UniProtKB - P78396 (CCNA1_HUMAN)
Cyclin-A1
CCNA1
Functioni
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
1 PublicationGO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- male meiosis I Source: ProtInc
- mitotic cell cycle phase transition Source: GO_Central
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- spermatogenesis Source: ProtInc
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
PathwayCommonsi | P78396 |
Reactomei | R-HSA-1538133, G0 and Early G1 R-HSA-170145, Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes R-HSA-171319, Telomere Extension By Telomerase R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence R-HSA-5689880, Ub-specific processing proteases R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-6804757, Regulation of TP53 Degradation R-HSA-68911, G2 Phase R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69205, G1/S-Specific Transcription R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69563, p53-Dependent G1 DNA Damage Response R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry |
SignaLinki | P78396 |
SIGNORi | P78396 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-A1 |
Gene namesi | Name:CCNA1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1577, CCNA1 |
MIMi | 604036, gene |
neXtProti | NX_P78396 |
VEuPathDBi | HostDB:ENSG00000133101 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoskeleton
- microtubule cytoskeleton Source: LIFEdb
Cytosol
- cytosol Source: ProtInc
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cyclin A1-CDK2 complex Source: Ensembl
- cyclin A2-CDK2 complex Source: GO_Central
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 8900 |
OpenTargetsi | ENSG00000133101 |
PharmGKBi | PA26147 |
Miscellaneous databases
Pharosi | P78396, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2094128 CHEMBL3038470 CHEMBL3885548 CHEMBL4296066 |
Genetic variation databases
BioMutai | CCNA1 |
DMDMi | 8134359 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080333 | 1 – 465 | Cyclin-A1Add BLAST | 465 |
Post-translational modificationi
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | P78396 |
jPOSTi | P78396 |
MassIVEi | P78396 |
MaxQBi | P78396 |
PaxDbi | P78396 |
PeptideAtlasi | P78396 |
PRIDEi | P78396 |
ProteomicsDBi | 57612 [P78396-1] 57613 [P78396-2] 6859 |
PTM databases
iPTMneti | P78396 |
PhosphoSitePlusi | P78396 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000133101, Expressed in testis and 136 other tissues |
ExpressionAtlasi | P78396, baseline and differential |
Genevisiblei | P78396, HS |
Organism-specific databases
HPAi | ENSG00000133101, Tissue enhanced (parathyroid gland, testis) |
Interactioni
Subunit structurei
Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins.
Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity).
Interacts with INCA1 (PubMed:15159402, PubMed:21540187).
Interacts with KLHDC9 (PubMed:15159402).
By similarity2 PublicationsBinary interactionsi
P78396
With | #Exp. | IntAct |
---|---|---|
CDKN1A [P38936] | 8 | EBI-375065,EBI-375077 |
CDKN1B [P46527] | 6 | EBI-375065,EBI-519280 |
Isoform 2 [P78396-2]
With | #Exp. | IntAct |
---|---|---|
PRKN - isoform 5 [O60260-5] | 3 | EBI-21770675,EBI-21251460 |
Protein-protein interaction databases
BioGRIDi | 114417, 52 interactors |
ComplexPortali | CPX-2003, Cyclin A1-CDK1 complex CPX-2005, Cyclin A1-CDK2 complex |
CORUMi | P78396 |
ELMi | P78396 |
IntActi | P78396, 16 interactors |
MINTi | P78396 |
STRINGi | 9606.ENSP00000255465 |
Chemistry databases
BindingDBi | P78396 |
Miscellaneous databases
RNActi | P78396, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0654, Eukaryota |
GeneTreei | ENSGT00940000157940 |
InParanoidi | P78396 |
OMAi | YKSSKYC |
OrthoDBi | 993640at2759 |
PhylomeDBi | P78396 |
TreeFami | TF101002 |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR039361, Cyclin IPR032447, Cyclin-A_N IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit PF16500, Cyclin_N2, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METGFPAIMY PGSFIGGWGE EYLSWEGPGL PDFVFQQQPV ESEAMHCSNP
60 70 80 90 100
KSGVVLATVA RGPDACQILT RAPLGQDPPQ RTVLGLLTAN GQYRRTCGQG
110 120 130 140 150
ITRIRCYSGS ENAFPPAGKK ALPDCGVQEP PKQGFDIYMD ELEQGDRDSC
160 170 180 190 200
SVREGMAFED VYEVDTGTLK SDLHFLLDFN TVSPMLVDSS LLSQSEDISS
210 220 230 240 250
LGTDVINVTE YAEEIYQYLR EAEIRHRPKA HYMKKQPDIT EGMRTILVDW
260 270 280 290 300
LVEVGEEYKL RAETLYLAVN FLDRFLSCMS VLRGKLQLVG TAAMLLASKY
310 320 330 340 350
EEIYPPEVDE FVYITDDTYT KRQLLKMEHL LLKVLAFDLT VPTTNQFLLQ
360 370 380 390 400
YLRRQGVCVR TENLAKYVAE LSLLEADPFL KYLPSLIAAA AFCLANYTVN
410 420 430 440 450
KHFWPETLAA FTGYSLSEIV PCLSELHKAY LDIPHRPQQA IREKYKASKY
460
LCVSLMEPPA VLLLQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 43 – 47 | EAMHC → SS in AAV38384 (Ref. 2) Curated | 5 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044257 | 1 – 44 | Missing in isoform 3. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_034392 | 38 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66838 mRNA Translation: AAB49754.1 BT019577 mRNA Translation: AAV38384.1 AK301897 mRNA Translation: BAH13579.1 AK316392 mRNA Translation: BAH14763.1 AL359767 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08565.1 CH471075 Genomic DNA Translation: EAX08566.1 BC036346 mRNA Translation: AAH36346.1 U97680 mRNA Translation: AAB60863.1 |
CCDSi | CCDS45030.1 [P78396-2] CCDS45031.1 [P78396-3] CCDS9357.1 [P78396-1] |
RefSeqi | NP_001104515.1, NM_001111045.1 [P78396-2] NP_001104516.1, NM_001111046.1 [P78396-3] NP_001104517.1, NM_001111047.1 [P78396-3] NP_003905.1, NM_003914.3 [P78396-1] XP_011533596.1, XM_011535294.2 [P78396-3] XP_011533597.1, XM_011535295.2 [P78396-3] XP_011533598.1, XM_011535296.2 [P78396-3] |
Genome annotation databases
Ensembli | ENST00000255465.7; ENSP00000255465.4; ENSG00000133101.10 ENST00000440264.5; ENSP00000400666.1; ENSG00000133101.10 [P78396-3] ENST00000625767.1; ENSP00000486017.1; ENSG00000133101.10 [P78396-2] ENST00000630422.2; ENSP00000486482.1; ENSG00000133101.10 [P78396-3] |
GeneIDi | 8900 |
KEGGi | hsa:8900 |
MANE-Selecti | ENST00000255465.7; ENSP00000255465.4; NM_003914.4; NP_003905.1 |
UCSCi | uc001uvr.5, human [P78396-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66838 mRNA Translation: AAB49754.1 BT019577 mRNA Translation: AAV38384.1 AK301897 mRNA Translation: BAH13579.1 AK316392 mRNA Translation: BAH14763.1 AL359767 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08565.1 CH471075 Genomic DNA Translation: EAX08566.1 BC036346 mRNA Translation: AAH36346.1 U97680 mRNA Translation: AAB60863.1 |
CCDSi | CCDS45030.1 [P78396-2] CCDS45031.1 [P78396-3] CCDS9357.1 [P78396-1] |
RefSeqi | NP_001104515.1, NM_001111045.1 [P78396-2] NP_001104516.1, NM_001111046.1 [P78396-3] NP_001104517.1, NM_001111047.1 [P78396-3] NP_003905.1, NM_003914.3 [P78396-1] XP_011533596.1, XM_011535294.2 [P78396-3] XP_011533597.1, XM_011535295.2 [P78396-3] XP_011533598.1, XM_011535296.2 [P78396-3] |
3D structure databases
AlphaFoldDBi | P78396 |
SMRi | P78396 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114417, 52 interactors |
ComplexPortali | CPX-2003, Cyclin A1-CDK1 complex CPX-2005, Cyclin A1-CDK2 complex |
CORUMi | P78396 |
ELMi | P78396 |
IntActi | P78396, 16 interactors |
MINTi | P78396 |
STRINGi | 9606.ENSP00000255465 |
Chemistry databases
BindingDBi | P78396 |
ChEMBLi | CHEMBL2094128 CHEMBL3038470 CHEMBL3885548 CHEMBL4296066 |
PTM databases
iPTMneti | P78396 |
PhosphoSitePlusi | P78396 |
Genetic variation databases
BioMutai | CCNA1 |
DMDMi | 8134359 |
Proteomic databases
EPDi | P78396 |
jPOSTi | P78396 |
MassIVEi | P78396 |
MaxQBi | P78396 |
PaxDbi | P78396 |
PeptideAtlasi | P78396 |
PRIDEi | P78396 |
ProteomicsDBi | 57612 [P78396-1] 57613 [P78396-2] 6859 |
Protocols and materials databases
Antibodypediai | 4520, 537 antibodies from 37 providers |
DNASUi | 8900 |
Genome annotation databases
Ensembli | ENST00000255465.7; ENSP00000255465.4; ENSG00000133101.10 ENST00000440264.5; ENSP00000400666.1; ENSG00000133101.10 [P78396-3] ENST00000625767.1; ENSP00000486017.1; ENSG00000133101.10 [P78396-2] ENST00000630422.2; ENSP00000486482.1; ENSG00000133101.10 [P78396-3] |
GeneIDi | 8900 |
KEGGi | hsa:8900 |
MANE-Selecti | ENST00000255465.7; ENSP00000255465.4; NM_003914.4; NP_003905.1 |
UCSCi | uc001uvr.5, human [P78396-1] |
Organism-specific databases
CTDi | 8900 |
DisGeNETi | 8900 |
GeneCardsi | CCNA1 |
HGNCi | HGNC:1577, CCNA1 |
HPAi | ENSG00000133101, Tissue enhanced (parathyroid gland, testis) |
MIMi | 604036, gene |
neXtProti | NX_P78396 |
OpenTargetsi | ENSG00000133101 |
PharmGKBi | PA26147 |
VEuPathDBi | HostDB:ENSG00000133101 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0654, Eukaryota |
GeneTreei | ENSGT00940000157940 |
InParanoidi | P78396 |
OMAi | YKSSKYC |
OrthoDBi | 993640at2759 |
PhylomeDBi | P78396 |
TreeFami | TF101002 |
Enzyme and pathway databases
PathwayCommonsi | P78396 |
Reactomei | R-HSA-1538133, G0 and Early G1 R-HSA-170145, Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes R-HSA-171319, Telomere Extension By Telomerase R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence R-HSA-5689880, Ub-specific processing proteases R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-6804757, Regulation of TP53 Degradation R-HSA-68911, G2 Phase R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69205, G1/S-Specific Transcription R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69563, p53-Dependent G1 DNA Damage Response R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry |
SignaLinki | P78396 |
SIGNORi | P78396 |
Miscellaneous databases
BioGRID-ORCSi | 8900, 9 hits in 1076 CRISPR screens |
ChiTaRSi | CCNA1, human |
GeneWikii | Cyclin_A1 |
GenomeRNAii | 8900 |
Pharosi | P78396, Tbio |
PROi | PR:P78396 |
RNActi | P78396, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000133101, Expressed in testis and 136 other tissues |
ExpressionAtlasi | P78396, baseline and differential |
Genevisiblei | P78396, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR039361, Cyclin IPR032447, Cyclin-A_N IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit PF16500, Cyclin_N2, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNA1_HUMAN | |
Accessioni | P78396Primary (citable) accession number: P78396 Secondary accession number(s): B7Z7E3 Q8IY91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 193 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families