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Protein

Iroquois-class homeodomain protein IRX-6

Gene

IRX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi144 – 207Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-6
Alternative name(s):
Homeodomain protein IRXB3
Iroquois homeobox protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IRX6
Synonyms:IRX7, IRXB3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000159387.7

Human Gene Nomenclature Database

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HGNCi
HGNC:14675 IRX6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606196 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P78412

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000159387

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29929

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IRX6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242594

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000491621 – 446Iroquois-class homeodomain protein IRX-6Add BLAST446

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P78412

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P78412

PeptideAtlas

More...
PeptideAtlasi
P78412

PRoteomics IDEntifications database

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PRIDEi
P78412

ProteomicsDB human proteome resource

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ProteomicsDBi
57617

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P78412

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P78412

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000159387 Expressed in 62 organ(s), highest expression level in apex of heart

CleanEx database of gene expression profiles

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CleanExi
HS_IRX6

Organism-specific databases

Human Protein Atlas

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HPAi
HPA018332

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
P78412, 11 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000290552

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P78412

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P78412

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0773 Eukaryota
ENOG410XPMQ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159909

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234546

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006180

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P78412

Identification of Orthologs from Complete Genome Data

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OMAi
LERRECG

Database of Orthologous Groups

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OrthoDBi
EOG091G0N9R

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P78412

TreeFam database of animal gene trees

More...
TreeFami
TF319371

Family and domain databases

Conserved Domains Database

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CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05920 Homeobox_KN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P78412-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFPHFGHPY RGASQFLASA SSSTTCCEST QRSVSDVASG STPAPALCCA
60 70 80 90 100
PYDSRLLGSA RPELGAALGI YGAPYAAAAA AQSYPGYLPY SPEPPSLYGA
110 120 130 140 150
LNPQYEFKEA AGSFTSSLAQ PGAYYPYERT LGQYQYERYG AVELSGAGRR
160 170 180 190 200
KNATRETTST LKAWLNEHRK NPYPTKGEKI MLAIITKMTL TQVSTWFANA
210 220 230 240 250
RRRLKKENKM TWAPKNKGGE ERKAEGGEED SLGCLTADTK EVTASQEARG
260 270 280 290 300
LRLSDLEDLE EEEEEEEEAE DEEVVATAGD RLTEFRKGAQ SLPGPCAAAR
310 320 330 340 350
EGRLERRECG LAAPRFSFND PSGSEEADFL SAETGSPRLT MHYPCLEKPR
360 370 380 390 400
IWSLAHTATA SAVEGAPPAR PRPRSPECRM IPGQPPASAR RLSVPRDSAC
410 420 430 440
DESSCIPKAF GNPKFALQGL PLNCAPCPRR SEPVVQCQYP SGAEAG
Length:446
Mass (Da):48,240
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E542FEDD5D06912
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti117S → G in AAB50003 (Ref. 5) Curated1
Sequence conflicti444Missing (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY335937 mRNA Translation: AAQ16543.1
AY335946 Genomic DNA Translation: AAQ16552.1
AK125053 mRNA Translation: BAC86033.1
CH471092 Genomic DNA Translation: EAW82823.1
BC136573 mRNA Translation: AAI36574.1
BC136576 mRNA Translation: AAI36577.1
U90305 mRNA Translation: AAB50003.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32449.1

NCBI Reference Sequences

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RefSeqi
NP_077311.2, NM_024335.2
XP_005256194.1, XM_005256137.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.369907

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000290552; ENSP00000290552; ENSG00000159387

Database of genes from NCBI RefSeq genomes

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GeneIDi
79190

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79190

UCSC genome browser

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UCSCi
uc002ehy.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335937 mRNA Translation: AAQ16543.1
AY335946 Genomic DNA Translation: AAQ16552.1
AK125053 mRNA Translation: BAC86033.1
CH471092 Genomic DNA Translation: EAW82823.1
BC136573 mRNA Translation: AAI36574.1
BC136576 mRNA Translation: AAI36577.1
U90305 mRNA Translation: AAB50003.1
CCDSiCCDS32449.1
RefSeqiNP_077311.2, NM_024335.2
XP_005256194.1, XM_005256137.2
UniGeneiHs.369907

3D structure databases

ProteinModelPortaliP78412
SMRiP78412
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP78412, 11 interactors
STRINGi9606.ENSP00000290552

PTM databases

iPTMnetiP78412
PhosphoSitePlusiP78412

Polymorphism and mutation databases

BioMutaiIRX6
DMDMi116242594

Proteomic databases

MaxQBiP78412
PaxDbiP78412
PeptideAtlasiP78412
PRIDEiP78412
ProteomicsDBi57617

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290552; ENSP00000290552; ENSG00000159387
GeneIDi79190
KEGGihsa:79190
UCSCiuc002ehy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79190
EuPathDBiHostDB:ENSG00000159387.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IRX6
HGNCiHGNC:14675 IRX6
HPAiHPA018332
MIMi606196 gene
neXtProtiNX_P78412
OpenTargetsiENSG00000159387
PharmGKBiPA29929

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00940000159909
HOGENOMiHOG000234546
HOVERGENiHBG006180
InParanoidiP78412
OMAiLERRECG
OrthoDBiEOG091G0N9R
PhylomeDBiP78412
TreeFamiTF319371

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
IRX6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79190

Protein Ontology

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PROi
PR:P78412

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000159387 Expressed in 62 organ(s), highest expression level in apex of heart
CleanExiHS_IRX6

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRX6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78412
Secondary accession number(s): B2RN06, Q7Z2K0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 17, 2006
Last modified: December 5, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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