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Protein

Iroquois-class homeodomain protein IRX-4

Gene

IRX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Likely to be an important mediator of ventricular differentiation during cardiac development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi143 – 204Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

  • establishment of animal organ orientation Source: Ensembl
  • heart development Source: ProtInc

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-4
Alternative name(s):
Homeodomain protein IRXA3
Iroquois homeobox protein 4
Gene namesi
Name:IRX4
Synonyms:IRXA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113430.9
HGNCiHGNC:6129 IRX4
MIMi606199 gene
neXtProtiNX_P78413

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi50805
OpenTargetsiENSG00000113430
PharmGKBiPA29927

Polymorphism and mutation databases

BioMutaiIRX4
DMDMi12644347

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491571 – 519Iroquois-class homeodomain protein IRX-4Add BLAST519

Proteomic databases

MaxQBiP78413
PaxDbiP78413
PeptideAtlasiP78413
PRIDEiP78413
ProteomicsDBi57618

PTM databases

iPTMnetiP78413
PhosphoSitePlusiP78413

Expressioni

Tissue specificityi

Predominantly expressed in cardiac ventricles.

Gene expression databases

BgeeiENSG00000113430 Expressed in 59 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_IRX4
ExpressionAtlasiP78413 baseline and differential
GenevisibleiP78413 HS

Organism-specific databases

HPAiHPA064094

Interactioni

Subunit structurei

Interacts with the vitamin D receptor VDR but doesn't affect its transactivation activity.1 Publication

Protein-protein interaction databases

BioGridi119125, 1 interactor
IntActiP78413, 1 interactor
STRINGi9606.ENSP00000231357

Structurei

3D structure databases

ProteinModelPortaliP78413
SMRiP78413
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi223 – 228Poly-Glu6
Compositional biasi375 – 382Poly-Ala8

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000234546
HOVERGENiHBG006180
InParanoidiP78413
OMAiQTEYPSC
OrthoDBiEOG091G0N9R
PhylomeDBiP78413

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P78413-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYPQFGYPY SSAPQFLMAT NSLSTCCESG GRTLADSGPA ASAQAPVYCP
60 70 80 90 100
VYESRLLATA RHELNSAAAL GVYGGPYGGS QGYGNYVTYG SEASAFYSLN
110 120 130 140 150
SFDSKDGSGS AHGGLAPAAA AYYPYEPALG QYPYDRYGTM DSGTRRKNAT
160 170 180 190 200
RETTSTLKAW LQEHRKNPYP TKGEKIMLAI ITKMTLTQVS TWFANARRRL
210 220 230 240 250
KKENKMTWPP RNKCADEKRP YAEGEEEEGG EEEAREEPLK SSKNAEPVGK
260 270 280 290 300
EEKELELSDL DDFDPLEAEP PACELKPPFH SLDGGLERVP AAPDGPVKEA
310 320 330 340 350
SGALRMSLAA GGGAALDEDL ERARSCLRSA AAGPEPLPGA EGGPQVCEAK
360 370 380 390 400
LGFVPAGASA GLEAKPRIWS LAHTATAAAA AATSLSQTEF PSCMLKRQGP
410 420 430 440 450
AAPAAVSSAP ATSPSVALPH SGALDRHQDS PVTSLRNWVD GVFHDPILRH
460 470 480 490 500
STLNQAWATA KGALLDPGPL GRSLGAGANV LTAPLARAFP PAVPQDAPAA
510
GAARELLALP KAGGKPFCA
Length:519
Mass (Da):54,445
Last modified:January 11, 2001 - v2
Checksum:iB2FFB278BEFC5AD2
GO
Isoform 2 (identifier: P78413-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-136: R → RIKRLGGHPHKGIGLDLSGLGRSPGSL

Show »
Length:545
Mass (Da):57,050
Checksum:i0A427E0A8DD7E77F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAS8D6RAS8_HUMAN
Iroquois-class homeodomain protein ...
IRX4
216Annotation score:
D6RC00D6RC00_HUMAN
Iroquois-class homeodomain protein ...
IRX4
196Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181I → T in AAB50004 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049583119A → T1 PublicationCorresponds to variant dbSNP:rs2232376Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054304136R → RIKRLGGHPHKGIGLDLSGL GRSPGSL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124733 mRNA Translation: AAF23887.1
AY335941 Genomic DNA Translation: AAQ16547.1
AB690778 mRNA Translation: BAL44219.1
AB690779 mRNA Translation: BAL44220.1
AB690780 mRNA Translation: BAL44221.1
AB690781 mRNA Translation: BAL44222.1
CH471102 Genomic DNA Translation: EAX08138.1
CH471102 Genomic DNA Translation: EAX08139.1
BC110912 mRNA Translation: AAI10913.1
BC136505 mRNA Translation: AAI36506.1
BC136506 mRNA Translation: AAI36507.1
U90306 mRNA Translation: AAB50004.1
CCDSiCCDS3867.1 [P78413-1]
CCDS75225.1 [P78413-2]
RefSeqiNP_001265561.1, NM_001278632.1 [P78413-1]
NP_001265562.1, NM_001278633.1 [P78413-2]
NP_001265563.1, NM_001278634.1 [P78413-1]
NP_001265564.1, NM_001278635.1 [P78413-2]
NP_057442.1, NM_016358.2 [P78413-1]
UniGeneiHs.196927

Genome annotation databases

EnsembliENST00000231357; ENSP00000231357; ENSG00000113430 [P78413-1]
ENST00000505790; ENSP00000423161; ENSG00000113430 [P78413-1]
ENST00000513692; ENSP00000424235; ENSG00000113430 [P78413-1]
ENST00000613726; ENSP00000482393; ENSG00000113430 [P78413-2]
ENST00000622814; ENSP00000481396; ENSG00000113430 [P78413-2]
GeneIDi50805
KEGGihsa:50805
UCSCiuc003jcz.2 human [P78413-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124733 mRNA Translation: AAF23887.1
AY335941 Genomic DNA Translation: AAQ16547.1
AB690778 mRNA Translation: BAL44219.1
AB690779 mRNA Translation: BAL44220.1
AB690780 mRNA Translation: BAL44221.1
AB690781 mRNA Translation: BAL44222.1
CH471102 Genomic DNA Translation: EAX08138.1
CH471102 Genomic DNA Translation: EAX08139.1
BC110912 mRNA Translation: AAI10913.1
BC136505 mRNA Translation: AAI36506.1
BC136506 mRNA Translation: AAI36507.1
U90306 mRNA Translation: AAB50004.1
CCDSiCCDS3867.1 [P78413-1]
CCDS75225.1 [P78413-2]
RefSeqiNP_001265561.1, NM_001278632.1 [P78413-1]
NP_001265562.1, NM_001278633.1 [P78413-2]
NP_001265563.1, NM_001278634.1 [P78413-1]
NP_001265564.1, NM_001278635.1 [P78413-2]
NP_057442.1, NM_016358.2 [P78413-1]
UniGeneiHs.196927

3D structure databases

ProteinModelPortaliP78413
SMRiP78413
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119125, 1 interactor
IntActiP78413, 1 interactor
STRINGi9606.ENSP00000231357

PTM databases

iPTMnetiP78413
PhosphoSitePlusiP78413

Polymorphism and mutation databases

BioMutaiIRX4
DMDMi12644347

Proteomic databases

MaxQBiP78413
PaxDbiP78413
PeptideAtlasiP78413
PRIDEiP78413
ProteomicsDBi57618

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231357; ENSP00000231357; ENSG00000113430 [P78413-1]
ENST00000505790; ENSP00000423161; ENSG00000113430 [P78413-1]
ENST00000513692; ENSP00000424235; ENSG00000113430 [P78413-1]
ENST00000613726; ENSP00000482393; ENSG00000113430 [P78413-2]
ENST00000622814; ENSP00000481396; ENSG00000113430 [P78413-2]
GeneIDi50805
KEGGihsa:50805
UCSCiuc003jcz.2 human [P78413-1]

Organism-specific databases

CTDi50805
DisGeNETi50805
EuPathDBiHostDB:ENSG00000113430.9
GeneCardsiIRX4
HGNCiHGNC:6129 IRX4
HPAiHPA064094
MIMi606199 gene
neXtProtiNX_P78413
OpenTargetsiENSG00000113430
PharmGKBiPA29927
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000234546
HOVERGENiHBG006180
InParanoidiP78413
OMAiQTEYPSC
OrthoDBiEOG091G0N9R
PhylomeDBiP78413

Miscellaneous databases

GeneWikiiIRX4
GenomeRNAii50805
PROiPR:P78413
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113430 Expressed in 59 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_IRX4
ExpressionAtlasiP78413 baseline and differential
GenevisibleiP78413 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIRX4_HUMAN
AccessioniPrimary (citable) accession number: P78413
Secondary accession number(s): B2RMW5
, D3DTC5, H1AFL0, H1AFL1, Q2NL64, Q9UHR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 11, 2001
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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