Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Claudin-10

Gene

CLDN10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28771254, PubMed:28686597).3 Publications

GO - Molecular functioni

GO - Biological processi

  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  • cell adhesion Source: ProtInc
  • ion transport Source: UniProtKB-KW
  • regulation of ion transport Source: UniProtKB

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-10
Alternative name(s):
Oligodendrocyte-specific protein-like
Short name:
OSP-like
Gene namesi
Name:CLDN10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000134873.9
HGNCiHGNC:2033 CLDN10
MIMi617579 gene
neXtProtiNX_P78369

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Topological domaini22 – 80ExtracellularSequence analysisAdd BLAST59
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 115CytoplasmicSequence analysisAdd BLAST14
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 160ExtracellularSequence analysisAdd BLAST24
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 228CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Involvement in diseasei

HELIX syndrome (HELIX)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by congenital heat intolerance, generalized anhidrosis, inability to produce tears, dry mouth, electrolyte imbalance, and ichthyosis.
See also OMIM:617671
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08005348N → K in HELIX; decreased function in regulation of paracellular ion transport as shown by reduced sodium permeability of cell layers expressing the mutant; affects self-interaction by inhibiting homodimerization in trans and promoting homodimerization in cis; no effect on localization to plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs759408749EnsemblClinVar.1
Natural variantiVAR_080054131S → L in HELIX; strongly reduced localization at the plasma membrane. 1 Publication1

Keywords - Diseasei

Disease mutation, Ichthyosis

Organism-specific databases

DisGeNETi9071
MalaCardsiCLDN10
MIMi617671 phenotype
OpenTargetsiENSG00000134873
PharmGKBiPA26558

Polymorphism and mutation databases

BioMutaiCLDN10
DMDMi6685311

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447571 – 228Claudin-10Add BLAST228

Proteomic databases

EPDiP78369
PaxDbiP78369
PeptideAtlasiP78369
PRIDEiP78369
ProteomicsDBi57597
57598 [P78369-2]

PTM databases

iPTMnetiP78369
PhosphoSitePlusiP78369

Expressioni

Tissue specificityi

Expressed in the kidney, eccrine sweat glands and in all layers of the epidermis. In the kidney, it is detected in the thick ascending limb of Henle's loop (TAL) (PubMed:28771254, PubMed:28686597). In the sweat glands, it is expressed in cells from secretory portions, corresponding to the clear cells (PubMed:28686597).2 Publications

Gene expression databases

BgeeiENSG00000134873
CleanExiHS_CLDN10
ExpressionAtlasiP78369 baseline and differential
GenevisibleiP78369 HS

Organism-specific databases

HPAiCAB012969
HPA042348

Interactioni

Subunit structurei

Can form homodimers both in trans (interaction between CLDN10 molecules in opposing membranes) and in cis (interaction between CLDN10 molecules within one membrane).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114529, 5 interactors
IntActiP78369, 7 interactors
STRINGi9606.ENSP00000299339

Structurei

3D structure databases

ProteinModelPortaliP78369
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The fourth transmembrane region (161-181) is necessary for integration into tight junctions.By similarity

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQ7E Eukaryota
ENOG410YF7U LUCA
GeneTreeiENSGT00760000119222
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiP78369
KOiK06087
OMAiGYAYNGA
OrthoDBiEOG091G0MX2
PhylomeDBiP78369
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003554 Claudin10
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF13 PTHR12002:SF13, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01383 CLAUDIN10
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P78369-1) [UniParc]FASTAAdd to basket
Also known as: Cldn10b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTASEIIA FMVSISGWVL VSSTLPTDYW KVSTIDGTVI TTATYWANLW
60 70 80 90 100
KACVTDSTGV SNCKDFPSML ALDGYIQACR GLMIAAVSLG FFGSIFALFG
110 120 130 140 150
MKCTKVGGSD KAKAKIACLA GIVFILSGLC SMTGCSLYAN KITTEFFDPL
160 170 180 190 200
FVEQKYELGA ALFIGWAGAS LCIIGGVIFC FSISDNNKTP RYTYNGATSV
210 220
MSSRTKYHGG EDFKTTNPSK QFDKNAYV
Length:228
Mass (Da):24,488
Last modified:August 1, 1998 - v2
Checksum:i11E66F9F10BCC87B
GO
Isoform 2 (identifier: P78369-2) [UniParc]FASTAAdd to basket
Also known as: Cldn10a

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTASEIIA...KDFPSMLALD → MSRAQIWALV...RPHFTIFKVA

Show »
Length:226
Mass (Da):24,251
Checksum:iC0AE190D115A1E01
GO
Isoform 3 (identifier: P78369-3) [UniParc]FASTAAdd to basket
Also known as: Cldn10a_i1

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTASEIIA...KDFPSMLALD → MSRAQIWALV...VYQGLWMNCA

Note: Produced by alternative splicing of isoform 2.
Show »
Length:207
Mass (Da):22,167
Checksum:i86D1BC78F6515B29
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08005348N → K in HELIX; decreased function in regulation of paracellular ion transport as shown by reduced sodium permeability of cell layers expressing the mutant; affects self-interaction by inhibiting homodimerization in trans and promoting homodimerization in cis; no effect on localization to plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs759408749EnsemblClinVar.1
Natural variantiVAR_080054131S → L in HELIX; strongly reduced localization at the plasma membrane. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0428981 – 73MASTA…MLALD → MSRAQIWALVSGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCAGNALGSFH CRPHFTIFKVA in isoform 2. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0535501 – 73MASTA…MLALD → MSRAQIWALVSGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCA in isoform 3. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89916 mRNA Translation: AAC79506.1
AK055855 mRNA Translation: BAB71030.1
AK315737 mRNA Translation: BAG38092.1
CR456845 mRNA Translation: CAG33126.1
AL139376 Genomic DNA No translation available.
AL357061 Genomic DNA No translation available.
AL627382 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX08955.1
BC010920 mRNA Translation: AAH10920.1
CCDSiCCDS9475.1 [P78369-2]
CCDS9476.1 [P78369-1]
RefSeqiNP_001153572.1, NM_001160100.1 [P78369-3]
NP_008915.1, NM_006984.4 [P78369-1]
NP_878268.1, NM_182848.3 [P78369-2]
UniGeneiHs.534377

Genome annotation databases

EnsembliENST00000299339; ENSP00000299339; ENSG00000134873 [P78369-1]
ENST00000376873; ENSP00000366069; ENSG00000134873 [P78369-2]
GeneIDi9071
KEGGihsa:9071
UCSCiuc001vmg.3 human [P78369-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCLD10_HUMAN
AccessioniPrimary (citable) accession number: P78369
Secondary accession number(s): Q6IBF9, Q96N78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: July 18, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health