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Protein

Reelin

Gene

RELN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2060Zinc 1By similarity1
Metal bindingi2073Zinc 1By similarity1
Metal bindingi2178Zinc 1By similarity1
Metal bindingi2263Zinc 1By similarity1
Metal bindingi2396Zinc 2By similarity1
Metal bindingi2398Zinc 2By similarity1
Metal bindingi2459Zinc 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protease, Serine protease
Biological processCell adhesion
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8866376 Reelin signalling pathway

SIGNOR Signaling Network Open Resource

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SIGNORi
P78509

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reelin (EC:3.4.21.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RELN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000189056.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9957 RELN

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600514 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P78509

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lissencephaly 2 (LIS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA classic type lissencephaly associated with ataxia, mental retardation, seizures and abnormalities of the cerebellum, hippocampus and brainstem.
See also OMIM:257320
Epilepsy, familial temporal lobe, 7 (ETL7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature.
See also OMIM:616436
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073862672P → L in ETL7. 1 PublicationCorresponds to variant dbSNP:rs201044262EnsemblClinVar.1
Natural variantiVAR_073863723Y → C in ETL7. 1 PublicationCorresponds to variant dbSNP:rs768119894EnsemblClinVar.1
Natural variantiVAR_073864763D → G in ETL7. 1 PublicationCorresponds to variant dbSNP:rs794727998EnsemblClinVar.1
Natural variantiVAR_073865798H → N in ETL7. 1 PublicationCorresponds to variant dbSNP:rs794727996EnsemblClinVar.1
Natural variantiVAR_073866844P → L in ETL7. 1 PublicationCorresponds to variant dbSNP:rs797045000EnsemblClinVar.1
Natural variantiVAR_0738672783G → C in ETL7. 1 PublicationCorresponds to variant dbSNP:rs794727997EnsemblClinVar.1
Natural variantiVAR_0738683176E → K in ETL7. 1 PublicationCorresponds to variant dbSNP:rs794727999EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Epilepsy, Lissencephaly

Organism-specific databases

DisGeNET

More...
DisGeNETi
5649

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
RELN

MalaCards human disease database

More...
MalaCardsi
RELN
MIMi257320 phenotype
616436 phenotype

Open Targets

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OpenTargetsi
ENSG00000189056

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
101046 Autosomal dominant epilepsy with auditory features
89844 Lissencephaly syndrome, Norman-Roberts type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34323

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RELN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452988

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003030426 – 3460ReelinAdd BLAST3435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 126PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi154 ↔ 178PROSITE-ProRule annotation
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi305N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi539 ↔ 580PROSITE-ProRule annotation
Disulfide bondi608 ↔ 613PROSITE-ProRule annotation
Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi674 ↔ 684PROSITE-ProRule annotation
Disulfide bondi691 ↔ 700PROSITE-ProRule annotation
Disulfide bondi894 ↔ 936PROSITE-ProRule annotation
Disulfide bondi967 ↔ 974PROSITE-ProRule annotation
Disulfide bondi1033 ↔ 1043PROSITE-ProRule annotation
Disulfide bondi1050 ↔ 1059PROSITE-ProRule annotation
Glycosylationi1266N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1270 ↔ 1309PROSITE-ProRule annotation
Disulfide bondi1338 ↔ 1347PROSITE-ProRule annotation
Glycosylationi1599N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1632 ↔ 1672PROSITE-ProRule annotation
Disulfide bondi1701 ↔ 1708PROSITE-ProRule annotation
Glycosylationi1749N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1920N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2100InterchainPROSITE-ProRule annotation
Disulfide bondi2132 ↔ 2142PROSITE-ProRule annotation
Disulfide bondi2136 ↔ 2148PROSITE-ProRule annotation
Glycosylationi2144N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2150 ↔ 2159PROSITE-ProRule annotation
Disulfide bondi2194 ↔ 2234PROSITE-ProRule annotation
Glycosylationi2268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2316N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2347 ↔ 2386PROSITE-ProRule annotation
Disulfide bondi2392 ↔ 2558PROSITE-ProRule annotation
Disulfide bondi2543 ↔ 2583PROSITE-ProRule annotation
Glycosylationi2568N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2793 ↔ 2800PROSITE-ProRule annotation
Disulfide bondi2856 ↔ 2866PROSITE-ProRule annotation
Disulfide bondi2860 ↔ 2871PROSITE-ProRule annotation
Disulfide bondi2873 ↔ 2882PROSITE-ProRule annotation
Disulfide bondi2918 ↔ 2965PROSITE-ProRule annotation
Glycosylationi2961N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3015N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi3072N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3159 ↔ 3169PROSITE-ProRule annotation
Glycosylationi3184N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3231 ↔ 3241PROSITE-ProRule annotation
Disulfide bondi3235 ↔ 3247PROSITE-ProRule annotation
Disulfide bondi3249 ↔ 3258PROSITE-ProRule annotation
Disulfide bondi3295 ↔ 3345PROSITE-ProRule annotation
Glycosylationi3411N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3438N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P78509

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P78509

PeptideAtlas

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PeptideAtlasi
P78509

PRoteomics IDEntifications database

More...
PRIDEi
P78509

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57628
57629 [P78509-2]
57630 [P78509-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P78509

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P78509

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% in patients with schizophrenia. Also expressed in fetal and adult liver.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal and postnatal brain and liver. Expression in postnatal human brain is high in the cerebellum.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000189056 Expressed in 214 organ(s), highest expression level in cerebellar hemisphere

CleanEx database of gene expression profiles

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CleanExi
HS_RELN

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P78509 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P78509 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA046512

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111630, 7 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000392423

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P78509

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P78509

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 190ReelinPROSITE-ProRule annotationAdd BLAST165
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati592 – 603BNR 1Add BLAST12
Domaini670 – 701EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Repeati798 – 809BNR 2Add BLAST12
Repeati951 – 962BNR 3Add BLAST12
Domaini1029 – 1060EGF-like 2PROSITE-ProRule annotationAdd BLAST32
Repeati1156 – 1167BNR 4Add BLAST12
Repeati1322 – 1333BNR 5Add BLAST12
Domaini1408 – 1441EGF-like 3PROSITE-ProRule annotationAdd BLAST34
Repeati1534 – 1545BNR 6Add BLAST12
Repeati1685 – 1696BNR 7Add BLAST12
Domaini1764 – 1795EGF-like 4PROSITE-ProRule annotationAdd BLAST32
Repeati1883 – 1894BNR 8Add BLAST12
Repeati2042 – 2053BNR 9Add BLAST12
Domaini2128 – 2160EGF-like 5PROSITE-ProRule annotationAdd BLAST33
Repeati2249 – 2260BNR 10Add BLAST12
Repeati2398 – 2409BNR 11Add BLAST12
Domaini2477 – 2508EGF-like 6PROSITE-ProRule annotationAdd BLAST32
Repeati2597 – 2608BNR 12Add BLAST12
Repeati2777 – 2788BNR 13Add BLAST12
Domaini2852 – 2883EGF-like 7PROSITE-ProRule annotationAdd BLAST32
Repeati2978 – 2989BNR 14Add BLAST12
Repeati3142 – 3154BNR 15Add BLAST13
Domaini3227 – 3259EGF-like 8PROSITE-ProRule annotationAdd BLAST33
Repeati3362 – 3373BNR 16Add BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3431 – 3460Arg-rich (basic)Add BLAST30

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The basic C-terminal region is essential for secretion.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the reelin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEXI Eukaryota
ENOG410XQKB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00580000081623

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG023117

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P78509

KEGG Orthology (KO)

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KOi
K06249

Identification of Orthologs from Complete Genome Data

More...
OMAi
NGGITWH

Database for complete collections of gene phylogenies

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PhylomeDBi
P78509

TreeFam database of animal gene trees

More...
TreeFami
TF106479

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08544 Reeler, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.260, 18 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR008979 Galactose-bd-like_sf
IPR002861 Reeler_dom
IPR034968 Reelin
IPR036278 Sialidase_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11841 PTHR11841, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02014 Reeler, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50939 SSF50939, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 6 hits
PS50026 EGF_3, 5 hits
PS51019 REELIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P78509-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERSGWARQT FLLALLLGAT LRARAAAGYY PRFSPFFFLC THHGELEGDG
60 70 80 90 100
EQGEVLISLH IAGNPTYYVP GQEYHVTIST STFFDGLLVT GLYTSTSVQA
110 120 130 140 150
SQSIGGSSAF GFGIMSDHQF GNQFMCSVVA SHVSHLPTTN LSFIWIAPPA
160 170 180 190 200
GTGCVNFMAT ATHRGQVIFK DALAQQLCEQ GAPTDVTVHP HLAEIHSDSI
210 220 230 240 250
ILRDDFDSYH QLQLNPNIWV ECNNCETGEQ CGAIMHGNAV TFCEPYGPRE
260 270 280 290 300
LITTGLNTTT ASVLQFSIGS GSCRFSYSDP SIIVLYAKNN SADWIQLEKI
310 320 330 340 350
RAPSNVSTII HILYLPEDAK GENVQFQWKQ ENLRVGEVYE ACWALDNILI
360 370 380 390 400
INSAHRQVVL EDSLDPVDTG NWLFFPGATV KHSCQSDGNS IYFHGNEGSE
410 420 430 440 450
FNFATTRDVD LSTEDIQEQW SEEFESQPTG WDVLGAVIGT ECGTIESGLS
460 470 480 490 500
MVFLKDGERK LCTPSMDTTG YGNLRFYFVM GGICDPGNSH ENDIILYAKI
510 520 530 540 550
EGRKEHITLD TLSYSSYKVP SLVSVVINPE LQTPATKFCL RQKNHQGHNR
560 570 580 590 600
NVWAVDFFHV LPVLPSTMSH MIQFSINLGC GTHQPGNSVS LEFSTNHGRS
610 620 630 640 650
WSLLHTECLP EICAGPHLPH STVYSSENYS GWNRITIPLP NAALTRNTRI
660 670 680 690 700
RWRQTGPILG NMWAIDNVYI GPSCLKFCSG RGQCTRHGCK CDPGFSGPAC
710 720 730 740 750
EMASQTFPMF ISESFGSSRL SSYHNFYSIR GAEVSFGCGV LASGKALVFN
760 770 780 790 800
KDGRRQLITS FLDSSQSRFL QFTLRLGSKS VLSTCRAPDQ PGEGVLLHYS
810 820 830 840 850
YDNGITWKLL EHYSYLSYHE PRIISVELPG DAKQFGIQFR WWQPYHSSQR
860 870 880 890 900
EDVWAIDEII MTSVLFNSIS LDFTNLVEVT QSLGFYLGNV QPYCGHDWTL
910 920 930 940 950
CFTGDSKLAS SMRYVETQSM QIGASYMIQF SLVMGCGQKY TPHMDNQVKL
960 970 980 990 1000
EYSTNHGLTW HLVQEECLPS MPSCQEFTSA SIYHASEFTQ WRRVIVLLPQ
1010 1020 1030 1040 1050
KTWSSATRFR WSQSYYTAQD EWALDSIYIG QQCPNMCSGH GSCDHGICRC
1060 1070 1080 1090 1100
DQGYQGTECH PEAALPSTIM SDFENQNGWE SDWQEVIGGE IVKPEQGCGV
1110 1120 1130 1140 1150
ISSGSSLYFS KAGKRQLVSW DLDTSWVDFV QFYIQIGGES ASCNKPDSRE
1160 1170 1180 1190 1200
EGVLLQYSNN GGIQWHLLAE MYFSDFSKPR FVYLELPAAA KTPCTRFRWW
1210 1220 1230 1240 1250
QPVFSGEDYD QWAVDDIIIL SEKQKQIIPV INPTLPQNFY EKPAFDYPMN
1260 1270 1280 1290 1300
QMSVWLMLAN EGMVKNETFC AATPSAMIFG KSDGDRFAVT RDLTLKPGYV
1310 1320 1330 1340 1350
LQFKLNIGCA NQFSSTAPVL LQYSHDAGMS WFLVKEGCYP ASAGKGCEGN
1360 1370 1380 1390 1400
SRELSEPTMY HTGDFEEWTR ITIVIPRSLA SSKTRFRWIQ ESSSQKNVPP
1410 1420 1430 1440 1450
FGLDGVYISE PCPSYCSGHG DCISGVCFCD LGYTAAQGTC VSNVPNHNEM
1460 1470 1480 1490 1500
FDRFEGKLSP LWYKITGAQV GTGCGTLNDG KSLYFNGPGK REARTVPLDT
1510 1520 1530 1540 1550
RNIRLVQFYI QIGSKTSGIT CIKPRTRNEG LIVQYSNDNG ILWHLLRELD
1560 1570 1580 1590 1600
FMSFLEPQII SIDLPQDAKT PATAFRWWQP QHGKHSAQWA LDDVLIGMND
1610 1620 1630 1640 1650
SSQTGFQDKF DGSIDLQANW YRIQGGQVDI DCLSMDTALI FTENIGKPRY
1660 1670 1680 1690 1700
AETWDFHVSA STFLQFEMSM GCSKPFSNSH SVQLQYSLNN GKDWHLVTEE
1710 1720 1730 1740 1750
CVPPTIGCLH YTESSIYTSE RFQNWKRITV YLPLSTISPR TRFRWIQANY
1760 1770 1780 1790 1800
TVGADSWAID NVVLASGCPW MCSGRGICDA GRCVCDRGFG GPYCVPVVPL
1810 1820 1830 1840 1850
PSILKDDFNG NLHPDLWPEV YGAERGNLNG ETIKSGTSLI FKGEGLRMLI
1860 1870 1880 1890 1900
SRDLDCTNTM YVQFSLRFIA KSTPERSHSI LLQFSISGGI TWHLMDEFYF
1910 1920 1930 1940 1950
PQTTNILFIN VPLPYTAQTN ATRFRLWQPY NNGKKEEIWI VDDFIIDGNN
1960 1970 1980 1990 2000
VNNPVMLLDT FDFGPREDNW FFYPGGNIGL YCPYSSKGAP EEDSAMVFVS
2010 2020 2030 2040 2050
NEVGEHSITT RDLNVNENTI IQFEINVGCS TDSSSADPVR LEFSRDFGAT
2060 2070 2080 2090 2100
WHLLLPLCYH SSSHVSSLCS TEHHPSSTYY AGTMQGWRRE VVHFGKLHLC
2110 2120 2130 2140 2150
GSVRFRWYQG FYPAGSQPVT WAIDNVYIGP QCEEMCNGQG SCINGTKCIC
2160 2170 2180 2190 2200
DPGYSGPTCK ISTKNPDFLK DDFEGQLESD RFLLMSGGKP SRKCGILSSG
2210 2220 2230 2240 2250
NNLFFNEDGL RMLMTRDLDL SHARFVQFFM RLGCGKGVPD PRSQPVLLQY
2260 2270 2280 2290 2300
SLNGGLSWSL LQEFLFSNSS NVGRYIALEI PLKARSGSTR LRWWQPSENG
2310 2320 2330 2340 2350
HFYSPWVIDQ ILIGGNISGN TVLEDDFTTL DSRKWLLHPG GTKMPVCGST
2360 2370 2380 2390 2400
GDALVFIEKA STRYVVSTDV AVNEDSFLQI DFAASCSVTD SCYAIELEYS
2410 2420 2430 2440 2450
VDLGLSWHPL VRDCLPTNVE CSRYHLQRIL VSDTFNKWTR ITLPLPPYTR
2460 2470 2480 2490 2500
SQATRFRWHQ PAPFDKQQTW AIDNVYIGDG CIDMCSGHGR CIQGNCVCDE
2510 2520 2530 2540 2550
QWGGLYCDDP ETSLPTQLKD NFNRAPSSQN WLTVNGGKLS TVCGAVASGM
2560 2570 2580 2590 2600
ALHFSGGCSR LLVTVDLNLT NAEFIQFYFM YGCLITPNNR NQGVLLEYSV
2610 2620 2630 2640 2650
NGGITWNLLM EIFYDQYSKP GFVNILLPPD AKEIATRFRW WQPRHDGLDQ
2660 2670 2680 2690 2700
NDWAIDNVLI SGSADQRTVM LDTFSSAPVP QHERSPADAG PVGRIAFDMF
2710 2720 2730 2740 2750
MEDKTSVNEH WLFHDDCTVE RFCDSPDGVM LCGSHDGREV YAVTHDLTPT
2760 2770 2780 2790 2800
EGWIMQFKIS VGCKVSEKIA QNQIHVQYST DFGVSWNYLV PQCLPADPKC
2810 2820 2830 2840 2850
SGSVSQPSVF FPTKGWKRIT YPLPESLVGN PVRFRFYQKY SDMQWAIDNF
2860 2870 2880 2890 2900
YLGPGCLDNC RGHGDCLREQ CICDPGYSGP NCYLTHTLKT FLKERFDSEE
2910 2920 2930 2940 2950
IKPDLWMSLE GGSTCTECGI LAEDTALYFG GSTVRQAVTQ DLDLRGAKFL
2960 2970 2980 2990 3000
QYWGRIGSEN NMTSCHRPIC RKEGVLLDYS TDGGITWTLL HEMDYQKYIS
3010 3020 3030 3040 3050
VRHDYILLPE DALTNTTRLR WWQPFVISNG IVVSGVERAQ WALDNILIGG
3060 3070 3080 3090 3100
AEINPSQLVD TFDDEGTSHE ENWSFYPNAV RTAGFCGNPS FHLYWPNKKK
3110 3120 3130 3140 3150
DKTHNALSSR ELIIQPGYMM QFKIVVGCEA TSCGDLHSVM LEYTKDARSD
3160 3170 3180 3190 3200
SWQLVQTQCL PSSSNSIGCS PFQFHEATIY NSVNSSSWKR ITIQLPDHVS
3210 3220 3230 3240 3250
SSATQFRWIQ KGEETEKQSW AIDHVYIGEA CPKLCSGHGY CTTGAICICD
3260 3270 3280 3290 3300
ESFQGDDCSV FSHDLPSYIK DNFESARVTE ANWETIQGGV IGSGCGQLAP
3310 3320 3330 3340 3350
YAHGDSLYFN GCQIRQAATK PLDLTRASKI MFVLQIGSMS QTDSCNSDLS
3360 3370 3380 3390 3400
GPHAVDKAVL LQYSVNNGIT WHVIAQHQPK DFTQAQRVSY NVPLEARMKG
3410 3420 3430 3440 3450
VLLRWWQPRH NGTGHDQWAL DHVEVVLVST RKQNYMMNFS RQHGLRHFYN
3460
RRRRSLRRYP
Length:3,460
Mass (Da):388,388
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A398EC17FA4EE1B
GO
Isoform 2 (identifier: P78509-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3428-3429: Missing.

Show »
Length:3,458
Mass (Da):388,201
Checksum:iA67B9EAF1DAE6F69
GO
Isoform 3 (identifier: P78509-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3428-3460: Missing.

Show »
Length:3,427
Mass (Da):384,093
Checksum:iE9DF2AE0AC29DB8C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQ66J3KQ66_HUMAN
Reelin
RELN
3,460Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2B0H7C2B0_HUMAN
Reelin
RELN
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti752D → E in AAC51105 (PubMed:9049633).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

A polymorphic GGC triplet repeat located in the 5'-UTR region of RELN gene, which harbors in the normal population 8 to 10 repeats, is significantly increased in autistic patients to carry 4 to 23 additional repeats.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073862672P → L in ETL7. 1 PublicationCorresponds to variant dbSNP:rs201044262EnsemblClinVar.1
Natural variantiVAR_073863723Y → C in ETL7. 1 PublicationCorresponds to variant dbSNP:rs768119894EnsemblClinVar.1
Natural variantiVAR_073864763D → G in ETL7. 1 PublicationCorresponds to variant dbSNP:rs794727998EnsemblClinVar.1
Natural variantiVAR_073865798H → N in ETL7. 1 PublicationCorresponds to variant dbSNP:rs794727996EnsemblClinVar.1
Natural variantiVAR_073866844P → L in ETL7. 1 PublicationCorresponds to variant dbSNP:rs797045000EnsemblClinVar.1
Natural variantiVAR_047977978T → A. Corresponds to variant dbSNP:rs3025962EnsemblClinVar.1
Natural variantiVAR_047978997L → V. Corresponds to variant dbSNP:rs362691EnsemblClinVar.1
Natural variantiVAR_0577121703P → R. Corresponds to variant dbSNP:rs2229860EnsemblClinVar.1
Natural variantiVAR_0738672783G → C in ETL7. 1 PublicationCorresponds to variant dbSNP:rs794727997EnsemblClinVar.1
Natural variantiVAR_0738683176E → K in ETL7. 1 PublicationCorresponds to variant dbSNP:rs794727999EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0055763428 – 3460Missing in isoform 3. CuratedAdd BLAST33
Alternative sequenceiVSP_0055753428 – 3429Missing in isoform 2. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U79716 mRNA Translation: AAC51105.1
AC002067 Genomic DNA Translation: AAM49151.1
AC006981 Genomic DNA No translation available.
AC073208 Genomic DNA Translation: AAP22355.1
AC005101 Genomic DNA Translation: AAP22330.1
AC000121 Genomic DNA Translation: AAB46357.2
AC006316 Genomic DNA Translation: AAD29127.1
AC005064 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24410.1
CH236947 Genomic DNA Translation: EAL24411.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34722.1 [P78509-2]
CCDS47680.1 [P78509-1]

NCBI Reference Sequences

More...
RefSeqi
NP_005036.2, NM_005045.3 [P78509-1]
NP_774959.1, NM_173054.2 [P78509-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.655654

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343529; ENSP00000345694; ENSG00000189056 [P78509-2]
ENST00000428762; ENSP00000392423; ENSG00000189056 [P78509-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5649

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5649

UCSC genome browser

More...
UCSCi
uc010liz.3 human [P78509-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Reelin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79716 mRNA Translation: AAC51105.1
AC002067 Genomic DNA Translation: AAM49151.1
AC006981 Genomic DNA No translation available.
AC073208 Genomic DNA Translation: AAP22355.1
AC005101 Genomic DNA Translation: AAP22330.1
AC000121 Genomic DNA Translation: AAB46357.2
AC006316 Genomic DNA Translation: AAD29127.1
AC005064 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24410.1
CH236947 Genomic DNA Translation: EAL24411.1
CCDSiCCDS34722.1 [P78509-2]
CCDS47680.1 [P78509-1]
RefSeqiNP_005036.2, NM_005045.3 [P78509-1]
NP_774959.1, NM_173054.2 [P78509-2]
UniGeneiHs.655654

3D structure databases

ProteinModelPortaliP78509
SMRiP78509
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111630, 7 interactors
STRINGi9606.ENSP00000392423

PTM databases

iPTMnetiP78509
PhosphoSitePlusiP78509

Polymorphism and mutation databases

BioMutaiRELN
DMDMi296452988

Proteomic databases

MaxQBiP78509
PaxDbiP78509
PeptideAtlasiP78509
PRIDEiP78509
ProteomicsDBi57628
57629 [P78509-2]
57630 [P78509-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343529; ENSP00000345694; ENSG00000189056 [P78509-2]
ENST00000428762; ENSP00000392423; ENSG00000189056 [P78509-1]
GeneIDi5649
KEGGihsa:5649
UCSCiuc010liz.3 human [P78509-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5649
DisGeNETi5649
EuPathDBiHostDB:ENSG00000189056.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RELN
GeneReviewsiRELN

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0033998
HIX0201200
HGNCiHGNC:9957 RELN
HPAiHPA046512
MalaCardsiRELN
MIMi257320 phenotype
600514 gene
616436 phenotype
neXtProtiNX_P78509
OpenTargetsiENSG00000189056
Orphaneti101046 Autosomal dominant epilepsy with auditory features
89844 Lissencephaly syndrome, Norman-Roberts type
PharmGKBiPA34323

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEXI Eukaryota
ENOG410XQKB LUCA
GeneTreeiENSGT00580000081623
HOVERGENiHBG023117
InParanoidiP78509
KOiK06249
OMAiNGGITWH
PhylomeDBiP78509
TreeFamiTF106479

Enzyme and pathway databases

ReactomeiR-HSA-8866376 Reelin signalling pathway
SIGNORiP78509

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RELN human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Reelin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5649

Protein Ontology

More...
PROi
PR:P78509

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000189056 Expressed in 214 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_RELN
ExpressionAtlasiP78509 baseline and differential
GenevisibleiP78509 HS

Family and domain databases

CDDicd08544 Reeler, 1 hit
Gene3Di2.60.120.260, 18 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR008979 Galactose-bd-like_sf
IPR002861 Reeler_dom
IPR034968 Reelin
IPR036278 Sialidase_sf
PANTHERiPTHR11841 PTHR11841, 5 hits
PfamiView protein in Pfam
PF02014 Reeler, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SUPFAMiSSF50939 SSF50939, 4 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 6 hits
PS50026 EGF_3, 5 hits
PS51019 REELIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRELN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78509
Secondary accession number(s): A4D0P9
, A4D0Q0, Q86UJ0, Q86UJ8, Q8NDV0, Q9UDQ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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