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Protein

Iroquois-class homeodomain protein IRX-6

Gene

IRX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi144 – 207Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-6
Alternative name(s):
Homeodomain protein IRXB3
Iroquois homeobox protein 6
Gene namesi
Name:IRX6
Synonyms:IRX7, IRXB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000159387.7
HGNCiHGNC:14675 IRX6
MIMi606196 gene
neXtProtiNX_P78412

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159387
PharmGKBiPA29929

Polymorphism and mutation databases

BioMutaiIRX6
DMDMi116242594

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491621 – 446Iroquois-class homeodomain protein IRX-6Add BLAST446

Proteomic databases

MaxQBiP78412
PaxDbiP78412
PeptideAtlasiP78412
PRIDEiP78412
ProteomicsDBi57617

PTM databases

iPTMnetiP78412
PhosphoSitePlusiP78412

Expressioni

Gene expression databases

BgeeiENSG00000159387 Expressed in 62 organ(s), highest expression level in apex of heart
CleanExiHS_IRX6

Organism-specific databases

HPAiHPA018332

Interactioni

Protein-protein interaction databases

IntActiP78412, 11 interactors
STRINGi9606.ENSP00000290552

Structurei

3D structure databases

ProteinModelPortaliP78412
SMRiP78412
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000234546
HOVERGENiHBG006180
InParanoidiP78412
OMAiLERRECG
OrthoDBiEOG091G0N9R
PhylomeDBiP78412
TreeFamiTF319371

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P78412-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFPHFGHPY RGASQFLASA SSSTTCCEST QRSVSDVASG STPAPALCCA
60 70 80 90 100
PYDSRLLGSA RPELGAALGI YGAPYAAAAA AQSYPGYLPY SPEPPSLYGA
110 120 130 140 150
LNPQYEFKEA AGSFTSSLAQ PGAYYPYERT LGQYQYERYG AVELSGAGRR
160 170 180 190 200
KNATRETTST LKAWLNEHRK NPYPTKGEKI MLAIITKMTL TQVSTWFANA
210 220 230 240 250
RRRLKKENKM TWAPKNKGGE ERKAEGGEED SLGCLTADTK EVTASQEARG
260 270 280 290 300
LRLSDLEDLE EEEEEEEEAE DEEVVATAGD RLTEFRKGAQ SLPGPCAAAR
310 320 330 340 350
EGRLERRECG LAAPRFSFND PSGSEEADFL SAETGSPRLT MHYPCLEKPR
360 370 380 390 400
IWSLAHTATA SAVEGAPPAR PRPRSPECRM IPGQPPASAR RLSVPRDSAC
410 420 430 440
DESSCIPKAF GNPKFALQGL PLNCAPCPRR SEPVVQCQYP SGAEAG
Length:446
Mass (Da):48,240
Last modified:October 17, 2006 - v3
Checksum:i4E542FEDD5D06912
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117S → G in AAB50003 (Ref. 5) Curated1
Sequence conflicti444Missing (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335937 mRNA Translation: AAQ16543.1
AY335946 Genomic DNA Translation: AAQ16552.1
AK125053 mRNA Translation: BAC86033.1
CH471092 Genomic DNA Translation: EAW82823.1
BC136573 mRNA Translation: AAI36574.1
BC136576 mRNA Translation: AAI36577.1
U90305 mRNA Translation: AAB50003.1
CCDSiCCDS32449.1
RefSeqiNP_077311.2, NM_024335.2
XP_005256194.1, XM_005256137.2
UniGeneiHs.369907

Genome annotation databases

EnsembliENST00000290552; ENSP00000290552; ENSG00000159387
GeneIDi79190
KEGGihsa:79190
UCSCiuc002ehy.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335937 mRNA Translation: AAQ16543.1
AY335946 Genomic DNA Translation: AAQ16552.1
AK125053 mRNA Translation: BAC86033.1
CH471092 Genomic DNA Translation: EAW82823.1
BC136573 mRNA Translation: AAI36574.1
BC136576 mRNA Translation: AAI36577.1
U90305 mRNA Translation: AAB50003.1
CCDSiCCDS32449.1
RefSeqiNP_077311.2, NM_024335.2
XP_005256194.1, XM_005256137.2
UniGeneiHs.369907

3D structure databases

ProteinModelPortaliP78412
SMRiP78412
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP78412, 11 interactors
STRINGi9606.ENSP00000290552

PTM databases

iPTMnetiP78412
PhosphoSitePlusiP78412

Polymorphism and mutation databases

BioMutaiIRX6
DMDMi116242594

Proteomic databases

MaxQBiP78412
PaxDbiP78412
PeptideAtlasiP78412
PRIDEiP78412
ProteomicsDBi57617

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290552; ENSP00000290552; ENSG00000159387
GeneIDi79190
KEGGihsa:79190
UCSCiuc002ehy.4 human

Organism-specific databases

CTDi79190
EuPathDBiHostDB:ENSG00000159387.7
GeneCardsiIRX6
HGNCiHGNC:14675 IRX6
HPAiHPA018332
MIMi606196 gene
neXtProtiNX_P78412
OpenTargetsiENSG00000159387
PharmGKBiPA29929
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000234546
HOVERGENiHBG006180
InParanoidiP78412
OMAiLERRECG
OrthoDBiEOG091G0N9R
PhylomeDBiP78412
TreeFamiTF319371

Miscellaneous databases

GeneWikiiIRX6
GenomeRNAii79190
PROiPR:P78412
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159387 Expressed in 62 organ(s), highest expression level in apex of heart
CleanExiHS_IRX6

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIRX6_HUMAN
AccessioniPrimary (citable) accession number: P78412
Secondary accession number(s): B2RN06, Q7Z2K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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