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UniProtKB - P78559 (MAP1A_HUMAN)

Protein

Microtubule-associated protein 1A

Gene

MAP1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 1A
Short name:
MAP-1A
Alternative name(s):
Proliferation-related protein p80
Cleaved into the following 2 chains:
MAP1A heavy chain
MAP1 light chain LC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP1A
Synonyms:MAP1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000166963.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:6835 MAP1A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600178 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P78559

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4130

Open Targets

More...OpenTargetsi		ENSG00000166963

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01196 Estramustine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAP1A

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104325

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000186001 – 2803Microtubule-associated protein 1AAdd BLAST2803
ChainiPRO_00004183761 – 2566MAP1A heavy chainAdd BLAST2566
ChainiPRO_00000186012567 – 2803MAP1 light chain LC2Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114PhosphoserineBy similarity1
Modified residuei117PhosphoserineCombined sources1
Modified residuei118PhosphoserineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei155PhosphoserineBy similarity1
Modified residuei177PhosphotyrosineBy similarity1
Modified residuei319PhosphoserineBy similarity1
Modified residuei322PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1
Modified residuei504PhosphothreonineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei612PhosphoserineCombined sources1
Modified residuei616PhosphothreonineCombined sources1
Modified residuei644PhosphoserineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei787PhosphoserineCombined sources1
Modified residuei874PhosphoserineBy similarity1
Modified residuei877PhosphoserineBy similarity1
Modified residuei878PhosphoserineBy similarity1
Modified residuei891PhosphoserineBy similarity1
Modified residuei894PhosphothreonineBy similarity1
Modified residuei896PhosphoserineCombined sources1
Modified residuei900PhosphoserineBy similarity1
Modified residuei909PhosphoserineCombined sources1
Modified residuei986PhosphoserineCombined sources1
Modified residuei996PhosphoserineBy similarity1
Modified residuei1004PhosphoserineBy similarity1
Modified residuei1013PhosphoserineBy similarity1
Modified residuei1019PhosphoserineBy similarity1
Modified residuei1029PhosphoserineBy similarity1
Modified residuei1069PhosphoserineCombined sources1
Modified residuei1144PhosphoserineBy similarity1
Modified residuei1146PhosphoserineBy similarity1
Modified residuei1160PhosphoserineCombined sources1
Modified residuei1172PhosphoserineCombined sources1
Modified residuei1190PhosphoserineCombined sources1
Modified residuei1200PhosphoserineCombined sources1
Modified residuei1203PhosphoserineCombined sources1
Modified residuei1209PhosphoserineBy similarity1
Modified residuei1218PhosphoserineCombined sources1
Modified residuei1221PhosphoserineBy similarity1
Modified residuei1264PhosphoserineBy similarity1
Modified residuei1326PhosphoserineCombined sources1
Modified residuei1329PhosphoserineCombined sources1
Modified residuei1544PhosphoserineBy similarity1
Modified residuei1600PhosphoserineCombined sources1
Modified residuei1626PhosphoserineCombined sources1
Modified residuei1654PhosphoserineCombined sources1
Modified residuei1675PhosphoserineCombined sources1
Modified residuei1749PhosphoserineCombined sources1
Modified residuei1762PhosphoserineCombined sources1
Modified residuei1776PhosphoserineCombined sources1
Modified residuei1791PhosphoserineCombined sources1
Modified residuei1797PhosphoserineCombined sources1
Modified residuei1801PhosphoserineCombined sources1
Modified residuei1812PhosphoserineBy similarity1
Modified residuei1818PhosphoserineCombined sources1
Modified residuei1931PhosphoserineBy similarity1
Modified residuei1957PhosphothreonineCombined sources1
Modified residuei2022PhosphoserineCombined sources1
Modified residuei2058PhosphothreonineBy similarity1
Modified residuei2074PhosphoserineCombined sources1
Modified residuei2104PhosphoserineCombined sources1
Modified residuei2106PhosphoserineCombined sources1
Modified residuei2108PhosphoserineBy similarity1
Modified residuei2235PhosphoserineBy similarity1
Modified residuei2252PhosphoserineBy similarity1
Modified residuei2256PhosphoserineBy similarity1
Modified residuei2259PhosphoserineBy similarity1
Modified residuei2260PhosphoserineBy similarity1
Modified residuei2449PhosphoserineCombined sources1
Modified residuei2649PhosphoserineCombined sources1
Modified residuei2664PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CSNK1D.By similarity
LC2 is generated from MAP1A by proteolytic processing.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P78559

MaxQB - The MaxQuant DataBase

More...MaxQBi		P78559

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P78559

PeptideAtlas

More...PeptideAtlasi		P78559

PRoteomics IDEntifications database

More...PRIDEi		P78559

ProteomicsDB human proteome resource

More...ProteomicsDBi		57652
57653 [P78559-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P78559

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P78559

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P78559

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166963 Expressed in 220 organ(s), highest expression level in lateral nuclear group of thalamus

CleanEx database of gene expression profiles

More...CleanExi		HS_MAP1A

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P78559 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P78559 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA039063
HPA039064
HPA066488

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DISC1Q9NRI53EBI-929047,EBI-529989

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110303, 24 interactors

Database of interacting proteins

More...DIPi		DIP-36377N

Protein interaction database and analysis system

More...IntActi		P78559, 15 interactors

Molecular INTeraction database

More...MINTi		P78559

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000300231

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P78559

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P78559

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati415 – 41713
Repeati420 – 42223
Repeati427 – 42933
Repeati431 – 43343
Repeati436 – 43853
Repeati440 – 44263
Repeati444 – 44673
Repeati449 – 45183
Repeati539 – 54193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni415 – 5419 X 3 AA repeats of K-K-[DE]Add BLAST127

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi309 – 496Lys-rich (basic)Add BLAST188

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAP1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3592 Eukaryota
ENOG410XRYM LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158701

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231839

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG052408

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P78559

KEGG Orthology (KO)

More...KOi		K10429

Database for complete collections of gene phylogenies

More...PhylomeDBi		P78559

TreeFam database of animal gene trees

More...TreeFami		TF350229

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026074 MAP1
IPR015656 MAP1A
IPR036866 RibonucZ/Hydroxyglut_hydro

The PANTHER Classification System

More...PANTHERi		PTHR13843 PTHR13843, 2 hits
PTHR13843:SF6 PTHR13843:SF6, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56281 SSF56281, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P78559-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGVAEFSEY VSETVDVPSP FDLLEPPTSG GFLKLSKPCC YIFPGGRGDS 
        60         70         80         90        100
ALFAVNGFNI LVDGGSDRKS CFWKLVRHLD RIDSVLLTHI GADNLPGING 
       110        120        130        140        150
LLQRKVAELE EEQSQGSSSY SDWVKNLISP ELGVVFFNVP EKLRLPDASR 
       160        170        180        190        200
KAKRSIEEAC LTLQHLNRLG IQAEPLYRVV SNTIEPLTLF HKMGVGRLDM 
       210        220        230        240        250
YVLNPVKDSK EMQFLMQKWA GNSKAKTGIV LPNGKEAEIS VPYLTSITAL 
       260        270        280        290        300
VVWLPANPTE KIVRVLFPGN APQNKILEGL EKLRHLDFLR YPVATQKDLA 
       310        320        330        340        350
SGAVPTNLKP SKIKQRADSK ESLKATTKTA VSKLAKREEV VEEGAKEARS 
       360        370        380        390        400
ELAKELAKTE KKAKESSEKP PEKPAKPERV KTESSEALKA EKRKLIKDKV 
       410        420        430        440        450
GKKHLKEKIS KLEEKKDKEK KEIKKERKEL KKDEGRKEEK KDAKKEEKRK 
       460        470        480        490        500
DTKPELKKIS KPDLKPFTPE VRKTLYKAKV PGRVKIDRSR AIRGEKELSS 
       510        520        530        540        550
EPQTPPAQKG TVPLPTISGH RELVLSSPED LTQDFEEMKR EERALLAEQR 
       560        570        580        590        600
DTGLGDKPFP LDTAEEGPPS TAIQGTPPSV PGLGQEEHVM KEKELVPEVP 
       610        620        630        640        650
EEQGSKDRGL DSGAETEEEK DTWEEKKQRE AERLPDRTEA REESEPEVKE 
       660        670        680        690        700
DVIEKAELEE MEEVHPSDEE EEDATKAEGF YQKHMQEPLK VTPRSREAFG 
       710        720        730        740        750
GRELGLQGKA PEKETSLFLS SLTTPAGATE HVSYIQDETI PGYSETEQTI 
       760        770        780        790        800
SDEEIHDEPE ERPAPPRFHT STYDLPGPEG AGPFEASQPA DSAVPATSGK 
       810        820        830        840        850
VYGTPETELT YPTNIVAAPL AEEEHVSSAT SITECDKLSS FATSVAEDQS 
       860        870        880        890        900
VASLTAPQTE ETGKSSLLLD TVTSIPSSRT EATQGLDYVP SAGTISPTSS 
       910        920        930        940        950
LEEDKGFKSP PCEDFSVTGE SEKRGEIIGK GLSGERAVEE EEEETANVEM 
       960        970        980        990       1000
SEKLCSQYGT PVFSAPGHAL HPGEPALGEA EERCLSPDDS TVKMASPPPS 
      1010       1020       1030       1040       1050
GPPSATHTPF HQSPVEEKSE PQDFQEADSW GDTKRTPGVG KEDAAEETVK 
      1060       1070       1080       1090       1100
PGPEEGTLEK EEKVPPPRSP QAQEAPVNID EGLTGCTIQL LPAQDKAIVF 
      1110       1120       1130       1140       1150
EIMEAGEPTG PILGAEALPG GLRTLPQEPG KPQKDEVLRY PDRSLSPEDA 
      1160       1170       1180       1190       1200
ESLSVLSVPS PDTANQEPTP KSPCGLTEQY LHKDRWPEVS PEDTQSLSLS 
      1210       1220       1230       1240       1250
EESPSKETSL DVSSKQLSPE SLGTLQFGEL NLGKEEMGHL MQAEDTSHHT 
      1260       1270       1280       1290       1300
APMSVPEPHA ATASPPTDGT TRYSAQTDIT DDSLDRKSPA SSFSHSTPSG 
      1310       1320       1330       1340       1350
NGKYLPGAIT SPDEHILTPD SSFSKSPESL PGPALEDIAI KWEDKVPGLK 
      1360       1370       1380       1390       1400
DRTSEQKKEP EPKDEVLQQK DKTLEHKEVV EPKDTAIYQK DEALHVKNEA 
      1410       1420       1430       1440       1450
VKQQDKALEQ KGRDLEQKDT ALEQKDKALE PKDKDLEEKD KALEQKDKIP 
      1460       1470       1480       1490       1500
EEKDKALEQK DTALEQKDKA LEPKDKDLEQ KDRVLEQKEK IPEEKDKALD 
      1510       1520       1530       1540       1550
QKVRSVEHKA PEDTVAEMKD RDLEQTDKAP EQKHQAQEQK DKVSEKKDQA 
      1560       1570       1580       1590       1600
LEQKYWALGQ KDEALEQNIQ ALEENHQTQE QESLVQEDKT RKPKMLEEKS 
      1610       1620       1630       1640       1650
PEKVKAMEEK LEALLEKTKA LGLEESLVQE GRAREQEEKY WRGQDVVQEW 
      1660       1670       1680       1690       1700
QETSPTREEP AGEQKELAPA WEDTSPEQDN RYWRGREDVA LEQDTYWREL 
      1710       1720       1730       1740       1750
SCERKVWFPH ELDGQGARPH YTEERESTFL DEGPDDEQEV PLREHATRSP 
      1760       1770       1780       1790       1800
WASDFKDFQE SSPQKGLEVE RWLAESPVGL PPEEEDKLTR SPFEIISPPA 
      1810       1820       1830       1840       1850
SPPEMVGQRV PSAPGQESPI PDPKLMPHMK NEPTTPSWLA DIPPWVPKDR 
      1860       1870       1880       1890       1900
PLPPAPLSPA PGPPTPAPES HTPAPFSWGT AEYDSVVAAV QEGAAELEGG 
      1910       1920       1930       1940       1950
PYSPLGKDYR KAEGEREEEG RAEAPDKSSH SSKVPEASKS HATTEPEQTE 
      1960       1970       1980       1990       2000
PEQREPTPYP DERSFQYADI YEQMMLTGLG PACPTREPPL GAAGDWPPCL 
      2010       2020       2030       2040       2050
STKEAAAGRN TSAEKELSSP ISPKSLQSDT PTFSYAALAG PTVPPRPEPG 
      2060       2070       2080       2090       2100
PSMEPSLTPP AVPPRAPILS KGPSPPLNGN ILSCSPDRRS PSPKESGRSH 
      2110       2120       2130       2140       2150
WDDSTSDSEL EKGAREQPEK EAQSPSPPHP IPMGSPTLWP ETEAHVSPPL 
      2160       2170       2180       2190       2200
DSHLGPARPS LDFPASAFGF SSLQPAPPQL PSPAEPRSAP CGSLAFSGDR 
      2210       2220       2230       2240       2250
ALALAPGPPT RTRHDEYLEV TKAPSLDSSL PQLPSPSSPG APLLSNLPRP 
      2260       2270       2280       2290       2300
ASPALSEGSS SEATTPVISS VAERFSPSLE AAEQESGELD PGMEPAAHSL 
      2310       2320       2330       2340       2350
WDLTPLSPAP PASLDLALAP APSLPGDMGD GILPCHLECS EAATEKPSPF 
      2360       2370       2380       2390       2400
QVPSEDCAAN GPTETSPNPP GPAPAKAENE EAAACPAWER GAWPEGAERS 
      2410       2420       2430       2440       2450
SRPDTLLSPE QPVCPAGGSG GPPSSASPEV EAGPQGCATE PRPHRGELSP 
      2460       2470       2480       2490       2500
SFLNPPLPPS IDDRDLSTEE VRLVGRGGRR RVGGPGTTGG PCPVTDETPP 
      2510       2520       2530       2540       2550
TSASDSGSSQ SDSDVPPETE ECPSITAEAA LDSDEDGDFL PVDKAGGVSG 
      2560       2570       2580       2590       2600
THHPRPGHDP PPLPQPDPRP SPPRPDVCMA DPEGLSSESG RVERLREKEK 
      2610       2620       2630       2640       2650
VQGRVGRRAP GKAKPASPAR RLDLRGKRSP TPGKGPADRA SRAPPRPRST 
      2660       2670       2680       2690       2700
TSQVTPAEEK DGHSPMSKGL VNGLKAGPMA LSSKGSSGAP VYVDLAYIPN 
      2710       2720       2730       2740       2750
HCSGKTADLD FFRRVRASYY VVSGNDPANG EPSRAVLDAL LEGKAQWGEN 
      2760       2770       2780       2790       2800
LQVTLIPTHD TEVTREWYQQ THEQQQQLNV LVLASSSTVV MQDESFPACK 

IEF
Length:2,803
Mass (Da):305,485
Last modified:November 30, 2010 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94733902420F1FFE
GO
Isoform 2 (identifier: P78559-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2752-2752: Q → QSV

Show »
Length:2,805
Mass (Da):305,671
Checksum:i28E9817E8116EF8A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGC8E9PGC8_HUMAN
Microtubule-associated protein 1A
MAP1A
3,041Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti134 – 135VV → IP in CAA87104 (Ref. 5) Curated2
Sequence conflicti249A → G in CAA87104 (Ref. 5) Curated1
Sequence conflicti263V → A in CAA87104 (Ref. 5) Curated1
Sequence conflicti296Q → H in AAD00355 (Ref. 4) Curated1
Sequence conflicti311S → G in CAA87104 (Ref. 5) Curated1
Sequence conflicti324K → Q in AAD00355 (Ref. 4) Curated1
Sequence conflicti414 – 419EKKDKE → KKKRNS in CAA87104 (Ref. 5) Curated6
Sequence conflicti424K → P in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti424K → P in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti426E → D in AAD00355 (Ref. 4) Curated1
Sequence conflicti431K → Q in AAD00355 (Ref. 4) Curated1
Sequence conflicti439E → D in AAD00355 (Ref. 4) Curated1
Sequence conflicti444K → R in AAD00355 (Ref. 4) Curated1
Sequence conflicti452 – 453TK → SS in AAD00355 (Ref. 4) Curated2
Sequence conflicti457K → R in AAD00355 (Ref. 4) Curated1
Sequence conflicti682Q → P in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti682Q → P in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti1025Q → K in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti1025Q → K in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti1303 – 1313KYLPGAITSPD → EVLTWGDHQALN in AAD00355 (Ref. 4) CuratedAdd BLAST11
Sequence conflicti1335 – 1341Missing in AAD00355 (Ref. 4) Curated7
Sequence conflicti1368Q → T in AAD00355 (Ref. 4) Curated1
Sequence conflicti1470A → T in AAD00355 (Ref. 4) Curated1
Sequence conflicti1714G → V in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti1714G → V in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti1869E → A in AAA81362 (PubMed:7629894).Curated1
Sequence conflicti1879 – 1883GTAEY → AHSRV in AAA81362 (PubMed:7629894).Curated5
Sequence conflicti2118P → A in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2118P → A in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2174Q → E in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2174Q → E in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2613A → D in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2613A → D in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2616A → V in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2616A → V in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2636P → S in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2636P → S in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2640A → V in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2640A → V in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2647P → S in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2647P → S in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2702C → W in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2702C → W in AAB41133 (PubMed:8812494).Curated1
Isoform 2 (identifier: P78559-2)
Sequence conflicti2753S → V in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2753S → V in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2754V → K in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2754V → K in AAB41133 (PubMed:8812494).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03970572F → L1 PublicationCorresponds to variant dbSNP:rs2584695Ensembl.1
Natural variantiVAR_039706335A → S1 PublicationCorresponds to variant dbSNP:rs1060935Ensembl.1
Natural variantiVAR_039707336K → T1 PublicationCorresponds to variant dbSNP:rs1060936Ensembl.1
Natural variantiVAR_039708353A → S1 PublicationCorresponds to variant dbSNP:rs1060937Ensembl.1
Natural variantiVAR_039709357A → S1 PublicationCorresponds to variant dbSNP:rs1060938Ensembl.1
Natural variantiVAR_039710364K → Q1 PublicationCorresponds to variant dbSNP:rs2602129Ensembl.1
Natural variantiVAR_039711485K → Q. Corresponds to variant dbSNP:rs2584715Ensembl.1
Natural variantiVAR_039712830T → A. Corresponds to variant dbSNP:rs3803337Ensembl.1
Natural variantiVAR_0397131078N → S. Corresponds to variant dbSNP:rs8034794Ensembl.1
Natural variantiVAR_0397141102I → T. Corresponds to variant dbSNP:rs8036179Ensembl.1
Natural variantiVAR_0397151185R → H. Corresponds to variant dbSNP:rs3803335Ensembl.1
Natural variantiVAR_0397161245D → N. Corresponds to variant dbSNP:rs12912505Ensembl.1
Natural variantiVAR_0397171461D → N. Corresponds to variant dbSNP:rs2245715Ensembl.1
Natural variantiVAR_0397181553Q → H. Corresponds to variant dbSNP:rs2584717Ensembl.1
Natural variantiVAR_0397191605K → N. Corresponds to variant dbSNP:rs2584697Ensembl.1
Natural variantiVAR_0397201650W → C1 PublicationCorresponds to variant dbSNP:rs1060943Ensembl.1
Natural variantiVAR_0397211690A → S1 PublicationCorresponds to variant dbSNP:rs1060946Ensembl.1
Natural variantiVAR_0397221827P → A. Corresponds to variant dbSNP:rs2229014Ensembl.1
Natural variantiVAR_0397231881A → P1 PublicationCorresponds to variant dbSNP:rs1060950Ensembl.1
Natural variantiVAR_0397241912A → V1 PublicationCorresponds to variant dbSNP:rs2584718Ensembl.1
Natural variantiVAR_0397251938S → R1 PublicationCorresponds to variant dbSNP:rs2584719Ensembl.1
Natural variantiVAR_0397262056S → R. Corresponds to variant dbSNP:rs1060953Ensembl.1
Natural variantiVAR_0397272214H → Y1 PublicationCorresponds to variant dbSNP:rs1060955Ensembl.1
Natural variantiVAR_0397282327D → V. Corresponds to variant dbSNP:rs8026745Ensembl.1
Natural variantiVAR_0594322405T → I. Corresponds to variant dbSNP:rs8027254Ensembl.1
Natural variantiVAR_0561222461I → T. Corresponds to variant dbSNP:rs8028849Ensembl.1
Natural variantiVAR_0594332465D → N. Corresponds to variant dbSNP:rs8027916Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0402402752Q → QSV in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U38291 Genomic DNA Translation: AAB41132.1
U38292 mRNA Translation: AAB41133.1
AC019011 Genomic DNA No translation available.
AF200415 mRNA Translation: AAF08305.2
U80458 mRNA Translation: AAD00355.1
Z47038 Genomic DNA Translation: CAA87104.1
U14577 mRNA Translation: AAA81362.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42031.1 [P78559-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I38857

NCBI Reference Sequences

More...RefSeqi		NP_002364.5, NM_002373.5 [P78559-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.194301
Hs.619338

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000300231; ENSP00000300231; ENSG00000166963 [P78559-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4130

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4130

UCSC genome browser

More...UCSCi		uc001zrt.4 human [P78559-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38291 Genomic DNA Translation: AAB41132.1
U38292 mRNA Translation: AAB41133.1
AC019011 Genomic DNA No translation available.
AF200415 mRNA Translation: AAF08305.2
U80458 mRNA Translation: AAD00355.1
Z47038 Genomic DNA Translation: CAA87104.1
U14577 mRNA Translation: AAA81362.1
CCDSiCCDS42031.1 [P78559-1]
PIRiI38857
RefSeqiNP_002364.5, NM_002373.5 [P78559-1]
UniGeneiHs.194301
Hs.619338

3D structure databases

ProteinModelPortaliP78559
SMRiP78559
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110303, 24 interactors
DIPiDIP-36377N
IntActiP78559, 15 interactors
MINTiP78559
STRINGi9606.ENSP00000300231

Chemistry databases

DrugBankiDB01196 Estramustine

PTM databases

CarbonylDBiP78559
iPTMnetiP78559
PhosphoSitePlusiP78559

Polymorphism and mutation databases

BioMutaiMAP1A
DMDMi313104325

Proteomic databases

EPDiP78559
MaxQBiP78559
PaxDbiP78559
PeptideAtlasiP78559
PRIDEiP78559
ProteomicsDBi57652
57653 [P78559-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300231; ENSP00000300231; ENSG00000166963 [P78559-1]
GeneIDi4130
KEGGihsa:4130
UCSCiuc001zrt.4 human [P78559-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4130
DisGeNETi4130
EuPathDBiHostDB:ENSG00000166963.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAP1A
HGNCiHGNC:6835 MAP1A
HPAiHPA039063
HPA039064
HPA066488
MIMi600178 gene
neXtProtiNX_P78559
OpenTargetsiENSG00000166963

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3592 Eukaryota
ENOG410XRYM LUCA
GeneTreeiENSGT00940000158701
HOGENOMiHOG000231839
HOVERGENiHBG052408
InParanoidiP78559
KOiK10429
PhylomeDBiP78559
TreeFamiTF350229

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAP1A human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MAP1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4130

Protein Ontology

More...PROi		PR:P78559

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166963 Expressed in 220 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExiHS_MAP1A
ExpressionAtlasiP78559 baseline and differential
GenevisibleiP78559 HS

Family and domain databases

InterProiView protein in InterPro
IPR026074 MAP1
IPR015656 MAP1A
IPR036866 RibonucZ/Hydroxyglut_hydro
PANTHERiPTHR13843 PTHR13843, 2 hits
PTHR13843:SF6 PTHR13843:SF6, 2 hits
SUPFAMiSSF56281 SSF56281, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAP1A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78559
Secondary accession number(s): O95643
, Q12973, Q15882, Q9UJT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: December 5, 2018
This is version 163 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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