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Entry version 150 (08 May 2019)
Sequence version 2 (11 Jan 2001)
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Protein

Iroquois-class homeodomain protein IRX-4

Gene

IRX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Likely to be an important mediator of ventricular differentiation during cardiac development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi143 – 204Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST62

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-4
Alternative name(s):
Homeodomain protein IRXA3
Iroquois homeobox protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IRX4
Synonyms:IRXA3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6129 IRX4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606199 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P78413

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
50805

Open Targets

More...
OpenTargetsi
ENSG00000113430

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29927

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IRX4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12644347

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000491571 – 519Iroquois-class homeodomain protein IRX-4Add BLAST519

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P78413

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P78413

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P78413

PeptideAtlas

More...
PeptideAtlasi
P78413

PRoteomics IDEntifications database

More...
PRIDEi
P78413

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57618

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P78413

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P78413

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in cardiac ventricles.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113430 Expressed in 59 organ(s), highest expression level in epithelium of mammary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P78413 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P78413 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA064094

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the vitamin D receptor VDR but doesn't affect its transactivation activity.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119125, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P78413, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000482393

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P78413

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi223 – 228Poly-Glu6
Compositional biasi375 – 382Poly-Ala8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0773 Eukaryota
ENOG410XPMQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234546

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P78413

Identification of Orthologs from Complete Genome Data

More...
OMAi
QTEYPSC

Database of Orthologous Groups

More...
OrthoDBi
814237at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P78413

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05920 Homeobox_KN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P78413-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYPQFGYPY SSAPQFLMAT NSLSTCCESG GRTLADSGPA ASAQAPVYCP
60 70 80 90 100
VYESRLLATA RHELNSAAAL GVYGGPYGGS QGYGNYVTYG SEASAFYSLN
110 120 130 140 150
SFDSKDGSGS AHGGLAPAAA AYYPYEPALG QYPYDRYGTM DSGTRRKNAT
160 170 180 190 200
RETTSTLKAW LQEHRKNPYP TKGEKIMLAI ITKMTLTQVS TWFANARRRL
210 220 230 240 250
KKENKMTWPP RNKCADEKRP YAEGEEEEGG EEEAREEPLK SSKNAEPVGK
260 270 280 290 300
EEKELELSDL DDFDPLEAEP PACELKPPFH SLDGGLERVP AAPDGPVKEA
310 320 330 340 350
SGALRMSLAA GGGAALDEDL ERARSCLRSA AAGPEPLPGA EGGPQVCEAK
360 370 380 390 400
LGFVPAGASA GLEAKPRIWS LAHTATAAAA AATSLSQTEF PSCMLKRQGP
410 420 430 440 450
AAPAAVSSAP ATSPSVALPH SGALDRHQDS PVTSLRNWVD GVFHDPILRH
460 470 480 490 500
STLNQAWATA KGALLDPGPL GRSLGAGANV LTAPLARAFP PAVPQDAPAA
510
GAARELLALP KAGGKPFCA
Length:519
Mass (Da):54,445
Last modified:January 11, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2FFB278BEFC5AD2
GO
Isoform 2 (identifier: P78413-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-136: R → RIKRLGGHPHKGIGLDLSGLGRSPGSL

Show »
Length:545
Mass (Da):57,050
Checksum:i0A427E0A8DD7E77F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAS8D6RAS8_HUMAN
Iroquois-class homeodomain protein ...
IRX4
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC00D6RC00_HUMAN
Iroquois-class homeodomain protein ...
IRX4
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti181I → T in AAB50004 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049583119A → T1 PublicationCorresponds to variant dbSNP:rs2232376Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054304136R → RIKRLGGHPHKGIGLDLSGL GRSPGSL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF124733 mRNA Translation: AAF23887.1
AY335941 Genomic DNA Translation: AAQ16547.1
AB690778 mRNA Translation: BAL44219.1
AB690779 mRNA Translation: BAL44220.1
AB690780 mRNA Translation: BAL44221.1
AB690781 mRNA Translation: BAL44222.1
CH471102 Genomic DNA Translation: EAX08138.1
CH471102 Genomic DNA Translation: EAX08139.1
BC110912 mRNA Translation: AAI10913.1
BC136505 mRNA Translation: AAI36506.1
BC136506 mRNA Translation: AAI36507.1
U90306 mRNA Translation: AAB50004.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3867.1 [P78413-1]
CCDS75225.1 [P78413-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001265561.1, NM_001278632.1 [P78413-1]
NP_001265562.1, NM_001278633.1 [P78413-2]
NP_001265563.1, NM_001278634.1 [P78413-1]
NP_001265564.1, NM_001278635.1 [P78413-2]
NP_057442.1, NM_016358.2 [P78413-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000231357; ENSP00000231357; ENSG00000113430 [P78413-1]
ENST00000505790; ENSP00000423161; ENSG00000113430 [P78413-1]
ENST00000513692; ENSP00000424235; ENSG00000113430 [P78413-1]
ENST00000613726; ENSP00000482393; ENSG00000113430 [P78413-2]
ENST00000622814; ENSP00000481396; ENSG00000113430 [P78413-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
50805

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:50805

UCSC genome browser

More...
UCSCi
uc003jcz.2 human [P78413-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124733 mRNA Translation: AAF23887.1
AY335941 Genomic DNA Translation: AAQ16547.1
AB690778 mRNA Translation: BAL44219.1
AB690779 mRNA Translation: BAL44220.1
AB690780 mRNA Translation: BAL44221.1
AB690781 mRNA Translation: BAL44222.1
CH471102 Genomic DNA Translation: EAX08138.1
CH471102 Genomic DNA Translation: EAX08139.1
BC110912 mRNA Translation: AAI10913.1
BC136505 mRNA Translation: AAI36506.1
BC136506 mRNA Translation: AAI36507.1
U90306 mRNA Translation: AAB50004.1
CCDSiCCDS3867.1 [P78413-1]
CCDS75225.1 [P78413-2]
RefSeqiNP_001265561.1, NM_001278632.1 [P78413-1]
NP_001265562.1, NM_001278633.1 [P78413-2]
NP_001265563.1, NM_001278634.1 [P78413-1]
NP_001265564.1, NM_001278635.1 [P78413-2]
NP_057442.1, NM_016358.2 [P78413-1]

3D structure databases

SMRiP78413
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119125, 1 interactor
IntActiP78413, 1 interactor
STRINGi9606.ENSP00000482393

PTM databases

iPTMnetiP78413
PhosphoSitePlusiP78413

Polymorphism and mutation databases

BioMutaiIRX4
DMDMi12644347

Proteomic databases

jPOSTiP78413
MaxQBiP78413
PaxDbiP78413
PeptideAtlasiP78413
PRIDEiP78413
ProteomicsDBi57618

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231357; ENSP00000231357; ENSG00000113430 [P78413-1]
ENST00000505790; ENSP00000423161; ENSG00000113430 [P78413-1]
ENST00000513692; ENSP00000424235; ENSG00000113430 [P78413-1]
ENST00000613726; ENSP00000482393; ENSG00000113430 [P78413-2]
ENST00000622814; ENSP00000481396; ENSG00000113430 [P78413-2]
GeneIDi50805
KEGGihsa:50805
UCSCiuc003jcz.2 human [P78413-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50805
DisGeNETi50805

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IRX4
HGNCiHGNC:6129 IRX4
HPAiHPA064094
MIMi606199 gene
neXtProtiNX_P78413
OpenTargetsiENSG00000113430
PharmGKBiPA29927

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00940000158596
HOGENOMiHOG000234546
InParanoidiP78413
OMAiQTEYPSC
OrthoDBi814237at2759
PhylomeDBiP78413

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
IRX4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
50805

Protein Ontology

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PROi
PR:P78413

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113430 Expressed in 59 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiP78413 baseline and differential
GenevisibleiP78413 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRX4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78413
Secondary accession number(s): B2RMW5
, D3DTC5, H1AFL0, H1AFL1, Q2NL64, Q9UHR2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 11, 2001
Last modified: May 8, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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