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Protein

Homeobox protein Nkx-6.1

Gene

NKX6-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi236 – 295HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-210745 Regulation of gene expression in beta cells
R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells
SIGNORiP78426

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-6.1
Alternative name(s):
Homeobox protein NK-6 homolog A
Gene namesi
Name:NKX6-1
Synonyms:NKX6A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163623.9
HGNCiHGNC:7839 NKX6-1
MIMi602563 gene
neXtProtiNX_P78426

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4825
OpenTargetsiENSG00000163623
PharmGKBiPA31646

Polymorphism and mutation databases

BioMutaiNKX6-1
DMDMi288558819

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489511 – 367Homeobox protein Nkx-6.1Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei189Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiP78426
PaxDbiP78426
PeptideAtlasiP78426
PRIDEiP78426
ProteomicsDBi57625

PTM databases

iPTMnetiP78426
PhosphoSitePlusiP78426

Expressioni

Tissue specificityi

Pancreatic beta cells.

Gene expression databases

BgeeiENSG00000163623 Expressed in 49 organ(s), highest expression level in lower esophagus
CleanExiHS_NKX6-1
ExpressionAtlasiP78426 baseline and differential
GenevisibleiP78426 HS

Organism-specific databases

HPAiCAB070169
HPA036774

Interactioni

Protein-protein interaction databases

BioGridi110889, 2 interactors
IntActiP78426, 1 interactor
MINTiP78426
STRINGi9606.ENSP00000295886

Structurei

3D structure databases

ProteinModelPortaliP78426
SMRiP78426
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 268Repressor domainBy similarityAdd BLAST167
Regioni306 – 367Involved in DNA-bindingBy similarityAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 61Poly-SerAdd BLAST13
Compositional biasi119 – 135Poly-SerAdd BLAST17
Compositional biasi136 – 150Poly-AlaAdd BLAST15
Compositional biasi168 – 173Poly-Pro6
Compositional biasi351 – 355Poly-Gly5

Domaini

The C-terminal domain contributes to sequence-specific DNA-binding.By similarity

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0847 Eukaryota
ENOG410XT1X LUCA
GeneTreeiENSGT00930000150864
HOGENOMiHOG000060127
HOVERGENiHBG070987
InParanoidiP78426
KOiK08030
OMAiVGAMEGP
OrthoDBiEOG091G142D
PhylomeDBiP78426
TreeFamiTF327063

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
IPR033630 NKX-6.1
PANTHERiPTHR24340:SF31 PTHR24340:SF31, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P78426-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAVGAMEGT RQSAFLLSSP PLAALHSMAE MKTPLYPAAY PPLPAGPPSS
60 70 80 90 100
SSSSSSSSSP SPPLGTHNPG GLKPPATGGL SSLGSPPQQL SAATPHGIND
110 120 130 140 150
ILSRPSMPVA SGAALPSASP SGSSSSSSSS ASASSASAAA AAAAAAAAAA
160 170 180 190 200
SSPAGLLAGL PRFSSLSPPP PPPGLYFSPS AAAVAAVGRY PKPLAELPGR
210 220 230 240 250
TPIFWPGVMQ SPPWRDARLA CTPHQGSILL DKDGKRKHTR PTFSGQQIFA
260 270 280 290 300
LEKTFEQTKY LAGPERARLA YSLGMTESQV KVWFQNRRTK WRKKHAAEMA
310 320 330 340 350
TAKKKQDSET ERLKGASENE EEDDDYNKPL DPNSDDEKIT QLLKKHKSSS
360
GGGGGLLLHA SEPESSS
Length:367
Mass (Da):37,849
Last modified:February 9, 2010 - v2
Checksum:i5C78F06C3CAE6486
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VWZ9F8VWZ9_HUMAN
Homeobox protein Nkx-6.1
NKX6-1
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100D → N in AAD11962 (PubMed:9119408).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66799, U66797, U66798 Genomic DNA Translation: AAD11962.1
AC096766 Genomic DNA No translation available.
CCDSiCCDS3607.1
RefSeqiNP_006159.2, NM_006168.2
UniGeneiHs.546270

Genome annotation databases

EnsembliENST00000295886; ENSP00000295886; ENSG00000163623
GeneIDi4825
KEGGihsa:4825
UCSCiuc003hpa.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66799, U66797, U66798 Genomic DNA Translation: AAD11962.1
AC096766 Genomic DNA No translation available.
CCDSiCCDS3607.1
RefSeqiNP_006159.2, NM_006168.2
UniGeneiHs.546270

3D structure databases

ProteinModelPortaliP78426
SMRiP78426
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110889, 2 interactors
IntActiP78426, 1 interactor
MINTiP78426
STRINGi9606.ENSP00000295886

PTM databases

iPTMnetiP78426
PhosphoSitePlusiP78426

Polymorphism and mutation databases

BioMutaiNKX6-1
DMDMi288558819

Proteomic databases

EPDiP78426
PaxDbiP78426
PeptideAtlasiP78426
PRIDEiP78426
ProteomicsDBi57625

Protocols and materials databases

DNASUi4825
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295886; ENSP00000295886; ENSG00000163623
GeneIDi4825
KEGGihsa:4825
UCSCiuc003hpa.2 human

Organism-specific databases

CTDi4825
DisGeNETi4825
EuPathDBiHostDB:ENSG00000163623.9
GeneCardsiNKX6-1
HGNCiHGNC:7839 NKX6-1
HPAiCAB070169
HPA036774
MIMi602563 gene
neXtProtiNX_P78426
OpenTargetsiENSG00000163623
PharmGKBiPA31646
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0847 Eukaryota
ENOG410XT1X LUCA
GeneTreeiENSGT00930000150864
HOGENOMiHOG000060127
HOVERGENiHBG070987
InParanoidiP78426
KOiK08030
OMAiVGAMEGP
OrthoDBiEOG091G142D
PhylomeDBiP78426
TreeFamiTF327063

Enzyme and pathway databases

ReactomeiR-HSA-210745 Regulation of gene expression in beta cells
R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells
SIGNORiP78426

Miscellaneous databases

ChiTaRSiNKX6-1 human
GeneWikiiNKX6-1
GenomeRNAii4825
PROiPR:P78426
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163623 Expressed in 49 organ(s), highest expression level in lower esophagus
CleanExiHS_NKX6-1
ExpressionAtlasiP78426 baseline and differential
GenevisibleiP78426 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
IPR033630 NKX-6.1
PANTHERiPTHR24340:SF31 PTHR24340:SF31, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNKX61_HUMAN
AccessioniPrimary (citable) accession number: P78426
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 9, 2010
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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