Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P78395 (PRAME_HUMAN)

Entry version 172 (02 Jun 2021)
Sequence version 1 (01 May 1997)
Previous versions | rss
Add a publicationFeedback
Protein

Melanoma antigen preferentially expressed in tumors

Gene

PRAME

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

1 Publication

Miscellaneous

Tumor antigen recognized by cytolytic T lymphocytes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processApoptosis, Differentiation, Growth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P78395

SIGNOR Signaling Network Open Resource

More...SIGNORi		P78395

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanoma antigen preferentially expressed in tumorsCurated
Alternative name(s):
Opa-interacting protein 4
Short name:
OIP-4
Preferentially expressed antigen of melanoma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRAMEImported
Synonyms:MAPEImported, OIP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9336, PRAME

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606021, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P78395

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000185686.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi470 – 471LL → VV: Loss of interaction with RARA and defective in repressing RARA signaling. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		23532

Open Targets

More...OpenTargetsi		ENSG00000185686

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33698

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P78395, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRAME

Domain mapping of disease mutations (DMDM)

More...DMDMi		6685631

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001569731 – 509Melanoma antigen preferentially expressed in tumorsAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P78395

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P78395

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P78395

MaxQB - The MaxQuant DataBase

More...MaxQBi		P78395

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P78395

PeptideAtlas

More...PeptideAtlasi		P78395

PRoteomics IDEntifications database

More...PRIDEi		P78395

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57611

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P78395

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P78395

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis. Detected in samples of kidney, brain and skin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185686, Expressed in right testis and 91 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P78395, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P78395, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185686, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RARA (via the ligand-binding domain); the interaction is direct and ligand (retinoic acid)-dependent.

Interacts with EZH2; required to repress RAR signaling.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117078, 59 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P78395

Protein interaction database and analysis system

More...IntActi		P78395, 32 interactors

Molecular INTeraction database

More...MINTi		P78395

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000445675

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P78395, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati116 – 145LRR 1; degenerateBy similarityAdd BLAST30
Repeati207 – 231LRR 2; degenerateBy similarityAdd BLAST25
Repeati232 – 258LRR 3; degenerateBy similarityAdd BLAST27
Repeati259 – 294LRR 4; degenerateBy similarityAdd BLAST36
Repeati295 – 320LRR 5By similarityAdd BLAST26
Repeati321 – 352LRR 6By similarityAdd BLAST32
Repeati353 – 371LRR 7By similarityAdd BLAST19
Repeati377 – 404LRR 8By similarityAdd BLAST28
Repeati405 – 429LRR 9By similarityAdd BLAST25

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni416 – 509Mediates interaction with RARA1 PublicationAdd BLAST94

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWSJ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234531

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_039635_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P78395

Identification of Orthologs from Complete Genome Data

More...OMAi		TFTFCGN

Database of Orthologous Groups

More...OrthoDBi		631249at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P78395

TreeFam database of animal gene trees

More...TreeFami		TF332708

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032675, LRR_dom_sf
IPR026271, PRAME_family

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038286, PRAME, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

P78395-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERRRLWGSI QSRYISMSVW TSPRRLVELA GQSLLKDEAL AIAALELLPR 
        60         70         80         90        100
ELFPPLFMAA FDGRHSQTLK AMVQAWPFTC LPLGVLMKGQ HLHLETFKAV 
       110        120        130        140        150
LDGLDVLLAQ EVRPRRWKLQ VLDLRKNSHQ DFWTVWSGNR ASLYSFPEPE 
       160        170        180        190        200
AAQPMTKKRK VDGLSTEAEQ PFIPVEVLVD LFLKEGACDE LFSYLIEKVK 
       210        220        230        240        250
RKKNVLRLCC KKLKIFAMPM QDIKMILKMV QLDSIEDLEV TCTWKLPTLA 
       260        270        280        290        300
KFSPYLGQMI NLRRLLLSHI HASSYISPEK EEQYIAQFTS QFLSLQCLQA 
       310        320        330        340        350
LYVDSLFFLR GRLDQLLRHV MNPLETLSIT NCRLSEGDVM HLSQSPSVSQ 
       360        370        380        390        400
LSVLSLSGVM LTDVSPEPLQ ALLERASATL QDLVFDECGI TDDQLLALLP 
       410        420        430        440        450
SLSHCSQLTT LSFYGNSISI SALQSLLQHL IGLSNLTHVL YPVPLESYED 
       460        470        480        490        500
IHGTLHLERL AYLHARLREL LCELGRPSMV WLSANPCPHC GDRTFYDPEP 

ILCPCFMPN
Length:509
Mass (Da):57,890
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5FFF3E7F7E82606
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MD04B5MD04_HUMAN
Melanoma antigen preferentially-exp...
PRAME
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMH2E7EMH2_HUMAN
Melanoma antigen preferentially-exp...
PRAME
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EW99E7EW99_HUMAN
Melanoma antigen preferentially-exp...
PRAME
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2P3H7C2P3_HUMAN
Melanoma antigen preferentially-exp...
PRAME
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCY4B5MCY4_HUMAN
Melanoma antigen preferentially-exp...
PRAME
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF80F8WF80_HUMAN
Melanoma antigen preferentially-exp...
PRAME
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JRX7A0A0G2JRX7_HUMAN
Melanoma antigen preferentially-exp...
PRAME
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JRX8A0A0G2JRX8_HUMAN
Melanoma antigen preferentially-exp...
PRAME
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti452H → D in AAC39560 (PubMed:9466265).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0212587W → R2 PublicationsCorresponds to variant dbSNP:rs1129172Ensembl.1
Natural variantiVAR_062137218M → V. Corresponds to variant dbSNP:rs41277507Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U65011 mRNA Translation: AAC51160.1
CR456549 mRNA Translation: CAG30435.1
AK312769 mRNA Translation: BAG35634.1
CH471095 Genomic DNA Translation: EAW59518.1
BC014074 mRNA Translation: AAH14074.1
BC022008 mRNA Translation: AAH22008.1
BC039731 mRNA Translation: AAH39731.1
AF025440 mRNA Translation: AAC39560.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13801.1

NCBI Reference Sequences

More...RefSeqi		NP_001278644.1, NM_001291715.1
NP_001278645.1, NM_001291716.1
NP_001278646.1, NM_001291717.1
NP_001278648.1, NM_001291719.1
NP_001305055.1, NM_001318126.1
NP_001305056.1, NM_001318127.1
NP_006106.1, NM_006115.4
NP_996836.1, NM_206953.2
NP_996837.1, NM_206954.2
NP_996838.1, NM_206955.2
NP_996839.1, NM_206956.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000398741; ENSP00000381726; ENSG00000185686
ENST00000398743; ENSP00000381728; ENSG00000185686
ENST00000402697; ENSP00000385198; ENSG00000185686
ENST00000405655; ENSP00000384343; ENSG00000185686
ENST00000539862; ENSP00000445097; ENSG00000275013
ENST00000543184; ENSP00000445675; ENSG00000185686
ENST00000617728; ENSP00000484066; ENSG00000275013
ENST00000626503; ENSP00000486485; ENSG00000275013
ENST00000628830; ENSP00000486330; ENSG00000275013

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23532

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23532

UCSC genome browser

More...UCSCi		uc032qia.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65011 mRNA Translation: AAC51160.1
CR456549 mRNA Translation: CAG30435.1
AK312769 mRNA Translation: BAG35634.1
CH471095 Genomic DNA Translation: EAW59518.1
BC014074 mRNA Translation: AAH14074.1
BC022008 mRNA Translation: AAH22008.1
BC039731 mRNA Translation: AAH39731.1
AF025440 mRNA Translation: AAC39560.1
CCDSiCCDS13801.1
RefSeqiNP_001278644.1, NM_001291715.1
NP_001278645.1, NM_001291716.1
NP_001278646.1, NM_001291717.1
NP_001278648.1, NM_001291719.1
NP_001305055.1, NM_001318126.1
NP_001305056.1, NM_001318127.1
NP_006106.1, NM_006115.4
NP_996836.1, NM_206953.2
NP_996837.1, NM_206954.2
NP_996838.1, NM_206955.2
NP_996839.1, NM_206956.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117078, 59 interactors
CORUMiP78395
IntActiP78395, 32 interactors
MINTiP78395
STRINGi9606.ENSP00000445675

PTM databases

iPTMnetiP78395
PhosphoSitePlusiP78395

Genetic variation databases

BioMutaiPRAME
DMDMi6685631

Proteomic databases

EPDiP78395
jPOSTiP78395
MassIVEiP78395
MaxQBiP78395
PaxDbiP78395
PeptideAtlasiP78395
PRIDEiP78395
ProteomicsDBi57611

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23630, 444 antibodies

The DNASU plasmid repository

More...DNASUi		23532

Genome annotation databases

EnsembliENST00000398741; ENSP00000381726; ENSG00000185686
ENST00000398743; ENSP00000381728; ENSG00000185686
ENST00000402697; ENSP00000385198; ENSG00000185686
ENST00000405655; ENSP00000384343; ENSG00000185686
ENST00000539862; ENSP00000445097; ENSG00000275013
ENST00000543184; ENSP00000445675; ENSG00000185686
ENST00000617728; ENSP00000484066; ENSG00000275013
ENST00000626503; ENSP00000486485; ENSG00000275013
ENST00000628830; ENSP00000486330; ENSG00000275013
GeneIDi23532
KEGGihsa:23532
UCSCiuc032qia.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23532
DisGeNETi23532

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRAME
HGNCiHGNC:9336, PRAME
HPAiENSG00000185686, Tissue enriched (testis)
MIMi606021, gene
neXtProtiNX_P78395
OpenTargetsiENSG00000185686
PharmGKBiPA33698
VEuPathDBiHostDB:ENSG00000185686.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWSJ, Eukaryota
GeneTreeiENSGT01030000234531
HOGENOMiCLU_039635_2_1_1
InParanoidiP78395
OMAiTFTFCGN
OrthoDBi631249at2759
PhylomeDBiP78395
TreeFamiTF332708

Enzyme and pathway databases

PathwayCommonsiP78395
SIGNORiP78395

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23532, 22 hits in 999 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRAME, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PRAME

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23532
PharosiP78395, Tbio

Protein Ontology

More...PROi		PR:P78395
RNActiP78395, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185686, Expressed in right testis and 91 other tissues
ExpressionAtlasiP78395, baseline and differential
GenevisibleiP78395, HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675, LRR_dom_sf
IPR026271, PRAME_family
PIRSFiPIRSF038286, PRAME, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRAME_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78395
Secondary accession number(s): B2R6Y7, O43481, Q8IXN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: June 2, 2021
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again