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Entry version 176 (13 Feb 2019)
Sequence version 1 (01 May 1997)
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Protein

ATP-sensitive inward rectifier potassium channel 10

Gene

KCNJ10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K+ recycling in distal tubules; this process is critical for Na+ reabsorption at the tubules.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei158Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi210 – 217ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP-activated inward rectifier potassium channel activity Source: ProtInc
  • ATP binding Source: UniProtKB-KW
  • G-protein activated inward rectifier potassium channel activity Source: Reactome
  • inward rectifier potassium channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandATP-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-1296067 Potassium transport channels
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.2.1.16 the inward rectifier k(+) channel (irk-c) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 10
Alternative name(s):
ATP-dependent inwardly rectifying potassium channel Kir4.1
Inward rectifier K(+) channel Kir1.2
Potassium channel, inwardly rectifying subfamily J member 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNJ10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000177807.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6256 KCNJ10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602208 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P78508

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 64CytoplasmicBy similarityAdd BLAST64
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei65 – 89Helical; Name=M1By similarityAdd BLAST25
Topological domaini90 – 114ExtracellularBy similarityAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei115 – 126Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei127 – 133Pore-formingBy similarity7
Topological domaini134 – 142ExtracellularBy similarity9
Transmembranei143 – 164Helical; Name=M2By similarityAdd BLAST22
Topological domaini165 – 379CytoplasmicBy similarityAdd BLAST215

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia.
See also OMIM:612780
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06305965R → P in SESAMES; no effect on localization to the basolateral membrane in kidney cells. 3 PublicationsCorresponds to variant dbSNP:rs137853066EnsemblClinVar.1
Natural variantiVAR_07274668L → P in SESAMES. 1 Publication1
Natural variantiVAR_06306077G → R in SESAMES; important loss of localization to the basolateral membrane in kidney cells; in non-tubular cells, does not form functional channels. 2 PublicationsCorresponds to variant dbSNP:rs137853072EnsemblClinVar.1
Natural variantiVAR_072747129I → V in SESAMES. 1 PublicationCorresponds to variant dbSNP:rs751625111Ensembl.1
Natural variantiVAR_063061140C → R in SESAMES; loss of localization to the basolateral membrane in kidney cells; in non-tubular cells, does not form functional channels. 2 PublicationsCorresponds to variant dbSNP:rs137853068EnsemblClinVar.1
Natural variantiVAR_063062164T → I in SESAMES; no effect on localization to the basolateral membrane in kidney cells. 2 PublicationsCorresponds to variant dbSNP:rs137853069EnsemblClinVar.1
Natural variantiVAR_063063167A → V in SESAMES; loss of localization to the basolateral membrane in kidney cells; in non-tubular cells, forms functional channels; important loss of MAGI1-binding when transfected in tubular MDCKII cells, but not in non-tubular HEK293T cells. 2 PublicationsCorresponds to variant dbSNP:rs137853070EnsemblClinVar.1
Natural variantiVAR_063064297R → C in SESAMES; no effect on localization to the basolateral membrane in kidney cells. 2 PublicationsCorresponds to variant dbSNP:rs137853071EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3766

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
KCNJ10

MalaCards human disease database

More...
MalaCardsi
KCNJ10
MIMi612780 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000177807

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
199343 EAST syndrome
705 Pendred syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30043

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2146348

Drug and drug target database

More...
DrugBanki
DB01392 Yohimbine

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
438

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNJ10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2493605

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001549531 – 379ATP-sensitive inward rectifier potassium channel 10Add BLAST379

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P78508

PeptideAtlas

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PeptideAtlasi
P78508

PRoteomics IDEntifications database

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PRIDEi
P78508

ProteomicsDB human proteome resource

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ProteomicsDBi
57627

Consortium for Top Down Proteomics

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TopDownProteomicsi
P78508

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P78508

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P78508

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177807 Expressed in 98 organ(s), highest expression level in C1 segment of cervical spinal cord

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P78508 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P78508 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA078302

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with Kir5.1/KCNJ16; this interaction is required for KCNJ16 localization to the basolateral membrane in kidney cells. Interacts with MAGI1, alone and possibly as a heterodimer with KCNJ16; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney cells (PubMed:24561201). Interacts with PATJ (By similarity).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109968, 19 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P78508

Protein interaction database and analysis system

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IntActi
P78508, 5 interactors

Molecular INTeraction database

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MINTi
P78508

STRING: functional protein association networks

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STRINGi
9606.ENSP00000357068

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P78508

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P78508

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P78508

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi128 – 133Selectivity filterBy similarity6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3827 Eukaryota
ENOG410XQ62 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153878

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000237326

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006178

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P78508

KEGG Orthology (KO)

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KOi
K05003

Identification of Orthologs from Complete Genome Data

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OMAi
IPLTFYH

Database of Orthologous Groups

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OrthoDBi
956263at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P78508

TreeFam database of animal gene trees

More...
TreeFami
TF313676

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.1400, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003269 K_chnl_inward-rec_Kir1.2
IPR013518 K_chnl_inward-rec_Kir_cyto
IPR040445 Kir_TM

The PANTHER Classification System

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PANTHERi
PTHR11767 PTHR11767, 1 hit
PTHR11767:SF21 PTHR11767:SF21, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01007 IRK, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF005465 GIRK_kir, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01322 KIR12CHANNEL
PR01320 KIRCHANNEL

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81296 SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P78508-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSVAKVYYS QTTQTESRPL MGPGIRRRRV LTKDGRSNVR MEHIADKRFL
60 70 80 90 100
YLKDLWTTFI DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELD
110 120 130 140 150
PPANHTPCVV QVHTLTGAFL FSLESQTTIG YGFRYISEEC PLAIVLLIAQ
160 170 180 190 200
LVLTTILEIF ITGTFLAKIA RPKKRAETIR FSQHAVVASH NGKPCLMIRV
210 220 230 240 250
ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV DTASDSPFLI
260 270 280 290 300
LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY
310 320 330 340 350
LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG
360 370
DPEKLKLEES LREQAEKEGS ALSVRISNV
Length:379
Mass (Da):42,508
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9DA013FF4003533
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PQP0A0A1W2PQP0_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ10
287Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPI0A0A1W2PPI0_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ10
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PP51A0A1W2PP51_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ10
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUX2A0A1B0GUX2_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ10
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQC0A0A1W2PQC0_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ10
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PP61A0A1W2PP61_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ10
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34036 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50L → P in AAB07046 (PubMed:10659995).Curated1
Sequence conflicti83G → V in AAH34036 (PubMed:15489334).Curated1
Sequence conflicti166L → Q in AAB07046 (PubMed:10659995).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06305965R → P in SESAMES; no effect on localization to the basolateral membrane in kidney cells. 3 PublicationsCorresponds to variant dbSNP:rs137853066EnsemblClinVar.1
Natural variantiVAR_07274668L → P in SESAMES. 1 Publication1
Natural variantiVAR_06306077G → R in SESAMES; important loss of localization to the basolateral membrane in kidney cells; in non-tubular cells, does not form functional channels. 2 PublicationsCorresponds to variant dbSNP:rs137853072EnsemblClinVar.1
Natural variantiVAR_072747129I → V in SESAMES. 1 PublicationCorresponds to variant dbSNP:rs751625111Ensembl.1
Natural variantiVAR_063061140C → R in SESAMES; loss of localization to the basolateral membrane in kidney cells; in non-tubular cells, does not form functional channels. 2 PublicationsCorresponds to variant dbSNP:rs137853068EnsemblClinVar.1
Natural variantiVAR_063062164T → I in SESAMES; no effect on localization to the basolateral membrane in kidney cells. 2 PublicationsCorresponds to variant dbSNP:rs137853069EnsemblClinVar.1
Natural variantiVAR_063063167A → V in SESAMES; loss of localization to the basolateral membrane in kidney cells; in non-tubular cells, forms functional channels; important loss of MAGI1-binding when transfected in tubular MDCKII cells, but not in non-tubular HEK293T cells. 2 PublicationsCorresponds to variant dbSNP:rs137853070EnsemblClinVar.1
Natural variantiVAR_034018271R → C1 PublicationCorresponds to variant dbSNP:rs1130183EnsemblClinVar.1
Natural variantiVAR_020339271R → H1 PublicationCorresponds to variant dbSNP:rs3795339EnsemblClinVar.1
Natural variantiVAR_063064297R → C in SESAMES; no effect on localization to the basolateral membrane in kidney cells. 2 PublicationsCorresponds to variant dbSNP:rs137853071EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U73192 Genomic DNA Translation: AAC50923.1
U73193 mRNA Translation: AAC50924.1
U52155 mRNA Translation: AAB07046.1
AL513302 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52749.1
BC034036 mRNA Translation: AAH34036.2 Different initiation.
BC131627 mRNA Translation: AAI31628.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1193.1

NCBI Reference Sequences

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RefSeqi
NP_002232.2, NM_002241.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.408960

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000368089; ENSP00000357068; ENSG00000177807
ENST00000638728; ENSP00000492619; ENSG00000177807
ENST00000638868; ENSP00000491250; ENSG00000177807
ENST00000644903; ENSP00000495557; ENSG00000177807

Database of genes from NCBI RefSeq genomes

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GeneIDi
3766

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3766

UCSC genome browser

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UCSCi
uc001fuw.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73192 Genomic DNA Translation: AAC50923.1
U73193 mRNA Translation: AAC50924.1
U52155 mRNA Translation: AAB07046.1
AL513302 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52749.1
BC034036 mRNA Translation: AAH34036.2 Different initiation.
BC131627 mRNA Translation: AAI31628.1
CCDSiCCDS1193.1
RefSeqiNP_002232.2, NM_002241.4
UniGeneiHs.408960

3D structure databases

ProteinModelPortaliP78508
SMRiP78508
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109968, 19 interactors
CORUMiP78508
IntActiP78508, 5 interactors
MINTiP78508
STRINGi9606.ENSP00000357068

Chemistry databases

BindingDBiP78508
ChEMBLiCHEMBL2146348
DrugBankiDB01392 Yohimbine
GuidetoPHARMACOLOGYi438

Protein family/group databases

TCDBi1.A.2.1.16 the inward rectifier k(+) channel (irk-c) family

PTM databases

iPTMnetiP78508
PhosphoSitePlusiP78508

Polymorphism and mutation databases

BioMutaiKCNJ10
DMDMi2493605

Proteomic databases

PaxDbiP78508
PeptideAtlasiP78508
PRIDEiP78508
ProteomicsDBi57627
TopDownProteomicsiP78508

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3766
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368089; ENSP00000357068; ENSG00000177807
ENST00000638728; ENSP00000492619; ENSG00000177807
ENST00000638868; ENSP00000491250; ENSG00000177807
ENST00000644903; ENSP00000495557; ENSG00000177807
GeneIDi3766
KEGGihsa:3766
UCSCiuc001fuw.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3766
DisGeNETi3766
EuPathDBiHostDB:ENSG00000177807.6

GeneCards: human genes, protein and diseases

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GeneCardsi
KCNJ10
GeneReviewsiKCNJ10
HGNCiHGNC:6256 KCNJ10
HPAiHPA078302
MalaCardsiKCNJ10
MIMi602208 gene
612780 phenotype
neXtProtiNX_P78508
OpenTargetsiENSG00000177807
Orphaneti199343 EAST syndrome
705 Pendred syndrome
PharmGKBiPA30043

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00940000153878
HOGENOMiHOG000237326
HOVERGENiHBG006178
InParanoidiP78508
KOiK05003
OMAiIPLTFYH
OrthoDBi956263at2759
PhylomeDBiP78508
TreeFamiTF313676

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-1296067 Potassium transport channels
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KCNJ10 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KCNJ10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3766

Protein Ontology

More...
PROi
PR:P78508

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177807 Expressed in 98 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiP78508 baseline and differential
GenevisibleiP78508 HS

Family and domain databases

Gene3Di2.60.40.1400, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003269 K_chnl_inward-rec_Kir1.2
IPR013518 K_chnl_inward-rec_Kir_cyto
IPR040445 Kir_TM
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF21 PTHR11767:SF21, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01322 KIR12CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCJ10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78508
Secondary accession number(s): A3KME7
, Q5VUT9, Q8N4I7, Q92808
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: February 13, 2019
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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