Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonuclease P protein subunit p38

Gene

RPP38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus.

Miscellaneous

Autoantibodies against RPP38 are found in sera from scleroderma patients.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • ribonuclease P activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6784531 tRNA processing in the nucleus
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p38 (EC:3.1.26.5)
Short name:
RNaseP protein p38
Gene namesi
Name:RPP38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000152464.14
HGNCiHGNC:30329 RPP38
MIMi606116 gene
neXtProtiNX_P78345

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10557
OpenTargetsiENSG00000152464
PharmGKBiPA134957031

Polymorphism and mutation databases

BioMutaiRPP38
DMDMi83305638

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001367832 – 283Ribonuclease P protein subunit p38Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei235PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP78345
MaxQBiP78345
PaxDbiP78345
PeptideAtlasiP78345
PRIDEiP78345
ProteomicsDBi57576

PTM databases

iPTMnetiP78345
PhosphoSitePlusiP78345

Expressioni

Gene expression databases

BgeeiENSG00000152464
CleanExiHS_RPP38
ExpressionAtlasiP78345 baseline and differential
GenevisibleiP78345 HS

Organism-specific databases

HPAiHPA045128
HPA050398

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RPP38 is probably a dimer.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115808, 50 interactors
CORUMiP78345
IntActiP78345, 23 interactors
STRINGi9606.ENSP00000367439

Structurei

3D structure databases

ProteinModelPortaliP78345
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 68Poly-Lys6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3387 Eukaryota
COG1358 LUCA
GeneTreeiENSGT00390000007526
HOGENOMiHOG000231566
HOVERGENiHBG060241
InParanoidiP78345
KOiK14523
OMAiTEPLESQ
OrthoDBiEOG091G0INQ
PhylomeDBiP78345
TreeFamiTF332558

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P78345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPQAPGR GSLRKTRPLV VKTSLNNPYI IRWSALESED MHFILQTLED
60 70 80 90 100
RLKAIGLQKI EDKKKKNKTP FLKKESREKC SIAVDISENL KEKKTDAKQQ
110 120 130 140 150
VSGWTPAHVR KQLAIGVNEV TRALERRELL LVLVCKSVKP AMITSHLIQL
160 170 180 190 200
SLSRSVPACQ VPRLSERIAP VIGLKCVLAL AFKKNTTDFV DEVRAIIPRV
210 220 230 240 250
PSLSVPWLQD RIEDSGENLE TEPLESQDRE LLDTSFEDLS KPKRKLADGR
260 270 280
QASVTLQPLK IKKLIPNPNK IRKPPKSKKA TPK
Length:283
Mass (Da):31,834
Last modified:December 6, 2005 - v2
Checksum:i233F3397DBDE4F18
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24S → A AA sequence (PubMed:9037013).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05181186I → V. Corresponds to variant dbSNP:rs3814171Ensembl.1
Natural variantiVAR_02396088E → D. Corresponds to variant dbSNP:rs1052157Ensembl.1
Natural variantiVAR_023961114A → V1 PublicationCorresponds to variant dbSNP:rs1132078Ensembl.1
Natural variantiVAR_023962181A → G2 PublicationsCorresponds to variant dbSNP:rs15772Ensembl.1
Natural variantiVAR_051812202S → R. Corresponds to variant dbSNP:rs12249258Ensembl.1
Natural variantiVAR_029298212I → T. Corresponds to variant dbSNP:rs10242Ensembl.1
Natural variantiVAR_051813250R → G. Corresponds to variant dbSNP:rs34040166Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77664 mRNA Translation: AAC51142.1
AK057006 mRNA Translation: BAG51842.1
CR541816 mRNA Translation: CAG46615.1
AK223418 mRNA Translation: BAD97138.1
AL590365 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86240.1
CH471072 Genomic DNA Translation: EAW86241.1
BC029494 mRNA Translation: AAH29494.1
CCDSiCCDS7108.1
RefSeqiNP_001091059.1, NM_001097590.2
NP_001252530.1, NM_001265601.1
NP_006405.2, NM_006414.4
NP_892117.1, NM_183005.4
XP_006717426.1, XM_006717363.1
XP_006717427.1, XM_006717364.3
XP_011517595.1, XM_011519293.1
XP_016870968.1, XM_017015479.1
XP_016870969.1, XM_017015480.1
XP_016870970.1, XM_017015481.1
UniGeneiHs.94986

Genome annotation databases

EnsembliENST00000378197; ENSP00000367439; ENSG00000152464
ENST00000378202; ENSP00000367444; ENSG00000152464
ENST00000378203; ENSP00000367445; ENSG00000152464
ENST00000616640; ENSP00000478982; ENSG00000152464
GeneIDi10557
KEGGihsa:10557
UCSCiuc001inx.6 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRPP38_HUMAN
AccessioniPrimary (citable) accession number: P78345
Secondary accession number(s): B3KPY0
, D3DRT8, Q53F71, Q8NHS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 6, 2005
Last modified: June 20, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health