UniProtKB - P78559 (MAP1A_HUMAN)
Microtubule-associated protein 1A
MAP1A
Functioni
Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
GO - Molecular functioni
- actin binding Source: ARUK-UCL
- cytoskeletal anchor activity Source: ARUK-UCL
- microtubule binding Source: ARUK-UCL
- structural molecule activity Source: ProtInc
- tau protein binding Source: ARUK-UCL
- tubulin binding Source: ARUK-UCL
GO - Biological processi
- anterograde axonal protein transport Source: ARUK-UCL
- associative learning Source: ARUK-UCL
- axonogenesis Source: GO_Central
- dendrite development Source: GO_Central
- memory Source: ARUK-UCL
- microtubule cytoskeleton organization Source: ARUK-UCL
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: ARUK-UCL
- negative regulation of protein localization to microtubule Source: ARUK-UCL
- neuron cellular homeostasis Source: ARUK-UCL
- neuron projection maintenance Source: ARUK-UCL
- positive regulation of protein localization Source: ARUK-UCL
- positive regulation of protein localization to cell surface Source: ARUK-UCL
- regulation of microtubule depolymerization Source: GO_Central
- regulation of synaptic plasticity Source: ARUK-UCL
- retrograde axonal protein transport Source: ARUK-UCL
- voluntary musculoskeletal movement Source: ARUK-UCL
Enzyme and pathway databases
PathwayCommonsi | P78559 |
SignaLinki | P78559 |
SIGNORi | P78559 |
Names & Taxonomyi
Protein namesi | Recommended name: Microtubule-associated protein 1AShort name: MAP-1A Alternative name(s): Proliferation-related protein p80 Cleaved into the following 2 chains: |
Gene namesi | Name:MAP1A Synonyms:MAP1L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6835, MAP1A |
MIMi | 600178, gene |
neXtProti | NX_P78559 |
VEuPathDBi | HostDB:ENSG00000166963 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Curated
Cytoskeleton
- dendritic microtubule Source: ARUK-UCL
- microtubule Source: GO_Central
- microtubule associated complex Source: GO_Central
Cytosol
- cytosol Source: GO_Central
Other locations
- axon Source: ARUK-UCL
- axon cytoplasm Source: GOC
- axon initial segment Source: ARUK-UCL
- cytoplasm Source: ARUK-UCL
- dendrite Source: ARUK-UCL
- dendritic branch Source: ARUK-UCL
- dendritic shaft Source: ARUK-UCL
- neuron projection Source: ARUK-UCL
- neuronal cell body Source: ARUK-UCL
- primary dendrite Source: ARUK-UCL
- synapse Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 4130 |
OpenTargetsi | ENSG00000166963 |
Miscellaneous databases
Pharosi | P78559, Tbio |
Chemistry databases
DrugBanki | DB01196, Estramustine |
Genetic variation databases
BioMutai | MAP1A |
DMDMi | 313104325 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000018600 | 1 – 2803 | Microtubule-associated protein 1AAdd BLAST | 2803 | |
ChainiPRO_0000418376 | 1 – 2566 | MAP1A heavy chainAdd BLAST | 2566 | |
ChainiPRO_0000018601 | 2567 – 2803 | MAP1 light chain LC2Add BLAST | 237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 114 | PhosphoserineBy similarity | 1 | |
Modified residuei | 117 | PhosphoserineCombined sources | 1 | |
Modified residuei | 118 | PhosphoserineBy similarity | 1 | |
Modified residuei | 121 | PhosphoserineBy similarity | 1 | |
Modified residuei | 155 | PhosphoserineBy similarity | 1 | |
Modified residuei | 177 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 319 | PhosphoserineBy similarity | 1 | |
Modified residuei | 322 | PhosphoserineBy similarity | 1 | |
Modified residuei | 384 | PhosphoserineBy similarity | 1 | |
Modified residuei | 504 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 526 | PhosphoserineCombined sources | 1 | |
Modified residuei | 527 | PhosphoserineCombined sources | 1 | |
Modified residuei | 605 | PhosphoserineCombined sources | 1 | |
Modified residuei | 612 | PhosphoserineCombined sources | 1 | |
Modified residuei | 616 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 644 | PhosphoserineCombined sources | 1 | |
Modified residuei | 667 | PhosphoserineCombined sources | 1 | |
Modified residuei | 787 | PhosphoserineCombined sources | 1 | |
Modified residuei | 874 | PhosphoserineBy similarity | 1 | |
Modified residuei | 877 | PhosphoserineBy similarity | 1 | |
Modified residuei | 878 | PhosphoserineBy similarity | 1 | |
Modified residuei | 891 | PhosphoserineBy similarity | 1 | |
Modified residuei | 894 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 896 | PhosphoserineCombined sources | 1 | |
Modified residuei | 900 | PhosphoserineBy similarity | 1 | |
Modified residuei | 909 | PhosphoserineCombined sources | 1 | |
Modified residuei | 986 | PhosphoserineCombined sources | 1 | |
Modified residuei | 996 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1004 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1013 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1019 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1029 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1069 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1144 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1146 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1160 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1172 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1190 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1200 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1203 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1209 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1218 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1221 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1264 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1326 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1329 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1544 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1600 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1626 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1654 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1675 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1749 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1762 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1776 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1791 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1797 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1801 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1812 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1818 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1931 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1957 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 2022 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2058 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 2074 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2104 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2106 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2108 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2235 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2252 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2256 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2259 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2260 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2449 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2649 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2664 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P78559 |
jPOSTi | P78559 |
MassIVEi | P78559 |
MaxQBi | P78559 |
PaxDbi | P78559 |
PeptideAtlasi | P78559 |
PRIDEi | P78559 |
ProteomicsDBi | 57652 [P78559-1] 57653 [P78559-2] |
PTM databases
CarbonylDBi | P78559 |
GlyGeni | P78559, 5 sites, 1 O-linked glycan (5 sites) |
iPTMneti | P78559 |
MetOSitei | P78559 |
PhosphoSitePlusi | P78559 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000166963, Expressed in lateral nuclear group of thalamus and 234 other tissues |
ExpressionAtlasi | P78559, baseline and differential |
Genevisiblei | P78559, HS |
Organism-specific databases
HPAi | ENSG00000166963, Tissue enriched (brain) |
Interactioni
Subunit structurei
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.
Interacts with TIAM2.
Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity). MAP1 light chain LC2:
Interacts with ELAVL4 (By similarity).
By similarityBinary interactionsi
P78559
With | #Exp. | IntAct |
---|---|---|
DISC1 [Q9NRI5] | 3 | EBI-929047,EBI-529989 |
MAP1LC3A [Q9H492] | 6 | EBI-929047,EBI-720768 |
SFN [P31947] | 3 | EBI-929047,EBI-476295 |
GO - Molecular functioni
- actin binding Source: ARUK-UCL
- microtubule binding Source: ARUK-UCL
- tau protein binding Source: ARUK-UCL
- tubulin binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 110303, 74 interactors |
DIPi | DIP-36377N |
IntActi | P78559, 24 interactors |
MINTi | P78559 |
STRINGi | 9606.ENSP00000300231 |
Miscellaneous databases
RNActi | P78559, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 415 – 417 | 1 | 3 | |
Repeati | 420 – 422 | 2 | 3 | |
Repeati | 427 – 429 | 3 | 3 | |
Repeati | 431 – 433 | 4 | 3 | |
Repeati | 436 – 438 | 5 | 3 | |
Repeati | 440 – 442 | 6 | 3 | |
Repeati | 444 – 446 | 7 | 3 | |
Repeati | 449 – 451 | 8 | 3 | |
Repeati | 539 – 541 | 9 | 3 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 302 – 466 | DisorderedSequence analysisAdd BLAST | 165 | |
Regioni | 415 – 541 | 9 X 3 AA repeats of K-K-[DE]Add BLAST | 127 | |
Regioni | 486 – 516 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 539 – 712 | DisorderedSequence analysisAdd BLAST | 174 | |
Regioni | 734 – 806 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 847 – 1080 | DisorderedSequence analysisAdd BLAST | 234 | |
Regioni | 1109 – 1548 | DisorderedSequence analysisAdd BLAST | 440 | |
Regioni | 1573 – 1605 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 1632 – 1684 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 1713 – 1879 | DisorderedSequence analysisAdd BLAST | 167 | |
Regioni | 1892 – 2673 | DisorderedSequence analysisAdd BLAST | 782 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 331 – 395 | Basic and acidic residuesSequence analysisAdd BLAST | 65 | |
Compositional biasi | 402 – 466 | Basic and acidic residuesSequence analysisAdd BLAST | 65 | |
Compositional biasi | 586 – 662 | Basic and acidic residuesSequence analysisAdd BLAST | 77 | |
Compositional biasi | 847 – 903 | Polar residuesSequence analysisAdd BLAST | 57 | |
Compositional biasi | 917 – 937 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1013 – 1067 | Basic and acidic residuesSequence analysisAdd BLAST | 55 | |
Compositional biasi | 1129 – 1146 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1150 – 1173 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1191 – 1225 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 1264 – 1278 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1286 – 1304 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1338 – 1548 | Basic and acidic residuesSequence analysisAdd BLAST | 211 | |
Compositional biasi | 1580 – 1605 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1656 – 1684 | Basic and acidic residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1713 – 1728 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1846 – 1871 | Pro residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1908 – 1934 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1943 – 1959 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 2005 – 2035 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 2042 – 2071 | Pro residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 2076 – 2090 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2091 – 2119 | Basic and acidic residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 2252 – 2272 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 2463 – 2477 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2494 – 2517 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 2555 – 2577 | Pro residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 2587 – 2606 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3592, Eukaryota |
GeneTreei | ENSGT00940000158701 |
InParanoidi | P78559 |
PhylomeDBi | P78559 |
TreeFami | TF350229 |
Family and domain databases
InterProi | View protein in InterPro IPR026074, MAP1 IPR015656, MAP1A IPR036866, RibonucZ/Hydroxyglut_hydro |
PANTHERi | PTHR13843, PTHR13843, 1 hit PTHR13843:SF6, PTHR13843:SF6, 1 hit |
SUPFAMi | SSF56281, SSF56281, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDGVAEFSEY VSETVDVPSP FDLLEPPTSG GFLKLSKPCC YIFPGGRGDS
60 70 80 90 100
ALFAVNGFNI LVDGGSDRKS CFWKLVRHLD RIDSVLLTHI GADNLPGING
110 120 130 140 150
LLQRKVAELE EEQSQGSSSY SDWVKNLISP ELGVVFFNVP EKLRLPDASR
160 170 180 190 200
KAKRSIEEAC LTLQHLNRLG IQAEPLYRVV SNTIEPLTLF HKMGVGRLDM
210 220 230 240 250
YVLNPVKDSK EMQFLMQKWA GNSKAKTGIV LPNGKEAEIS VPYLTSITAL
260 270 280 290 300
VVWLPANPTE KIVRVLFPGN APQNKILEGL EKLRHLDFLR YPVATQKDLA
310 320 330 340 350
SGAVPTNLKP SKIKQRADSK ESLKATTKTA VSKLAKREEV VEEGAKEARS
360 370 380 390 400
ELAKELAKTE KKAKESSEKP PEKPAKPERV KTESSEALKA EKRKLIKDKV
410 420 430 440 450
GKKHLKEKIS KLEEKKDKEK KEIKKERKEL KKDEGRKEEK KDAKKEEKRK
460 470 480 490 500
DTKPELKKIS KPDLKPFTPE VRKTLYKAKV PGRVKIDRSR AIRGEKELSS
510 520 530 540 550
EPQTPPAQKG TVPLPTISGH RELVLSSPED LTQDFEEMKR EERALLAEQR
560 570 580 590 600
DTGLGDKPFP LDTAEEGPPS TAIQGTPPSV PGLGQEEHVM KEKELVPEVP
610 620 630 640 650
EEQGSKDRGL DSGAETEEEK DTWEEKKQRE AERLPDRTEA REESEPEVKE
660 670 680 690 700
DVIEKAELEE MEEVHPSDEE EEDATKAEGF YQKHMQEPLK VTPRSREAFG
710 720 730 740 750
GRELGLQGKA PEKETSLFLS SLTTPAGATE HVSYIQDETI PGYSETEQTI
760 770 780 790 800
SDEEIHDEPE ERPAPPRFHT STYDLPGPEG AGPFEASQPA DSAVPATSGK
810 820 830 840 850
VYGTPETELT YPTNIVAAPL AEEEHVSSAT SITECDKLSS FATSVAEDQS
860 870 880 890 900
VASLTAPQTE ETGKSSLLLD TVTSIPSSRT EATQGLDYVP SAGTISPTSS
910 920 930 940 950
LEEDKGFKSP PCEDFSVTGE SEKRGEIIGK GLSGERAVEE EEEETANVEM
960 970 980 990 1000
SEKLCSQYGT PVFSAPGHAL HPGEPALGEA EERCLSPDDS TVKMASPPPS
1010 1020 1030 1040 1050
GPPSATHTPF HQSPVEEKSE PQDFQEADSW GDTKRTPGVG KEDAAEETVK
1060 1070 1080 1090 1100
PGPEEGTLEK EEKVPPPRSP QAQEAPVNID EGLTGCTIQL LPAQDKAIVF
1110 1120 1130 1140 1150
EIMEAGEPTG PILGAEALPG GLRTLPQEPG KPQKDEVLRY PDRSLSPEDA
1160 1170 1180 1190 1200
ESLSVLSVPS PDTANQEPTP KSPCGLTEQY LHKDRWPEVS PEDTQSLSLS
1210 1220 1230 1240 1250
EESPSKETSL DVSSKQLSPE SLGTLQFGEL NLGKEEMGHL MQAEDTSHHT
1260 1270 1280 1290 1300
APMSVPEPHA ATASPPTDGT TRYSAQTDIT DDSLDRKSPA SSFSHSTPSG
1310 1320 1330 1340 1350
NGKYLPGAIT SPDEHILTPD SSFSKSPESL PGPALEDIAI KWEDKVPGLK
1360 1370 1380 1390 1400
DRTSEQKKEP EPKDEVLQQK DKTLEHKEVV EPKDTAIYQK DEALHVKNEA
1410 1420 1430 1440 1450
VKQQDKALEQ KGRDLEQKDT ALEQKDKALE PKDKDLEEKD KALEQKDKIP
1460 1470 1480 1490 1500
EEKDKALEQK DTALEQKDKA LEPKDKDLEQ KDRVLEQKEK IPEEKDKALD
1510 1520 1530 1540 1550
QKVRSVEHKA PEDTVAEMKD RDLEQTDKAP EQKHQAQEQK DKVSEKKDQA
1560 1570 1580 1590 1600
LEQKYWALGQ KDEALEQNIQ ALEENHQTQE QESLVQEDKT RKPKMLEEKS
1610 1620 1630 1640 1650
PEKVKAMEEK LEALLEKTKA LGLEESLVQE GRAREQEEKY WRGQDVVQEW
1660 1670 1680 1690 1700
QETSPTREEP AGEQKELAPA WEDTSPEQDN RYWRGREDVA LEQDTYWREL
1710 1720 1730 1740 1750
SCERKVWFPH ELDGQGARPH YTEERESTFL DEGPDDEQEV PLREHATRSP
1760 1770 1780 1790 1800
WASDFKDFQE SSPQKGLEVE RWLAESPVGL PPEEEDKLTR SPFEIISPPA
1810 1820 1830 1840 1850
SPPEMVGQRV PSAPGQESPI PDPKLMPHMK NEPTTPSWLA DIPPWVPKDR
1860 1870 1880 1890 1900
PLPPAPLSPA PGPPTPAPES HTPAPFSWGT AEYDSVVAAV QEGAAELEGG
1910 1920 1930 1940 1950
PYSPLGKDYR KAEGEREEEG RAEAPDKSSH SSKVPEASKS HATTEPEQTE
1960 1970 1980 1990 2000
PEQREPTPYP DERSFQYADI YEQMMLTGLG PACPTREPPL GAAGDWPPCL
2010 2020 2030 2040 2050
STKEAAAGRN TSAEKELSSP ISPKSLQSDT PTFSYAALAG PTVPPRPEPG
2060 2070 2080 2090 2100
PSMEPSLTPP AVPPRAPILS KGPSPPLNGN ILSCSPDRRS PSPKESGRSH
2110 2120 2130 2140 2150
WDDSTSDSEL EKGAREQPEK EAQSPSPPHP IPMGSPTLWP ETEAHVSPPL
2160 2170 2180 2190 2200
DSHLGPARPS LDFPASAFGF SSLQPAPPQL PSPAEPRSAP CGSLAFSGDR
2210 2220 2230 2240 2250
ALALAPGPPT RTRHDEYLEV TKAPSLDSSL PQLPSPSSPG APLLSNLPRP
2260 2270 2280 2290 2300
ASPALSEGSS SEATTPVISS VAERFSPSLE AAEQESGELD PGMEPAAHSL
2310 2320 2330 2340 2350
WDLTPLSPAP PASLDLALAP APSLPGDMGD GILPCHLECS EAATEKPSPF
2360 2370 2380 2390 2400
QVPSEDCAAN GPTETSPNPP GPAPAKAENE EAAACPAWER GAWPEGAERS
2410 2420 2430 2440 2450
SRPDTLLSPE QPVCPAGGSG GPPSSASPEV EAGPQGCATE PRPHRGELSP
2460 2470 2480 2490 2500
SFLNPPLPPS IDDRDLSTEE VRLVGRGGRR RVGGPGTTGG PCPVTDETPP
2510 2520 2530 2540 2550
TSASDSGSSQ SDSDVPPETE ECPSITAEAA LDSDEDGDFL PVDKAGGVSG
2560 2570 2580 2590 2600
THHPRPGHDP PPLPQPDPRP SPPRPDVCMA DPEGLSSESG RVERLREKEK
2610 2620 2630 2640 2650
VQGRVGRRAP GKAKPASPAR RLDLRGKRSP TPGKGPADRA SRAPPRPRST
2660 2670 2680 2690 2700
TSQVTPAEEK DGHSPMSKGL VNGLKAGPMA LSSKGSSGAP VYVDLAYIPN
2710 2720 2730 2740 2750
HCSGKTADLD FFRRVRASYY VVSGNDPANG EPSRAVLDAL LEGKAQWGEN
2760 2770 2780 2790 2800
LQVTLIPTHD TEVTREWYQQ THEQQQQLNV LVLASSSTVV MQDESFPACK
IEF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PGC8 | E9PGC8_HUMAN | Microtubule-associated protein 1A | MAP1A | 3,041 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 134 – 135 | VV → IP in CAA87104 (Ref. 5) Curated | 2 | ||
Sequence conflicti | 249 | A → G in CAA87104 (Ref. 5) Curated | 1 | ||
Sequence conflicti | 263 | V → A in CAA87104 (Ref. 5) Curated | 1 | ||
Sequence conflicti | 296 | Q → H in AAD00355 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 311 | S → G in CAA87104 (Ref. 5) Curated | 1 | ||
Sequence conflicti | 324 | K → Q in AAD00355 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 414 – 419 | EKKDKE → KKKRNS in CAA87104 (Ref. 5) Curated | 6 | ||
Sequence conflicti | 424 | K → P in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 424 | K → P in AAB41133 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 426 | E → D in AAD00355 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 431 | K → Q in AAD00355 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 439 | E → D in AAD00355 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 444 | K → R in AAD00355 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 452 – 453 | TK → SS in AAD00355 (Ref. 4) Curated | 2 | ||
Sequence conflicti | 457 | K → R in AAD00355 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 682 | Q → P in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 682 | Q → P in AAB41133 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 1025 | Q → K in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 1025 | Q → K in AAB41133 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 1303 – 1313 | KYLPGAITSPD → EVLTWGDHQALN in AAD00355 (Ref. 4) CuratedAdd BLAST | 11 | ||
Sequence conflicti | 1335 – 1341 | Missing in AAD00355 (Ref. 4) Curated | 7 | ||
Sequence conflicti | 1368 | Q → T in AAD00355 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 1470 | A → T in AAD00355 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 1714 | G → V in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 1714 | G → V in AAB41133 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 1869 | E → A in AAA81362 (PubMed:7629894).Curated | 1 | ||
Sequence conflicti | 1879 – 1883 | GTAEY → AHSRV in AAA81362 (PubMed:7629894).Curated | 5 | ||
Sequence conflicti | 2118 | P → A in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2118 | P → A in AAB41133 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2174 | Q → E in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2174 | Q → E in AAB41133 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2613 | A → D in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2613 | A → D in AAB41133 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2616 | A → V in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2616 | A → V in AAB41133 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2636 | P → S in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2636 | P → S in AAB41133 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2640 | A → V in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2640 | A → V in AAB41133 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2647 | P → S in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2647 | P → S in AAB41133 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2702 | C → W in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2702 | C → W in AAB41133 (PubMed:8812494).Curated | 1 | ||
Isoform 2 (identifier: P78559-2) | |||||
Sequence conflicti | 2753 | S → V in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2753 | S → V in AAB41133 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2754 | V → K in AAB41132 (PubMed:8812494).Curated | 1 | ||
Sequence conflicti | 2754 | V → K in AAB41133 (PubMed:8812494).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039705 | 72 | F → L1 PublicationCorresponds to variant dbSNP:rs2584695Ensembl. | 1 | |
Natural variantiVAR_039706 | 335 | A → S1 PublicationCorresponds to variant dbSNP:rs1060935Ensembl. | 1 | |
Natural variantiVAR_039707 | 336 | K → T1 PublicationCorresponds to variant dbSNP:rs1060936Ensembl. | 1 | |
Natural variantiVAR_039708 | 353 | A → S1 PublicationCorresponds to variant dbSNP:rs1060937Ensembl. | 1 | |
Natural variantiVAR_039709 | 357 | A → S1 PublicationCorresponds to variant dbSNP:rs1060938Ensembl. | 1 | |
Natural variantiVAR_039710 | 364 | K → Q1 PublicationCorresponds to variant dbSNP:rs2602129Ensembl. | 1 | |
Natural variantiVAR_039711 | 485 | K → Q. Corresponds to variant dbSNP:rs2584715Ensembl. | 1 | |
Natural variantiVAR_039712 | 830 | T → A. Corresponds to variant dbSNP:rs3803337Ensembl. | 1 | |
Natural variantiVAR_039713 | 1078 | N → S. Corresponds to variant dbSNP:rs8034794Ensembl. | 1 | |
Natural variantiVAR_039714 | 1102 | I → T. Corresponds to variant dbSNP:rs8036179Ensembl. | 1 | |
Natural variantiVAR_039715 | 1185 | R → H. Corresponds to variant dbSNP:rs3803335Ensembl. | 1 | |
Natural variantiVAR_039716 | 1245 | D → N. Corresponds to variant dbSNP:rs12912505Ensembl. | 1 | |
Natural variantiVAR_039717 | 1461 | D → N. Corresponds to variant dbSNP:rs2245715Ensembl. | 1 | |
Natural variantiVAR_039718 | 1553 | Q → H. Corresponds to variant dbSNP:rs2584717Ensembl. | 1 | |
Natural variantiVAR_039719 | 1605 | K → N. Corresponds to variant dbSNP:rs2584697Ensembl. | 1 | |
Natural variantiVAR_039720 | 1650 | W → C1 PublicationCorresponds to variant dbSNP:rs1060943Ensembl. | 1 | |
Natural variantiVAR_039721 | 1690 | A → S1 PublicationCorresponds to variant dbSNP:rs1060946Ensembl. | 1 | |
Natural variantiVAR_039722 | 1827 | P → A. Corresponds to variant dbSNP:rs2229014Ensembl. | 1 | |
Natural variantiVAR_039723 | 1881 | A → P1 PublicationCorresponds to variant dbSNP:rs1060950Ensembl. | 1 | |
Natural variantiVAR_039724 | 1912 | A → V1 PublicationCorresponds to variant dbSNP:rs2584718Ensembl. | 1 | |
Natural variantiVAR_039725 | 1938 | S → R1 PublicationCorresponds to variant dbSNP:rs2584719Ensembl. | 1 | |
Natural variantiVAR_039726 | 2056 | S → R. Corresponds to variant dbSNP:rs1060953Ensembl. | 1 | |
Natural variantiVAR_039727 | 2214 | H → Y1 PublicationCorresponds to variant dbSNP:rs1060955Ensembl. | 1 | |
Natural variantiVAR_039728 | 2327 | D → V. Corresponds to variant dbSNP:rs8026745Ensembl. | 1 | |
Natural variantiVAR_059432 | 2405 | T → I. Corresponds to variant dbSNP:rs8027254Ensembl. | 1 | |
Natural variantiVAR_056122 | 2461 | I → T. Corresponds to variant dbSNP:rs8028849Ensembl. | 1 | |
Natural variantiVAR_059433 | 2465 | D → N. Corresponds to variant dbSNP:rs8027916Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040240 | 2752 | Q → QSV in isoform 2. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U38291 Genomic DNA Translation: AAB41132.1 U38292 mRNA Translation: AAB41133.1 AC019011 Genomic DNA No translation available. AF200415 mRNA Translation: AAF08305.2 U80458 mRNA Translation: AAD00355.1 Z47038 Genomic DNA Translation: CAA87104.1 U14577 mRNA Translation: AAA81362.1 |
CCDSi | CCDS42031.1 [P78559-1] |
PIRi | I38857 |
RefSeqi | NP_002364.5, NM_002373.5 [P78559-1] |
Genome annotation databases
Ensembli | ENST00000300231.6; ENSP00000300231.5; ENSG00000166963.13 |
GeneIDi | 4130 |
KEGGi | hsa:4130 |
MANE-Selecti | ENST00000300231.6; ENSP00000300231.5; NM_002373.6; NP_002364.5 |
UCSCi | uc001zrt.4, human [P78559-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U38291 Genomic DNA Translation: AAB41132.1 U38292 mRNA Translation: AAB41133.1 AC019011 Genomic DNA No translation available. AF200415 mRNA Translation: AAF08305.2 U80458 mRNA Translation: AAD00355.1 Z47038 Genomic DNA Translation: CAA87104.1 U14577 mRNA Translation: AAA81362.1 |
CCDSi | CCDS42031.1 [P78559-1] |
PIRi | I38857 |
RefSeqi | NP_002364.5, NM_002373.5 [P78559-1] |
3D structure databases
SMRi | P78559 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110303, 74 interactors |
DIPi | DIP-36377N |
IntActi | P78559, 24 interactors |
MINTi | P78559 |
STRINGi | 9606.ENSP00000300231 |
Chemistry databases
DrugBanki | DB01196, Estramustine |
PTM databases
CarbonylDBi | P78559 |
GlyGeni | P78559, 5 sites, 1 O-linked glycan (5 sites) |
iPTMneti | P78559 |
MetOSitei | P78559 |
PhosphoSitePlusi | P78559 |
Genetic variation databases
BioMutai | MAP1A |
DMDMi | 313104325 |
Proteomic databases
EPDi | P78559 |
jPOSTi | P78559 |
MassIVEi | P78559 |
MaxQBi | P78559 |
PaxDbi | P78559 |
PeptideAtlasi | P78559 |
PRIDEi | P78559 |
ProteomicsDBi | 57652 [P78559-1] 57653 [P78559-2] |
Protocols and materials databases
Antibodypediai | 6277, 142 antibodies from 24 providers |
DNASUi | 4130 |
Genome annotation databases
Ensembli | ENST00000300231.6; ENSP00000300231.5; ENSG00000166963.13 |
GeneIDi | 4130 |
KEGGi | hsa:4130 |
MANE-Selecti | ENST00000300231.6; ENSP00000300231.5; NM_002373.6; NP_002364.5 |
UCSCi | uc001zrt.4, human [P78559-1] |
Organism-specific databases
CTDi | 4130 |
DisGeNETi | 4130 |
GeneCardsi | MAP1A |
HGNCi | HGNC:6835, MAP1A |
HPAi | ENSG00000166963, Tissue enriched (brain) |
MIMi | 600178, gene |
neXtProti | NX_P78559 |
OpenTargetsi | ENSG00000166963 |
VEuPathDBi | HostDB:ENSG00000166963 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3592, Eukaryota |
GeneTreei | ENSGT00940000158701 |
InParanoidi | P78559 |
PhylomeDBi | P78559 |
TreeFami | TF350229 |
Enzyme and pathway databases
PathwayCommonsi | P78559 |
SignaLinki | P78559 |
SIGNORi | P78559 |
Miscellaneous databases
BioGRID-ORCSi | 4130, 16 hits in 1077 CRISPR screens |
ChiTaRSi | MAP1A, human |
GeneWikii | MAP1A |
GenomeRNAii | 4130 |
Pharosi | P78559, Tbio |
PROi | PR:P78559 |
RNActi | P78559, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166963, Expressed in lateral nuclear group of thalamus and 234 other tissues |
ExpressionAtlasi | P78559, baseline and differential |
Genevisiblei | P78559, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026074, MAP1 IPR015656, MAP1A IPR036866, RibonucZ/Hydroxyglut_hydro |
PANTHERi | PTHR13843, PTHR13843, 1 hit PTHR13843:SF6, PTHR13843:SF6, 1 hit |
SUPFAMi | SSF56281, SSF56281, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MAP1A_HUMAN | |
Accessioni | P78559Primary (citable) accession number: P78559 Secondary accession number(s): O95643 Q9UJT4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 30, 2010 | |
Last modified: | May 25, 2022 | |
This is version 183 of the entry and version 6 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families