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Protein

Death domain-containing protein CRADD

Gene

CRADD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.

GO - Molecular functioni

  • death domain binding Source: BHF-UCL
  • protease binding Source: BHF-UCL
  • protein binding, bridging Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
SignaLinkiP78560

Names & Taxonomyi

Protein namesi
Recommended name:
Death domain-containing protein CRADD
Alternative name(s):
Caspase and RIP adapter with death domain
RIP-associated protein with a death domain
Gene namesi
Name:CRADD
Synonyms:RAIDD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000169372.12
HGNCiHGNC:2340 CRADD
MIMi603454 gene
neXtProtiNX_P78560

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal recessive 34, with variant lissencephaly (MRT34)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.
See also OMIM:614499
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067536128G → R in MRT34. 1 PublicationCorresponds to variant dbSNP:rs387906861EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi8738
MalaCardsiCRADD
MIMi614499 phenotype
OpenTargetsiENSG00000169372
Orphaneti88616 Autosomal recessive non-syndromic intellectual disability
PharmGKBiPA26860

Polymorphism and mutation databases

BioMutaiCRADD
DMDMi2498833

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793261 – 199Death domain-containing protein CRADDAdd BLAST199

Proteomic databases

EPDiP78560
PaxDbiP78560
PeptideAtlasiP78560
PRIDEiP78560
ProteomicsDBi57654

PTM databases

iPTMnetiP78560
PhosphoSitePlusiP78560

Expressioni

Tissue specificityi

Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.

Gene expression databases

BgeeiENSG00000169372 Expressed in 211 organ(s), highest expression level in left adrenal gland
CleanExiHS_CRADD
ExpressionAtlasiP78560 baseline and differential
GenevisibleiP78560 HS

Organism-specific databases

HPAiCAB005337

Interactioni

Subunit structurei

Interacts with PIDD.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114275, 22 interactors
CORUMiP78560
IntActiP78560, 18 interactors
MINTiP78560
STRINGi9606.ENSP00000327647

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP78560
SMRiP78560
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78560

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 91CARDPROSITE-ProRule annotationAdd BLAST91
Domaini116 – 188DeathPROSITE-ProRule annotationAdd BLAST73

Domaini

Contains a death domain involved in the binding of RIP protein.
The CARD domain mediates the interaction with caspase-2.

Phylogenomic databases

eggNOGiENOG410IJAM Eukaryota
ENOG4111SYE LUCA
GeneTreeiENSGT00390000014448
HOGENOMiHOG000111965
HOVERGENiHBG051112
InParanoidiP78560
KOiK02832
OMAiLGPEWEH
OrthoDBiEOG091G0M3P
PhylomeDBiP78560
TreeFamiTF333055

Family and domain databases

CDDicd08319 Death_RAIDD, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR037939 CRADD
IPR037926 CRADD_Death
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
PANTHERiPTHR15034 PTHR15034, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF00531 Death, 1 hit
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50017 DEATH_DOMAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P78560-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG
60 70 80 90 100
LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG
110 120 130 140 150
DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA
160 170 180 190
NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE
Length:199
Mass (Da):22,745
Last modified:May 1, 1997 - v1
Checksum:i3437CC612C85E402
GO
Isoform 2 (identifier: P78560-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-199: DRLTGIPSHI...DPSLLLHMLE → CWP

Note: No experimental confirmation available.
Show »
Length:103
Mass (Da):11,826
Checksum:i04DFF4A1F09D0B56
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VVY5F8VVY5_HUMAN
Death domain-containing protein CRA...
CRADD
130Annotation score:
F5H7C2F5H7C2_HUMAN
Death domain-containing protein CRA...
CRADD
121Annotation score:
F8VV49F8VV49_HUMAN
Death domain-containing protein CRA...
CRADD
115Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067536128G → R in MRT34. 1 PublicationCorresponds to variant dbSNP:rs387906861EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056892101 – 199DRLTG…LHMLE → CWP in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84388 mRNA Translation: AAC50952.1
U79115 mRNA Translation: AAB42217.1
AK294986 mRNA Translation: BAH11941.1
AC012085 Genomic DNA No translation available.
AC012464 Genomic DNA No translation available.
AC025261 Genomic DNA No translation available.
BC017042 mRNA Translation: AAH17042.1
CCDSiCCDS9048.1 [P78560-1]
RefSeqiNP_001307028.1, NM_001320099.1 [P78560-1]
NP_001307029.1, NM_001320100.1
NP_001307030.1, NM_001320101.1
NP_003796.1, NM_003805.4 [P78560-1]
XP_016875633.1, XM_017020144.1 [P78560-2]
UniGeneiHs.38533
Hs.591016
Hs.660031
Hs.719191

Genome annotation databases

EnsembliENST00000332896; ENSP00000327647; ENSG00000169372 [P78560-1]
ENST00000542893; ENSP00000439068; ENSG00000169372 [P78560-1]
ENST00000551065; ENSP00000448425; ENSG00000169372 [P78560-2]
GeneIDi8738
KEGGihsa:8738
UCSCiuc058rts.1 human [P78560-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84388 mRNA Translation: AAC50952.1
U79115 mRNA Translation: AAB42217.1
AK294986 mRNA Translation: BAH11941.1
AC012085 Genomic DNA No translation available.
AC012464 Genomic DNA No translation available.
AC025261 Genomic DNA No translation available.
BC017042 mRNA Translation: AAH17042.1
CCDSiCCDS9048.1 [P78560-1]
RefSeqiNP_001307028.1, NM_001320099.1 [P78560-1]
NP_001307029.1, NM_001320100.1
NP_001307030.1, NM_001320101.1
NP_003796.1, NM_003805.4 [P78560-1]
XP_016875633.1, XM_017020144.1 [P78560-2]
UniGeneiHs.38533
Hs.591016
Hs.660031
Hs.719191

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O71X-ray2.00A94-199[»]
2OF5X-ray3.20A/B/C/D/E/F/G94-199[»]
3CRDNMR-A1-100[»]
ProteinModelPortaliP78560
SMRiP78560
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114275, 22 interactors
CORUMiP78560
IntActiP78560, 18 interactors
MINTiP78560
STRINGi9606.ENSP00000327647

PTM databases

iPTMnetiP78560
PhosphoSitePlusiP78560

Polymorphism and mutation databases

BioMutaiCRADD
DMDMi2498833

Proteomic databases

EPDiP78560
PaxDbiP78560
PeptideAtlasiP78560
PRIDEiP78560
ProteomicsDBi57654

Protocols and materials databases

DNASUi8738
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332896; ENSP00000327647; ENSG00000169372 [P78560-1]
ENST00000542893; ENSP00000439068; ENSG00000169372 [P78560-1]
ENST00000551065; ENSP00000448425; ENSG00000169372 [P78560-2]
GeneIDi8738
KEGGihsa:8738
UCSCiuc058rts.1 human [P78560-1]

Organism-specific databases

CTDi8738
DisGeNETi8738
EuPathDBiHostDB:ENSG00000169372.12
GeneCardsiCRADD
HGNCiHGNC:2340 CRADD
HPAiCAB005337
MalaCardsiCRADD
MIMi603454 gene
614499 phenotype
neXtProtiNX_P78560
OpenTargetsiENSG00000169372
Orphaneti88616 Autosomal recessive non-syndromic intellectual disability
PharmGKBiPA26860
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJAM Eukaryota
ENOG4111SYE LUCA
GeneTreeiENSGT00390000014448
HOGENOMiHOG000111965
HOVERGENiHBG051112
InParanoidiP78560
KOiK02832
OMAiLGPEWEH
OrthoDBiEOG091G0M3P
PhylomeDBiP78560
TreeFamiTF333055

Enzyme and pathway databases

ReactomeiR-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
SignaLinkiP78560

Miscellaneous databases

ChiTaRSiCRADD human
EvolutionaryTraceiP78560
GeneWikiiCRADD
GenomeRNAii8738
PROiPR:P78560
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169372 Expressed in 211 organ(s), highest expression level in left adrenal gland
CleanExiHS_CRADD
ExpressionAtlasiP78560 baseline and differential
GenevisibleiP78560 HS

Family and domain databases

CDDicd08319 Death_RAIDD, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR037939 CRADD
IPR037926 CRADD_Death
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
PANTHERiPTHR15034 PTHR15034, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF00531 Death, 1 hit
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50017 DEATH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRADD_HUMAN
AccessioniPrimary (citable) accession number: P78560
Secondary accession number(s): B7Z2Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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