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Protein

Iroquois-class homeodomain protein IRX-3

Gene

IRX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi125 – 188Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-3
Alternative name(s):
Homeodomain protein IRXB1
Iroquois homeobox protein 3
Gene namesi
Name:IRX3
Synonyms:IRXB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000177508.11
HGNCiHGNC:14360 IRX3
MIMi612985 gene
neXtProtiNX_P78415

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79191
OpenTargetsiENSG00000177508
PharmGKBiPA29926

Polymorphism and mutation databases

BioMutaiIRX3
DMDMi47117874

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491551 – 501Iroquois-class homeodomain protein IRX-3Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei323PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP78415
MaxQBiP78415
PaxDbiP78415
PeptideAtlasiP78415
PRIDEiP78415
ProteomicsDBi57620

PTM databases

iPTMnetiP78415
PhosphoSitePlusiP78415

Expressioni

Gene expression databases

BgeeiENSG00000177508 Expressed in 180 organ(s), highest expression level in thoracic mammary gland
CleanExiHS_IRX3
ExpressionAtlasiP78415 baseline and differential
GenevisibleiP78415 HS

Organism-specific databases

HPAiHPA062522

Interactioni

Protein-protein interaction databases

DIPiDIP-62120N
IntActiP78415, 1 interactor
STRINGi9606.ENSP00000331608

Structurei

3D structure databases

ProteinModelPortaliP78415
SMRiP78415
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 70Poly-Ala9
Compositional biasi201 – 267Asp/Glu-rich (acidic)Add BLAST67
Compositional biasi229 – 232Poly-Glu4
Compositional biasi304 – 433Pro-richAdd BLAST130
Compositional biasi388 – 394Poly-Ala7
Compositional biasi446 – 450Poly-Ala5

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000234546
HOVERGENiHBG006180
InParanoidiP78415
OMAiNWTNRAF
OrthoDBiEOG091G0N9R
PhylomeDBiP78415
TreeFamiTF319371

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P78415-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFPQLGYQY IRPLYPSERP GAAGGSGGSA GARGGLGAGA SELNASGSLS
60 70 80 90 100
NVLSSVYGAP YAAAAAAAAA QGYGAFLPYA AELPIFPQLG AQYELKDSPG
110 120 130 140 150
VQHPAAAAAF PHPHPAFYPY GQYQFGDPSR PKNATRESTS TLKAWLNEHR
160 170 180 190 200
KNPYPTKGEK IMLAIITKMT LTQVSTWFAN ARRRLKKENK MTWAPRSRTD
210 220 230 240 250
EEGNAYGSER EEEDEEEDEE DGKRELELEE EELGGEEEDT GGEGLADDDE
260 270 280 290 300
DEEIDLENLD GAATEPELSL AGAARRDGDL GLGPISDSKN SDSEDSSEGL
310 320 330 340 350
EDRPLPVLSL APAPPPVAVA SPSLPSPPVS LDPCAPAPAP ASALQKPKIW
360 370 380 390 400
SLAETATSPD NPRRSPPGAG GSPPGAAVAP SALQLSPAAA AAAAHRLVSA
410 420 430 440 450
PLGKFPAWTN RPFPGPPPGP RLHPLSLLGS APPHLLGLPG AAGHPAAAAA
460 470 480 490 500
FARPAEPEGG TDRCSALEVE KKLLKTAFQP VPRRPQNHLD AALVLSALSS

S
Length:501
Mass (Da):52,119
Last modified:May 10, 2004 - v3
Checksum:i638D984ED0BEF6C9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QR11J3QR11_HUMAN
Iroquois-class homeodomain protein ...
IRX3
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti222G → C in AAQ16549 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061267422L → P1 PublicationCorresponds to variant dbSNP:rs1450355Ensembl.1
Natural variantiVAR_055957479Q → H. Corresponds to variant dbSNP:rs1126960Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335942 Genomic DNA Translation: AAQ16548.1
AY335943 mRNA Translation: AAQ16549.1
BC023667 mRNA Translation: AAH23667.1
U90308 mRNA Translation: AAB50006.1
CCDSiCCDS10750.1
RefSeqiNP_077312.2, NM_024336.2
UniGeneiHs.499205

Genome annotation databases

EnsembliENST00000329734; ENSP00000331608; ENSG00000177508
GeneIDi79191
KEGGihsa:79191
UCSCiuc002eht.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335942 Genomic DNA Translation: AAQ16548.1
AY335943 mRNA Translation: AAQ16549.1
BC023667 mRNA Translation: AAH23667.1
U90308 mRNA Translation: AAB50006.1
CCDSiCCDS10750.1
RefSeqiNP_077312.2, NM_024336.2
UniGeneiHs.499205

3D structure databases

ProteinModelPortaliP78415
SMRiP78415
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-62120N
IntActiP78415, 1 interactor
STRINGi9606.ENSP00000331608

PTM databases

iPTMnetiP78415
PhosphoSitePlusiP78415

Polymorphism and mutation databases

BioMutaiIRX3
DMDMi47117874

Proteomic databases

EPDiP78415
MaxQBiP78415
PaxDbiP78415
PeptideAtlasiP78415
PRIDEiP78415
ProteomicsDBi57620

Protocols and materials databases

DNASUi79191
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329734; ENSP00000331608; ENSG00000177508
GeneIDi79191
KEGGihsa:79191
UCSCiuc002eht.2 human

Organism-specific databases

CTDi79191
DisGeNETi79191
EuPathDBiHostDB:ENSG00000177508.11
GeneCardsiIRX3
HGNCiHGNC:14360 IRX3
HPAiHPA062522
MIMi612985 gene
neXtProtiNX_P78415
OpenTargetsiENSG00000177508
PharmGKBiPA29926
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000234546
HOVERGENiHBG006180
InParanoidiP78415
OMAiNWTNRAF
OrthoDBiEOG091G0N9R
PhylomeDBiP78415
TreeFamiTF319371

Miscellaneous databases

ChiTaRSiIRX3 human
GeneWikiiIRX3
GenomeRNAii79191
PROiPR:P78415
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177508 Expressed in 180 organ(s), highest expression level in thoracic mammary gland
CleanExiHS_IRX3
ExpressionAtlasiP78415 baseline and differential
GenevisibleiP78415 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIRX3_HUMAN
AccessioniPrimary (citable) accession number: P78415
Secondary accession number(s): Q7Z4A4, Q7Z4A5, Q8IVC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: November 7, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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