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UniProtKB - P78536 (ADA17_HUMAN)

Protein

Disintegrin and metalloproteinase domain-containing protein 17

Gene

ADAM17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843).5 Publications

Catalytic activityi

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.3 Publications

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi184Zinc; in inhibited formBy similarity1
Metal bindingi405Zinc; catalytic1 Publication1
Active sitei406PROSITE-ProRule annotation1 Publication1
Metal bindingi409Zinc; catalytic1 Publication1
Metal bindingi415Zinc; catalytic1 Publication1

GO - Molecular functioni

  • endopeptidase activity Source: ARUK-UCL
  • integrin binding Source: BHF-UCL
  • interleukin-6 receptor binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • metalloendopeptidase activity Source: UniProtKB
  • metallopeptidase activity Source: BHF-UCL
  • Notch binding Source: UniProtKB
  • PDZ domain binding Source: BHF-UCL
  • peptidase activity Source: ARUK-UCL
  • SH3 domain binding Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processNotch signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.86 2681
ReactomeiR-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-1442490 Collagen degradation
R-HSA-177929 Signaling by EGFR
R-HSA-193692 Regulated proteolysis of p75NTR
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-5362798 Release of Hh-Np from the secreting cell
R-HSA-75893 TNF signaling
R-HSA-982772 Growth hormone receptor signaling
SignaLinkiP78536
SIGNORiP78536

Protein family/group databases

MEROPSiM12.217
TCDBi8.A.77.1.2 the sheddase (sheddase) family

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 17 (EC:3.4.24.863 Publications)
Short name:
ADAM 17
Alternative name(s):
Snake venom-like protease
TNF-alpha convertase
TNF-alpha-converting enzyme
CD_antigen: CD156b
Gene namesi
Name:ADAM17
Synonyms:CSVP, TACE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000151694.12
HGNCiHGNC:195 ADAM17
MIMi603639 gene
neXtProtiNX_P78536

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini215 – 671ExtracellularSequence analysisAdd BLAST457
Transmembranei672 – 692HelicalSequence analysisAdd BLAST21
Topological domaini693 – 824CytoplasmicSequence analysisAdd BLAST132

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Inflammatory skin and bowel disease, neonatal, 1 (NISBD1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized.
See also OMIM:614328

Organism-specific databases

DisGeNETi6868
MalaCardsiADAM17
MIMi614328 phenotype
OpenTargetsiENSG00000151694
Orphaneti294023 Neonatal inflammatory skin and bowel disease
PharmGKBiPA24512

Chemistry databases

ChEMBLiCHEMBL3706
DrugBankiDB07145 (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE
DB06943 (3S)-1-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}pyrrolidine-3-thiol
DB07079 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol
DB07233 N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan
GuidetoPHARMACOLOGYi1662

Polymorphism and mutation databases

BioMutaiADAM17
DMDMi14423632

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17By similarityAdd BLAST17
PropeptideiPRO_000002908818 – 2141 PublicationAdd BLAST197
ChainiPRO_0000029089215 – 824Disintegrin and metalloproteinase domain-containing protein 17Add BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi225 ↔ 3331 Publication
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi365 ↔ 4691 Publication
Disulfide bondi423 ↔ 4531 Publication
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi534 ↔ 555By similarity
Glycosylationi539N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi551N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi573 ↔ 582By similarity
Disulfide bondi578 ↔ 591By similarity
Disulfide bondi593 ↔ 600By similarity
Glycosylationi594N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei735Phosphothreonine; by MAPK142 Publications1
Modified residuei761PhosphothreonineCombined sources1
Modified residuei767PhosphoserineBy similarity1
Modified residuei791PhosphoserineCombined sources1
Modified residuei819Phosphoserine1 Publication1

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791. Phosphorylation at THR-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding.3 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

EPDiP78536
MaxQBiP78536
PaxDbiP78536
PeptideAtlasiP78536
PRIDEiP78536
ProteomicsDBi57637
57638 [P78536-2]

PTM databases

GlyConnecti1180
iPTMnetiP78536
PhosphoSitePlusiP78536
SwissPalmiP78536

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.

Inductioni

In arthritis-affected cartilage.

Gene expression databases

BgeeiENSG00000151694 Expressed in 242 organ(s), highest expression level in oocyte
CleanExiHS_ADAM17
ExpressionAtlasiP78536 baseline and differential
GenevisibleiP78536 HS

Organism-specific databases

HPAiCAB025906
HPA010738
HPA051575

Interactioni

Subunit structurei

Interacts with MAD2L1, MAPK14 and MUC1.2 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi112731, 22 interactors
DIPiDIP-31044N
IntActiP78536, 12 interactors
MINTiP78536
STRINGi9606.ENSP00000309968

Chemistry databases

BindingDBiP78536

Structurei

Secondary structure

1824
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP78536
SMRiP78536
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78536

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 474Peptidase M12BPROSITE-ProRule annotationAdd BLAST252
Domaini475 – 563DisintegrinPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni603 – 671Crambin-likeAdd BLAST69

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi182 – 189Cysteine switchBy similarity8
Motifi731 – 738SH3-bindingSequence analysis8
Motifi741 – 748SH3-bindingSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 99Poly-Val4
Compositional biasi564 – 602Cys-richAdd BLAST39

Domaini

Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity).By similarity
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Keywords - Domaini

SH3-binding, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3658 Eukaryota
ENOG410XQWB LUCA
GeneTreeiENSGT00670000097974
HOGENOMiHOG000033797
HOVERGENiHBG050457
InParanoidiP78536
KOiK06059
OMAiVCSDKNS
OrthoDBiEOG091G03AL
PhylomeDBiP78536
TreeFamiTF314733

Family and domain databases

CDDicd14246 ADAM17_MPD, 1 hit
cd04270 ZnMc_TACE_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR034025 ADAM10_ADAM17
IPR032029 ADAM17_MPD
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
PfamiView protein in Pfam
PF16698 ADAM17_MPD, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS00142 ZINC_PROTEASE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: P78536-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRQSLLFLTS VVPFVLAPRP PDDPGFGPHQ RLEKLDSLLS DYDILSLSNI 
        60         70         80         90        100
QQHSVRKRDL QTSTHVETLL TFSALKRHFK LYLTSSTERF SQNFKVVVVD 
       110        120        130        140        150
GKNESEYTVK WQDFFTGHVV GEPDSRVLAH IRDDDVIIRI NTDGAEYNIE 
       160        170        180        190        200
PLWRFVNDTK DKRMLVYKSE DIKNVSRLQS PKVCGYLKVD NEELLPKGLV 
       210        220        230        240        250
DREPPEELVH RVKRRADPDP MKNTCKLLVV ADHRFYRYMG RGEESTTTNY 
       260        270        280        290        300
LIELIDRVDD IYRNTSWDNA GFKGYGIQIE QIRILKSPQE VKPGEKHYNM 
       310        320        330        340        350
AKSYPNEEKD AWDVKMLLEQ FSFDIAEEAS KVCLAHLFTY QDFDMGTLGL 
       360        370        380        390        400
AYVGSPRANS HGGVCPKAYY SPVGKKNIYL NSGLTSTKNY GKTILTKEAD 
       410        420        430        440        450
LVTTHELGHN FGAEHDPDGL AECAPNEDQG GKYVMYPIAV SGDHENNKMF 
       460        470        480        490        500
SNCSKQSIYK TIESKAQECF QERSNKVCGN SRVDEGEECD PGIMYLNNDT 
       510        520        530        540        550
CCNSDCTLKE GVQCSDRNSP CCKNCQFETA QKKCQEAINA TCKGVSYCTG 
       560        570        580        590        600
NSSECPPPGN AEDDTVCLDL GKCKDGKCIP FCEREQQLES CACNETDNSC 
       610        620        630        640        650
KVCCRDLSGR CVPYVDAEQK NLFLRKGKPC TVGFCDMNGK CEKRVQDVIE 
       660        670        680        690        700
RFWDFIDQLS INTFGKFLAD NIVGSVLVFS LIFWIPFSIL VHCVDKKLDK 
       710        720        730        740        750
QYESLSLFHP SNVEMLSSMD SASVRIIKPF PAPQTPGRLQ PAPVIPSAPA 
       760        770        780        790        800
APKLDHQRMD TIQEDPSTDS HMDEDGFEKD PFPNSSTAAK SFEDLTDHPV 
       810        820 
TRSEKAASFK LQRQNRVDSK ETEC
Length:824
Mass (Da):93,021
Last modified:May 1, 1997 - v1
Checksum:i5B1032F6B88A837F
GO
Isoform B (identifier: P78536-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     695-824: Missing.

Note: No experimental confirmation available.
Show »
Length:694
Mass (Da):78,543
Checksum:i9DD63A5B13490AA1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EUI5E7EUI5_HUMAN
Disintegrin and metalloproteinase d...
ADAM17
285Annotation score:
A6H8L4A6H8L4_HUMAN
ADAM17 protein
ADAM17
258Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109V → A in AAC39721 (PubMed:9574564).Curated1
Sequence conflicti563D → N in AAC39721 (PubMed:9574564).Curated1
Sequence conflicti801T → A in AAC39721 (PubMed:9574564).Curated1
Sequence conflicti818D → N in AAC39721 (PubMed:9574564).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051586162K → E. Corresponds to variant dbSNP:rs34431503Ensembl.1
Natural variantiVAR_051587202R → G. Corresponds to variant dbSNP:rs2230818EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005478695 – 824Missing in isoform B. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86755 mRNA Translation: AAB51586.1
U69611 mRNA Translation: AAB51514.1
U69612 mRNA Translation: AAB53014.1
U92649 mRNA Translation: AAC39721.1
CCDSiCCDS1665.1 [P78536-1]
RefSeqiNP_003174.3, NM_003183.5 [P78536-1]
UniGeneiHs.404914
Hs.570189
Hs.744980

Genome annotation databases

EnsembliENST00000310823; ENSP00000309968; ENSG00000151694 [P78536-1]
GeneIDi6868
KEGGihsa:6868
UCSCiuc002qzu.5 human [P78536-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Tumor necrosis factor alpha-converting enzyme entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86755 mRNA Translation: AAB51586.1
U69611 mRNA Translation: AAB51514.1
U69612 mRNA Translation: AAB53014.1
U92649 mRNA Translation: AAC39721.1
CCDSiCCDS1665.1 [P78536-1]
RefSeqiNP_003174.3, NM_003183.5 [P78536-1]
UniGeneiHs.404914
Hs.570189
Hs.744980

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BKCX-ray2.00A/C/E/I219-474[»]
1ZXCX-ray2.28A/B215-477[»]
2A8HX-ray2.30A/B215-477[»]
2DDFX-ray1.70A/B218-474[»]
2FV5X-ray2.10A/B216-475[»]
2FV9X-ray2.02A/B218-475[»]
2I47X-ray1.90A/B/C/D212-492[»]
2M2FNMR-A581-642[»]
2OI0X-ray2.00A216-477[»]
3B92X-ray2.00A216-474[»]
3CKIX-ray2.30A219-474[»]
3E8RX-ray1.90A/B215-477[»]
3EDZX-ray1.90A/B215-477[»]
3EWJX-ray1.80A/B215-477[»]
3G42X-ray2.10A/B/C/D212-492[»]
3KMCX-ray1.80A/B215-476[»]
3KMEX-ray1.85A/B215-476[»]
3L0TX-ray1.92A/B215-476[»]
3L0VX-ray1.75A/B215-476[»]
3LE9X-ray1.85A/B215-476[»]
3LEAX-ray2.00A/B215-476[»]
3LGPX-ray1.90A/B215-476[»]
3O64X-ray1.88A/B215-476[»]
ProteinModelPortaliP78536
SMRiP78536
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112731, 22 interactors
DIPiDIP-31044N
IntActiP78536, 12 interactors
MINTiP78536
STRINGi9606.ENSP00000309968

Chemistry databases

BindingDBiP78536
ChEMBLiCHEMBL3706
DrugBankiDB07145 (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE
DB06943 (3S)-1-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}pyrrolidine-3-thiol
DB07079 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol
DB07233 N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan
GuidetoPHARMACOLOGYi1662

Protein family/group databases

MEROPSiM12.217
TCDBi8.A.77.1.2 the sheddase (sheddase) family

PTM databases

GlyConnecti1180
iPTMnetiP78536
PhosphoSitePlusiP78536
SwissPalmiP78536

Polymorphism and mutation databases

BioMutaiADAM17
DMDMi14423632

Proteomic databases

EPDiP78536
MaxQBiP78536
PaxDbiP78536
PeptideAtlasiP78536
PRIDEiP78536
ProteomicsDBi57637
57638 [P78536-2]

Protocols and materials databases

DNASUi6868
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310823; ENSP00000309968; ENSG00000151694 [P78536-1]
GeneIDi6868
KEGGihsa:6868
UCSCiuc002qzu.5 human [P78536-1]

Organism-specific databases

CTDi6868
DisGeNETi6868
EuPathDBiHostDB:ENSG00000151694.12
GeneCardsiADAM17
HGNCiHGNC:195 ADAM17
HPAiCAB025906
HPA010738
HPA051575
MalaCardsiADAM17
MIMi603639 gene
614328 phenotype
neXtProtiNX_P78536
OpenTargetsiENSG00000151694
Orphaneti294023 Neonatal inflammatory skin and bowel disease
PharmGKBiPA24512
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3658 Eukaryota
ENOG410XQWB LUCA
GeneTreeiENSGT00670000097974
HOGENOMiHOG000033797
HOVERGENiHBG050457
InParanoidiP78536
KOiK06059
OMAiVCSDKNS
OrthoDBiEOG091G03AL
PhylomeDBiP78536
TreeFamiTF314733

Enzyme and pathway databases

BRENDAi3.4.24.86 2681
ReactomeiR-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-1442490 Collagen degradation
R-HSA-177929 Signaling by EGFR
R-HSA-193692 Regulated proteolysis of p75NTR
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-5362798 Release of Hh-Np from the secreting cell
R-HSA-75893 TNF signaling
R-HSA-982772 Growth hormone receptor signaling
SignaLinkiP78536
SIGNORiP78536

Miscellaneous databases

ChiTaRSiADAM17 human
EvolutionaryTraceiP78536
GeneWikiiADAM17
GenomeRNAii6868
PROiPR:P78536
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151694 Expressed in 242 organ(s), highest expression level in oocyte
CleanExiHS_ADAM17
ExpressionAtlasiP78536 baseline and differential
GenevisibleiP78536 HS

Family and domain databases

CDDicd14246 ADAM17_MPD, 1 hit
cd04270 ZnMc_TACE_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR034025 ADAM10_ADAM17
IPR032029 ADAM17_MPD
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
PfamiView protein in Pfam
PF16698 ADAM17_MPD, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA17_HUMAN
AccessioniPrimary (citable) accession number: P78536
Secondary accession number(s): O60226
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 211 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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