UniProtKB - P78424 (PO6F2_HUMAN)

BLAST

>sp|P78424|PO6F2_HUMAN POU domain, class 6, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU6F2 PE=1 SV=3
MSALLQDPMIAGQVSKPLLSVRSEMNAELRGEDKAATSDSELNEPLLAPVESNDSEDTPS
KLFGARGNPALSDPGTPDQHQASQTHPPFPVGPQPLLTAQQLASAVAGVMPGGPPALNQP
ILIPFNMAGQLGGQQGLVLTLPTANLTNIQGLVAAAAAGGIMTLPLQNLQATSSLNSQLQ
QLQLQLQQQQQQQQQQPPPSTNQHPQPAPQAPSQSQQQPLQPTPPQQPPPASQQPPAPTS
QLQQAPQPQQHQPHSHSQNQNQPSPTQQSSSPPQKPSQSPGHGLPSPLTPPNPLQLVNNP
LASQAAAAAAAMSSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSSQAA
SGTQGLQVQPITPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQPSQTSV
GQAASQGNLLHLAHSQASMSQSPVRQASSSSSSSSSSSALSVGQLVSNPQTAAGEVDGVN
LEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRHTILRSHFFLPQEAQE
NTIASSLTAKLNPGLLYPARFEKLDITPKSAQKIKPVLERWMAEAEARHRAGMQNLTEFI
GSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQ
ALKNTIKRLKQHEPATAVPLEPLTDSLEENS

Align

Format
Add to basket Added to basket
History
Entry version 168 (10 Oct 2018)
Sequence version 3 (05 Apr 2011)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

POU domain, class 6, transcription factor 2

Gene

POU6F2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	607 – 666	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity
Source: UniProtKB
Traceable author statementⁱ
- 8601806
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

central nervous system development
Source: ProtInc
Traceable author statementⁱ
- 8601806
ganglion mother cell fate determination
Source: ProtInc
Traceable author statementⁱ
- 8601806
regulation of transcription, DNA-templated
Source: UniProtKB
Traceable author statementⁱ
- 8601806
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 8601806
visual perception
Source: ProtInc
Traceable author statementⁱ
- 8601806

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: POU domain, class 6, transcription factor 2 Alternative name(s): Retina-derived POU domain factor 1 Short name: RPF-1
Gene namesⁱ	Name:POU6F2 Synonyms:RPF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106536.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21694 POU6F2
MIMⁱ	609062 gene
neXtProtⁱ	NX_P78424

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hereditary susceptibility to Wilms tumor 5 (WT5)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionPediatric malignancy of kidney and one of the most common solid cancers in childhood.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11281
MalaCards human disease database More...MalaCardsⁱ	POU6F2
MIMⁱ	601583 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000106536
Orphanetⁱ	654 Nephroblastoma
PharmGKBⁱ	PA134969420

Polymorphism and mutation databases

BioMutaⁱ	POU6F2
DMDMⁱ	327478564

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000100762	1 – 691	POU domain, class 6, transcription factor 2Add BLAST		691

Proteomic databases

PaxDbⁱ	P78424
PeptideAtlas More...PeptideAtlasⁱ	P78424
PRIDEⁱ	P78424
ProteomicsDBⁱ	57623 57624 [P78424-2]

PTM databases

iPTMnetⁱ	P78424
PhosphoSitePlusⁱ	P78424

Expressionⁱ

Tissue specificityⁱ

Expressed only within the CNS, where its expression is restricted to the medical habenulla, to a dispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in the retina.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000106536 Expressed in 66 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_POU6F2
ExpressionAtlasⁱ	P78424 baseline and differential
Genevisibleⁱ	P78424 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
EIF3F	O00303	4	EBI-12029004,EBI-711990
FHL2	Q14192	4	EBI-12029004,EBI-701903
POU2F1	P14859-6	4	EBI-12029004,EBI-11526590

Protein-protein interaction databases

BioGridⁱ	116437, 1 interactor
IntActⁱ	P78424, 141 interactors
STRINGⁱ	9606.ENSP00000384004

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P78424
SMRⁱ	P78424
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	476 – 586	POU-specificPROSITE-ProRule annotationAdd BLAST		111

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	167 – 446	Gln-richAdd BLAST	280
Compositional biasⁱ	197 – 293	Pro-richAdd BLAST	97
Compositional biasⁱ	435 – 461	Ser-richAdd BLAST	27

Sequence similaritiesⁱ

Belongs to the POU transcription factor family. Class-6 subfamily.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG3802 Eukaryota ENOG410XQ7X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149093
HOVERGENⁱ	HBG008230
InParanoidⁱ	P78424
KEGG Orthology (KO) More...KOⁱ	K09368
OMAⁱ	GTPDQHQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04YJ
PhylomeDBⁱ	P78424
TreeFamⁱ	TF350705

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR013847 POU IPR033056 POU6F2 IPR000327 POU_dom
PANTHERⁱ	PTHR11636:SF68 PTHR11636:SF68, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00157 Pou, 2 hits
PRINTSⁱ	PR00028 POUDOMAIN
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00352 POU, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 2 hits
PROSITEⁱ	View protein in PROSITE PS50071 HOMEOBOX_2, 1 hit PS00035 POU_1, 1 hit PS00465 POU_2, 1 hit PS51179 POU_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P78424-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSALLQDPMI AGQVSKPLLS VRSEMNAELR GEDKAATSDS ELNEPLLAPV 
        60         70         80         90        100
ESNDSEDTPS KLFGARGNPA LSDPGTPDQH QASQTHPPFP VGPQPLLTAQ 
       110        120        130        140        150
QLASAVAGVM PGGPPALNQP ILIPFNMAGQ LGGQQGLVLT LPTANLTNIQ 
       160        170        180        190        200
GLVAAAAAGG IMTLPLQNLQ ATSSLNSQLQ QLQLQLQQQQ QQQQQQPPPS 
       210        220        230        240        250
TNQHPQPAPQ APSQSQQQPL QPTPPQQPPP ASQQPPAPTS QLQQAPQPQQ 
       260        270        280        290        300
HQPHSHSQNQ NQPSPTQQSS SPPQKPSQSP GHGLPSPLTP PNPLQLVNNP 
       310        320        330        340        350
LASQAAAAAA AMSSIASSQA FGNALSSLQG VTGQLVTNAQ GQIIGTIPLM 
       360        370        380        390        400
PNPGPSSQAA SGTQGLQVQP ITPQLLTNAQ GQIIATVIGN QILPVINTQG 
       410        420        430        440        450
ITLSPIKPGQ QLHQPSQTSV GQAASQGNLL HLAHSQASMS QSPVRQASSS 
       460        470        480        490        500
SSSSSSSSAL SVGQLVSNPQ TAAGEVDGVN LEEIREFAKA FKIRRLSLGL 
       510        520        530        540        550
TQTQVGQALS ATEGPAYSQS AICRHTILRS HFFLPQEAQE NTIASSLTAK 
       560        570        580        590        600
LNPGLLYPAR FEKLDITPKS AQKIKPVLER WMAEAEARHR AGMQNLTEFI 
       610        620        630        640        650
GSEPSKKRKR RTSFTPQALE ILNAHFEKNT HPSGQEMTEI AEKLNYDREV 
       660        670        680        690 
VRVWFCNKRQ ALKNTIKRLK QHEPATAVPL EPLTDSLEEN S

Note: Major isoform.

Length:691

Mass (Da):73,265

Last modified:April 5, 2011 - v3

Checksum:ⁱ3460C858ECBB5535

Isoform 2 (identifier: P78424-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
524-559: Missing.

« Hide

        10         20         30         40         50
MSALLQDPMI AGQVSKPLLS VRSEMNAELR GEDKAATSDS ELNEPLLAPV 
        60         70         80         90        100
ESNDSEDTPS KLFGARGNPA LSDPGTPDQH QASQTHPPFP VGPQPLLTAQ 
       110        120        130        140        150
QLASAVAGVM PGGPPALNQP ILIPFNMAGQ LGGQQGLVLT LPTANLTNIQ 
       160        170        180        190        200
GLVAAAAAGG IMTLPLQNLQ ATSSLNSQLQ QLQLQLQQQQ QQQQQQPPPS 
       210        220        230        240        250
TNQHPQPAPQ APSQSQQQPL QPTPPQQPPP ASQQPPAPTS QLQQAPQPQQ 
       260        270        280        290        300
HQPHSHSQNQ NQPSPTQQSS SPPQKPSQSP GHGLPSPLTP PNPLQLVNNP 
       310        320        330        340        350
LASQAAAAAA AMSSIASSQA FGNALSSLQG VTGQLVTNAQ GQIIGTIPLM 
       360        370        380        390        400
PNPGPSSQAA SGTQGLQVQP ITPQLLTNAQ GQIIATVIGN QILPVINTQG 
       410        420        430        440        450
ITLSPIKPGQ QLHQPSQTSV GQAASQGNLL HLAHSQASMS QSPVRQASSS 
       460        470        480        490        500
SSSSSSSSAL SVGQLVSNPQ TAAGEVDGVN LEEIREFAKA FKIRRLSLGL 
       510        520        530        540        550
TQTQVGQALS ATEGPAYSQS AICRFEKLDI TPKSAQKIKP VLERWMAEAE 
       560        570        580        590        600
ARHRAGMQNL TEFIGSEPSK KRKRRTSFTP QALEILNAHF EKNTHPSGQE 
       610        620        630        640        650
MTEIAEKLNY DREVVRVWFC NKRQALKNTI KRLKQHEPAT AVPLEPLTDS 

LEENS

Show »

Length:655

Mass (Da):69,248

Checksum:ⁱAB9FFB1A958C3978

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YK27	H0YK27_HUMAN	POU domain protein POU domain protein	POU6F2	636	Annotation score:
H0YL15	H0YL15_HUMAN	POU domain, class 6, transcription ... POU domain, class 6, transcription factor 2	POU6F2	403	Annotation score:
H0YKR5	H0YKR5_HUMAN	POU domain, class 6, transcription ... POU domain, class 6, transcription factor 2	POU6F2	412	Annotation score:
H7C2B2	H7C2B2_HUMAN	POU domain, class 6, transcription ... POU domain, class 6, transcription factor 2	POU6F2	142	Annotation score:
C9JSC0	C9JSC0_HUMAN	POU domain, class 6, transcription ... POU domain, class 6, transcription factor 2	POU6F2	144	Annotation score:

Sequence cautionⁱ

The sequence AAB49727 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence AAB49728 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAS07475 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence EAL23992 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	196	Q → QQ in AAB49727 (PubMed:8601806).Curated	1
Sequence conflictⁱ	196	Q → QQ in AAB49728 (PubMed:8601806).Curated	1
Sequence conflictⁱ	258	Q → H in AAB49727 (PubMed:8601806).Curated	1
Sequence conflictⁱ	258	Q → H in AAB49728 (PubMed:8601806).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_022419	192	Q → H in WT5. 1 Publication	1
Natural variantⁱVAR_028410	199	P → L. Corresponds to variant dbSNP:rs2074936Ensembl.	1
Natural variantⁱVAR_028411	500	L → M. Corresponds to variant dbSNP:rs4992268Ensembl.	1
Natural variantⁱVAR_028412	639	E → K. Corresponds to variant dbSNP:rs7804851Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002336	524 – 559	Missing in isoform 2. 1 PublicationAdd BLAST		36

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U91934 Genomic DNA Translation: AAB49727.1 Sequence problems. U91935 mRNA Translation: AAB49728.1 Different initiation. AC005483 Genomic DNA Translation: AAC83404.2 AC073345 Genomic DNA Translation: AAS07475.1 Different initiation. AC092174 Genomic DNA Translation: AAP21873.1 AC011292 Genomic DNA No translation available. CH236951 Genomic DNA Translation: EAL23992.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34620.2 [P78424-1] CCDS55103.1 [P78424-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001159490.1, NM_001166018.1 [P78424-2] NP_009183.3, NM_007252.3 [P78424-1]
UniGeneⁱ	Hs.137106

Genome annotation databases

Ensemblⁱ	ENST00000403058; ENSP00000384004; ENSG00000106536 [P78424-1] ENST00000518318; ENSP00000430514; ENSG00000106536 [P78424-2]
GeneIDⁱ	11281
KEGGⁱ	hsa:11281
UCSC genome browser More...UCSCⁱ	uc003thb.3 human [P78424-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P78424	POU domain protein		PANPA		691	UniRef100_P78424

Protein	Similar proteins		Species	Score	Length	Source
P78424	POU domain protein		PANPA		691	UniRef90_P78424
POU domain protein		PAPAN		716
POU domain protein		HUMAN		691
POU domain protein		PONAB		691
POU domain protein		AOTNA		690
+55
P78424-2	POU domain protein		PANTR		654	UniRef90_P78424-2
POU domain protein		ERIEU		652
POU domain protein		DIPOR		642
POU domain protein		ODORO		626
POU domain, class 6, transcription factor 2-like isoform X2		LIPVE		625
+25

Protein	Similar proteins		Species	Score	Length	Source
P78424	POU domain, class 6, transcription factor 2		MOUSE		691	UniRef50_P78424
POU domain protein		PANPA		691
POU domain protein		PAPAN		716
POU domain protein		PONAB		691
POU domain protein		HUMAN		691
+424
P78424-2	POU domain protein		PANTR		654	UniRef50_P78424-2
POU domain protein		ERIEU		652
POU domain protein		DIPOR		642
POU domain protein		ODORO		626
POU domain, class 6, transcription factor 2-like isoform X2		LIPVE		625
+43

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U91934 Genomic DNA Translation: AAB49727.1 Sequence problems. U91935 mRNA Translation: AAB49728.1 Different initiation. AC005483 Genomic DNA Translation: AAC83404.2 AC073345 Genomic DNA Translation: AAS07475.1 Different initiation. AC092174 Genomic DNA Translation: AAP21873.1 AC011292 Genomic DNA No translation available. CH236951 Genomic DNA Translation: EAL23992.1 Sequence problems.
CCDSⁱ	CCDS34620.2 [P78424-1] CCDS55103.1 [P78424-2]
RefSeqⁱ	NP_001159490.1, NM_001166018.1 [P78424-2] NP_009183.3, NM_007252.3 [P78424-1]
UniGeneⁱ	Hs.137106

3D structure databases

ProteinModelPortalⁱ	P78424
SMRⁱ	P78424
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116437, 1 interactor
IntActⁱ	P78424, 141 interactors
STRINGⁱ	9606.ENSP00000384004

PTM databases

iPTMnetⁱ	P78424
PhosphoSitePlusⁱ	P78424

Polymorphism and mutation databases

BioMutaⁱ	POU6F2
DMDMⁱ	327478564

Proteomic databases

PaxDbⁱ	P78424
PeptideAtlasⁱ	P78424
PRIDEⁱ	P78424
ProteomicsDBⁱ	57623 57624 [P78424-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11281
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000403058; ENSP00000384004; ENSG00000106536 [P78424-1] ENST00000518318; ENSP00000430514; ENSG00000106536 [P78424-2]
GeneIDⁱ	11281
KEGGⁱ	hsa:11281
UCSCⁱ	uc003thb.3 human [P78424-1]

Organism-specific databases

CTDⁱ	11281
DisGeNETⁱ	11281
EuPathDBⁱ	HostDB:ENSG00000106536.19
GeneCardsⁱ	POU6F2
HGNCⁱ	HGNC:21694 POU6F2
MalaCardsⁱ	POU6F2
MIMⁱ	601583 phenotype 609062 gene
neXtProtⁱ	NX_P78424
OpenTargetsⁱ	ENSG00000106536
Orphanetⁱ	654 Nephroblastoma
PharmGKBⁱ	PA134969420
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3802 Eukaryota ENOG410XQ7X LUCA
GeneTreeⁱ	ENSGT00920000149093
HOVERGENⁱ	HBG008230
InParanoidⁱ	P78424
KOⁱ	K09368
OMAⁱ	GTPDQHQ
OrthoDBⁱ	EOG091G04YJ
PhylomeDBⁱ	P78424
TreeFamⁱ	TF350705

Miscellaneous databases

ChiTaRSⁱ	POU6F2 human
GenomeRNAiⁱ	11281
Protein Ontology More...PROⁱ	PR:P78424
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000106536 Expressed in 66 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_POU6F2
ExpressionAtlasⁱ	P78424 baseline and differential
Genevisibleⁱ	P78424 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR013847 POU IPR033056 POU6F2 IPR000327 POU_dom
PANTHERⁱ	PTHR11636:SF68 PTHR11636:SF68, 1 hit
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00157 Pou, 2 hits
PRINTSⁱ	PR00028 POUDOMAIN
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00352 POU, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 2 hits
PROSITEⁱ	View protein in PROSITE PS50071 HOMEOBOX_2, 1 hit PS00035 POU_1, 1 hit PS00465 POU_2, 1 hit PS51179 POU_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PO6F2_HUMAN
Accessionⁱ	P78424Primary (citable) accession number: P78424 Secondary accession number(s): A4D1W2 , C4AMB9, P78425, Q75ME8, Q86UM6, Q9UDS7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
	Last sequence update:	April 5, 2011
	Last modified:	October 10, 2018
	This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P78424 (PO6F2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

POU domain, class 6, transcription factor 2

POU6F2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ