Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P78371 (TCPB_HUMAN)

Entry version 202 (07 Apr 2021)
Sequence version 4 (23 Jan 2007)
Previous versions | rss
Add a publicationFeedback
Protein

T-complex protein 1 subunit beta

Gene

CCT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).Curated2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P78371

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960, Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450, Folding of actin by CCT/TriC
R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5620922, BBSome-mediated cargo-targeting to cilium
R-HSA-6798695, Neutrophil degranulation
R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

SIGNOR Signaling Network Open Resource

More...SIGNORi		P78371

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-complex protein 1 subunit beta
Short name:
TCP-1-beta
Alternative name(s):
CCT-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCT2
Synonyms:99D8.1, CCTB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1615, CCT2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605139, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P78371

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166226.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10576

Open Targets

More...OpenTargetsi		ENSG00000166226

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26179

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P78371, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCT2

Domain mapping of disease mutations (DMDM)

More...DMDMi		6094436

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001283162 – 535T-complex protein 1 subunit betaAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei3PhosphoserineCombined sources1
Modified residuei13N6-acetyllysineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei154N6-acetyllysineCombined sources1
Modified residuei181N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei260PhosphoserineCombined sources1
Modified residuei261PhosphothreonineCombined sources1
Isoform 2 (identifier: P78371-2)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-39
CPTAC-40

Encyclopedia of Proteome Dynamics

More...EPDi		P78371

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P78371

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P78371

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P78371

PeptideAtlas

More...PeptideAtlasi		P78371

PRoteomics IDEntifications database

More...PRIDEi		P78371

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57599 [P78371-1]
57600 [P78371-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P78371-1 [P78371-1]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P78371

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00297779

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P78371

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P78371

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P78371

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P78371

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P78371

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P78371

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166226, Expressed in testis and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P78371, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P78371, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166226, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:20080638, PubMed:25467444).

Interacts with PACRG (PubMed:14532270).

Interacts with FLCN (PubMed:27353360).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115827, 452 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6030, Chaperonin-containing T-complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P78371

Database of interacting proteins

More...DIPi		DIP-38123N

Protein interaction database and analysis system

More...IntActi		P78371, 256 interactors

Molecular INTeraction database

More...MINTi		P78371

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000299300

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P78371, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P78371

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0363, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000074930

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P78371

Identification of Orthologs from Complete Genome Data

More...OMAi		HQPQRIE

Database for complete collections of gene phylogenies

More...PhylomeDBi		P78371

TreeFam database of animal gene trees

More...TreeFami		TF105645

Family and domain databases

Conserved Domains Database

More...CDDi		cd03336, TCP1_beta, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012716, Chap_CCT_beta
IPR017998, Chaperone_TCP-1
IPR002194, Chaperonin_TCP-1_CS
IPR002423, Cpn60/TCP-1
IPR027409, GroEL-like_apical_dom_sf
IPR027413, GROEL-like_equatorial_sf
IPR027410, TCP-1-like_intermed_sf

The PANTHER Classification System

More...PANTHERi		PTHR11353:SF23, PTHR11353:SF23, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00118, Cpn60_TCP1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00304, TCOMPLEXTCP1

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48592, SSF48592, 1 hit
SSF52029, SSF52029, 1 hit
SSF54849, SSF54849, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02341, chap_CCT_beta, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00750, TCP1_1, 1 hit
PS00751, TCP1_2, 1 hit
PS00995, TCP1_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P78371-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLSLAPVN IFKAGADEER AETARLTSFI GAIAIGDLVK STLGPKGMDK 
        60         70         80         90        100
ILLSSGRDAS LMVTNDGATI LKNIGVDNPA AKVLVDMSRV QDDEVGDGTT 
       110        120        130        140        150
SVTVLAAELL REAESLIAKK IHPQTIIAGW REATKAAREA LLSSAVDHGS 
       160        170        180        190        200
DEVKFRQDLM NIAGTTLSSK LLTHHKDHFT KLAVEAVLRL KGSGNLEAIH 
       210        220        230        240        250
IIKKLGGSLA DSYLDEGFLL DKKIGVNQPK RIENAKILIA NTGMDTDKIK 
       260        270        280        290        300
IFGSRVRVDS TAKVAEIEHA EKEKMKEKVE RILKHGINCF INRQLIYNYP 
       310        320        330        340        350
EQLFGAAGVM AIEHADFAGV ERLALVTGGE IASTFDHPEL VKLGSCKLIE 
       360        370        380        390        400
EVMIGEDKLI HFSGVALGEA CTIVLRGATQ QILDEAERSL HDALCVLAQT 
       410        420        430        440        450
VKDSRTVYGG GCSEMLMAHA VTQLANRTPG KEAVAMESYA KALRMLPTII 
       460        470        480        490        500
ADNAGYDSAD LVAQLRAAHS EGNTTAGLDM REGTIGDMAI LGITESFQVK 
       510        520        530 
RQVLLSAAEA AEVILRVDNI IKAAPRKRVP DHHPC
Length:535
Mass (Da):57,488
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57F9E1720D84A31F
GO
Isoform 2 (identifier: P78371-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Show »
Length:488
Mass (Da):52,718
Checksum:i5947D87827A365E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GWF6F5GWF6_HUMAN
CCT-beta
CCT2
530Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQ14F8VQ14_HUMAN
CCT-beta
CCT2
416Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51I → T in BAH11729 (PubMed:14702039).Curated1
Sequence conflicti126I → T in CAG33352 (Ref. 5) Curated1
Sequence conflicti354I → T in BAF83456 (PubMed:14702039).Curated1
Sequence conflicti438S → P in BAH13640 (PubMed:14702039).Curated1
Sequence conflicti444R → K in BAG70037 (PubMed:19054851).Curated1
Sequence conflicti444R → K in BAG70160 (PubMed:19054851).Curated1
Sequence conflicti504L → P in CAG33352 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0426481 – 47Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF026293 mRNA Translation: AAC96012.1
AF026166 mRNA Translation: AAC98906.1
BT019966 mRNA Translation: AAV38769.1
AK290767 mRNA Translation: BAF83456.1
AK294307 mRNA Translation: BAH11729.1
AK302157 mRNA Translation: BAH13640.1
AK316397 mRNA Translation: BAH14768.1
AK316408 mRNA Translation: BAH14779.1
CR457071 mRNA Translation: CAG33352.1
AB451223 mRNA Translation: BAG70037.1
AB451346 mRNA Translation: BAG70160.1
AC018921 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97230.1
BC113514 mRNA Translation: AAI13515.1
BC113516 mRNA Translation: AAI13517.1
U91327 Genomic DNA Translation: AAB67249.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55843.1 [P78371-2]
CCDS8991.1 [P78371-1]

NCBI Reference Sequences

More...RefSeqi		NP_001185771.1, NM_001198842.1 [P78371-2]
NP_006422.1, NM_006431.2 [P78371-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000299300; ENSP00000299300; ENSG00000166226 [P78371-1]
ENST00000543146; ENSP00000445471; ENSG00000166226 [P78371-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10576

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10576

UCSC genome browser

More...UCSCi		uc010stl.2, human [P78371-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026293 mRNA Translation: AAC96012.1
AF026166 mRNA Translation: AAC98906.1
BT019966 mRNA Translation: AAV38769.1
AK290767 mRNA Translation: BAF83456.1
AK294307 mRNA Translation: BAH11729.1
AK302157 mRNA Translation: BAH13640.1
AK316397 mRNA Translation: BAH14768.1
AK316408 mRNA Translation: BAH14779.1
CR457071 mRNA Translation: CAG33352.1
AB451223 mRNA Translation: BAG70037.1
AB451346 mRNA Translation: BAG70160.1
AC018921 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97230.1
BC113514 mRNA Translation: AAI13515.1
BC113516 mRNA Translation: AAI13517.1
U91327 Genomic DNA Translation: AAB67249.1
CCDSiCCDS55843.1 [P78371-2]
CCDS8991.1 [P78371-1]
RefSeqiNP_001185771.1, NM_001198842.1 [P78371-2]
NP_006422.1, NM_006431.2 [P78371-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6NR8electron microscopy7.80B/J16-524[»]
6NR9electron microscopy8.50B/J16-524[»]
6NRAelectron microscopy7.70B/J16-524[»]
6NRBelectron microscopy8.70B/J16-524[»]
6NRCelectron microscopy8.30B/J16-524[»]
6NRDelectron microscopy8.20B/J16-524[»]
6QB8electron microscopy3.97B/b1-535[»]
SMRiP78371
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115827, 452 interactors
ComplexPortaliCPX-6030, Chaperonin-containing T-complex
CORUMiP78371
DIPiDIP-38123N
IntActiP78371, 256 interactors
MINTiP78371
STRINGi9606.ENSP00000299300

PTM databases

iPTMnetiP78371
MetOSiteiP78371
PhosphoSitePlusiP78371
SwissPalmiP78371

Genetic variation databases

BioMutaiCCT2
DMDMi6094436

2D gel databases

OGPiP78371
REPRODUCTION-2DPAGEiIPI00297779
SWISS-2DPAGEiP78371
UCD-2DPAGEiP78371

Proteomic databases

CPTACiCPTAC-39
CPTAC-40
EPDiP78371
jPOSTiP78371
MassIVEiP78371
PaxDbiP78371
PeptideAtlasiP78371
PRIDEiP78371
ProteomicsDBi57599 [P78371-1]
57600 [P78371-2]
TopDownProteomicsiP78371-1 [P78371-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		762, 352 antibodies

The DNASU plasmid repository

More...DNASUi		10576

Genome annotation databases

EnsembliENST00000299300; ENSP00000299300; ENSG00000166226 [P78371-1]
ENST00000543146; ENSP00000445471; ENSG00000166226 [P78371-2]
GeneIDi10576
KEGGihsa:10576
UCSCiuc010stl.2, human [P78371-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10576
DisGeNETi10576

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCT2
HGNCiHGNC:1615, CCT2
HPAiENSG00000166226, Low tissue specificity
MIMi605139, gene
neXtProtiNX_P78371
OpenTargetsiENSG00000166226
PharmGKBiPA26179
VEuPathDBiHostDB:ENSG00000166226.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0363, Eukaryota
GeneTreeiENSGT00550000074930
InParanoidiP78371
OMAiHQPQRIE
PhylomeDBiP78371
TreeFamiTF105645

Enzyme and pathway databases

PathwayCommonsiP78371
ReactomeiR-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960, Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450, Folding of actin by CCT/TriC
R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5620922, BBSome-mediated cargo-targeting to cilium
R-HSA-6798695, Neutrophil degranulation
R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SIGNORiP78371

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10576, 764 hits in 983 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCT2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CCT2_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10576
PharosiP78371, Tbio

Protein Ontology

More...PROi		PR:P78371
RNActiP78371, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166226, Expressed in testis and 245 other tissues
ExpressionAtlasiP78371, baseline and differential
GenevisibleiP78371, HS

Family and domain databases

CDDicd03336, TCP1_beta, 1 hit
Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012716, Chap_CCT_beta
IPR017998, Chaperone_TCP-1
IPR002194, Chaperonin_TCP-1_CS
IPR002423, Cpn60/TCP-1
IPR027409, GroEL-like_apical_dom_sf
IPR027413, GROEL-like_equatorial_sf
IPR027410, TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF23, PTHR11353:SF23, 1 hit
PfamiView protein in Pfam
PF00118, Cpn60_TCP1, 1 hit
PRINTSiPR00304, TCOMPLEXTCP1
SUPFAMiSSF48592, SSF48592, 1 hit
SSF52029, SSF52029, 1 hit
SSF54849, SSF54849, 1 hit
TIGRFAMsiTIGR02341, chap_CCT_beta, 1 hit
PROSITEiView protein in PROSITE
PS00750, TCP1_1, 1 hit
PS00751, TCP1_2, 1 hit
PS00995, TCP1_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCPB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78371
Secondary accession number(s): A8K402
, B5BTY7, B7Z243, B7Z7K4, B7ZAT2, Q14D36, Q6IAT3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 202 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again