UniProtKB - P78789 (AAKB_SCHPO)
5'-AMP-activated protein kinase subunit beta
amk2
Functioni
Beta subunit of AMP-activated protein kinase (AMPK), which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the AMPK kinase complex.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 250 – 252 | ADP; shared with subunit gammaCombined sources | 3 |
GO - Molecular functioni
- protein kinase binding Source: GO_Central
- protein kinase regulator activity Source: PomBase
GO - Biological processi
- CAMKK-AMPK signaling cascade Source: PomBase
- induction of conjugation with cellular fusion Source: PomBase
- regulation of protein kinase activity Source: InterPro
- signal transduction Source: GO_Central
Enzyme and pathway databases
Reactomei | R-SPO-1632852, Macroautophagy R-SPO-163680, AMPK inhibits chREBP transcriptional activation activity R-SPO-200425, Carnitine metabolism R-SPO-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-SPO-5628897, TP53 Regulates Metabolic Genes |
Protein family/group databases
CAZyi | CBM48, Carbohydrate-Binding Module Family 48 |
Names & Taxonomyi
Protein namesi | Recommended name: 5'-AMP-activated protein kinase subunit betaShort name: AMPK subunit beta |
Gene namesi | Name:amk2 ORF Names:SPCC1919.03cImported |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPCC1919.03c, amk2 |
VEuPathDBi | FungiDB:SPCC1919.03c |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: PomBase
Nucleus
- nucleus Source: PomBase
Plasma Membrane
- plasma membrane Source: PomBase
Other locations
- cytoplasm Source: PomBase
- nucleotide-activated protein kinase complex Source: PomBase
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000339125 | 1 – 298 | 5'-AMP-activated protein kinase subunit betaAdd BLAST | 298 |
Proteomic databases
MaxQBi | P78789 |
PaxDbi | P78789 |
PTM databases
iPTMneti | P78789 |
SwissPalmi | P78789 |
Interactioni
Subunit structurei
AMPK is a heterotrimer of an alpha catalytic subunit (ssp2), a beta (amk2) and a gamma non-catalytic subunits (cbs2). The beta subunit serves as a bridge between the catalytic and the regulatory subunit.
By similarityGO - Molecular functioni
- protein kinase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 275702, 631 interactors |
DIPi | DIP-29521N |
IntActi | P78789, 2 interactors |
STRINGi | 4896.SPCC1919.03c.1 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P78789 |
SMRi | P78789 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P78789 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 98 | DisorderedSequence analysisAdd BLAST | 98 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 36 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 55 – 81 | Polar residuesSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1616, Eukaryota |
HOGENOMi | CLU_070949_2_1_1 |
InParanoidi | P78789 |
OMAi | PPHKPWE |
PhylomeDBi | P78789 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR032640, AMPK1_CBM IPR006828, ASC_dom IPR037256, ASC_dom_sf IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR030077, SIP2/GAL83 |
PANTHERi | PTHR10343:SF84, PTHR10343:SF84, 1 hit |
Pfami | View protein in Pfam PF16561, AMPK1_CBM, 1 hit PF04739, AMPKBI, 1 hit |
SMARTi | View protein in SMART SM01010, AMPKBI, 1 hit |
SUPFAMi | SSF160219, SSF160219, 1 hit SSF81296, SSF81296, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MGNVQSQEGE TRAHAVPSQD ATTTPDNANN VPKEPRAQSM ISIAADDLNQ
60 70 80 90 100
EGEMSDDNQQ EGGNNRTSQN GTSGSSGHTK RRSQTSGKKT HQPYSGPCVP
110 120 130 140 150
TIIRWRGGGE VVYVTGSFSR WKKKIQLLKS EDYTVLLQLR PGTQRFKFLV
160 170 180 190 200
DGIWCCSSDF PTATDAEGNL YNYLEVEANE KLGASIDERL SQVHTDLPME
210 220 230 240 250
EKSESEQYST EIPAFLTSNT LQELKLPKPP SLPPHLEKCI LNSNTAYKED
260 270 280 290
QSVLPNPNHV LLNHLAAANT QLGVLALSAT TRYHRKYVTT AMFKNFDV
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D89138 mRNA Translation: BAA13800.1 Different initiation. CU329672 Genomic DNA Translation: CAA22634.1 AB027823 Genomic DNA Translation: BAA87127.1 |
PIRi | T41228 T42415 |
RefSeqi | NP_588485.1, NM_001023476.2 |
Genome annotation databases
EnsemblFungii | SPCC1919.03c.1; SPCC1919.03c.1:pep; SPCC1919.03c |
GeneIDi | 2539130 |
KEGGi | spo:SPCC1919.03c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D89138 mRNA Translation: BAA13800.1 Different initiation. CU329672 Genomic DNA Translation: CAA22634.1 AB027823 Genomic DNA Translation: BAA87127.1 |
PIRi | T41228 T42415 |
RefSeqi | NP_588485.1, NM_001023476.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2OOX | X-ray | 2.60 | B/D | 203-298 | [»] | |
2OOY | X-ray | 2.88 | B/D | 203-298 | [»] | |
2QR1 | X-ray | 2.70 | B/D | 203-298 | [»] | |
2QRC | X-ray | 2.70 | B/D | 203-298 | [»] | |
2QRD | X-ray | 2.41 | B/D | 203-298 | [»] | |
2QRE | X-ray | 3.01 | B/D | 203-298 | [»] | |
AlphaFoldDBi | P78789 | |||||
SMRi | P78789 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 275702, 631 interactors |
DIPi | DIP-29521N |
IntActi | P78789, 2 interactors |
STRINGi | 4896.SPCC1919.03c.1 |
Protein family/group databases
CAZyi | CBM48, Carbohydrate-Binding Module Family 48 |
PTM databases
iPTMneti | P78789 |
SwissPalmi | P78789 |
Proteomic databases
MaxQBi | P78789 |
PaxDbi | P78789 |
Genome annotation databases
EnsemblFungii | SPCC1919.03c.1; SPCC1919.03c.1:pep; SPCC1919.03c |
GeneIDi | 2539130 |
KEGGi | spo:SPCC1919.03c |
Organism-specific databases
PomBasei | SPCC1919.03c, amk2 |
VEuPathDBi | FungiDB:SPCC1919.03c |
Phylogenomic databases
eggNOGi | KOG1616, Eukaryota |
HOGENOMi | CLU_070949_2_1_1 |
InParanoidi | P78789 |
OMAi | PPHKPWE |
PhylomeDBi | P78789 |
Enzyme and pathway databases
Reactomei | R-SPO-1632852, Macroautophagy R-SPO-163680, AMPK inhibits chREBP transcriptional activation activity R-SPO-200425, Carnitine metabolism R-SPO-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-SPO-5628897, TP53 Regulates Metabolic Genes |
Miscellaneous databases
EvolutionaryTracei | P78789 |
PROi | PR:P78789 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR032640, AMPK1_CBM IPR006828, ASC_dom IPR037256, ASC_dom_sf IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR030077, SIP2/GAL83 |
PANTHERi | PTHR10343:SF84, PTHR10343:SF84, 1 hit |
Pfami | View protein in Pfam PF16561, AMPK1_CBM, 1 hit PF04739, AMPKBI, 1 hit |
SMARTi | View protein in SMART SM01010, AMPKBI, 1 hit |
SUPFAMi | SSF160219, SSF160219, 1 hit SSF81296, SSF81296, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AAKB_SCHPO | |
Accessioni | P78789Primary (citable) accession number: P78789 Secondary accession number(s): Q1L851, Q9UU43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families