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Protein

mRNA export factor

Gene

RAE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in mitotic bipolar spindle formation (PubMed:17172455). Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.1 Publication

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • RNA binding Source: GO_Central
  • ubiquitin binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus
SignaLinkiP78406

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor
Alternative name(s):
Rae1 protein homolog
mRNA-associated protein mrnp 41
Gene namesi
Name:RAE1
Synonyms:MRNP41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101146.12
HGNCiHGNC:9828 RAE1
MIMi603343 gene
neXtProtiNX_P78406

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8480
OpenTargetsiENSG00000101146
PharmGKBiPA34182

Polymorphism and mutation databases

BioMutaiRAE1
DMDMi3122666

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511811 – 368mRNA export factorAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP78406
MaxQBiP78406
PaxDbiP78406
PeptideAtlasiP78406
PRIDEiP78406
ProteomicsDBi57614
TopDownProteomicsiP78406

PTM databases

iPTMnetiP78406
PhosphoSitePlusiP78406
SwissPalmiP78406

Expressioni

Gene expression databases

BgeeiENSG00000101146 Expressed in 224 organ(s), highest expression level in amniotic fluid
CleanExiHS_RAE1
ExpressionAtlasiP78406 baseline and differential
GenevisibleiP78406 HS

Organism-specific databases

HPAiHPA048795

Interactioni

Subunit structurei

Interacts with NUMA1 (via N-terminal end of the coiled-coil domain); this interaction promotes spindle formation in mitosis (PubMed:17172455). Interacts with NUP98 (PubMed:20498086). Interacts with MYCBP2 (PubMed:22357847).3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114054, 147 interactors
DIPiDIP-41063N
IntActiP78406, 47 interactors
MINTiP78406
STRINGi9606.ENSP00000360286

Structurei

Secondary structure

1368
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP78406
SMRiP78406
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78406

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 79WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST43
Repeati84 – 114WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST31
Repeati125 – 157WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST33
Repeati168 – 206WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati215 – 255WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST41
Repeati271 – 301WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST31
Repeati310 – 346WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST37

Sequence similaritiesi

Belongs to the WD repeat rae1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0647 Eukaryota
ENOG410XQ1M LUCA
GeneTreeiENSGT00530000063440
HOVERGENiHBG002942
InParanoidiP78406
KOiK14298
PhylomeDBiP78406
TreeFamiTF105481

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037631 Gle2/RAE1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10971:SF11 PTHR10971:SF11, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P78406-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLFGTTSGF GTSGTSMFGS ATTDNHNPMK DIEVTSSPDD SIGCLSFSPP
60 70 80 90 100
TLPGNFLIAG SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK
110 120 130 140 150
VFTASCDKTA KMWDLSSNQA IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD
160 170 180 190 200
KTLKFWDTRS SNPMMVLQLP ERCYCADVIY PMAVVATAER GLIVYQLENQ
210 220 230 240 250
PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV AIHYINPPNP
260 270 280 290 300
AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW
310 320 330 340 350
DKDARTKLKT SEQLDQPISA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK
360
NYIFLRNAAE ELKPRNKK
Length:368
Mass (Da):40,968
Last modified:May 1, 1997 - v1
Checksum:i89A99C34BA668A97
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQ57E9PQ57_HUMAN
mRNA export factor
RAE1
437Annotation score:
E9PPG9E9PPG9_HUMAN
mRNA export factor
RAE1
217Annotation score:
B0QZ36B0QZ36_HUMAN
mRNA export factor
RAE1
137Annotation score:
B0QZ37B0QZ37_HUMAN
mRNA export factor
RAE1
87Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10F → L in AAC28127 (PubMed:9256445).Curated1
Sequence conflicti31D → G in AAC28127 (PubMed:9256445).Curated1
Sequence conflicti56F → S in AAC28127 (PubMed:9256445).Curated1
Sequence conflicti120A → V in AAR04856 (Ref. 3) Curated1
Sequence conflicti158T → N in AAC28127 (PubMed:9256445).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84720 mRNA Translation: AAC28126.1
U85943 mRNA Translation: AAC28127.1
AY349350 mRNA Translation: AAR04856.1
AK292247 mRNA Translation: BAF84936.1
AL135939 Genomic DNA No translation available.
AL109955 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75523.1
CH471077 Genomic DNA Translation: EAW75524.1
CH471077 Genomic DNA Translation: EAW75525.1
BC103754 mRNA Translation: AAI03755.1
BC106924 mRNA Translation: AAI06925.1
BC106923 mRNA Translation: AAI06924.1
CCDSiCCDS13458.1
RefSeqiNP_001015885.1, NM_001015885.1
NP_003601.1, NM_003610.3
XP_005260639.2, XM_005260582.2
XP_011527390.1, XM_011529088.2
XP_011527391.1, XM_011529089.1
UniGeneiHs.371698

Genome annotation databases

EnsembliENST00000371242; ENSP00000360286; ENSG00000101146
ENST00000395840; ENSP00000379181; ENSG00000101146
ENST00000395841; ENSP00000379182; ENSG00000101146
GeneIDi8480
KEGGihsa:8480
UCSCiuc002xyg.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84720 mRNA Translation: AAC28126.1
U85943 mRNA Translation: AAC28127.1
AY349350 mRNA Translation: AAR04856.1
AK292247 mRNA Translation: BAF84936.1
AL135939 Genomic DNA No translation available.
AL109955 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75523.1
CH471077 Genomic DNA Translation: EAW75524.1
CH471077 Genomic DNA Translation: EAW75525.1
BC103754 mRNA Translation: AAI03755.1
BC106924 mRNA Translation: AAI06925.1
BC106923 mRNA Translation: AAI06924.1
CCDSiCCDS13458.1
RefSeqiNP_001015885.1, NM_001015885.1
NP_003601.1, NM_003610.3
XP_005260639.2, XM_005260582.2
XP_011527390.1, XM_011529088.2
XP_011527391.1, XM_011529089.1
UniGeneiHs.371698

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MMYX-ray1.65A/C/E/G1-368[»]
4OWRX-ray3.15A31-368[»]
ProteinModelPortaliP78406
SMRiP78406
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114054, 147 interactors
DIPiDIP-41063N
IntActiP78406, 47 interactors
MINTiP78406
STRINGi9606.ENSP00000360286

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiP78406
PhosphoSitePlusiP78406
SwissPalmiP78406

Polymorphism and mutation databases

BioMutaiRAE1
DMDMi3122666

Proteomic databases

EPDiP78406
MaxQBiP78406
PaxDbiP78406
PeptideAtlasiP78406
PRIDEiP78406
ProteomicsDBi57614
TopDownProteomicsiP78406

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371242; ENSP00000360286; ENSG00000101146
ENST00000395840; ENSP00000379181; ENSG00000101146
ENST00000395841; ENSP00000379182; ENSG00000101146
GeneIDi8480
KEGGihsa:8480
UCSCiuc002xyg.4 human

Organism-specific databases

CTDi8480
DisGeNETi8480
EuPathDBiHostDB:ENSG00000101146.12
GeneCardsiRAE1
HGNCiHGNC:9828 RAE1
HPAiHPA048795
MIMi603343 gene
neXtProtiNX_P78406
OpenTargetsiENSG00000101146
PharmGKBiPA34182
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0647 Eukaryota
ENOG410XQ1M LUCA
GeneTreeiENSGT00530000063440
HOVERGENiHBG002942
InParanoidiP78406
KOiK14298
PhylomeDBiP78406
TreeFamiTF105481

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus
SignaLinkiP78406

Miscellaneous databases

ChiTaRSiRAE1 human
EvolutionaryTraceiP78406
GeneWikiiRAE1
GenomeRNAii8480
PROiPR:P78406
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101146 Expressed in 224 organ(s), highest expression level in amniotic fluid
CleanExiHS_RAE1
ExpressionAtlasiP78406 baseline and differential
GenevisibleiP78406 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037631 Gle2/RAE1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10971:SF11 PTHR10971:SF11, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAE1L_HUMAN
AccessioniPrimary (citable) accession number: P78406
Secondary accession number(s): A8K882
, O15306, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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