residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1616, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_070949_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P78789

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPHKPWE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P78789

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032640, AMPK1_CBM
IPR006828, ASC_dom
IPR037256, ASC_dom_sf
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR030077, SIP2/GAL83

The PANTHER Classification System

More...
PANTHERi
PTHR10343:SF84, PTHR10343:SF84, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16561, AMPK1_CBM, 1 hit
PF04739, AMPKBI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01010, AMPKBI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160219, SSF160219, 1 hit
SSF81296, SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P78789-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNVQSQEGE TRAHAVPSQD ATTTPDNANN VPKEPRAQSM ISIAADDLNQ
60 70 80 90 100
EGEMSDDNQQ EGGNNRTSQN GTSGSSGHTK RRSQTSGKKT HQPYSGPCVP
110 120 130 140 150
TIIRWRGGGE VVYVTGSFSR WKKKIQLLKS EDYTVLLQLR PGTQRFKFLV
160 170 180 190 200
DGIWCCSSDF PTATDAEGNL YNYLEVEANE KLGASIDERL SQVHTDLPME
210 220 230 240 250
EKSESEQYST EIPAFLTSNT LQELKLPKPP SLPPHLEKCI LNSNTAYKED
260 270 280 290
QSVLPNPNHV LLNHLAAANT QLGVLALSAT TRYHRKYVTT AMFKNFDV
Length:298
Mass (Da):32,970
Last modified:May 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9D5A078C166E730
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13800 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D89138 mRNA Translation: BAA13800.1 Different initiation.
CU329672 Genomic DNA Translation: CAA22634.1
AB027823 Genomic DNA Translation: BAA87127.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T41228
T42415

NCBI Reference Sequences

More...
RefSeqi
NP_588485.1, NM_001023476.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC1919.03c.1; SPCC1919.03c.1:pep; SPCC1919.03c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539130

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC1919.03c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89138 mRNA Translation: BAA13800.1 Different initiation.
CU329672 Genomic DNA Translation: CAA22634.1
AB027823 Genomic DNA Translation: BAA87127.1
PIRiT41228
T42415
RefSeqiNP_588485.1, NM_001023476.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OOXX-ray2.60B/D203-298[»]
2OOYX-ray2.88B/D203-298[»]
2QR1X-ray2.70B/D203-298[»]
2QRCX-ray2.70B/D203-298[»]
2QRDX-ray2.41B/D203-298[»]
2QREX-ray3.01B/D203-298[»]
SMRiP78789
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi275702, 631 interactors
DIPiDIP-29521N
IntActiP78789, 2 interactors
STRINGi4896.SPCC1919.03c.1

Protein family/group databases

CAZyiCBM48, Carbohydrate-Binding Module Family 48

PTM databases

iPTMnetiP78789
SwissPalmiP78789

Proteomic databases

MaxQBiP78789
PaxDbiP78789
PRIDEiP78789

Genome annotation databases

EnsemblFungiiSPCC1919.03c.1; SPCC1919.03c.1:pep; SPCC1919.03c
GeneIDi2539130
KEGGispo:SPCC1919.03c

Organism-specific databases

PomBaseiSPCC1919.03c, amk2
VEuPathDBiFungiDB:SPCC1919.03c

Phylogenomic databases

eggNOGiKOG1616, Eukaryota
HOGENOMiCLU_070949_2_1_1
InParanoidiP78789
OMAiPPHKPWE
PhylomeDBiP78789

Enzyme and pathway databases

ReactomeiR-SPO-1632852, Macroautophagy
R-SPO-163680, AMPK inhibits chREBP transcriptional activation activity
R-SPO-200425, Carnitine metabolism
R-SPO-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-SPO-5628897, TP53 Regulates Metabolic Genes

Miscellaneous databases

EvolutionaryTraceiP78789

Protein Ontology

More...
PROi
PR:P78789

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR032640, AMPK1_CBM
IPR006828, ASC_dom
IPR037256, ASC_dom_sf
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR030077, SIP2/GAL83
PANTHERiPTHR10343:SF84, PTHR10343:SF84, 1 hit
PfamiView protein in Pfam
PF16561, AMPK1_CBM, 1 hit
PF04739, AMPKBI, 1 hit
SMARTiView protein in SMART
SM01010, AMPKBI, 1 hit
SUPFAMiSSF160219, SSF160219, 1 hit
SSF81296, SSF81296, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAAKB_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78789
Secondary accession number(s): Q1L851, Q9UU43
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 1, 2000
Last modified: September 29, 2021
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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