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Protein

UDP-galactose translocator

Gene

SLC35A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • UDP-galactose transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • carbohydrate transport Source: UniProtKB-KW
  • galactose metabolic process Source: ProtInc
  • UDP-galactose transmembrane transport Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5619072 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)
R-HSA-727802 Transport of nucleotide sugars

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.7.12.6 the drug/metabolite transporter (dmt) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-galactose translocator
Alternative name(s):
Solute carrier family 35 member A2
UDP-galactose transporter
Short name:
UDP-Gal-Tr
Short name:
UGT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC35A2
Synonyms:UGALT, UGT, UGTL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000102100.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11022 SLC35A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
314375 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P78381

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital disorder of glycosylation 2M (CDG2M)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by developmental delay, hypotonia, ocular anomalies, and brain malformations. Othere more variable clinical features included seizures, hypsarrhythmia, poor feeding, microcephaly, recurrent infections, dysmorphic features, shortened limbs, and coagulation defects. Congenital disorders of glycosylation are caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins and a wide variety of clinical features. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
See also OMIM:300896
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071699213S → F in CDG2M. 1 PublicationCorresponds to variant dbSNP:rs587777436EnsemblClinVar.1
Natural variantiVAR_069773331V → I in CDG2M. 1 PublicationCorresponds to variant dbSNP:rs587776961EnsemblClinVar.1

Keywords - Diseasei

Congenital disorder of glycosylation, Disease mutation, Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
7355

MalaCards human disease database

More...
MalaCardsi
SLC35A2
MIMi300896 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000102100

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
356961 SLC35A2-CDG

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35890

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3430867

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC35A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2499228

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002133531 – 396UDP-galactose translocatorAdd BLAST396

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P78381

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P78381

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P78381

PeptideAtlas

More...
PeptideAtlasi
P78381

PRoteomics IDEntifications database

More...
PRIDEi
P78381

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57603
57604 [P78381-2]
57605 [P78381-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P78381

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P78381

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102100 Expressed in 218 organ(s), highest expression level in oviduct epithelium

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC35A2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P78381 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P78381 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036087

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SLC35A3.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SLC35A3Q9Y2D23EBI-8101118,EBI-3917581

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113202, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P78381

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P78381

Protein interaction database and analysis system

More...
IntActi
P78381, 6 interactors

Molecular INTeraction database

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MINTi
P78381

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000247138

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P78381

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2234 Eukaryota
COG0697 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154054

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000216649

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG071267

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P78381

KEGG Orthology (KO)

More...
KOi
K15272

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTHQQPP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0CHS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P78381

TreeFam database of animal gene trees

More...
TreeFami
TF315345

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007271 Nuc_sug_transpt

The PANTHER Classification System

More...
PANTHERi
PTHR10231 PTHR10231, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04142 Nuc_sug_transp, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005799 UDP-gal_transpt, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P78381-1) [UniParc]FASTAAdd to basket
Also known as: UGT2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVGAGGST AAPGPGAVSA GALEPGTASA AHRRLKYISL AVLVVQNASL
60 70 80 90 100
ILSIRYARTL PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF
110 120 130 140 150
LHEAVLVQYV DTLKLAVPSL IYTLQNNLQY VAISNLPAAT FQVTYQLKIL
160 170 180 190 200
TTALFSVLML NRSLSRLQWA SLLLLFTGVA IVQAQQAGGG GPRPLDQNPG
210 220 230 240 250
AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL FGTALGLVGL
260 270 280 290 300
WWAEGTAVAT RGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA
310 320 330 340 350
TSLSIVLSTV ASIRLFGFHV DPLFALGAGL VIGAVYLYSL PRGAAKAIAS
360 370 380 390
ASASASGPCV HQQPPGQPPP PQLSSHRGDL ITEPFLPKLL TKVKGS
Length:396
Mass (Da):41,307
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EC1DC9532FE9221
GO
Isoform 2 (identifier: P78381-2) [UniParc]FASTAAdd to basket
Also known as: UGT1

The sequence of this isoform differs from the canonical sequence as follows:
     389-396: LLTKVKGS → SVLVK

Show »
Length:393
Mass (Da):41,007
Checksum:i34D31807D3805A7A
GO
Isoform 3 (identifier: P78381-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-396: VTYQLKILTT...PKLLTKVKGS → PSPRCSQSHS...FGRWSFLPGH

Show »
Length:242
Mass (Da):25,184
Checksum:i7AB122B6343CC9EC
GO
Isoform 4 (identifier: P78381-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-30: A → AELLLTWEEAEARGQGLPQPLPDTSVRIP
     389-396: LLTKVKGS → SVLVK

Note: No experimental confirmation available.
Show »
Length:421
Mass (Da):44,106
Checksum:i11D42242F410B56C
GO
Isoform 5 (identifier: P78381-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-91: Missing.
     389-396: LLTKVKGS → SVLVK

Note: No experimental confirmation available.
Show »
Length:332
Mass (Da):34,194
Checksum:i7FC8A3C442E4C31B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DE15B4DE15_HUMAN
cDNA FLJ53300, highly similar to UD...
SLC35A2
406Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NFI1A6NFI1_HUMAN
UDP-galactose translocator
SLC35A2
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NKM8A6NKM8_HUMAN
UDP-galactose translocator
SLC35A2
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NGW4A6NGW4_HUMAN
UDP-galactose translocator
SLC35A2
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DSH7B4DSH7_HUMAN
cDNA FLJ59970, highly similar to UD...
SLC35A2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR61A0A0U1RR61_HUMAN
UDP-galactose translocator
SLC35A2
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR48A0A0U1RR48_HUMAN
UDP-galactose translocator
SLC35A2
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCV5C9JCV5_HUMAN
UDP-galactose translocator
SLC35A2
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRG4A0A0U1RRG4_HUMAN
UDP-galactose translocator
SLC35A2
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0X1KG77A0A0X1KG77_HUMAN
UDP-galactose translocator
SLC35A2
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti85L → P in BAF82973 (PubMed:14702039).Curated1
Sequence conflicti110V → A in BAG60694 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071699213S → F in CDG2M. 1 PublicationCorresponds to variant dbSNP:rs587777436EnsemblClinVar.1
Natural variantiVAR_036579252W → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_079035258V → M Found in a patient with Rett syndrome-like phenotype; unknown pathological significance. 1 Publication1
Natural variantiVAR_069773331V → I in CDG2M. 1 PublicationCorresponds to variant dbSNP:rs587776961EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05433530A → AELLLTWEEAEARGQGLPQP LPDTSVRIP in isoform 4. 1 Publication1
Alternative sequenceiVSP_05519731 – 91Missing in isoform 5. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_042029143 – 396VTYQL…KVKGS → PSPRCSQSHSLCLCLRLRAL RSPAASRAATTTAAVFPPWR PHHGALSAKVSAGEVRAGSN GGTQGRGTGVEGVGHLQDPS RHPPGPGSSGFGRWSFLPGH in isoform 3. 2 PublicationsAdd BLAST254
Alternative sequenceiVSP_003728389 – 396LLTKVKGS → SVLVK in isoform 2, isoform 4 and isoform 5. 2 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D88146 mRNA Translation: BAA13545.1
D84454 mRNA Translation: BAA12673.1
AB042425 Genomic DNA Translation: BAA95614.1
AB042425 Genomic DNA Translation: BAA95615.1
AK290284 mRNA Translation: BAF82973.1
AK292816 mRNA Translation: BAF85505.1
AK293415 mRNA Translation: BAG56922.1
AK298484 mRNA Translation: BAG60694.1
AF207550 Genomic DNA No translation available.
CH471224 Genomic DNA Translation: EAW50733.1
CH471224 Genomic DNA Translation: EAW50734.1
BC035747 mRNA Translation: AAH35747.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14311.1 [P78381-1]
CCDS35247.1 [P78381-3]
CCDS43937.1 [P78381-2]
CCDS65253.1 [P78381-5]
CCDS65254.1 [P78381-4]

Protein sequence database of the Protein Information Resource

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PIRi
JC5022

NCBI Reference Sequences

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RefSeqi
NP_001027460.1, NM_001032289.2 [P78381-3]
NP_001035963.1, NM_001042498.2 [P78381-2]
NP_001269576.1, NM_001282647.1
NP_001269577.1, NM_001282648.1
NP_001269578.1, NM_001282649.1 [P78381-5]
NP_001269579.1, NM_001282650.1
NP_001269580.1, NM_001282651.1 [P78381-4]
NP_005651.1, NM_005660.2 [P78381-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.21899

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000247138; ENSP00000247138; ENSG00000102100 [P78381-1]
ENST00000376521; ENSP00000365704; ENSG00000102100 [P78381-2]
ENST00000445167; ENSP00000402726; ENSG00000102100 [P78381-3]
ENST00000452555; ENSP00000416002; ENSG00000102100 [P78381-4]
ENST00000635285; ENSP00000489484; ENSG00000102100 [P78381-2]
ENST00000635589; ENSP00000489197; ENSG00000102100 [P78381-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7355

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7355

UCSC genome browser

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UCSCi
uc004dlo.3 human [P78381-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88146 mRNA Translation: BAA13545.1
D84454 mRNA Translation: BAA12673.1
AB042425 Genomic DNA Translation: BAA95614.1
AB042425 Genomic DNA Translation: BAA95615.1
AK290284 mRNA Translation: BAF82973.1
AK292816 mRNA Translation: BAF85505.1
AK293415 mRNA Translation: BAG56922.1
AK298484 mRNA Translation: BAG60694.1
AF207550 Genomic DNA No translation available.
CH471224 Genomic DNA Translation: EAW50733.1
CH471224 Genomic DNA Translation: EAW50734.1
BC035747 mRNA Translation: AAH35747.1
CCDSiCCDS14311.1 [P78381-1]
CCDS35247.1 [P78381-3]
CCDS43937.1 [P78381-2]
CCDS65253.1 [P78381-5]
CCDS65254.1 [P78381-4]
PIRiJC5022
RefSeqiNP_001027460.1, NM_001032289.2 [P78381-3]
NP_001035963.1, NM_001042498.2 [P78381-2]
NP_001269576.1, NM_001282647.1
NP_001269577.1, NM_001282648.1
NP_001269578.1, NM_001282649.1 [P78381-5]
NP_001269579.1, NM_001282650.1
NP_001269580.1, NM_001282651.1 [P78381-4]
NP_005651.1, NM_005660.2 [P78381-1]
UniGeneiHs.21899

3D structure databases

ProteinModelPortaliP78381
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113202, 6 interactors
CORUMiP78381
ELMiP78381
IntActiP78381, 6 interactors
MINTiP78381
STRINGi9606.ENSP00000247138

Chemistry databases

ChEMBLiCHEMBL3430867

Protein family/group databases

TCDBi2.A.7.12.6 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetiP78381
PhosphoSitePlusiP78381

Polymorphism and mutation databases

BioMutaiSLC35A2
DMDMi2499228

Proteomic databases

EPDiP78381
MaxQBiP78381
PaxDbiP78381
PeptideAtlasiP78381
PRIDEiP78381
ProteomicsDBi57603
57604 [P78381-2]
57605 [P78381-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247138; ENSP00000247138; ENSG00000102100 [P78381-1]
ENST00000376521; ENSP00000365704; ENSG00000102100 [P78381-2]
ENST00000445167; ENSP00000402726; ENSG00000102100 [P78381-3]
ENST00000452555; ENSP00000416002; ENSG00000102100 [P78381-4]
ENST00000635285; ENSP00000489484; ENSG00000102100 [P78381-2]
ENST00000635589; ENSP00000489197; ENSG00000102100 [P78381-5]
GeneIDi7355
KEGGihsa:7355
UCSCiuc004dlo.3 human [P78381-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7355
DisGeNETi7355
EuPathDBiHostDB:ENSG00000102100.15

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC35A2
HGNCiHGNC:11022 SLC35A2
HPAiHPA036087
MalaCardsiSLC35A2
MIMi300896 phenotype
314375 gene
neXtProtiNX_P78381
OpenTargetsiENSG00000102100
Orphaneti356961 SLC35A2-CDG
PharmGKBiPA35890

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2234 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00940000154054
HOGENOMiHOG000216649
HOVERGENiHBG071267
InParanoidiP78381
KOiK15272
OMAiCTHQQPP
OrthoDBiEOG091G0CHS
PhylomeDBiP78381
TreeFamiTF315345

Enzyme and pathway databases

ReactomeiR-HSA-5619072 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)
R-HSA-727802 Transport of nucleotide sugars

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC35A2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC35A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7355

Protein Ontology

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PROi
PR:P78381

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102100 Expressed in 218 organ(s), highest expression level in oviduct epithelium
CleanExiHS_SLC35A2
ExpressionAtlasiP78381 baseline and differential
GenevisibleiP78381 HS

Family and domain databases

InterProiView protein in InterPro
IPR007271 Nuc_sug_transpt
PANTHERiPTHR10231 PTHR10231, 1 hit
PfamiView protein in Pfam
PF04142 Nuc_sug_transp, 1 hit
PIRSFiPIRSF005799 UDP-gal_transpt, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS35A2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78381
Secondary accession number(s): A8K2L9
, A8K9V1, B4DE11, B4DPT2, E7EW45, Q8IV21, Q92553
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: December 5, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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