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UniProtKB - P78358 (CTG1B_HUMAN)
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- tRNA threonylcarbamoyladenosine metabolic process Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | P78358 |
SignaLinki | P78358 |
Names & Taxonomyi
Protein namesi | Recommended name: Cancer/testis antigen 1Alternative name(s): Autoimmunogenic cancer/testis antigen NY-ESO-1 Cancer/testis antigen 6.1 Short name: CT6.1 L antigen family member 2 Short name: LAGE-2 |
Gene namesi | Name:CTAG1A Synonyms:CTAG, CTAG1, ESO1, LAGE2, LAGE2A AND Name:CTAG1B Synonyms:LAGE2B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24198, CTAG1A HGNC:2491, CTAG1B |
MIMi | 300156, gene 300657, gene |
neXtProti | NX_P78358 |
VEuPathDBi | HostDB:ENSG00000184033 HostDB:ENSG00000268651 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: LIFEdb
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 1485 246100 |
OpenTargetsi | ENSG00000184033 |
PharmGKBi | PA134979749 |
Miscellaneous databases
Pharosi | P78358, Tbio |
Genetic variation databases
BioMutai | CTAG1A |
DMDMi | 6014739 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218922 | 1 – 180 | Cancer/testis antigen 1Add BLAST | 180 |
Proteomic databases
MassIVEi | P78358 |
PaxDbi | P78358 |
PeptideAtlasi | P78358 |
PRIDEi | P78358 |
ProteomicsDBi | 57589 [P78358-1] 57590 [P78358-2] |
TopDownProteomicsi | P78358-1 [P78358-1] |
PTM databases
iPTMneti | P78358 |
PhosphoSitePlusi | P78358 |
Expressioni
Tissue specificityi
Expressed in testis and ovary and in a wide variety of cancers. Detected in uterine myometrium. Expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000184033, Expressed in right testis and 26 other tissues |
ExpressionAtlasi | P78358, baseline |
Genevisiblei | P78358, HS |
Organism-specific databases
HPAi | ENSG00000184033, Tissue enriched (testis) ENSG00000268651, Tissue enriched (testis) |
Interactioni
Binary interactionsi
P78358
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 107867, 110 interactors 128863, 79 interactors |
IntActi | P78358, 76 interactors |
STRINGi | 9606.ENSP00000332602 |
Miscellaneous databases
RNActi | P78358, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P78358 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P78358 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 66 | DisorderedSequence analysisAdd BLAST | 66 |
Sequence similaritiesi
Belongs to the CTAG/PCC1 family.Curated
Phylogenomic databases
eggNOGi | ENOG502TM3F, Eukaryota |
GeneTreei | ENSGT00410000025802 |
HOGENOMi | CLU_113770_0_0_1 |
InParanoidi | P78358 |
OMAi | FLFRISI |
OrthoDBi | 1584653at2759 |
PhylomeDBi | P78358 |
TreeFami | TF337064 |
Family and domain databases
InterProi | View protein in InterPro IPR015419, CTAG/Pcc1 |
PANTHERi | PTHR31283, PTHR31283, 1 hit |
Pfami | View protein in Pfam PF09341, Pcc1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P78358-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA
60 70 80 90 100
ARASGPGGGA PRGPHGGAAS GLNGCCRCGA RGPESRLLEF YLAMPFATPM
110 120 130 140 150
EAELARRSLA QDAPPLPVPG VLLKEFTVSG NILTIRLTAA DHRQLQLSIS
160 170 180
SCLQQLSLLM WITQCFLPVF LAQPPSGQRR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MTT5 | A0A0A0MTT5_HUMAN | Cancer/testis antigen 1 | CTAG1A | 210 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028548 | 135 – 180 | IRLTA…SGQRR → MSVQDQDRDGAWVGGGHSVA GWGLGSAYTPRSGC in isoform 2. 1 PublicationAdd BLAST | 46 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U87459 mRNA Translation: AAB49693.1 AJ003149 mRNA Translation: CAA05908.1 AF038567 mRNA Translation: AAD05202.1 AJ275977 Genomic DNA Translation: CAB76943.1 AF277315 Genomic DNA Translation: AAL27013.1 AF277315 Genomic DNA Translation: AAL27014.1 CH471172 Genomic DNA Translation: EAW72673.1 CH471172 Genomic DNA Translation: EAW72674.1 BC130362 mRNA Translation: AAI30363.1 BC130364 mRNA Translation: AAI30365.1 AJ275978 mRNA Translation: CAB76945.1 |
CCDSi | CCDS14758.1 [P78358-1] CCDS44025.1 [P78358-1] |
RefSeqi | NP_001318.1, NM_001327.2 [P78358-1] NP_640343.1, NM_139250.1 [P78358-1] |
Genome annotation databases
Ensembli | ENST00000328435; ENSP00000332602; ENSG00000184033 ENST00000359887; ENSP00000352953; ENSG00000184033 [P78358-2] ENST00000593606; ENSP00000472220; ENSG00000268651 [P78358-2] ENST00000599837; ENSP00000469441; ENSG00000268651 |
GeneIDi | 1485 246100 |
KEGGi | hsa:1485 hsa:246100 |
MANE-Selecti | ENST00000328435.3; ENSP00000332602.2; NM_001327.3; NP_001318.1 ENST00000599837.3; ENSP00000469441.1; NM_139250.2; NP_640343.1 |
UCSCi | uc004fme.3, human [P78358-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U87459 mRNA Translation: AAB49693.1 AJ003149 mRNA Translation: CAA05908.1 AF038567 mRNA Translation: AAD05202.1 AJ275977 Genomic DNA Translation: CAB76943.1 AF277315 Genomic DNA Translation: AAL27013.1 AF277315 Genomic DNA Translation: AAL27014.1 CH471172 Genomic DNA Translation: EAW72673.1 CH471172 Genomic DNA Translation: EAW72674.1 BC130362 mRNA Translation: AAI30363.1 BC130364 mRNA Translation: AAI30365.1 AJ275978 mRNA Translation: CAB76945.1 |
CCDSi | CCDS14758.1 [P78358-1] CCDS44025.1 [P78358-1] |
RefSeqi | NP_001318.1, NM_001327.2 [P78358-1] NP_640343.1, NM_139250.1 [P78358-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1S9W | X-ray | 2.20 | C | 157-165 | [»] | |
2BNQ | X-ray | 1.70 | C | 157-164 | [»] | |
2BNR | X-ray | 1.90 | C | 157-165 | [»] | |
2F53 | X-ray | 2.10 | C | 157-165 | [»] | |
2F54 | X-ray | 2.70 | C/H | 157-165 | [»] | |
2P5E | X-ray | 1.89 | C | 157-165 | [»] | |
2P5W | X-ray | 2.20 | C | 157-165 | [»] | |
2PYE | X-ray | 2.30 | C | 157-165 | [»] | |
3GJF | X-ray | 1.90 | C/F | 157-164 | [»] | |
3HAE | X-ray | 2.90 | C/F/M/R | 157-164 | [»] | |
3KLA | X-ray | 1.65 | C/F | 157-165 | [»] | |
6AT5 | X-ray | 1.50 | C | 60-72 | [»] | |
6AVF | X-ray | 2.03 | P | 60-72 | [»] | |
6AVG | X-ray | 2.60 | P/Q | 60-72 | [»] | |
6RP9 | X-ray | 3.12 | C/H | 157-165 | [»] | |
6RPA | X-ray | 2.56 | C | 157-164 | [»] | |
6RPB | X-ray | 2.50 | C/H/M/R | 157-164 | [»] | |
SMRi | P78358 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107867, 110 interactors 128863, 79 interactors |
IntActi | P78358, 76 interactors |
STRINGi | 9606.ENSP00000332602 |
PTM databases
iPTMneti | P78358 |
PhosphoSitePlusi | P78358 |
Genetic variation databases
BioMutai | CTAG1A |
DMDMi | 6014739 |
Proteomic databases
MassIVEi | P78358 |
PaxDbi | P78358 |
PeptideAtlasi | P78358 |
PRIDEi | P78358 |
ProteomicsDBi | 57589 [P78358-1] 57590 [P78358-2] |
TopDownProteomicsi | P78358-1 [P78358-1] |
Protocols and materials databases
ABCDi | P78358, 2 sequenced antibodies |
Antibodypediai | 4225, 807 antibodies from 28 providers 74750, 44 antibodies from 14 providers |
DNASUi | 246100 |
Genome annotation databases
Ensembli | ENST00000328435; ENSP00000332602; ENSG00000184033 ENST00000359887; ENSP00000352953; ENSG00000184033 [P78358-2] ENST00000593606; ENSP00000472220; ENSG00000268651 [P78358-2] ENST00000599837; ENSP00000469441; ENSG00000268651 |
GeneIDi | 1485 246100 |
KEGGi | hsa:1485 hsa:246100 |
MANE-Selecti | ENST00000328435.3; ENSP00000332602.2; NM_001327.3; NP_001318.1 ENST00000599837.3; ENSP00000469441.1; NM_139250.2; NP_640343.1 |
UCSCi | uc004fme.3, human [P78358-1] |
Organism-specific databases
CTDi | 1485 246100 |
DisGeNETi | 1485 246100 |
GeneCardsi | CTAG1A CTAG1B |
HGNCi | HGNC:24198, CTAG1A HGNC:2491, CTAG1B |
HPAi | ENSG00000184033, Tissue enriched (testis) ENSG00000268651, Tissue enriched (testis) |
MIMi | 300156, gene 300657, gene |
neXtProti | NX_P78358 |
OpenTargetsi | ENSG00000184033 |
PharmGKBi | PA134979749 |
VEuPathDBi | HostDB:ENSG00000184033 HostDB:ENSG00000268651 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TM3F, Eukaryota |
GeneTreei | ENSGT00410000025802 |
HOGENOMi | CLU_113770_0_0_1 |
InParanoidi | P78358 |
OMAi | FLFRISI |
OrthoDBi | 1584653at2759 |
PhylomeDBi | P78358 |
TreeFami | TF337064 |
Enzyme and pathway databases
PathwayCommonsi | P78358 |
SignaLinki | P78358 |
Miscellaneous databases
BioGRID-ORCSi | 1485, 107 hits in 572 CRISPR screens 246100, 10 hits in 551 CRISPR screens |
EvolutionaryTracei | P78358 |
GeneWikii | CTAG1B |
Pharosi | P78358, Tbio |
PROi | PR:P78358 |
RNActi | P78358, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184033, Expressed in right testis and 26 other tissues |
ExpressionAtlasi | P78358, baseline |
Genevisiblei | P78358, HS |
Family and domain databases
InterProi | View protein in InterPro IPR015419, CTAG/Pcc1 |
PANTHERi | PTHR31283, PTHR31283, 1 hit |
Pfami | View protein in Pfam PF09341, Pcc1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CTG1B_HUMAN | |
Accessioni | P78358Primary (citable) accession number: P78358 Secondary accession number(s): A1L417 Q9NY13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | May 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families