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Protein

C-C motif chemokine 20

Gene

CCL20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255).1 PublicationBy similarity8 Publications

GO - Molecular functioni

  • CCR6 chemokine receptor binding Source: UniProtKB
  • chemokine activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Cytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6783783 Interleukin-10 signaling
SIGNORiP78556

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 20
Alternative name(s):
Beta-chemokine exodus-1
CC chemokine LARC
Liver and activation-regulated chemokine
Macrophage inflammatory protein 3 alpha
Short name:
MIP-3-alpha
Small-inducible cytokine A20
Cleaved into the following 3 chains:
Gene namesi
Name:CCL20
Synonyms:LARC, MIP3A, SCYA20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115009.11
HGNCiHGNC:10619 CCL20
MIMi601960 gene
neXtProtiNX_P78556

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6364
OpenTargetsiENSG00000115009
PharmGKBiPA35551

Polymorphism and mutation databases

BioMutaiCCL20
DMDMi2829668

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000521727 – 96C-C motif chemokine 20Add BLAST70
ChainiPRO_000004185427 – 93CCL20(1-67)Add BLAST67
ChainiPRO_000004185527 – 90CCL20(1-64)Add BLAST64
ChainiPRO_000004185628 – 96CCL20(2-70)Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 58
Disulfide bondi33 ↔ 74

Post-translational modificationi

C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP78556
PeptideAtlasiP78556
PRIDEiP78556
ProteomicsDBi57650
57651 [P78556-2]

Miscellaneous databases

PMAP-CutDBiP78556

Expressioni

Tissue specificityi

Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.5 Publications

Inductioni

By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate (PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10.3 Publications

Gene expression databases

BgeeiENSG00000115009 Expressed in 131 organ(s), highest expression level in epithelium of nasopharynx
CleanExiHS_CCL20
GenevisibleiP78556 HS

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112267, 3 interactors
DIPiDIP-5864N
IntActiP78556, 12 interactors
MINTiP78556
STRINGi9606.ENSP00000351671

Structurei

Secondary structure

196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP78556
SMRiP78556
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78556

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2BK Eukaryota
ENOG410ZGME LUCA
GeneTreeiENSGT00530000064223
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP78556
KOiK14625
OMAiCCLRYTE
OrthoDBiEOG091G168B
PhylomeDBiP78556
TreeFamiTF334888

Family and domain databases

CDDicd01119 Chemokine_CC_DCCL, 1 hit
InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR034133 Chemokine_CC_DCCL
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: P78556-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCCTKSLLLA ALMSVLLLHL CGESEAASNF DCCLGYTDRI LHPKFIVGFT
60 70 80 90
RQLANEGCDI NAIIFHTKKK LSVCANPKQT WVKYIVRLLS KKVKNM
Length:96
Mass (Da):10,762
Last modified:May 1, 1997 - v1
Checksum:i1ED19EC2E1AC70AD
GO
Isoform 2 (identifier: P78556-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.

Show »
Length:95
Mass (Da):10,691
Checksum:iBFDB243C51B59960
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y806A0A2R8Y806_HUMAN
C-C motif chemokine 20
CCL20
25Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01191547V → M. Corresponds to variant dbSNP:rs1049617Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00106126Missing in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77035 mRNA Translation: AAC50943.1
D86955 mRNA Translation: BAA13191.1
U64197 mRNA Translation: AAB61534.1
AC073065 Genomic DNA Translation: AAX93214.1
BC020698 mRNA Translation: AAH20698.1
CCDSiCCDS2469.1 [P78556-1]
CCDS46536.1 [P78556-2]
RefSeqiNP_001123518.1, NM_001130046.1 [P78556-2]
NP_004582.1, NM_004591.2 [P78556-1]
UniGeneiHs.75498

Genome annotation databases

EnsembliENST00000358813; ENSP00000351671; ENSG00000115009 [P78556-1]
ENST00000409189; ENSP00000386273; ENSG00000115009 [P78556-2]
GeneIDi6364
KEGGihsa:6364
UCSCiuc002vpl.3 human [P78556-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL20 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77035 mRNA Translation: AAC50943.1
D86955 mRNA Translation: BAA13191.1
U64197 mRNA Translation: AAB61534.1
AC073065 Genomic DNA Translation: AAX93214.1
BC020698 mRNA Translation: AAH20698.1
CCDSiCCDS2469.1 [P78556-1]
CCDS46536.1 [P78556-2]
RefSeqiNP_001123518.1, NM_001130046.1 [P78556-2]
NP_004582.1, NM_004591.2 [P78556-1]
UniGeneiHs.75498

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M8AX-ray1.70A/B27-96[»]
2HCIX-ray1.81A/B27-95[»]
2JYONMR-A27-96[»]
5UR7X-ray2.00A/B27-96[»]
ProteinModelPortaliP78556
SMRiP78556
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112267, 3 interactors
DIPiDIP-5864N
IntActiP78556, 12 interactors
MINTiP78556
STRINGi9606.ENSP00000351671

Polymorphism and mutation databases

BioMutaiCCL20
DMDMi2829668

Proteomic databases

PaxDbiP78556
PeptideAtlasiP78556
PRIDEiP78556
ProteomicsDBi57650
57651 [P78556-2]

Protocols and materials databases

DNASUi6364
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358813; ENSP00000351671; ENSG00000115009 [P78556-1]
ENST00000409189; ENSP00000386273; ENSG00000115009 [P78556-2]
GeneIDi6364
KEGGihsa:6364
UCSCiuc002vpl.3 human [P78556-1]

Organism-specific databases

CTDi6364
DisGeNETi6364
EuPathDBiHostDB:ENSG00000115009.11
GeneCardsiCCL20
HGNCiHGNC:10619 CCL20
MIMi601960 gene
neXtProtiNX_P78556
OpenTargetsiENSG00000115009
PharmGKBiPA35551
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2BK Eukaryota
ENOG410ZGME LUCA
GeneTreeiENSGT00530000064223
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP78556
KOiK14625
OMAiCCLRYTE
OrthoDBiEOG091G168B
PhylomeDBiP78556
TreeFamiTF334888

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6783783 Interleukin-10 signaling
SIGNORiP78556

Miscellaneous databases

EvolutionaryTraceiP78556
GeneWikiiCCL20
GenomeRNAii6364
PMAP-CutDBiP78556
PROiPR:P78556
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115009 Expressed in 131 organ(s), highest expression level in epithelium of nasopharynx
CleanExiHS_CCL20
GenevisibleiP78556 HS

Family and domain databases

CDDicd01119 Chemokine_CC_DCCL, 1 hit
InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR034133 Chemokine_CC_DCCL
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL20_HUMAN
AccessioniPrimary (citable) accession number: P78556
Secondary accession number(s): Q53S51, Q99664
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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