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Protein

T-complex protein 1 subunit beta

Gene

CCT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).Curated2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein binding involved in protein folding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-6798695 Neutrophil degranulation
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P78371

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-complex protein 1 subunit beta
Short name:
TCP-1-beta
Alternative name(s):
CCT-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCT2
Synonyms:99D8.1, CCTB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000166226.12

Human Gene Nomenclature Database

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HGNCi
HGNC:1615 CCT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605139 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P78371

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10576

Open Targets

More...
OpenTargetsi
ENSG00000166226

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26179

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCT2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6094436

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001283162 – 535T-complex protein 1 subunit betaAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei3PhosphoserineCombined sources1
Modified residuei13N6-acetyllysineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei154N6-acetyllysineCombined sources1
Modified residuei181N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei260PhosphoserineCombined sources1
Modified residuei261PhosphothreonineCombined sources1
Isoform 2 (identifier: P78371-2)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P78371

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P78371

PeptideAtlas

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PeptideAtlasi
P78371

PRoteomics IDEntifications database

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PRIDEi
P78371

ProteomicsDB human proteome resource

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ProteomicsDBi
57599
57600 [P78371-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P78371-1 [P78371-1]

2D gel databases

USC-OGP 2-DE database

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OGPi
P78371

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00297779

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P78371

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P78371

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P78371

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P78371

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P78371

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166226 Expressed in 232 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_CCT2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P78371 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P78371 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003197
HPA003198

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:20080638, PubMed:25467444). Interacts with PACRG (PubMed:14532270). Interacts with FLCN (PubMed:27353360).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115827, 354 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P78371

Database of interacting proteins

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DIPi
DIP-38123N

Protein interaction database and analysis system

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IntActi
P78371, 139 interactors

Molecular INTeraction database

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MINTi
P78371

STRING: functional protein association networks

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STRINGi
9606.ENSP00000299300

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P78371

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0363 Eukaryota
COG0459 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00550000074930

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000226736

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001052

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P78371

KEGG Orthology (KO)

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KOi
K09494

Identification of Orthologs from Complete Genome Data

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OMAi
PGVHQPQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G07BP

Database for complete collections of gene phylogenies

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PhylomeDBi
P78371

TreeFam database of animal gene trees

More...
TreeFami
TF105645

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03336 TCP1_beta, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012716 Chap_CCT_beta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf

The PANTHER Classification System

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PANTHERi
PTHR11353:SF23 PTHR11353:SF23, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00118 Cpn60_TCP1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00304 TCOMPLEXTCP1

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR02341 chap_CCT_beta, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P78371-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLSLAPVN IFKAGADEER AETARLTSFI GAIAIGDLVK STLGPKGMDK
60 70 80 90 100
ILLSSGRDAS LMVTNDGATI LKNIGVDNPA AKVLVDMSRV QDDEVGDGTT
110 120 130 140 150
SVTVLAAELL REAESLIAKK IHPQTIIAGW REATKAAREA LLSSAVDHGS
160 170 180 190 200
DEVKFRQDLM NIAGTTLSSK LLTHHKDHFT KLAVEAVLRL KGSGNLEAIH
210 220 230 240 250
IIKKLGGSLA DSYLDEGFLL DKKIGVNQPK RIENAKILIA NTGMDTDKIK
260 270 280 290 300
IFGSRVRVDS TAKVAEIEHA EKEKMKEKVE RILKHGINCF INRQLIYNYP
310 320 330 340 350
EQLFGAAGVM AIEHADFAGV ERLALVTGGE IASTFDHPEL VKLGSCKLIE
360 370 380 390 400
EVMIGEDKLI HFSGVALGEA CTIVLRGATQ QILDEAERSL HDALCVLAQT
410 420 430 440 450
VKDSRTVYGG GCSEMLMAHA VTQLANRTPG KEAVAMESYA KALRMLPTII
460 470 480 490 500
ADNAGYDSAD LVAQLRAAHS EGNTTAGLDM REGTIGDMAI LGITESFQVK
510 520 530
RQVLLSAAEA AEVILRVDNI IKAAPRKRVP DHHPC
Length:535
Mass (Da):57,488
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57F9E1720D84A31F
GO
Isoform 2 (identifier: P78371-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:488
Mass (Da):52,718
Checksum:i5947D87827A365E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GWF6F5GWF6_HUMAN
T-complex protein 1 subunit beta
CCT2
530Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQ14F8VQ14_HUMAN
T-complex protein 1 subunit beta
CCT2
416Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51I → T in BAH11729 (PubMed:14702039).Curated1
Sequence conflicti126I → T in CAG33352 (Ref. 5) Curated1
Sequence conflicti354I → T in BAF83456 (PubMed:14702039).Curated1
Sequence conflicti438S → P in BAH13640 (PubMed:14702039).Curated1
Sequence conflicti444R → K in BAG70037 (PubMed:19054851).Curated1
Sequence conflicti444R → K in BAG70160 (PubMed:19054851).Curated1
Sequence conflicti504L → P in CAG33352 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0426481 – 47Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF026293 mRNA Translation: AAC96012.1
AF026166 mRNA Translation: AAC98906.1
BT019966 mRNA Translation: AAV38769.1
AK290767 mRNA Translation: BAF83456.1
AK294307 mRNA Translation: BAH11729.1
AK302157 mRNA Translation: BAH13640.1
AK316397 mRNA Translation: BAH14768.1
AK316408 mRNA Translation: BAH14779.1
CR457071 mRNA Translation: CAG33352.1
AB451223 mRNA Translation: BAG70037.1
AB451346 mRNA Translation: BAG70160.1
AC018921 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97230.1
BC113514 mRNA Translation: AAI13515.1
BC113516 mRNA Translation: AAI13517.1
U91327 Genomic DNA Translation: AAB67249.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS55843.1 [P78371-2]
CCDS8991.1 [P78371-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001185771.1, NM_001198842.1 [P78371-2]
NP_006422.1, NM_006431.2 [P78371-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.189772

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299300; ENSP00000299300; ENSG00000166226 [P78371-1]
ENST00000543146; ENSP00000445471; ENSG00000166226 [P78371-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10576

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10576

UCSC genome browser

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UCSCi
uc010stl.2 human [P78371-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026293 mRNA Translation: AAC96012.1
AF026166 mRNA Translation: AAC98906.1
BT019966 mRNA Translation: AAV38769.1
AK290767 mRNA Translation: BAF83456.1
AK294307 mRNA Translation: BAH11729.1
AK302157 mRNA Translation: BAH13640.1
AK316397 mRNA Translation: BAH14768.1
AK316408 mRNA Translation: BAH14779.1
CR457071 mRNA Translation: CAG33352.1
AB451223 mRNA Translation: BAG70037.1
AB451346 mRNA Translation: BAG70160.1
AC018921 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97230.1
BC113514 mRNA Translation: AAI13515.1
BC113516 mRNA Translation: AAI13517.1
U91327 Genomic DNA Translation: AAB67249.1
CCDSiCCDS55843.1 [P78371-2]
CCDS8991.1 [P78371-1]
RefSeqiNP_001185771.1, NM_001198842.1 [P78371-2]
NP_006422.1, NM_006431.2 [P78371-1]
UniGeneiHs.189772

3D structure databases

ProteinModelPortaliP78371
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115827, 354 interactors
CORUMiP78371
DIPiDIP-38123N
IntActiP78371, 139 interactors
MINTiP78371
STRINGi9606.ENSP00000299300

PTM databases

iPTMnetiP78371
PhosphoSitePlusiP78371
SwissPalmiP78371

Polymorphism and mutation databases

BioMutaiCCT2
DMDMi6094436

2D gel databases

OGPiP78371
REPRODUCTION-2DPAGEiIPI00297779
SWISS-2DPAGEiP78371
UCD-2DPAGEiP78371

Proteomic databases

EPDiP78371
PaxDbiP78371
PeptideAtlasiP78371
PRIDEiP78371
ProteomicsDBi57599
57600 [P78371-2]
TopDownProteomicsiP78371-1 [P78371-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10576
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299300; ENSP00000299300; ENSG00000166226 [P78371-1]
ENST00000543146; ENSP00000445471; ENSG00000166226 [P78371-2]
GeneIDi10576
KEGGihsa:10576
UCSCiuc010stl.2 human [P78371-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10576
DisGeNETi10576
EuPathDBiHostDB:ENSG00000166226.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCT2
HGNCiHGNC:1615 CCT2
HPAiHPA003197
HPA003198
MIMi605139 gene
neXtProtiNX_P78371
OpenTargetsiENSG00000166226
PharmGKBiPA26179

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0363 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074930
HOGENOMiHOG000226736
HOVERGENiHBG001052
InParanoidiP78371
KOiK09494
OMAiPGVHQPQ
OrthoDBiEOG091G07BP
PhylomeDBiP78371
TreeFamiTF105645

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-6798695 Neutrophil degranulation
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SIGNORiP78371

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCT2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CCT2_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10576

Protein Ontology

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PROi
PR:P78371

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166226 Expressed in 232 organ(s), highest expression level in testis
CleanExiHS_CCT2
ExpressionAtlasiP78371 baseline and differential
GenevisibleiP78371 HS

Family and domain databases

CDDicd03336 TCP1_beta, 1 hit
Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012716 Chap_CCT_beta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF23 PTHR11353:SF23, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02341 chap_CCT_beta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCPB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78371
Secondary accession number(s): A8K402
, B5BTY7, B7Z243, B7Z7K4, B7ZAT2, Q14D36, Q6IAT3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 186 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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