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UniProtKB - P78396 (CCNA1_HUMAN)

Protein

Cyclin-A1

Gene

CCNA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.1 Publication

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
  • protein kinase binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-1538133 G0 and Early G1
R-HSA-170145 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-68911 G2 Phase
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69563 p53-Dependent G1 DNA Damage Response
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
SignaLinkiP78396
SIGNORiP78396

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-A1
Gene namesi
Name:CCNA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000133101.9
HGNCiHGNC:1577 CCNA1
MIMi604036 gene
neXtProtiNX_P78396

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8900
OpenTargetsiENSG00000133101
PharmGKBiPA26147

Chemistry databases

ChEMBLiCHEMBL3885548

Polymorphism and mutation databases

BioMutaiCCNA1
DMDMi8134359

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803331 – 465Cyclin-A1Add BLAST465

Post-translational modificationi

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiP78396
MaxQBiP78396
PaxDbiP78396
PeptideAtlasiP78396
PRIDEiP78396
ProteomicsDBi57612
57613 [P78396-2]

PTM databases

iPTMnetiP78396
PhosphoSitePlusiP78396

Expressioni

Tissue specificityi

Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.

Developmental stagei

Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases.

Gene expression databases

BgeeiENSG00000133101 Expressed in 116 organ(s), highest expression level in testis
CleanExiHS_CCNA1
ExpressionAtlasiP78396 baseline and differential
GenevisibleiP78396 HS

Organism-specific databases

HPAiHPA060646

Interactioni

Subunit structurei

Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 (PubMed:15159402, PubMed:21540187). Interacts with KLHDC9 (PubMed:15159402).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDKN1AP389363EBI-375065,EBI-375077

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi114417, 50 interactors
ComplexPortaliCPX-2003 Cyclin A1-CDK1 complex
CPX-2005 Cyclin A1-CDK2 complex
CORUMiP78396
ELMiP78396
IntActiP78396, 10 interactors
MINTiP78396
STRINGi9606.ENSP00000255465

Chemistry databases

BindingDBiP78396

Structurei

3D structure databases

ProteinModelPortaliP78396
SMRiP78396
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi388 – 391Poly-Ala4

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0654 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000167672
HOVERGENiHBG106244
InParanoidiP78396
KOiK06627
OMAiDACQMIT
OrthoDBiEOG091G090I
PhylomeDBiP78396
TreeFamiTF101002

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P78396-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METGFPAIMY PGSFIGGWGE EYLSWEGPGL PDFVFQQQPV ESEAMHCSNP 
        60         70         80         90        100
KSGVVLATVA RGPDACQILT RAPLGQDPPQ RTVLGLLTAN GQYRRTCGQG 
       110        120        130        140        150
ITRIRCYSGS ENAFPPAGKK ALPDCGVQEP PKQGFDIYMD ELEQGDRDSC 
       160        170        180        190        200
SVREGMAFED VYEVDTGTLK SDLHFLLDFN TVSPMLVDSS LLSQSEDISS 
       210        220        230        240        250
LGTDVINVTE YAEEIYQYLR EAEIRHRPKA HYMKKQPDIT EGMRTILVDW 
       260        270        280        290        300
LVEVGEEYKL RAETLYLAVN FLDRFLSCMS VLRGKLQLVG TAAMLLASKY 
       310        320        330        340        350
EEIYPPEVDE FVYITDDTYT KRQLLKMEHL LLKVLAFDLT VPTTNQFLLQ 
       360        370        380        390        400
YLRRQGVCVR TENLAKYVAE LSLLEADPFL KYLPSLIAAA AFCLANYTVN 
       410        420        430        440        450
KHFWPETLAA FTGYSLSEIV PCLSELHKAY LDIPHRPQQA IREKYKASKY 
       460 
LCVSLMEPPA VLLLQ
Length:465
Mass (Da):52,358
Last modified:May 1, 1997 - v1
Checksum:iC9C023EEA1CF036D
GO
Isoform 2 (identifier: P78396-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-38: Missing.

Show »
Length:464
Mass (Da):52,230
Checksum:iE67C6E6D741B7D73
GO
Isoform 3 (identifier: P78396-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Show »
Length:421
Mass (Da):47,494
Checksum:i33F2BA565699105C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43 – 47EAMHC → SS in AAV38384 (Ref. 2) Curated5

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442571 – 44Missing in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_03439238Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66838 mRNA Translation: AAB49754.1
BT019577 mRNA Translation: AAV38384.1
AK301897 mRNA Translation: BAH13579.1
AK316392 mRNA Translation: BAH14763.1
AL359767 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08565.1
CH471075 Genomic DNA Translation: EAX08566.1
BC036346 mRNA Translation: AAH36346.1
U97680 mRNA Translation: AAB60863.1
CCDSiCCDS45030.1 [P78396-2]
CCDS45031.1 [P78396-3]
CCDS9357.1 [P78396-1]
RefSeqiNP_001104515.1, NM_001111045.1 [P78396-2]
NP_001104516.1, NM_001111046.1 [P78396-3]
NP_001104517.1, NM_001111047.1 [P78396-3]
NP_003905.1, NM_003914.3 [P78396-1]
XP_011533596.1, XM_011535294.2 [P78396-3]
XP_011533597.1, XM_011535295.2 [P78396-3]
XP_011533598.1, XM_011535296.2 [P78396-3]
UniGeneiHs.417050

Genome annotation databases

EnsembliENST00000255465; ENSP00000255465; ENSG00000133101 [P78396-1]
ENST00000440264; ENSP00000400666; ENSG00000133101 [P78396-3]
ENST00000625767; ENSP00000486017; ENSG00000133101 [P78396-2]
ENST00000630422; ENSP00000486482; ENSG00000133101 [P78396-3]
GeneIDi8900
KEGGihsa:8900
UCSCiuc001uvr.5 human [P78396-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66838 mRNA Translation: AAB49754.1
BT019577 mRNA Translation: AAV38384.1
AK301897 mRNA Translation: BAH13579.1
AK316392 mRNA Translation: BAH14763.1
AL359767 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08565.1
CH471075 Genomic DNA Translation: EAX08566.1
BC036346 mRNA Translation: AAH36346.1
U97680 mRNA Translation: AAB60863.1
CCDSiCCDS45030.1 [P78396-2]
CCDS45031.1 [P78396-3]
CCDS9357.1 [P78396-1]
RefSeqiNP_001104515.1, NM_001111045.1 [P78396-2]
NP_001104516.1, NM_001111046.1 [P78396-3]
NP_001104517.1, NM_001111047.1 [P78396-3]
NP_003905.1, NM_003914.3 [P78396-1]
XP_011533596.1, XM_011535294.2 [P78396-3]
XP_011533597.1, XM_011535295.2 [P78396-3]
XP_011533598.1, XM_011535296.2 [P78396-3]
UniGeneiHs.417050

3D structure databases

ProteinModelPortaliP78396
SMRiP78396
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114417, 50 interactors
ComplexPortaliCPX-2003 Cyclin A1-CDK1 complex
CPX-2005 Cyclin A1-CDK2 complex
CORUMiP78396
ELMiP78396
IntActiP78396, 10 interactors
MINTiP78396
STRINGi9606.ENSP00000255465

Chemistry databases

BindingDBiP78396
ChEMBLiCHEMBL3885548

PTM databases

iPTMnetiP78396
PhosphoSitePlusiP78396

Polymorphism and mutation databases

BioMutaiCCNA1
DMDMi8134359

Proteomic databases

EPDiP78396
MaxQBiP78396
PaxDbiP78396
PeptideAtlasiP78396
PRIDEiP78396
ProteomicsDBi57612
57613 [P78396-2]

Protocols and materials databases

DNASUi8900
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255465; ENSP00000255465; ENSG00000133101 [P78396-1]
ENST00000440264; ENSP00000400666; ENSG00000133101 [P78396-3]
ENST00000625767; ENSP00000486017; ENSG00000133101 [P78396-2]
ENST00000630422; ENSP00000486482; ENSG00000133101 [P78396-3]
GeneIDi8900
KEGGihsa:8900
UCSCiuc001uvr.5 human [P78396-1]

Organism-specific databases

CTDi8900
DisGeNETi8900
EuPathDBiHostDB:ENSG00000133101.9
GeneCardsiCCNA1
HGNCiHGNC:1577 CCNA1
HPAiHPA060646
MIMi604036 gene
neXtProtiNX_P78396
OpenTargetsiENSG00000133101
PharmGKBiPA26147
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0654 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000167672
HOVERGENiHBG106244
InParanoidiP78396
KOiK06627
OMAiDACQMIT
OrthoDBiEOG091G090I
PhylomeDBiP78396
TreeFamiTF101002

Enzyme and pathway databases

ReactomeiR-HSA-1538133 G0 and Early G1
R-HSA-170145 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-68911 G2 Phase
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69563 p53-Dependent G1 DNA Damage Response
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
SignaLinkiP78396
SIGNORiP78396

Miscellaneous databases

ChiTaRSiCCNA1 human
GeneWikiiCyclin_A1
GenomeRNAii8900
PROiPR:P78396
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133101 Expressed in 116 organ(s), highest expression level in testis
CleanExiHS_CCNA1
ExpressionAtlasiP78396 baseline and differential
GenevisibleiP78396 HS

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCNA1_HUMAN
AccessioniPrimary (citable) accession number: P78396
Secondary accession number(s): B7Z7E3
, Q5T3V0, Q5U0G2, Q8IY91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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