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Protein

T-complex protein 1 subunit beta

Gene

CCT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).Curated2 Publications

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein binding involved in protein folding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-6798695 Neutrophil degranulation
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SIGNORiP78371

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit beta
Short name:
TCP-1-beta
Alternative name(s):
CCT-beta
Gene namesi
Name:CCT2
Synonyms:99D8.1, CCTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166226.12
HGNCiHGNC:1615 CCT2
MIMi605139 gene
neXtProtiNX_P78371

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10576
OpenTargetsiENSG00000166226
PharmGKBiPA26179

Polymorphism and mutation databases

BioMutaiCCT2
DMDMi6094436

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00001283162 – 535T-complex protein 1 subunit betaAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei3PhosphoserineCombined sources1
Modified residuei13N6-acetyllysineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei154N6-acetyllysineCombined sources1
Modified residuei181N6-acetyllysineCombined sources1
Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei260PhosphoserineCombined sources1
Modified residuei261PhosphothreonineCombined sources1
Isoform 2 (identifier: P78371-2)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP78371
PaxDbiP78371
PeptideAtlasiP78371
PRIDEiP78371
ProteomicsDBi57599
57600 [P78371-2]
TopDownProteomicsiP78371-1 [P78371-1]

2D gel databases

OGPiP78371
REPRODUCTION-2DPAGEiIPI00297779
SWISS-2DPAGEiP78371
UCD-2DPAGEiP78371

PTM databases

iPTMnetiP78371
PhosphoSitePlusiP78371
SwissPalmiP78371

Expressioni

Gene expression databases

BgeeiENSG00000166226 Expressed in 232 organ(s), highest expression level in testis
CleanExiHS_CCT2
ExpressionAtlasiP78371 baseline and differential
GenevisibleiP78371 HS

Organism-specific databases

HPAiHPA003197
HPA003198

Interactioni

Subunit structurei

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:20080638, PubMed:25467444). Interacts with PACRG (PubMed:14532270). Interacts with FLCN (PubMed:27353360).4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115827, 336 interactors
CORUMiP78371
DIPiDIP-38123N
IntActiP78371, 137 interactors
MINTiP78371
STRINGi9606.ENSP00000299300

Structurei

3D structure databases

ProteinModelPortaliP78371
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0363 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074930
HOGENOMiHOG000226736
HOVERGENiHBG001052
InParanoidiP78371
KOiK09494
OMAiPGVHQPQ
OrthoDBiEOG091G07BP
PhylomeDBiP78371
TreeFamiTF105645

Family and domain databases

CDDicd03336 TCP1_beta, 1 hit
Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012716 Chap_CCT_beta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF23 PTHR11353:SF23, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02341 chap_CCT_beta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P78371-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLSLAPVN IFKAGADEER AETARLTSFI GAIAIGDLVK STLGPKGMDK
60 70 80 90 100
ILLSSGRDAS LMVTNDGATI LKNIGVDNPA AKVLVDMSRV QDDEVGDGTT
110 120 130 140 150
SVTVLAAELL REAESLIAKK IHPQTIIAGW REATKAAREA LLSSAVDHGS
160 170 180 190 200
DEVKFRQDLM NIAGTTLSSK LLTHHKDHFT KLAVEAVLRL KGSGNLEAIH
210 220 230 240 250
IIKKLGGSLA DSYLDEGFLL DKKIGVNQPK RIENAKILIA NTGMDTDKIK
260 270 280 290 300
IFGSRVRVDS TAKVAEIEHA EKEKMKEKVE RILKHGINCF INRQLIYNYP
310 320 330 340 350
EQLFGAAGVM AIEHADFAGV ERLALVTGGE IASTFDHPEL VKLGSCKLIE
360 370 380 390 400
EVMIGEDKLI HFSGVALGEA CTIVLRGATQ QILDEAERSL HDALCVLAQT
410 420 430 440 450
VKDSRTVYGG GCSEMLMAHA VTQLANRTPG KEAVAMESYA KALRMLPTII
460 470 480 490 500
ADNAGYDSAD LVAQLRAAHS EGNTTAGLDM REGTIGDMAI LGITESFQVK
510 520 530
RQVLLSAAEA AEVILRVDNI IKAAPRKRVP DHHPC
Length:535
Mass (Da):57,488
Last modified:January 23, 2007 - v4
Checksum:i57F9E1720D84A31F
GO
Isoform 2 (identifier: P78371-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:488
Mass (Da):52,718
Checksum:i5947D87827A365E3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GWF6F5GWF6_HUMAN
T-complex protein 1 subunit beta
CCT2
530Annotation score:
F8VQ14F8VQ14_HUMAN
T-complex protein 1 subunit beta
CCT2
416Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51I → T in BAH11729 (PubMed:14702039).Curated1
Sequence conflicti126I → T in CAG33352 (Ref. 5) Curated1
Sequence conflicti354I → T in BAF83456 (PubMed:14702039).Curated1
Sequence conflicti438S → P in BAH13640 (PubMed:14702039).Curated1
Sequence conflicti444R → K in BAG70037 (PubMed:19054851).Curated1
Sequence conflicti444R → K in BAG70160 (PubMed:19054851).Curated1
Sequence conflicti504L → P in CAG33352 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0426481 – 47Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026293 mRNA Translation: AAC96012.1
AF026166 mRNA Translation: AAC98906.1
BT019966 mRNA Translation: AAV38769.1
AK290767 mRNA Translation: BAF83456.1
AK294307 mRNA Translation: BAH11729.1
AK302157 mRNA Translation: BAH13640.1
AK316397 mRNA Translation: BAH14768.1
AK316408 mRNA Translation: BAH14779.1
CR457071 mRNA Translation: CAG33352.1
AB451223 mRNA Translation: BAG70037.1
AB451346 mRNA Translation: BAG70160.1
AC018921 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97230.1
BC113514 mRNA Translation: AAI13515.1
BC113516 mRNA Translation: AAI13517.1
U91327 Genomic DNA Translation: AAB67249.1
CCDSiCCDS55843.1 [P78371-2]
CCDS8991.1 [P78371-1]
RefSeqiNP_001185771.1, NM_001198842.1 [P78371-2]
NP_006422.1, NM_006431.2 [P78371-1]
UniGeneiHs.189772

Genome annotation databases

EnsembliENST00000299300; ENSP00000299300; ENSG00000166226 [P78371-1]
ENST00000543146; ENSP00000445471; ENSG00000166226 [P78371-2]
GeneIDi10576
KEGGihsa:10576
UCSCiuc010stl.2 human [P78371-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026293 mRNA Translation: AAC96012.1
AF026166 mRNA Translation: AAC98906.1
BT019966 mRNA Translation: AAV38769.1
AK290767 mRNA Translation: BAF83456.1
AK294307 mRNA Translation: BAH11729.1
AK302157 mRNA Translation: BAH13640.1
AK316397 mRNA Translation: BAH14768.1
AK316408 mRNA Translation: BAH14779.1
CR457071 mRNA Translation: CAG33352.1
AB451223 mRNA Translation: BAG70037.1
AB451346 mRNA Translation: BAG70160.1
AC018921 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97230.1
BC113514 mRNA Translation: AAI13515.1
BC113516 mRNA Translation: AAI13517.1
U91327 Genomic DNA Translation: AAB67249.1
CCDSiCCDS55843.1 [P78371-2]
CCDS8991.1 [P78371-1]
RefSeqiNP_001185771.1, NM_001198842.1 [P78371-2]
NP_006422.1, NM_006431.2 [P78371-1]
UniGeneiHs.189772

3D structure databases

ProteinModelPortaliP78371
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115827, 336 interactors
CORUMiP78371
DIPiDIP-38123N
IntActiP78371, 137 interactors
MINTiP78371
STRINGi9606.ENSP00000299300

PTM databases

iPTMnetiP78371
PhosphoSitePlusiP78371
SwissPalmiP78371

Polymorphism and mutation databases

BioMutaiCCT2
DMDMi6094436

2D gel databases

OGPiP78371
REPRODUCTION-2DPAGEiIPI00297779
SWISS-2DPAGEiP78371
UCD-2DPAGEiP78371

Proteomic databases

EPDiP78371
PaxDbiP78371
PeptideAtlasiP78371
PRIDEiP78371
ProteomicsDBi57599
57600 [P78371-2]
TopDownProteomicsiP78371-1 [P78371-1]

Protocols and materials databases

DNASUi10576
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299300; ENSP00000299300; ENSG00000166226 [P78371-1]
ENST00000543146; ENSP00000445471; ENSG00000166226 [P78371-2]
GeneIDi10576
KEGGihsa:10576
UCSCiuc010stl.2 human [P78371-1]

Organism-specific databases

CTDi10576
DisGeNETi10576
EuPathDBiHostDB:ENSG00000166226.12
GeneCardsiCCT2
HGNCiHGNC:1615 CCT2
HPAiHPA003197
HPA003198
MIMi605139 gene
neXtProtiNX_P78371
OpenTargetsiENSG00000166226
PharmGKBiPA26179
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0363 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074930
HOGENOMiHOG000226736
HOVERGENiHBG001052
InParanoidiP78371
KOiK09494
OMAiPGVHQPQ
OrthoDBiEOG091G07BP
PhylomeDBiP78371
TreeFamiTF105645

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-6798695 Neutrophil degranulation
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SIGNORiP78371

Miscellaneous databases

ChiTaRSiCCT2 human
GeneWikiiCCT2_(gene)
GenomeRNAii10576
PROiPR:P78371
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166226 Expressed in 232 organ(s), highest expression level in testis
CleanExiHS_CCT2
ExpressionAtlasiP78371 baseline and differential
GenevisibleiP78371 HS

Family and domain databases

CDDicd03336 TCP1_beta, 1 hit
Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012716 Chap_CCT_beta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF23 PTHR11353:SF23, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02341 chap_CCT_beta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCPB_HUMAN
AccessioniPrimary (citable) accession number: P78371
Secondary accession number(s): A8K402
, B5BTY7, B7Z243, B7Z7K4, B7ZAT2, Q14D36, Q6IAT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 185 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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