UniProtKB - P78345 (RPP38_HUMAN)
Ribonuclease P protein subunit p38
RPP38
Functioni
Miscellaneous
Catalytic activityi
- Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.4 Publications EC:3.1.26.5
GO - Molecular functioni
- ribonuclease P activity Source: UniProtKB-EC
- ribonuclease P RNA binding Source: UniProtKB
GO - Biological processi
- rRNA processing Source: UniProtKB-KW
- tRNA 5'-leader removal Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, RNA-binding |
Biological process | rRNA processing, tRNA processing |
Enzyme and pathway databases
Reactomei | R-HSA-6784531 tRNA processing in the nucleus R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: Ribonuclease P protein subunit p38 (EC:3.1.26.54 Publications)Short name: RNaseP protein p38 |
Gene namesi | Name:RPP38 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30329 RPP38 |
MIMi | 606116 gene |
neXtProti | NX_P78345 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- fibrillar center Source: HPA
- nucleolus Source: UniProtKB
- nucleoplasm Source: Reactome
Other locations
- multimeric ribonuclease P complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10557 |
OpenTargetsi | ENSG00000152464 |
PharmGKBi | PA134957031 |
Miscellaneous databases
Pharosi | P78345 |
Polymorphism and mutation databases
BioMutai | RPP38 |
DMDMi | 83305638 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000136783 | 2 – 283 | Ribonuclease P protein subunit p38Add BLAST | 282 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 12 | PhosphoserineCombined sources | 1 | |
Modified residuei | 226 | PhosphoserineCombined sources | 1 | |
Modified residuei | 235 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P78345 |
jPOSTi | P78345 |
MassIVEi | P78345 |
MaxQBi | P78345 |
PaxDbi | P78345 |
PeptideAtlasi | P78345 |
PRIDEi | P78345 |
ProteomicsDBi | 57576 |
PTM databases
iPTMneti | P78345 |
PhosphoSitePlusi | P78345 |
Expressioni
Gene expression databases
Bgeei | ENSG00000152464 Expressed in 219 organ(s), highest expression level in testis |
ExpressionAtlasi | P78345 baseline and differential |
Genevisiblei | P78345 HS |
Organism-specific databases
HPAi | HPA045128 HPA050398 |
Interactioni
Subunit structurei
Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:9037013, PubMed:10444065, PubMed:9630247, PubMed:16723659, PubMed:30454648). RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:9037013, PubMed:9630247, PubMed:10444065, PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:16723659, PubMed:28115465).
6 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGridi | 115808, 61 interactors |
CORUMi | P78345 |
IntActi | P78345, 36 interactors |
STRINGi | 9606.ENSP00000478982 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 63 – 68 | Poly-Lys | 6 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3387 Eukaryota COG1358 LUCA |
GeneTreei | ENSGT00390000007526 |
HOGENOMi | HOG000231566 |
InParanoidi | P78345 |
KOi | K14523 |
OMAi | WLQDRTE |
OrthoDBi | 1485783at2759 |
PhylomeDBi | P78345 |
TreeFami | TF332558 |
Family and domain databases
Gene3Di | 3.30.1330.30, 1 hit |
InterProi | View protein in InterPro IPR029064 L30e-like IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45 IPR042848 Rpp38 |
PANTHERi | PTHR46948 PTHR46948, 1 hit |
Pfami | View protein in Pfam PF01248 Ribosomal_L7Ae, 1 hit |
SUPFAMi | SSF55315 SSF55315, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAAAPQAPGR GSLRKTRPLV VKTSLNNPYI IRWSALESED MHFILQTLED
60 70 80 90 100
RLKAIGLQKI EDKKKKNKTP FLKKESREKC SIAVDISENL KEKKTDAKQQ
110 120 130 140 150
VSGWTPAHVR KQLAIGVNEV TRALERRELL LVLVCKSVKP AMITSHLIQL
160 170 180 190 200
SLSRSVPACQ VPRLSERIAP VIGLKCVLAL AFKKNTTDFV DEVRAIIPRV
210 220 230 240 250
PSLSVPWLQD RIEDSGENLE TEPLESQDRE LLDTSFEDLS KPKRKLADGR
260 270 280
QASVTLQPLK IKKLIPNPNK IRKPPKSKKA TPK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5VUC3 | Q5VUC3_HUMAN | Ribonuclease P protein subunit p38 | RPP38 | 168 | Annotation score: | ||
Q5VUC9 | Q5VUC9_HUMAN | Ribonuclease P protein subunit p38 | RPP38 | 145 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 | S → A AA sequence (PubMed:9037013).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051811 | 86 | I → V. Corresponds to variant dbSNP:rs3814171Ensembl. | 1 | |
Natural variantiVAR_023960 | 88 | E → D. Corresponds to variant dbSNP:rs1052157Ensembl. | 1 | |
Natural variantiVAR_023961 | 114 | A → V1 PublicationCorresponds to variant dbSNP:rs1132078Ensembl. | 1 | |
Natural variantiVAR_023962 | 181 | A → G2 PublicationsCorresponds to variant dbSNP:rs15772Ensembl. | 1 | |
Natural variantiVAR_051812 | 202 | S → R. Corresponds to variant dbSNP:rs12249258Ensembl. | 1 | |
Natural variantiVAR_029298 | 212 | I → T. Corresponds to variant dbSNP:rs10242Ensembl. | 1 | |
Natural variantiVAR_051813 | 250 | R → G. Corresponds to variant dbSNP:rs34040166Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77664 mRNA Translation: AAC51142.1 AK057006 mRNA Translation: BAG51842.1 CR541816 mRNA Translation: CAG46615.1 AK223418 mRNA Translation: BAD97138.1 AL590365 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86240.1 CH471072 Genomic DNA Translation: EAW86241.1 BC029494 mRNA Translation: AAH29494.1 |
CCDSi | CCDS7108.1 |
RefSeqi | NP_001091059.1, NM_001097590.2 NP_001252530.1, NM_001265601.1 NP_006405.2, NM_006414.4 NP_892117.1, NM_183005.4 XP_006717426.1, XM_006717363.1 XP_006717427.1, XM_006717364.3 XP_011517595.1, XM_011519293.1 XP_016870968.1, XM_017015479.1 XP_016870969.1, XM_017015480.1 XP_016870970.1, XM_017015481.1 |
Genome annotation databases
Ensembli | ENST00000378197; ENSP00000367439; ENSG00000152464 ENST00000378202; ENSP00000367444; ENSG00000152464 ENST00000378203; ENSP00000367445; ENSG00000152464 ENST00000616640; ENSP00000478982; ENSG00000152464 |
GeneIDi | 10557 |
KEGGi | hsa:10557 |
UCSCi | uc001inx.6 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77664 mRNA Translation: AAC51142.1 AK057006 mRNA Translation: BAG51842.1 CR541816 mRNA Translation: CAG46615.1 AK223418 mRNA Translation: BAD97138.1 AL590365 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86240.1 CH471072 Genomic DNA Translation: EAW86241.1 BC029494 mRNA Translation: AAH29494.1 |
CCDSi | CCDS7108.1 |
RefSeqi | NP_001091059.1, NM_001097590.2 NP_001252530.1, NM_001265601.1 NP_006405.2, NM_006414.4 NP_892117.1, NM_183005.4 XP_006717426.1, XM_006717363.1 XP_006717427.1, XM_006717364.3 XP_011517595.1, XM_011519293.1 XP_016870968.1, XM_017015479.1 XP_016870969.1, XM_017015480.1 XP_016870970.1, XM_017015481.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6AHR | electron microscopy | 3.92 | C | 1-283 | [»] | |
6AHU | electron microscopy | 3.66 | C | 1-283 | [»] | |
SMRi | P78345 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 115808, 61 interactors |
CORUMi | P78345 |
IntActi | P78345, 36 interactors |
STRINGi | 9606.ENSP00000478982 |
PTM databases
iPTMneti | P78345 |
PhosphoSitePlusi | P78345 |
Polymorphism and mutation databases
BioMutai | RPP38 |
DMDMi | 83305638 |
Proteomic databases
EPDi | P78345 |
jPOSTi | P78345 |
MassIVEi | P78345 |
MaxQBi | P78345 |
PaxDbi | P78345 |
PeptideAtlasi | P78345 |
PRIDEi | P78345 |
ProteomicsDBi | 57576 |
Protocols and materials databases
DNASUi | 10557 |
Genome annotation databases
Ensembli | ENST00000378197; ENSP00000367439; ENSG00000152464 ENST00000378202; ENSP00000367444; ENSG00000152464 ENST00000378203; ENSP00000367445; ENSG00000152464 ENST00000616640; ENSP00000478982; ENSG00000152464 |
GeneIDi | 10557 |
KEGGi | hsa:10557 |
UCSCi | uc001inx.6 human |
Organism-specific databases
CTDi | 10557 |
DisGeNETi | 10557 |
GeneCardsi | RPP38 |
HGNCi | HGNC:30329 RPP38 |
HPAi | HPA045128 HPA050398 |
MIMi | 606116 gene |
neXtProti | NX_P78345 |
OpenTargetsi | ENSG00000152464 |
PharmGKBi | PA134957031 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3387 Eukaryota COG1358 LUCA |
GeneTreei | ENSGT00390000007526 |
HOGENOMi | HOG000231566 |
InParanoidi | P78345 |
KOi | K14523 |
OMAi | WLQDRTE |
OrthoDBi | 1485783at2759 |
PhylomeDBi | P78345 |
TreeFami | TF332558 |
Enzyme and pathway databases
Reactomei | R-HSA-6784531 tRNA processing in the nucleus R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
ChiTaRSi | RPP38 human |
GeneWikii | RPP38 |
GenomeRNAii | 10557 |
Pharosi | P78345 |
PROi | PR:P78345 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152464 Expressed in 219 organ(s), highest expression level in testis |
ExpressionAtlasi | P78345 baseline and differential |
Genevisiblei | P78345 HS |
Family and domain databases
Gene3Di | 3.30.1330.30, 1 hit |
InterProi | View protein in InterPro IPR029064 L30e-like IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45 IPR042848 Rpp38 |
PANTHERi | PTHR46948 PTHR46948, 1 hit |
Pfami | View protein in Pfam PF01248 Ribosomal_L7Ae, 1 hit |
SUPFAMi | SSF55315 SSF55315, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPP38_HUMAN | |
Accessioni | P78345Primary (citable) accession number: P78345 Secondary accession number(s): B3KPY0 Q8NHS8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | December 6, 2005 | |
Last modified: | November 13, 2019 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Ribosomal proteins
Ribosomal proteins families and list of entries - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references