UniProtKB - P78595 (CDR2_CANAL)
Protein
Multidrug resistance protein CDR2
Gene
CDR2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Functioni
Multidrug efflux transporter. Confers resistance to azole antifungal agents, to other antifungals (terbinafine, amorolfine) and to a variety of metabolic inhibitors.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 893 – 900 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- phosphatidylcholine floppase activity Source: CGD
- phosphatidylethanolamine floppase activity Source: CGD
- phosphatidylserine floppase activity Source: CGD
GO - Biological processi
- cellular response to drug Source: CGD
- xenobiotic detoxification by transmembrane export across the plasma membrane Source: CGD
Keywordsi
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Protein family/group databases
TCDBi | 3.A.1.205.5, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Multidrug resistance protein CDR2 |
Gene namesi | Name:CDR2 Ordered Locus Names:CAALFM_C304890WA ORF Names:CaO19.13379, CaO19.5958 |
Organismi | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Taxonomic identifieri | 237561 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Candida/Lodderomyces clade › Candida › |
Proteomesi |
|
Organism-specific databases
CGDi | CAL0000197349, CDR2 |
VEuPathDBi | FungiDB:C3_04890W_A |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Extracellular region or secreted
- extracellular vesicle Source: CGD
Plasma Membrane
- plasma membrane Source: CGD
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: CGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 511 | CytoplasmicSequence analysisAdd BLAST | 511 | |
Transmembranei | 512 – 532 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 546 – 566 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 596 – 616 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 621 – 641 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 660 – 680 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 763 – 783 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 784 – 1193 | CytoplasmicSequence analysisAdd BLAST | 410 | |
Transmembranei | 1194 – 1214 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1229 – 1249 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1279 – 1299 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1315 – 1335 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1354 – 1374 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1465 – 1485 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093436 | 1 – 1499 | Multidrug resistance protein CDR2Add BLAST | 1499 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 1218359, 9 interactors |
STRINGi | 5476.C4YQP2 |
Chemistry databases
BindingDBi | P78595 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 148 – 402 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 255 | |
Domaini | 857 – 1101 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 245 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0065, Eukaryota |
HOGENOMi | CLU_000604_35_0_1 |
InParanoidi | P78595 |
OMAi | HLQTTTV |
OrthoDBi | 324553at2759 |
Family and domain databases
CDDi | cd03233, ABCG_PDR_domain1, 1 hit cd03232, ABCG_PDR_domain2, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR013525, ABC_2_trans IPR029481, ABC_trans_N IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR034001, ABCG_PDR_1 IPR034003, ABCG_PDR_2 IPR005285, Drug-R_PDR/CDR IPR027417, P-loop_NTPase IPR010929, PDR_CDR_ABC |
Pfami | View protein in Pfam PF01061, ABC2_membrane, 2 hits PF00005, ABC_tran, 2 hits PF14510, ABC_trans_N, 1 hit PF06422, PDR_CDR, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
TIGRFAMsi | TIGR00956, 3a01205, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
P78595-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTANTSLSQ QLDEKPWVDA SDNSSVQEYQ GFDATASHNI QDLARKLTHG
60 70 80 90 100
STNGDHHSAN DLARYLSHMS DIPGVSPFNG NISHEQLDPD SENFNAKYWV
110 120 130 140 150
KNLKKLFESD SDYYKPSKLG VAYRNLRAYG IANDSDYQPT VTNALWKFTT
160 170 180 190 200
EAINKLKKPD DSKYFDILKS MDAIMRPGEL TVVLGRPGAG CSTLLKTIAV
210 220 230 240 250
NTYGFHIGKE SQITYDGLSP HDIERHYRGD VIYSAETDVH FPHLSVGDTL
260 270 280 290 300
EFAARLRTPQ NRGEGIDRET YAKHMASVYM ATYGLSHTRN TNVGNDFVRG
310 320 330 340 350
VSGGERKRVS IAEASLSGAN IQCWDNATRG LDSATALEFI RALKTSATIL
360 370 380 390 400
DTTPLIAIYQ CSQDAYELFD NVVVLYEGYQ IFFGKASKAK EYFENMGWKC
410 420 430 440 450
PQRQTTADFL TSLTNPAERE PLPGYEDKVP RTAQEFETFW KNSPEYAELT
460 470 480 490 500
KEIDEYFVEC ERSNTGETYR ESHVAKQSNN TRPSSPYTVS FFMQVRYVIA
510 520 530 540 550
RNFLRMKGDP SIPLISILSQ LVMGLILASV FFNLRKSTDT FYFRGGALFF
560 570 580 590 600
SVLFNAFSSL LEILSLYEAR PIVEKHRKYA LYRPSADALA SIISELPVKL
610 620 630 640 650
LMTMSFNIVY YFMVNLRRTA GNFFFYWLMC ASCTLVMSHM FRSIGAVTTT
660 670 680 690 700
IATAMSLSTV FLLAMIIYAG FVLPIPYILG WSRWIRYINP VTYIFESLMV
710 720 730 740 750
NEFHGREFEC GQYIPSGPGF ENLPVENKVC TTVGSTPGST VVQGTEYIKL
760 770 780 790 800
AYQFYSSHKW RNFGITVAFA VFFLGVYVAL TEFNKGAMQK GEIVLFLKGS
810 820 830 840 850
LKKHKRKTAA SNKGDIEAGP VAGKLDYQDE AEAVNNEKFT EKGSTGSVDF
860 870 880 890 900
PENREIFFWR DLTYQVKIKK EDRVILDHVD GWVKPGQITA LMGASGAGKT
910 920 930 940 950
TLLNCLSERV TTGIITDGER LVNGHALDSS FQRSIGYVQQ QDVHLETTTV
960 970 980 990 1000
REALQFSAYL RQSNKISKKE KDDYVDYVID LLEMTDYADA LVGVAGEGLN
1010 1020 1030 1040 1050
VEQRKRLTIG VELVAKPKLL LFLDEPTSGL DSQTAWSICK LMRKLADHGQ
1060 1070 1080 1090 1100
AILCTIHQPS ALIMAEFDKL LFLQKGGRTA YFGELGENCQ TMINYFEKYG
1110 1120 1130 1140 1150
ADPCPKEANP AEWMLQVVGA APGSHAKQDY FEVWRNSSEY QAVREEINRM
1160 1170 1180 1190 1200
EAELSKLPRD NDPEALLKYA APLWKQYLLV SWRTIVQDWR SPGYIYSKLI
1210 1220 1230 1240 1250
LVISSSLFIG FSFFKSKNNL QGLQSQMLAV FMFFVPFTTF IDQMLPYFVK
1260 1270 1280 1290 1300
HRAVYEVREA PSRTFSWFAF IAGQITSEIP FQIVVGTISY FCWYYPVGLY
1310 1320 1330 1340 1350
ANAEPTDSVN SRGVLMWMLL TAFYVYTSTM GQLAISLNEL IDNAANLATT
1360 1370 1380 1390 1400
LFTLCLMFCG VLAGPNVIPG FWIFMYRCNP FTYLIQAILS TGLANAKVTC
1410 1420 1430 1440 1450
APRELVTLKP PMGETCSSFI GPYTEAAGGY FSTNSDGTCS VCRIDSTNQF
1460 1470 1480 1490
LESINALFSQ RWRNFGIFVA FIGINIILTI FFYWLARVPK GNREKKMKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | K → N in AAB96797 (PubMed:9043118).Curated | 1 | |
Sequence conflicti | 475 | A → G in AAB96797 (PubMed:9043118).Curated | 1 | |
Sequence conflicti | 788 | M → S in AAB96797 (PubMed:9043118).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U63812 Genomic DNA Translation: AAB96797.1 CP017625 Genomic DNA Translation: AOW28505.1 |
RefSeqi | XP_723169.1, XM_718076.2 |
Genome annotation databases
GeneIDi | 3635265 |
KEGGi | cal:CAALFM_C304890WA |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U63812 Genomic DNA Translation: AAB96797.1 CP017625 Genomic DNA Translation: AOW28505.1 |
RefSeqi | XP_723169.1, XM_718076.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 1218359, 9 interactors |
STRINGi | 5476.C4YQP2 |
Chemistry databases
BindingDBi | P78595 |
ChEMBLi | CHEMBL1163105 |
Protein family/group databases
TCDBi | 3.A.1.205.5, the atp-binding cassette (abc) superfamily |
Genome annotation databases
GeneIDi | 3635265 |
KEGGi | cal:CAALFM_C304890WA |
Organism-specific databases
CGDi | CAL0000197349, CDR2 |
VEuPathDBi | FungiDB:C3_04890W_A |
Phylogenomic databases
eggNOGi | KOG0065, Eukaryota |
HOGENOMi | CLU_000604_35_0_1 |
InParanoidi | P78595 |
OMAi | HLQTTTV |
OrthoDBi | 324553at2759 |
Miscellaneous databases
PROi | PR:P78595 |
Family and domain databases
CDDi | cd03233, ABCG_PDR_domain1, 1 hit cd03232, ABCG_PDR_domain2, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR013525, ABC_2_trans IPR029481, ABC_trans_N IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR034001, ABCG_PDR_1 IPR034003, ABCG_PDR_2 IPR005285, Drug-R_PDR/CDR IPR027417, P-loop_NTPase IPR010929, PDR_CDR_ABC |
Pfami | View protein in Pfam PF01061, ABC2_membrane, 2 hits PF00005, ABC_tran, 2 hits PF14510, ABC_trans_N, 1 hit PF06422, PDR_CDR, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
TIGRFAMsi | TIGR00956, 3a01205, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDR2_CANAL | |
Accessioni | P78595Primary (citable) accession number: P78595 Secondary accession number(s): A0A1D8PK27, Q5ANE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 19, 2011 | |
Last modified: | February 10, 2021 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Candida albicans
Candida albicans: entries and gene names - SIMILARITY comments
Index of protein domains and families