RAE1

Functionⁱ

Plays a role in mitotic bipolar spindle formation (PubMed:17172455). Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.1 Publication

GO - Molecular functionⁱ

microtubule binding
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 15851029
RNA binding
Source: GO_Central
Inferred from direct assayⁱ
- 9256445
ubiquitin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
cellular response to organic cyclic compound Source: Ensembl
mRNA export from nucleus Source: Reactome
regulation of mitotic spindle organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17172455
transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
viral process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, Mitosis, Transport

Biological process

Cell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169408 ISG15 antiviral mechanism R-HSA-159227 Transport of the SLBP independent Mature mRNA R-HSA-159230 Transport of the SLBP Dependant Mature mRNA R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-165054 Rev-mediated nuclear export of HIV RNA R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168276 NS1 Mediated Effects on Host Pathways R-HSA-168325 Viral Messenger RNA Synthesis R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-180746 Nuclear import of Rev protein R-HSA-180910 Vpr-mediated nuclear import of PICs R-HSA-191859 snRNP Assembly R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-3232142 SUMOylation of ubiquitinylation proteins R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-4085377 SUMOylation of SUMOylation proteins R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-4570464 SUMOylation of RNA binding proteins R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-5578749 Transcriptional regulation by small RNAs R-HSA-6784531 tRNA processing in the nucleus
SignaLinkⁱ	P78406

Reactomeⁱ

R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

SignaLinkⁱ

P78406

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: mRNA export factor Alternative name(s): Rae1 protein homolog mRNA-associated protein mrnp 41
Gene namesⁱ	Name:RAE1 Synonyms:MRNP41
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101146.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9828 RAE1
MIMⁱ	603343 gene
neXtProtⁱ	NX_P78406

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8480
Open Targets More...OpenTargetsⁱ	ENSG00000101146
PharmGKBⁱ	PA34182

Polymorphism and mutation databases

BioMutaⁱ	RAE1
DMDMⁱ	3122666

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051181	1 – 368	mRNA export factorAdd BLAST		368

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	229	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P78406
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P78406
PaxDbⁱ	P78406
PeptideAtlas More...PeptideAtlasⁱ	P78406
PRIDEⁱ	P78406
ProteomicsDBⁱ	57614
TopDownProteomicsⁱ	P78406

PTM databases

iPTMnetⁱ	P78406
PhosphoSitePlusⁱ	P78406
SwissPalmⁱ	P78406

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101146 Expressed in 224 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_RAE1
ExpressionAtlasⁱ	P78406 baseline and differential
Genevisibleⁱ	P78406 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048795

HPAⁱ

HPA048795

Interactionⁱ

Subunit structureⁱ

Interacts with NUMA1 (via N-terminal end of the coiled-coil domain); this interaction promotes spindle formation in mitosis (PubMed:17172455). Interacts with NUP98 (PubMed:20498086). Interacts with MYCBP2 (PubMed:22357847).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NUMA1	Q14980	6	EBI-724495,EBI-521611
NUP98	P52948	7	EBI-724495,EBI-295727
ORF10	E5LBS6	2	EBI-724495,EBI-14033439	From Human herpesvirus 8.
SMC1A	Q14683	5	EBI-724495,EBI-80690

GO - Molecular functionⁱ

microtubule binding
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 15851029
ubiquitin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114054, 147 interactors
Database of interacting proteins More...DIPⁱ	DIP-41063N
IntActⁱ	P78406, 47 interactors
Molecular INTeraction database More...MINTⁱ	P78406
STRINGⁱ	9606.ENSP00000360286

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	42 – 47	Combined sources	6
Beta strandⁱ	52 – 61	Combined sources	10
Beta strandⁱ	64 – 71	Combined sources	8
Beta strandⁱ	77 – 84	Combined sources	8
Beta strandⁱ	89 – 94	Combined sources	6
Beta strandⁱ	98 – 105	Combined sources	8
Beta strandⁱ	108 – 114	Combined sources	7
Turnⁱ	115 – 118	Combined sources	4
Beta strandⁱ	119 – 125	Combined sources	7
Beta strandⁱ	130 – 137	Combined sources	8
Beta strandⁱ	142 – 148	Combined sources	7
Beta strandⁱ	151 – 156	Combined sources	6
Beta strandⁱ	164 – 168	Combined sources	5
Beta strandⁱ	173 – 179	Combined sources	7
Beta strandⁱ	182 – 187	Combined sources	6
Helixⁱ	188 – 190	Combined sources	3
Beta strandⁱ	192 – 196	Combined sources	5
Beta strandⁱ	198 – 200	Combined sources	3
Beta strandⁱ	202 – 206	Combined sources	5
Beta strandⁱ	215 – 222	Combined sources	8
Beta strandⁱ	228 – 235	Combined sources	8
Beta strandⁱ	238 – 246	Combined sources	9
Helixⁱ	250 – 253	Combined sources	4
Beta strandⁱ	254 – 258	Combined sources	5
Beta strandⁱ	260 – 262	Combined sources	3
Beta strandⁱ	264 – 266	Combined sources	3
Beta strandⁱ	271 – 273	Combined sources	3
Beta strandⁱ	276 – 281	Combined sources	6
Turnⁱ	283 – 285	Combined sources	3
Beta strandⁱ	288 – 292	Combined sources	5
Beta strandⁱ	297 – 301	Combined sources	5
Turnⁱ	302 – 305	Combined sources	4
Beta strandⁱ	306 – 310	Combined sources	5
Beta strandⁱ	318 – 323	Combined sources	6
Beta strandⁱ	330 – 334	Combined sources	5
Helixⁱ	342 – 344	Combined sources	3
Beta strandⁱ	352 – 356	Combined sources	5
Turnⁱ	359 – 362	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P78406
SMRⁱ	P78406
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P78406

EvolutionaryTraceⁱ

P78406

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	37 – 79	WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST	43
Repeatⁱ	84 – 114	WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST	31
Repeatⁱ	125 – 157	WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST	33
Repeatⁱ	168 – 206	WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST	39
Repeatⁱ	215 – 255	WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST	41
Repeatⁱ	271 – 301	WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST	31
Repeatⁱ	310 – 346	WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST	37

Sequence similaritiesⁱ

Belongs to the WD repeat rae1 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0647 Eukaryota ENOG410XQ1M LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063440
HOVERGENⁱ	HBG002942
InParanoidⁱ	P78406
KEGG Orthology (KO) More...KOⁱ	K14298
PhylomeDBⁱ	P78406
TreeFamⁱ	TF105481

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR037631 Gle2/RAE1 IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR10971:SF11 PTHR10971:SF11, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 2 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 4 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 2 hits PS50082 WD_REPEATS_2, 3 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

P78406-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLFGTTSGF GTSGTSMFGS ATTDNHNPMK DIEVTSSPDD SIGCLSFSPP 
        60         70         80         90        100
TLPGNFLIAG SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK 
       110        120        130        140        150
VFTASCDKTA KMWDLSSNQA IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD 
       160        170        180        190        200
KTLKFWDTRS SNPMMVLQLP ERCYCADVIY PMAVVATAER GLIVYQLENQ 
       210        220        230        240        250
PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV AIHYINPPNP 
       260        270        280        290        300
AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW 
       310        320        330        340        350
DKDARTKLKT SEQLDQPISA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK 
       360 
NYIFLRNAAE ELKPRNKK

Length:368

Mass (Da):40,968

Last modified:May 1, 1997 - v1

Checksum:ⁱ89A99C34BA668A97

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PQ57	E9PQ57_HUMAN	mRNA export factor mRNA export factor	RAE1	437	Annotation score:
E9PPG9	E9PPG9_HUMAN	mRNA export factor mRNA export factor	RAE1	217	Annotation score:
B0QZ36	B0QZ36_HUMAN	mRNA export factor mRNA export factor	RAE1	137	Annotation score:
B0QZ37	B0QZ37_HUMAN	mRNA export factor mRNA export factor	RAE1	87	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	10	F → L in AAC28127 (PubMed:9256445).Curated	1
Sequence conflictⁱ	31	D → G in AAC28127 (PubMed:9256445).Curated	1
Sequence conflictⁱ	56	F → S in AAC28127 (PubMed:9256445).Curated	1
Sequence conflictⁱ	120	A → V in AAR04856 (Ref. 3) Curated	1
Sequence conflictⁱ	158	T → N in AAC28127 (PubMed:9256445).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U84720 mRNA Translation: AAC28126.1 U85943 mRNA Translation: AAC28127.1 AY349350 mRNA Translation: AAR04856.1 AK292247 mRNA Translation: BAF84936.1 AL135939 Genomic DNA No translation available. AL109955 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75523.1 CH471077 Genomic DNA Translation: EAW75524.1 CH471077 Genomic DNA Translation: EAW75525.1 BC103754 mRNA Translation: AAI03755.1 BC106924 mRNA Translation: AAI06925.1 BC106923 mRNA Translation: AAI06924.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13458.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001015885.1, NM_001015885.1 NP_003601.1, NM_003610.3 XP_005260639.2, XM_005260582.2 XP_011527390.1, XM_011529088.2 XP_011527391.1, XM_011529089.1
UniGeneⁱ	Hs.371698

Genome annotation databases

Ensemblⁱ	ENST00000371242; ENSP00000360286; ENSG00000101146 ENST00000395840; ENSP00000379181; ENSG00000101146 ENST00000395841; ENSP00000379182; ENSG00000101146
GeneIDⁱ	8480
KEGGⁱ	hsa:8480
UCSC genome browser More...UCSCⁱ	uc002xyg.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P78406	mRNA export factor		PONAB		368	UniRef100_P78406
Ribonucleic acid export 1		MACMU		368
RAE1 RNA export 1 homolog		PANTR		368
Ribonucleic acid export 1		RHIBE		368
Ribonucleic acid export 1		MACNE		368
+8

Protein	Similar proteins		Species	Score	Length	Source
P78406	mRNA export factor		PONAB		368	UniRef90_P78406
Ribonucleic acid export 1		MACMU		368
RAE1 RNA export 1 homolog		PANTR		368
Ribonucleic acid export 1		RHIBE		368
Ribonucleic acid export 1		MACNE		368
+11

Protein	Similar proteins		Species	Score	Length	Source
P78406	mRNA export factor		PONAB		368	UniRef50_P78406
mRNA export factor		RAT		368
mRNA export factor		MOUSE		368
mRNA export factor		BOVIN		368
mRNA export factor		DANRE		368
+341

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U84720 mRNA Translation: AAC28126.1 U85943 mRNA Translation: AAC28127.1 AY349350 mRNA Translation: AAR04856.1 AK292247 mRNA Translation: BAF84936.1 AL135939 Genomic DNA No translation available. AL109955 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75523.1 CH471077 Genomic DNA Translation: EAW75524.1 CH471077 Genomic DNA Translation: EAW75525.1 BC103754 mRNA Translation: AAI03755.1 BC106924 mRNA Translation: AAI06925.1 BC106923 mRNA Translation: AAI06924.1
CCDSⁱ	CCDS13458.1
RefSeqⁱ	NP_001015885.1, NM_001015885.1 NP_003601.1, NM_003610.3 XP_005260639.2, XM_005260582.2 XP_011527390.1, XM_011529088.2 XP_011527391.1, XM_011529089.1
UniGeneⁱ	Hs.371698

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3MMY	X-ray	1.65	A/C/E/G	1-368	[»]
	4OWR	X-ray	3.15	A	31-368	[»]
ProteinModelPortalⁱ	P78406
SMRⁱ	P78406
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114054, 147 interactors
DIPⁱ	DIP-41063N
IntActⁱ	P78406, 47 interactors
MINTⁱ	P78406
STRINGⁱ	9606.ENSP00000360286

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	P78406
PhosphoSitePlusⁱ	P78406
SwissPalmⁱ	P78406

Polymorphism and mutation databases

BioMutaⁱ	RAE1
DMDMⁱ	3122666

Proteomic databases

EPDⁱ	P78406
MaxQBⁱ	P78406
PaxDbⁱ	P78406
PeptideAtlasⁱ	P78406
PRIDEⁱ	P78406
ProteomicsDBⁱ	57614
TopDownProteomicsⁱ	P78406

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000371242; ENSP00000360286; ENSG00000101146 ENST00000395840; ENSP00000379181; ENSG00000101146 ENST00000395841; ENSP00000379182; ENSG00000101146
GeneIDⁱ	8480
KEGGⁱ	hsa:8480
UCSCⁱ	uc002xyg.4 human

Organism-specific databases

CTDⁱ	8480
DisGeNETⁱ	8480
EuPathDBⁱ	HostDB:ENSG00000101146.12
GeneCardsⁱ	RAE1
HGNCⁱ	HGNC:9828 RAE1
HPAⁱ	HPA048795
MIMⁱ	603343 gene
neXtProtⁱ	NX_P78406
OpenTargetsⁱ	ENSG00000101146
PharmGKBⁱ	PA34182
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0647 Eukaryota ENOG410XQ1M LUCA
GeneTreeⁱ	ENSGT00530000063440
HOVERGENⁱ	HBG002942
InParanoidⁱ	P78406
KOⁱ	K14298
PhylomeDBⁱ	P78406
TreeFamⁱ	TF105481

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169408 ISG15 antiviral mechanism R-HSA-159227 Transport of the SLBP independent Mature mRNA R-HSA-159230 Transport of the SLBP Dependant Mature mRNA R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-165054 Rev-mediated nuclear export of HIV RNA R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168276 NS1 Mediated Effects on Host Pathways R-HSA-168325 Viral Messenger RNA Synthesis R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-180746 Nuclear import of Rev protein R-HSA-180910 Vpr-mediated nuclear import of PICs R-HSA-191859 snRNP Assembly R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-3232142 SUMOylation of ubiquitinylation proteins R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-4085377 SUMOylation of SUMOylation proteins R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-4570464 SUMOylation of RNA binding proteins R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-5578749 Transcriptional regulation by small RNAs R-HSA-6784531 tRNA processing in the nucleus
SignaLinkⁱ	P78406

Reactomeⁱ

R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

SignaLinkⁱ

P78406

Miscellaneous databases

ChiTaRSⁱ	RAE1 human
EvolutionaryTraceⁱ	P78406
GeneWikiⁱ	RAE1
GenomeRNAiⁱ	8480
Protein Ontology More...PROⁱ	PR:P78406
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101146 Expressed in 224 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_RAE1
ExpressionAtlasⁱ	P78406 baseline and differential
Genevisibleⁱ	P78406 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR037631 Gle2/RAE1 IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR10971:SF11 PTHR10971:SF11, 1 hit
Pfamⁱ	View protein in Pfam PF00400 WD40, 2 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 4 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 2 hits PS50082 WD_REPEATS_2, 3 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAE1L_HUMAN
Accessionⁱ	P78406Primary (citable) accession number: P78406 Secondary accession number(s): A8K882 Q9NQM6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P78406 (RAE1L_HUMAN)

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mRNA export factor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Other locations

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ