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Protein

Claudin-10

Gene

CLDN10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28771254, PubMed:28686597).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  • cell adhesion Source: ProtInc
  • ion transport Source: UniProtKB-KW
  • regulation of ion transport Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-420029 Tight junction interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Claudin-10
Alternative name(s):
Oligodendrocyte-specific protein-like
Short name:
OSP-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLDN10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000134873.9

Human Gene Nomenclature Database

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HGNCi
HGNC:2033 CLDN10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617579 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P78369

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 80ExtracellularSequence analysisAdd BLAST59
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 115CytoplasmicSequence analysisAdd BLAST14
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 160ExtracellularSequence analysisAdd BLAST24
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 228CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

HELIX syndrome (HELIX)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by congenital heat intolerance, generalized anhidrosis, inability to produce tears, dry mouth, electrolyte imbalance, and ichthyosis.
See also OMIM:617671
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08005348N → K in HELIX; decreased function in regulation of paracellular ion transport as shown by reduced sodium permeability of cell layers expressing the mutant; affects self-interaction by inhibiting homodimerization in trans and promoting homodimerization in cis; no effect on localization to plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs759408749EnsemblClinVar.1
Natural variantiVAR_080054131S → L in HELIX; strongly reduced localization at the plasma membrane. 1 Publication1

Keywords - Diseasei

Disease mutation, Ichthyosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
9071

MalaCards human disease database

More...
MalaCardsi
CLDN10
MIMi617671 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000134873

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26558

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLDN10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6685311

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001447571 – 228Claudin-10Add BLAST228

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P78369

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P78369

PeptideAtlas

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PeptideAtlasi
P78369

PRoteomics IDEntifications database

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PRIDEi
P78369

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57597
57598 [P78369-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P78369

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P78369

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the kidney, eccrine sweat glands and in all layers of the epidermis. In the kidney, it is detected in the thick ascending limb of Henle's loop (TAL) (PubMed:28771254, PubMed:28686597). In the sweat glands, it is expressed in cells from secretory portions, corresponding to the clear cells (PubMed:28686597).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134873 Expressed in 165 organ(s), highest expression level in body of pancreas

CleanEx database of gene expression profiles

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CleanExi
HS_CLDN10

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P78369 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P78369 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB012969
HPA042348

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homodimers both in trans (interaction between CLDN10 molecules in opposing membranes) and in cis (interaction between CLDN10 molecules within one membrane).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114529, 5 interactors

Protein interaction database and analysis system

More...
IntActi
P78369, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299339

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P78369

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P78369

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The fourth transmembrane region (161-181) is necessary for integration into tight junctions.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ7E Eukaryota
ENOG410YF7U LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155232

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000220937

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000643

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P78369

KEGG Orthology (KO)

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KOi
K06087

Identification of Orthologs from Complete Genome Data

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OMAi
GYAYNGA

Database of Orthologous Groups

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OrthoDBi
EOG091G0MX2

Database for complete collections of gene phylogenies

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PhylomeDBi
P78369

TreeFam database of animal gene trees

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TreeFami
TF331936

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006187 Claudin
IPR003554 Claudin10
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin

The PANTHER Classification System

More...
PANTHERi
PTHR12002 PTHR12002, 1 hit
PTHR12002:SF13 PTHR12002:SF13, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00822 PMP22_Claudin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01383 CLAUDIN10

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01346 CLAUDIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P78369-1) [UniParc]FASTAAdd to basket
Also known as: Cldn10b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASTASEIIA FMVSISGWVL VSSTLPTDYW KVSTIDGTVI TTATYWANLW
60 70 80 90 100
KACVTDSTGV SNCKDFPSML ALDGYIQACR GLMIAAVSLG FFGSIFALFG
110 120 130 140 150
MKCTKVGGSD KAKAKIACLA GIVFILSGLC SMTGCSLYAN KITTEFFDPL
160 170 180 190 200
FVEQKYELGA ALFIGWAGAS LCIIGGVIFC FSISDNNKTP RYTYNGATSV
210 220
MSSRTKYHGG EDFKTTNPSK QFDKNAYV
Length:228
Mass (Da):24,488
Last modified:August 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11E66F9F10BCC87B
GO
Isoform 2 (identifier: P78369-2) [UniParc]FASTAAdd to basket
Also known as: Cldn10a

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTASEIIA...KDFPSMLALD → MSRAQIWALV...RPHFTIFKVA

Show »
Length:226
Mass (Da):24,251
Checksum:iC0AE190D115A1E01
GO
Isoform 3 (identifier: P78369-3) [UniParc]FASTAAdd to basket
Also known as: Cldn10a_i1

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTASEIIA...KDFPSMLALD → MSRAQIWALV...VYQGLWMNCA

Note: Produced by alternative splicing of isoform 2.
Show »
Length:207
Mass (Da):22,167
Checksum:i86D1BC78F6515B29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5W075Q5W075_HUMAN
Claudin-10
CLDN10
73Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08005348N → K in HELIX; decreased function in regulation of paracellular ion transport as shown by reduced sodium permeability of cell layers expressing the mutant; affects self-interaction by inhibiting homodimerization in trans and promoting homodimerization in cis; no effect on localization to plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs759408749EnsemblClinVar.1
Natural variantiVAR_080054131S → L in HELIX; strongly reduced localization at the plasma membrane. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0428981 – 73MASTA…MLALD → MSRAQIWALVSGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCAGNALGSFH CRPHFTIFKVA in isoform 2. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0535501 – 73MASTA…MLALD → MSRAQIWALVSGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCA in isoform 3. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U89916 mRNA Translation: AAC79506.1
AK055855 mRNA Translation: BAB71030.1
AK315737 mRNA Translation: BAG38092.1
CR456845 mRNA Translation: CAG33126.1
AL139376 Genomic DNA No translation available.
AL357061 Genomic DNA No translation available.
AL627382 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX08955.1
BC010920 mRNA Translation: AAH10920.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9475.1 [P78369-2]
CCDS9476.1 [P78369-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001153572.1, NM_001160100.1 [P78369-3]
NP_008915.1, NM_006984.4 [P78369-1]
NP_878268.1, NM_182848.3 [P78369-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.534377

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299339; ENSP00000299339; ENSG00000134873 [P78369-1]
ENST00000376873; ENSP00000366069; ENSG00000134873 [P78369-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9071

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9071

UCSC genome browser

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UCSCi
uc001vmg.3 human [P78369-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89916 mRNA Translation: AAC79506.1
AK055855 mRNA Translation: BAB71030.1
AK315737 mRNA Translation: BAG38092.1
CR456845 mRNA Translation: CAG33126.1
AL139376 Genomic DNA No translation available.
AL357061 Genomic DNA No translation available.
AL627382 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX08955.1
BC010920 mRNA Translation: AAH10920.1
CCDSiCCDS9475.1 [P78369-2]
CCDS9476.1 [P78369-1]
RefSeqiNP_001153572.1, NM_001160100.1 [P78369-3]
NP_008915.1, NM_006984.4 [P78369-1]
NP_878268.1, NM_182848.3 [P78369-2]
UniGeneiHs.534377

3D structure databases

ProteinModelPortaliP78369
SMRiP78369
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114529, 5 interactors
IntActiP78369, 7 interactors
STRINGi9606.ENSP00000299339

PTM databases

iPTMnetiP78369
PhosphoSitePlusiP78369

Polymorphism and mutation databases

BioMutaiCLDN10
DMDMi6685311

Proteomic databases

EPDiP78369
PaxDbiP78369
PeptideAtlasiP78369
PRIDEiP78369
ProteomicsDBi57597
57598 [P78369-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9071
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299339; ENSP00000299339; ENSG00000134873 [P78369-1]
ENST00000376873; ENSP00000366069; ENSG00000134873 [P78369-2]
GeneIDi9071
KEGGihsa:9071
UCSCiuc001vmg.3 human [P78369-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9071
DisGeNETi9071
EuPathDBiHostDB:ENSG00000134873.9

GeneCards: human genes, protein and diseases

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GeneCardsi
CLDN10
HGNCiHGNC:2033 CLDN10
HPAiCAB012969
HPA042348
MalaCardsiCLDN10
MIMi617579 gene
617671 phenotype
neXtProtiNX_P78369
OpenTargetsiENSG00000134873
PharmGKBiPA26558

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IQ7E Eukaryota
ENOG410YF7U LUCA
GeneTreeiENSGT00940000155232
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiP78369
KOiK06087
OMAiGYAYNGA
OrthoDBiEOG091G0MX2
PhylomeDBiP78369
TreeFamiTF331936

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CLDN10 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CLDN10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9071

Protein Ontology

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PROi
PR:P78369

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000134873 Expressed in 165 organ(s), highest expression level in body of pancreas
CleanExiHS_CLDN10
ExpressionAtlasiP78369 baseline and differential
GenevisibleiP78369 HS

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003554 Claudin10
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF13 PTHR12002:SF13, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01383 CLAUDIN10
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLD10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78369
Secondary accession number(s): Q6IBF9, Q96N78
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: December 5, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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