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Protein

Protein BTG2

Gene

BTG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.By similarity5 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
SIGNORiP78543

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG2
Alternative name(s):
BTG family member 2
NGF-inducible anti-proliferative protein PC3
Gene namesi
Name:BTG2
Synonyms:PC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159388.5
HGNCiHGNC:1131 BTG2
MIMi601597 gene
neXtProtiNX_P78543

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi53H → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi65Y → A: Abolishes interaction with CNOT7 and CNOT8. 2 Publications1
Mutagenesisi75D → A: Abolishes interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi103W → A: Abolishes interaction with CNOT7 and CNOT8; impairs anti-proliferative activity. 2 Publications1
Mutagenesisi105D → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi115E → A: Impairs interaction with CNOT7. Inhibits CNOT7 mRNA deadenylase activity. 1 Publication1
Mutagenesisi147S → A: Impairs phosphorylation by MAPK1 and MAPK3, and decreases PIN1-binding. 1 Publication1
Mutagenesisi148P → A: Impairs PIN1-binding. 1 Publication1
Mutagenesisi149S → A: Impairs phosphorylation by MAPK14, and decreases PIN1-binding. 1 Publication1

Organism-specific databases

DisGeNETi7832
OpenTargetsiENSG00000159388
PharmGKBiPA25451

Polymorphism and mutation databases

BioMutaiBTG2
DMDMi3023409

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438041 – 158Protein BTG2Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147Phosphoserine; by MAPK1 and MAPK31 Publication1
Modified residuei149Phosphoserine; by MAPK141 Publication1

Post-translational modificationi

Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP78543
MaxQBiP78543
PaxDbiP78543
PeptideAtlasiP78543
PRIDEiP78543
ProteomicsDBi57645

PTM databases

iPTMnetiP78543
PhosphoSitePlusiP78543

Expressioni

Gene expression databases

BgeeiENSG00000159388 Expressed in 231 organ(s), highest expression level in mucosa of stomach
CleanExiHS_BTG2
GenevisibleiP78543 HS

Organism-specific databases

HPAiHPA002355

Interactioni

Subunit structurei

Interacts with PRKCABP (By similarity). Interacts with CNOT7 and CNOT8; indicative for an association with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization.By similarity6 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi113593, 19 interactors
ELMiP78543
IntActiP78543, 5 interactors
MINTiP78543
STRINGi9606.ENSP00000290551

Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP78543
SMRiP78543
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78543

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000290200
HOVERGENiHBG004907
InParanoidiP78543
KOiK14443
OMAiPSKNYIM
OrthoDBiEOG091G0RS0
PhylomeDBiP78543
TreeFamiTF105272

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
IPR033328 BTG2
PANTHERiPTHR22978:SF29 PTHR22978:SF29, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequencei

Sequence statusi: Complete.

P78543-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHGKGTDML PEIAAAVGFL SSLLRTRGCV SEQRLKVFSG ALQEALTEHY
60 70 80 90 100
KHHWFPEKPS KGSGYRCIRI NHKMDPIISR VASQIGLSQP QLHQLLPSEL
110 120 130 140 150
TLWVDPYEVS YRIGEDGSIC VLYEEAPLAA SCGLLTCKNQ VLLGRSSPSK

NYVMAVSS
Length:158
Mass (Da):17,416
Last modified:May 1, 1997 - v1
Checksum:iFFAA1844CC360209
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048437153V → M. Corresponds to variant dbSNP:rs12039961Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72649 mRNA Translation: AAB37580.1
Y09943 mRNA Translation: CAA71074.1
AF361937 Genomic DNA Translation: AAL05626.1
AL513326 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91475.1
CH471067 Genomic DNA Translation: EAW91476.1
BC105948 mRNA Translation: AAI05949.1
BC105949 mRNA Translation: AAI05950.1
CCDSiCCDS1437.1
RefSeqiNP_006754.1, NM_006763.2
UniGeneiHs.519162

Genome annotation databases

EnsembliENST00000290551; ENSP00000290551; ENSG00000159388
ENST00000475157; ENSP00000433553; ENSG00000159388
GeneIDi7832
KEGGihsa:7832
UCSCiuc001gzq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72649 mRNA Translation: AAB37580.1
Y09943 mRNA Translation: CAA71074.1
AF361937 Genomic DNA Translation: AAL05626.1
AL513326 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91475.1
CH471067 Genomic DNA Translation: EAW91476.1
BC105948 mRNA Translation: AAI05949.1
BC105949 mRNA Translation: AAI05950.1
CCDSiCCDS1437.1
RefSeqiNP_006754.1, NM_006763.2
UniGeneiHs.519162

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DJUX-ray2.26B7-128[»]
3E9VX-ray1.70A8-127[»]
ProteinModelPortaliP78543
SMRiP78543
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113593, 19 interactors
ELMiP78543
IntActiP78543, 5 interactors
MINTiP78543
STRINGi9606.ENSP00000290551

PTM databases

iPTMnetiP78543
PhosphoSitePlusiP78543

Polymorphism and mutation databases

BioMutaiBTG2
DMDMi3023409

Proteomic databases

EPDiP78543
MaxQBiP78543
PaxDbiP78543
PeptideAtlasiP78543
PRIDEiP78543
ProteomicsDBi57645

Protocols and materials databases

DNASUi7832
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290551; ENSP00000290551; ENSG00000159388
ENST00000475157; ENSP00000433553; ENSG00000159388
GeneIDi7832
KEGGihsa:7832
UCSCiuc001gzq.4 human

Organism-specific databases

CTDi7832
DisGeNETi7832
EuPathDBiHostDB:ENSG00000159388.5
GeneCardsiBTG2
HGNCiHGNC:1131 BTG2
HPAiHPA002355
MIMi601597 gene
neXtProtiNX_P78543
OpenTargetsiENSG00000159388
PharmGKBiPA25451
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000290200
HOVERGENiHBG004907
InParanoidiP78543
KOiK14443
OMAiPSKNYIM
OrthoDBiEOG091G0RS0
PhylomeDBiP78543
TreeFamiTF105272

Enzyme and pathway databases

ReactomeiR-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
SIGNORiP78543

Miscellaneous databases

ChiTaRSiBTG2 human
EvolutionaryTraceiP78543
GeneWikiiBTG2
GenomeRNAii7832
PROiPR:P78543
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159388 Expressed in 231 organ(s), highest expression level in mucosa of stomach
CleanExiHS_BTG2
GenevisibleiP78543 HS

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
IPR033328 BTG2
PANTHERiPTHR22978:SF29 PTHR22978:SF29, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBTG2_HUMAN
AccessioniPrimary (citable) accession number: P78543
Secondary accession number(s): A0A024R986, Q3KR25, Q5VUT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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