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UniProtKB - P78746 (CHSD_ASPFU)
Protein
Chitin synthase D
Gene
chsD
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Functioni
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
CuratedCatalytic activityi
- [(1→4)-N-acetyl-β-D-glucosaminyl](n) + UDP-N-acetyl-α-D-glucosamine = [(1→4)-N-acetyl-β-D-glucosaminyl](n+1) + H+ + UDPEC:2.4.1.16
GO - Molecular functioni
- chitin synthase activity Source: GO_Central
GO - Biological processi
- cell wall organization Source: UniProtKB-KW
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Cell wall biogenesis/degradation |
Protein family/group databases
CAZyi | GT2, Glycosyltransferase Family 2 |
Names & Taxonomyi
Protein namesi | Recommended name: Chitin synthase D (EC:2.4.1.16)Alternative name(s): Chitin-UDP acetyl-glucosaminyl transferase D Class-VI chitin synthase D |
Gene namesi | Name:chsD ORF Names:AfA5C5.045, AFUA_1G12600 |
Organismi | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
Taxonomic identifieri | 330879 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Fumigati › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell periphery Source: GO_Central
- cell septum Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 26 – 46 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 55 – 75 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 412 – 432 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 434 – 454 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 464 – 484 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193681 | 1 – 745 | Chitin synthase DAdd BLAST | 745 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 613 – 635 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 672 – 745 | DisorderedSequence analysisAdd BLAST | 74 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2571, Eukaryota |
HOGENOMi | CLU_012773_0_0_1 |
InParanoidi | P78746 |
OrthoDBi | 240304at2759 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR004835, Chitin_synth IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR22914, PTHR22914, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
P78746-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIVLFTLLRW APISPVFSMR TMHANLAHRG IFLPVMIVTL PLPVHLRRRF
60 70 80 90 100
PAQMVLMLQW FAFGMFSVLL IIPWLLCVYR LVTHSPGRTK RIKQVLDDRT
110 120 130 140 150
APKTVVVMPV YKEAPETLIR AIDSVVDCDY PANCIHVFLS YDGCLIDESY
160 170 180 190 200
LRLIEHLGIP ITLESYPQSI DVTYKDARIT VSRFKHGGKR HCQKQTFRLI
210 220 230 240 250
DMVYADYLER HDNLFVLFID SDCILDRVCL QNFMYDMELK PGSKHDMLAM
260 270 280 290 300
TGVITSTTDR GSLLTLLQDM EYVHGQLFER SVESSCGAVT CLPGALTMLR
310 320 330 340 350
FSAFRKMAKY YFADKAEQCE DFFDYGKCHL GEDRWLTHLF MVGARKRYQI
360 370 380 390 400
QMCAGAFCKT EAVQTFSSLL KQRRRWFLGF ITNEVCMLTD VRLWKRYPLL
410 420 430 440 450
CLVRFMQNTI RTTALLFFII ALSLITTSSS INDLPVGFIA ISLGLNYVLM
460 470 480 490 500
FYLGAKLKRY KAWLFPLMFI LNPFFNWLYM VYGILTAGQR TWGGPRADAA
510 520 530 540 550
TADEHTSPEE AVELAKAQGD ELNVDLTTFR SRGDEKSVPI HPSEKIDGRF
560 570 580 590 600
SAPELPDGYD SNLNDSNAAL TELMTPLPSV PRIGIHTYPS SDSILTSDSL
610 620 630 640 650
SSIHLPLKVE ELTGDNDNMK PYPDRQPRDT SSLHQMQRTC SNGIVASDSC
660 670 680 690 700
SSQDDASEMV NKPEILSPSA HILPHPSQAT ESSSGEDIYP LHLPSPHQHE
710 720 730 740
AHFAPLNAST RGSMEGNTPE VQRPRRKLPG IPRPIRAQKD PESMV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 – 29 | Missing in EAL90592 (PubMed:16372009).CuratedAdd BLAST | 20 | |
Sequence conflicti | 16 – 20 | Missing in CAF31978 (PubMed:14998527).Curated | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62614 Genomic DNA Translation: AAB60781.1 BX649606 Genomic DNA Translation: CAF31978.1 AAHF01000004 Genomic DNA Translation: EAL90592.1 |
RefSeqi | XP_752630.1, XM_747537.1 |
Genome annotation databases
GeneIDi | 3510460 |
KEGGi | afm:AFUA_1G12600 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62614 Genomic DNA Translation: AAB60781.1 BX649606 Genomic DNA Translation: CAF31978.1 AAHF01000004 Genomic DNA Translation: EAL90592.1 |
RefSeqi | XP_752630.1, XM_747537.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 746128.CADAFUBP00001186 |
Protein family/group databases
CAZyi | GT2, Glycosyltransferase Family 2 |
Genome annotation databases
GeneIDi | 3510460 |
KEGGi | afm:AFUA_1G12600 |
Phylogenomic databases
eggNOGi | KOG2571, Eukaryota |
HOGENOMi | CLU_012773_0_0_1 |
InParanoidi | P78746 |
OrthoDBi | 240304at2759 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR004835, Chitin_synth IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR22914, PTHR22914, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CHSD_ASPFU | |
Accessioni | P78746Primary (citable) accession number: P78746 Secondary accession number(s): Q4WSJ0, Q6MYM5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families