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Protein

Glypican-5

Gene

GPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928 HS-GAG biosynthesis
R-HSA-2024096 HS-GAG degradation
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3656237 Defective EXT2 causes exostoses 2
R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-5362798 Release of Hh-Np from the secreting cell
R-HSA-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-5
Cleaved into the following chain:
Gene namesi
Name:GPC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000179399.14
HGNCiHGNC:4453 GPC5
MIMi602446 gene
neXtProtiNX_P78333

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2262
OpenTargetsiENSG00000179399
PharmGKBiPA28834

Polymorphism and mutation databases

BioMutaiGPC5
DMDMi2829667

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000012320? – 572Removed in mature formSequence analysis
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001231925 – ?Glypican-5
ChainiPRO_000033384925 – ?Secreted glypican-5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi486O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi495O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi507O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi509O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi527N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

Proteomic databases

MaxQBiP78333
PaxDbiP78333
PeptideAtlasiP78333
PRIDEiP78333
ProteomicsDBi57571

PTM databases

iPTMnetiP78333
PhosphoSitePlusiP78333

Expressioni

Tissue specificityi

In adult, primarily expressed in the brain. Also detected in fetal brain, lung and liver.2 Publications

Gene expression databases

BgeeiENSG00000179399
CleanExiHS_GPC5
ExpressionAtlasiP78333 baseline and differential
GenevisibleiP78333 HS

Organism-specific databases

HPAiHPA040152
HPA044081

Interactioni

Protein-protein interaction databases

BioGridi108553, 6 interactors
IntActiP78333, 3 interactors
STRINGi9606.ENSP00000366267

Structurei

3D structure databases

ProteinModelPortaliP78333
SMRiP78333
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821 Eukaryota
ENOG410XST2 LUCA
GeneTreeiENSGT00550000074430
HOGENOMiHOG000049177
HOVERGENiHBG005896
InParanoidiP78333
KOiK08111
OMAiFPVAYHQ
OrthoDBiEOG091G06T6
PhylomeDBiP78333
TreeFamiTF105317

Family and domain databases

InterProiView protein in InterPro
IPR001863 Glypican
IPR031188 Glypican-5
IPR019803 Glypican_CS
PANTHERiPTHR10822 PTHR10822, 1 hit
PTHR10822:SF12 PTHR10822:SF12, 1 hit
PfamiView protein in Pfam
PF01153 Glypican, 1 hit
PROSITEiView protein in PROSITE
PS01207 GLYPICAN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P78333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAQTWPVGF RCLLLLALVG SARSEGVQTC EEVRKLFQWR LLGAVRGLPD
60 70 80 90 100
SPRAGPDLQV CISKKPTCCT RKMEERYQIA ARQDMQQFLQ TSSSTLKFLI
110 120 130 140 150
SRNAAAFQET LETLIKQAEN YTSILFCSTY RNMALEAAAS VQEFFTDVGL
160 170 180 190 200
YLFGADVNPE EFVNRFFDSL FPLVYNHLIN PGVTDSSLEY SECIRMARRD
210 220 230 240 250
VSPFGNIPQR VMGQMGRSLL PSRTFLQALN LGIEVINTTD YLHFSKECSR
260 270 280 290 300
ALLKMQYCPH CQGLALTKPC MGYCLNVMRG CLAHMAELNP HWHAYIRSLE
310 320 330 340 350
ELSDAMHGTY DIGHVLLNFH LLVNDAVLQA HLNGQKLLEQ VNRICGRPVR
360 370 380 390 400
TPTQSPRCSF DQSKEKHGMK TTTRNSEETL ANRRKEFINS LRLYRSFYGG
410 420 430 440 450
LADQLCANEL AAADGLPCWN GEDIVKSYTQ RVVGNGIKAQ SGNPEVKVKG
460 470 480 490 500
IDPVINQIID KLKHVVQLLQ GRSPKPDKWE LLQLGSGGGM VEQVSGDCDD
510 520 530 540 550
EDGCGGSGSG EVKRTLKITD WMPDDMNFSD VKQIHQTDTG STLDTTGAGC
560 570
AVATESMTFT LISVVMLLPG IW
Length:572
Mass (Da):63,707
Last modified:May 1, 1997 - v1
Checksum:iA17969FE0DD0D308
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205G → C in AAC12261 (PubMed:9331333).Curated1
Sequence conflicti245S → F in AAC12261 (PubMed:9331333).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024228155A → V. Corresponds to variant dbSNP:rs553717Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66033 mRNA Translation: AAC51118.1
AF001462 mRNA Translation: AAC12261.1
AK312815 mRNA Translation: BAG35673.1
AL157363 Genomic DNA No translation available.
AL138714 Genomic DNA No translation available.
AL157821 Genomic DNA No translation available.
AL163537 Genomic DNA No translation available.
AL162456 Genomic DNA No translation available.
BC039730 mRNA Translation: AAH39730.1
CCDSiCCDS9468.1
RefSeqiNP_004457.1, NM_004466.5
UniGeneiHs.655675

Genome annotation databases

EnsembliENST00000377067; ENSP00000366267; ENSG00000179399
GeneIDi2262
KEGGihsa:2262
UCSCiuc010tif.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGPC5_HUMAN
AccessioniPrimary (citable) accession number: P78333
Secondary accession number(s): B2R726, O60436, Q9BX27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: July 18, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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