UniProtKB - P78406 (RAE1L_HUMAN)
Protein
mRNA export factor
Gene
RAE1
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in mitotic bipolar spindle formation (PubMed:17172455). Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.1 Publication
GO - Molecular functioni
- microtubule binding Source: UniProtKB
- RNA binding Source: GO_Central
- ubiquitin binding Source: GO_Central
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cellular response to organic cyclic compound Source: Ensembl
- intracellular transport of virus Source: Reactome
- mRNA export from nucleus Source: Reactome
- protein sumoylation Source: Reactome
- regulation of cellular response to heat Source: Reactome
- regulation of gene silencing by miRNA Source: Reactome
- regulation of glycolytic process Source: Reactome
- regulation of mitotic spindle organization Source: UniProtKB
- RNA export from nucleus Source: GO_Central
- transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery Source: GO_Central
- tRNA export from nucleus Source: Reactome
- viral process Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis, Transport |
Enzyme and pathway databases
PathwayCommonsi | P78406 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-159227, Transport of the SLBP independent Mature mRNA R-HSA-159230, Transport of the SLBP Dependant Mature mRNA R-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-165054, Rev-mediated nuclear export of HIV RNA R-HSA-168271, Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168276, NS1 Mediated Effects on Host Pathways R-HSA-168325, Viral Messenger RNA Synthesis R-HSA-168333, NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-180746, Nuclear import of Rev protein R-HSA-180910, Vpr-mediated nuclear import of PICs R-HSA-191859, snRNP Assembly R-HSA-3108214, SUMOylation of DNA damage response and repair proteins R-HSA-3232142, SUMOylation of ubiquitinylation proteins R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly R-HSA-3371453, Regulation of HSF1-mediated heat shock response R-HSA-4085377, SUMOylation of SUMOylation proteins R-HSA-4551638, SUMOylation of chromatin organization proteins R-HSA-4570464, SUMOylation of RNA binding proteins R-HSA-4615885, SUMOylation of DNA replication proteins R-HSA-5578749, Transcriptional regulation by small RNAs R-HSA-5619107, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-6784531, tRNA processing in the nucleus R-HSA-9609690, HCMV Early Events R-HSA-9610379, HCMV Late Events |
SignaLinki | P78406 |
SIGNORi | P78406 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: mRNA export factorAlternative name(s): Rae1 protein homolog mRNA-associated protein mrnp 41 |
Gene namesi | Name:RAE1 Synonyms:MRNP41 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000101146.12 |
HGNCi | HGNC:9828, RAE1 |
MIMi | 603343, gene |
neXtProti | NX_P78406 |
Subcellular locationi
Cytoskeleton
- spindle pole 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Recruited from interphase nuclei to spindle MTs during mitosis.1 Publication
Cytoskeleton
- mitotic spindle pole Source: UniProtKB
Nucleus
- nuclear envelope Source: GO_Central
- nuclear pore Source: GO_Central
- nucleus Source: ProtInc
Other locations
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 8480 |
OpenTargetsi | ENSG00000101146 |
PharmGKBi | PA34182 |
Miscellaneous databases
Pharosi | P78406, Tbio |
Polymorphism and mutation databases
BioMutai | RAE1 |
DMDMi | 3122666 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051181 | 1 – 368 | mRNA export factorAdd BLAST | 368 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 229 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P78406 |
jPOSTi | P78406 |
MassIVEi | P78406 |
MaxQBi | P78406 |
PaxDbi | P78406 |
PeptideAtlasi | P78406 |
PRIDEi | P78406 |
ProteomicsDBi | 57614 |
TopDownProteomicsi | P78406 |
PTM databases
iPTMneti | P78406 |
PhosphoSitePlusi | P78406 |
SwissPalmi | P78406 |
Expressioni
Gene expression databases
Bgeei | ENSG00000101146, Expressed in amniotic fluid and 237 other tissues |
ExpressionAtlasi | P78406, baseline and differential |
Genevisiblei | P78406, HS |
Organism-specific databases
HPAi | ENSG00000101146, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP78406
With | #Exp. | IntAct |
---|---|---|
NUMA1 [Q14980] | 6 | EBI-724495,EBI-521611 |
NUP98 [P52948] | 7 | EBI-724495,EBI-295727 |
SMC1A [Q14683] | 5 | EBI-724495,EBI-80690 |
ORF10 [E5LBS6] from Human herpesvirus 8. | 2 | EBI-724495,EBI-14033439 |
GO - Molecular functioni
- microtubule binding Source: UniProtKB
- ubiquitin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114054, 166 interactors |
ComplexPortali | CPX-873, Nuclear pore complex |
DIPi | DIP-41063N |
IntActi | P78406, 64 interactors |
MINTi | P78406 |
STRINGi | 9606.ENSP00000379182 |
Miscellaneous databases
RNActi | P78406, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P78406 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P78406 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 37 – 79 | WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST | 43 | |
Repeati | 84 – 114 | WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST | 31 | |
Repeati | 125 – 157 | WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST | 33 | |
Repeati | 168 – 206 | WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST | 39 | |
Repeati | 215 – 255 | WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST | 41 | |
Repeati | 271 – 301 | WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST | 31 | |
Repeati | 310 – 346 | WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the WD repeat rae1 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0647, Eukaryota |
GeneTreei | ENSGT00950000183091 |
HOGENOMi | CLU_038526_1_0_1 |
InParanoidi | P78406 |
OrthoDBi | 1048963at2759 |
PhylomeDBi | P78406 |
TreeFami | TF105481 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR037631, Gle2/RAE1 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10971:SF11, PTHR10971:SF11, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P78406-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLFGTTSGF GTSGTSMFGS ATTDNHNPMK DIEVTSSPDD SIGCLSFSPP
60 70 80 90 100
TLPGNFLIAG SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK
110 120 130 140 150
VFTASCDKTA KMWDLSSNQA IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD
160 170 180 190 200
KTLKFWDTRS SNPMMVLQLP ERCYCADVIY PMAVVATAER GLIVYQLENQ
210 220 230 240 250
PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV AIHYINPPNP
260 270 280 290 300
AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW
310 320 330 340 350
DKDARTKLKT SEQLDQPISA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK
360
NYIFLRNAAE ELKPRNKK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PQ57 | E9PQ57_HUMAN | Rae1 protein homolog | RAE1 | 437 | Annotation score: | ||
E9PPG9 | E9PPG9_HUMAN | Rae1 protein homolog | RAE1 | 217 | Annotation score: | ||
B0QZ36 | B0QZ36_HUMAN | Rae1 protein homolog | RAE1 | 137 | Annotation score: | ||
B0QZ37 | B0QZ37_HUMAN | mRNA export factor | RAE1 | 87 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | F → L in AAC28127 (PubMed:9256445).Curated | 1 | |
Sequence conflicti | 31 | D → G in AAC28127 (PubMed:9256445).Curated | 1 | |
Sequence conflicti | 56 | F → S in AAC28127 (PubMed:9256445).Curated | 1 | |
Sequence conflicti | 120 | A → V in AAR04856 (Ref. 3) Curated | 1 | |
Sequence conflicti | 158 | T → N in AAC28127 (PubMed:9256445).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U84720 mRNA Translation: AAC28126.1 U85943 mRNA Translation: AAC28127.1 AY349350 mRNA Translation: AAR04856.1 AK292247 mRNA Translation: BAF84936.1 AL135939 Genomic DNA No translation available. AL109955 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75523.1 CH471077 Genomic DNA Translation: EAW75524.1 CH471077 Genomic DNA Translation: EAW75525.1 BC103754 mRNA Translation: AAI03755.1 BC106924 mRNA Translation: AAI06925.1 BC106923 mRNA Translation: AAI06924.1 |
CCDSi | CCDS13458.1 |
RefSeqi | NP_001015885.1, NM_001015885.1 NP_003601.1, NM_003610.3 XP_005260639.2, XM_005260582.2 XP_011527390.1, XM_011529088.2 XP_011527391.1, XM_011529089.1 |
Genome annotation databases
Ensembli | ENST00000371242; ENSP00000360286; ENSG00000101146 ENST00000395840; ENSP00000379181; ENSG00000101146 ENST00000395841; ENSP00000379182; ENSG00000101146 |
GeneIDi | 8480 |
KEGGi | hsa:8480 |
UCSCi | uc002xyg.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U84720 mRNA Translation: AAC28126.1 U85943 mRNA Translation: AAC28127.1 AY349350 mRNA Translation: AAR04856.1 AK292247 mRNA Translation: BAF84936.1 AL135939 Genomic DNA No translation available. AL109955 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75523.1 CH471077 Genomic DNA Translation: EAW75524.1 CH471077 Genomic DNA Translation: EAW75525.1 BC103754 mRNA Translation: AAI03755.1 BC106924 mRNA Translation: AAI06925.1 BC106923 mRNA Translation: AAI06924.1 |
CCDSi | CCDS13458.1 |
RefSeqi | NP_001015885.1, NM_001015885.1 NP_003601.1, NM_003610.3 XP_005260639.2, XM_005260582.2 XP_011527390.1, XM_011529088.2 XP_011527391.1, XM_011529089.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3MMY | X-ray | 1.65 | A/C/E/G | 1-368 | [»] | |
4OWR | X-ray | 3.15 | A | 31-368 | [»] | |
SMRi | P78406 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114054, 166 interactors |
ComplexPortali | CPX-873, Nuclear pore complex |
DIPi | DIP-41063N |
IntActi | P78406, 64 interactors |
MINTi | P78406 |
STRINGi | 9606.ENSP00000379182 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | P78406 |
PhosphoSitePlusi | P78406 |
SwissPalmi | P78406 |
Polymorphism and mutation databases
BioMutai | RAE1 |
DMDMi | 3122666 |
Proteomic databases
EPDi | P78406 |
jPOSTi | P78406 |
MassIVEi | P78406 |
MaxQBi | P78406 |
PaxDbi | P78406 |
PeptideAtlasi | P78406 |
PRIDEi | P78406 |
ProteomicsDBi | 57614 |
TopDownProteomicsi | P78406 |
Protocols and materials databases
Antibodypediai | 14158, 280 antibodies |
Genome annotation databases
Ensembli | ENST00000371242; ENSP00000360286; ENSG00000101146 ENST00000395840; ENSP00000379181; ENSG00000101146 ENST00000395841; ENSP00000379182; ENSG00000101146 |
GeneIDi | 8480 |
KEGGi | hsa:8480 |
UCSCi | uc002xyg.4, human |
Organism-specific databases
CTDi | 8480 |
DisGeNETi | 8480 |
EuPathDBi | HostDB:ENSG00000101146.12 |
GeneCardsi | RAE1 |
HGNCi | HGNC:9828, RAE1 |
HPAi | ENSG00000101146, Tissue enhanced (testis) |
MIMi | 603343, gene |
neXtProti | NX_P78406 |
OpenTargetsi | ENSG00000101146 |
PharmGKBi | PA34182 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0647, Eukaryota |
GeneTreei | ENSGT00950000183091 |
HOGENOMi | CLU_038526_1_0_1 |
InParanoidi | P78406 |
OrthoDBi | 1048963at2759 |
PhylomeDBi | P78406 |
TreeFami | TF105481 |
Enzyme and pathway databases
PathwayCommonsi | P78406 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-159227, Transport of the SLBP independent Mature mRNA R-HSA-159230, Transport of the SLBP Dependant Mature mRNA R-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-165054, Rev-mediated nuclear export of HIV RNA R-HSA-168271, Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168276, NS1 Mediated Effects on Host Pathways R-HSA-168325, Viral Messenger RNA Synthesis R-HSA-168333, NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-180746, Nuclear import of Rev protein R-HSA-180910, Vpr-mediated nuclear import of PICs R-HSA-191859, snRNP Assembly R-HSA-3108214, SUMOylation of DNA damage response and repair proteins R-HSA-3232142, SUMOylation of ubiquitinylation proteins R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly R-HSA-3371453, Regulation of HSF1-mediated heat shock response R-HSA-4085377, SUMOylation of SUMOylation proteins R-HSA-4551638, SUMOylation of chromatin organization proteins R-HSA-4570464, SUMOylation of RNA binding proteins R-HSA-4615885, SUMOylation of DNA replication proteins R-HSA-5578749, Transcriptional regulation by small RNAs R-HSA-5619107, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-6784531, tRNA processing in the nucleus R-HSA-9609690, HCMV Early Events R-HSA-9610379, HCMV Late Events |
SignaLinki | P78406 |
SIGNORi | P78406 |
Miscellaneous databases
BioGRID-ORCSi | 8480, 719 hits in 853 CRISPR screens |
ChiTaRSi | RAE1, human |
EvolutionaryTracei | P78406 |
GeneWikii | RAE1 |
GenomeRNAii | 8480 |
Pharosi | P78406, Tbio |
PROi | PR:P78406 |
RNActi | P78406, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101146, Expressed in amniotic fluid and 237 other tissues |
ExpressionAtlasi | P78406, baseline and differential |
Genevisiblei | P78406, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR037631, Gle2/RAE1 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10971:SF11, PTHR10971:SF11, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAE1L_HUMAN | |
Accessioni | P78406Primary (citable) accession number: P78406 Secondary accession number(s): A8K882 Q9NQM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | May 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 195 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM