KRT85

Functionⁱ

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

GO - Molecular functionⁱ

structural molecule activity
Source: ProtInc
Traceable author statementⁱ
- 9084137

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cornification Source: Reactome
epidermis development
Source: ProtInc
Traceable author statementⁱ
- 9084137
keratinization Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6805567 Keratinization R-HSA-6809371 Formation of the cornified envelope

Reactomeⁱ

R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Keratin, type II cuticular Hb5 Alternative name(s): Hair keratin K2.12 Keratin-85 Short name: K85 Type II hair keratin Hb5 Type-II keratin Kb25
Gene namesⁱ	Name:KRT85 Synonyms:KRTHB5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135443.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6462 KRT85
MIMⁱ	602767 gene
neXtProtⁱ	NX_P78386

Subcellular locationⁱ

GO - Cellular component

Keywords - Cellular componentⁱ

Intermediate filament, Keratin

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ectodermal dysplasia 4, hair/nail type (ECTD4)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. ECTD4 is characterized by complete alopecia, hypotricosis and nail dystrophy in all digits. There is no evidence of any other abnormality. Inheritance can be autosomal dominant or recessive.

Keywords - Diseaseⁱ

Disease mutation, Ectodermal dysplasia, Hypotrichosis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3891
MalaCards human disease database More...MalaCardsⁱ	KRT85
MIMⁱ	602032 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000135443
Orphanetⁱ	69084 Pure hair and nail ectodermal dysplasia
PharmGKBⁱ	PA30251

Polymorphism and mutation databases

BioMutaⁱ	KRT85
DMDMⁱ	48474780

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000063702	1 – 507	Keratin, type II cuticular Hb5Add BLAST		507

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	229	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	P78386
PeptideAtlas More...PeptideAtlasⁱ	P78386
PRIDEⁱ	P78386
ProteomicsDBⁱ	12676 57610

PTM databases

iPTMnetⁱ	P78386
PhosphoSitePlusⁱ	P78386
SwissPalmⁱ	P78386

Expressionⁱ

Tissue specificityⁱ

Synthesis occurs immediately above a small population of matrix cells at the base of the hair bulb and the trichocytes lining the dermal papilla and extends upward through the matrix and ends in the lower part of the cortex of the hair shaft.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000135443 Expressed in 59 organ(s), highest expression level in hair follicle
CleanExⁱ	HS_KRT85
ExpressionAtlasⁱ	P78386 baseline and differential
Genevisibleⁱ	P78386 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049778

HPAⁱ

HPA049778

Interactionⁱ

Subunit structureⁱ

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridⁱ	110089, 19 interactors
IntActⁱ	P78386, 37 interactors
STRINGⁱ	9606.ENSP00000257901

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P78386
SMRⁱ	P78386
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	123 – 434	IF rodPROSITE-ProRule annotationAdd BLAST		312

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 123	HeadAdd BLAST	123
Regionⁱ	124 – 158	Coil 1AAdd BLAST	35
Regionⁱ	159 – 168	Linker 1	10
Regionⁱ	169 – 269	Coil 1BAdd BLAST	101
Regionⁱ	270 – 286	Linker 12Add BLAST	17
Regionⁱ	287 – 430	Coil 2Add BLAST	144
Regionⁱ	431 – 507	TailAdd BLAST	77

Sequence similaritiesⁱ

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IH1H Eukaryota ENOG41113GZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144006
HOGENOMⁱ	HOG000230976
HOVERGENⁱ	HBG013015
InParanoidⁱ	P78386
KEGG Orthology (KO) More...KOⁱ	K07605
OMAⁱ	RCCESNM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06FG
PhylomeDBⁱ	P78386
TreeFamⁱ	TF332742

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR032444 Keratin_2_head IPR003054 Keratin_II
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit PF16208 Keratin_2_head, 1 hit
PRINTSⁱ	PR01276 TYPE2KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P78386-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSCRSYRISS GCGVTRNFSS CSAVAPKTGN RCCISAAPYR GVSCYRGLTG 
        60         70         80         90        100
FGSRSLCNLG SCGPRIAVGG FRAGSCGRSF GYRSGGVCGP SPPCITTVSV 
       110        120        130        140        150
NESLLTPLNL EIDPNAQCVK QEEKEQIKSL NSRFAAFIDK VRFLEQQNKL 
       160        170        180        190        200
LETKWQFYQN QRCCESNLEP LFSGYIETLR REAECVEADS GRLASELNHV 
       210        220        230        240        250
QEVLEGYKKK YEEEVALRAT AENEFVVLKK DVDCAYLRKS DLEANVEALV 
       260        270        280        290        300
EESSFLRRLY EEEIRVLQAH ISDTSVIVKM DNSRDLNMDC IIAEIKAQYD 
       310        320        330        340        350
DVASRSRAEA ESWYRSKCEE MKATVIRHGE TLRRTKEEIN ELNRMIQRLT 
       360        370        380        390        400
AEIENAKCQR AKLEAAVAEA EQQGEAALSD ARCKLAELEG ALQKAKQDMA 
       410        420        430        440        450
CLLKEYQEVM NSKLGLDIEI ATYRRLLEGE EHRLCEGVGS VNVCVSSSRG 
       460        470        480        490        500
GVSCGGLSYS TTPGRQITSG PSAIGGSITV VAPDSCAPCQ PRSSSFSCGS 

SRSVRFA

Length:507

Mass (Da):55,802

Last modified:May 1, 1997 - v1

Checksum:ⁱ0A3E5ABEAAF4C04D

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F5GYI5	F5GYI5_HUMAN		Keratin, type II cuticular Hb5 Keratin, type II cuticular Hb5	KRT85	295	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	155	W → V in CAB76830 (PubMed:10692104).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029657	78	R → H in ECTD4. 1 PublicationCorresponds to variant dbSNP:rs61630004EnsemblClinVar.		1
Natural variantⁱVAR_049804	155	W → L. Corresponds to variant dbSNP:rs2852471Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X99140 mRNA Translation: CAA67577.1 Y19210 Genomic DNA Translation: CAB76830.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8824.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001287739.1, NM_001300810.1 NP_002274.1, NM_002283.3
UniGeneⁱ	Hs.182507

Genome annotation databases

Ensemblⁱ	ENST00000257901; ENSP00000257901; ENSG00000135443
GeneIDⁱ	3891
KEGGⁱ	hsa:3891
UCSC genome browser More...UCSCⁱ	uc001sag.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P78386	Keratin, type II cuticular Hb5		MOUSE		507	UniRef90_P78386
Keratin, type II microfibrillar, component 5		SHEEP		502
Keratin 85		SAIBB		509
Uncharacterized protein		MYOLU		508
Uncharacterized protein (Fragment)		AILME		508
+131

Protein	Similar proteins		Species	Score	Length	Source
P78386	Keratin, type II cuticular Hb3		HUMAN		493	UniRef50_P78385
Keratin, type II cuticular Hb1		MOUSE		481
Keratin, type II cytoskeletal		XENLA		513
Keratin, type II microfibrillar, component 5		SHEEP		502
Uncharacterized protein		PAPAN		506
+652

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X99140 mRNA Translation: CAA67577.1 Y19210 Genomic DNA Translation: CAB76830.1
CCDSⁱ	CCDS8824.1
RefSeqⁱ	NP_001287739.1, NM_001300810.1 NP_002274.1, NM_002283.3
UniGeneⁱ	Hs.182507

3D structure databases

ProteinModelPortalⁱ	P78386
SMRⁱ	P78386
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110089, 19 interactors
IntActⁱ	P78386, 37 interactors
STRINGⁱ	9606.ENSP00000257901

PTM databases

iPTMnetⁱ	P78386
PhosphoSitePlusⁱ	P78386
SwissPalmⁱ	P78386

Polymorphism and mutation databases

BioMutaⁱ	KRT85
DMDMⁱ	48474780

Proteomic databases

PaxDbⁱ	P78386
PeptideAtlasⁱ	P78386
PRIDEⁱ	P78386
ProteomicsDBⁱ	12676 57610

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3891
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000257901; ENSP00000257901; ENSG00000135443
GeneIDⁱ	3891
KEGGⁱ	hsa:3891
UCSCⁱ	uc001sag.4 human

Organism-specific databases

CTDⁱ	3891
DisGeNETⁱ	3891
EuPathDBⁱ	HostDB:ENSG00000135443.8
GeneCardsⁱ	KRT85
HGNCⁱ	HGNC:6462 KRT85
HPAⁱ	HPA049778
MalaCardsⁱ	KRT85
MIMⁱ	602032 phenotype 602767 gene
neXtProtⁱ	NX_P78386
OpenTargetsⁱ	ENSG00000135443
Orphanetⁱ	69084 Pure hair and nail ectodermal dysplasia
PharmGKBⁱ	PA30251
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IH1H Eukaryota ENOG41113GZ LUCA
GeneTreeⁱ	ENSGT00910000144006
HOGENOMⁱ	HOG000230976
HOVERGENⁱ	HBG013015
InParanoidⁱ	P78386
KOⁱ	K07605
OMAⁱ	RCCESNM
OrthoDBⁱ	EOG091G06FG
PhylomeDBⁱ	P78386
TreeFamⁱ	TF332742

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6805567 Keratinization R-HSA-6809371 Formation of the cornified envelope

Reactomeⁱ

R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

GeneWikiⁱ	KRT85
GenomeRNAiⁱ	3891
Protein Ontology More...PROⁱ	PR:P78386
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135443 Expressed in 59 organ(s), highest expression level in hair follicle
CleanExⁱ	HS_KRT85
ExpressionAtlasⁱ	P78386 baseline and differential
Genevisibleⁱ	P78386 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR032444 Keratin_2_head IPR003054 Keratin_II
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit
Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit PF16208 Keratin_2_head, 1 hit
PRINTSⁱ	PR01276 TYPE2KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KRT85_HUMAN
Accessionⁱ	P78386Primary (citable) accession number: P78386 Secondary accession number(s): Q9NSB1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - P78386 (KRT85_HUMAN)

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Keratin, type II cuticular Hb5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ