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UniProtKB - P78406 (RAE1L_HUMAN)

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Protein

mRNA export factor

Gene

RAE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in mitotic bipolar spindle formation (PubMed:17172455). Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.1 Publication

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • RNA binding Source: GO_Central
  • ubiquitin binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus
SignaLinkiP78406

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor
Alternative name(s):
Rae1 protein homolog
mRNA-associated protein mrnp 41
Gene namesi
Name:RAE1
Synonyms:MRNP41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101146.12
HGNCiHGNC:9828 RAE1
MIMi603343 gene
neXtProtiNX_P78406

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8480
OpenTargetsiENSG00000101146
PharmGKBiPA34182

Polymorphism and mutation databases

BioMutaiRAE1
DMDMi3122666

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511811 – 368mRNA export factorAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP78406
MaxQBiP78406
PaxDbiP78406
PeptideAtlasiP78406
PRIDEiP78406
ProteomicsDBi57614
TopDownProteomicsiP78406

PTM databases

iPTMnetiP78406
PhosphoSitePlusiP78406
SwissPalmiP78406

Expressioni

Gene expression databases

BgeeiENSG00000101146
CleanExiHS_RAE1
ExpressionAtlasiP78406 baseline and differential
GenevisibleiP78406 HS

Organism-specific databases

HPAiHPA048795

Interactioni

Subunit structurei

Interacts with NUMA1 (via N-terminal end of the coiled-coil domain); this interaction promotes spindle formation in mitosis (PubMed:17172455). Interacts with NUP98 (PubMed:20498086). Interacts with MYCBP2 (PubMed:22357847).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • ubiquitin binding Source: GO_Central
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi114054, 138 interactors
DIPiDIP-41063N
IntActiP78406, 48 interactors
MINTiP78406
STRINGi9606.ENSP00000360286

Structurei

Secondary structure

1368
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 47Combined sources6
Beta strandi52 – 61Combined sources10
Beta strandi64 – 71Combined sources8
Beta strandi77 – 84Combined sources8
Beta strandi89 – 94Combined sources6
Beta strandi98 – 105Combined sources8
Beta strandi108 – 114Combined sources7
Turni115 – 118Combined sources4
Beta strandi119 – 125Combined sources7
Beta strandi130 – 137Combined sources8
Beta strandi142 – 148Combined sources7
Beta strandi151 – 156Combined sources6
Beta strandi164 – 168Combined sources5
Beta strandi173 – 179Combined sources7
Beta strandi182 – 187Combined sources6
Helixi188 – 190Combined sources3
Beta strandi192 – 196Combined sources5
Beta strandi198 – 200Combined sources3
Beta strandi202 – 206Combined sources5
Beta strandi215 – 222Combined sources8
Beta strandi228 – 235Combined sources8
Beta strandi238 – 246Combined sources9
Helixi250 – 253Combined sources4
Beta strandi254 – 258Combined sources5
Beta strandi260 – 262Combined sources3
Beta strandi264 – 266Combined sources3
Beta strandi271 – 273Combined sources3
Beta strandi276 – 281Combined sources6
Turni283 – 285Combined sources3
Beta strandi288 – 292Combined sources5
Beta strandi297 – 301Combined sources5
Turni302 – 305Combined sources4
Beta strandi306 – 310Combined sources5
Beta strandi318 – 323Combined sources6
Beta strandi330 – 334Combined sources5
Helixi342 – 344Combined sources3
Beta strandi352 – 356Combined sources5
Turni359 – 362Combined sources4

3D structure databases

ProteinModelPortaliP78406
SMRiP78406
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78406

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 79WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST43
Repeati84 – 114WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST31
Repeati125 – 157WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST33
Repeati168 – 206WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati215 – 255WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST41
Repeati271 – 301WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST31
Repeati310 – 346WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST37

Sequence similaritiesi

Belongs to the WD repeat rae1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0647 Eukaryota
ENOG410XQ1M LUCA
GeneTreeiENSGT00530000063440
HOVERGENiHBG002942
InParanoidiP78406
KOiK14298
PhylomeDBiP78406
TreeFamiTF105481

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037631 Gle2/RAE1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10971:SF11 PTHR10971:SF11, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P78406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFGTTSGF GTSGTSMFGS ATTDNHNPMK DIEVTSSPDD SIGCLSFSPP 
        60         70         80         90        100
TLPGNFLIAG SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK 
       110        120        130        140        150
VFTASCDKTA KMWDLSSNQA IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD 
       160        170        180        190        200
KTLKFWDTRS SNPMMVLQLP ERCYCADVIY PMAVVATAER GLIVYQLENQ 
       210        220        230        240        250
PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV AIHYINPPNP 
       260        270        280        290        300
AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW 
       310        320        330        340        350
DKDARTKLKT SEQLDQPISA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK 
       360 
NYIFLRNAAE ELKPRNKK
Length:368
Mass (Da):40,968
Last modified:May 1, 1997 - v1
Checksum:i89A99C34BA668A97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10F → L in AAC28127 (PubMed:9256445).Curated1
Sequence conflicti31D → G in AAC28127 (PubMed:9256445).Curated1
Sequence conflicti56F → S in AAC28127 (PubMed:9256445).Curated1
Sequence conflicti120A → V in AAR04856 (Ref. 3) Curated1
Sequence conflicti158T → N in AAC28127 (PubMed:9256445).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84720 mRNA Translation: AAC28126.1
U85943 mRNA Translation: AAC28127.1
AY349350 mRNA Translation: AAR04856.1
AK292247 mRNA Translation: BAF84936.1
AL135939 Genomic DNA No translation available.
AL109955 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75523.1
CH471077 Genomic DNA Translation: EAW75524.1
CH471077 Genomic DNA Translation: EAW75525.1
BC103754 mRNA Translation: AAI03755.1
BC106924 mRNA Translation: AAI06925.1
BC106923 mRNA Translation: AAI06924.1
CCDSiCCDS13458.1
RefSeqiNP_001015885.1, NM_001015885.1
NP_003601.1, NM_003610.3
XP_005260639.2, XM_005260582.2
XP_011527390.1, XM_011529088.2
XP_011527391.1, XM_011529089.1
UniGeneiHs.371698

Genome annotation databases

EnsembliENST00000371242; ENSP00000360286; ENSG00000101146
ENST00000395840; ENSP00000379181; ENSG00000101146
ENST00000395841; ENSP00000379182; ENSG00000101146
GeneIDi8480
KEGGihsa:8480
UCSCiuc002xyg.4 human

Similar proteinsi

Entry informationi

Entry nameiRAE1L_HUMAN
AccessioniPrimary (citable) accession number: P78406
Secondary accession number(s): A8K882
, O15306, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: July 18, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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