UniProtKB - P78332 (RBM6_HUMAN)
Protein
RNA-binding protein 6
Gene
RBM6
Organism
Homo sapiens (Human)
Status
Functioni
Specifically binds poly(G) RNA homopolymers in vitro.
GO - Molecular functioni
- DNA binding Source: ProtInc
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA splicing, via spliceosome Source: GO_Central
- RNA processing Source: ProtInc
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | P78332 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein 6Alternative name(s): Lung cancer antigen NY-LU-12 Protein G16 RNA-binding motif protein 6 RNA-binding protein DEF-3 |
Gene namesi | Name:RBM6 Synonyms:DEF3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9903, RBM6 |
MIMi | 606886, gene |
neXtProti | NX_P78332 |
VEuPathDBi | HostDB:ENSG00000004534.14 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10180 |
OpenTargetsi | ENSG00000004534 |
PharmGKBi | PA34268 |
Miscellaneous databases
Pharosi | P78332, Tbio |
Genetic variation databases
BioMutai | RBM6 |
DMDMi | 116242749 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081760 | 1 – 1123 | RNA-binding protein 6Add BLAST | 1123 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | PhosphoserineCombined sources | 1 | |
Cross-linki | 36 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 240 | PhosphoserineCombined sources | 1 | |
Cross-linki | 331 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 344 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 360 | PhosphoserineCombined sources | 1 | |
Modified residuei | 362 | PhosphoserineCombined sources | 1 | |
Cross-linki | 386 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 453 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 469 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 569 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 871 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 879 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 887 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 891 | PhosphoserineCombined sources | 1 | |
Cross-linki | 935 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 948 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 991 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1019 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1022 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1025 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1042 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1046 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1066 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P78332 |
jPOSTi | P78332 |
MassIVEi | P78332 |
MaxQBi | P78332 |
PaxDbi | P78332 |
PeptideAtlasi | P78332 |
PRIDEi | P78332 |
ProteomicsDBi | 5671 57570 [P78332-1] 69630 |
PTM databases
iPTMneti | P78332 |
PhosphoSitePlusi | P78332 |
Expressioni
Tissue specificityi
Ubiquitous in adults.
Gene expression databases
Bgeei | ENSG00000004534, Expressed in endocervix and 240 other tissues |
ExpressionAtlasi | P78332, baseline and differential |
Genevisiblei | P78332, HS |
Organism-specific databases
HPAi | ENSG00000004534, Low tissue specificity |
Interactioni
Subunit structurei
May interact with FAM168B.
Binary interactionsi
Hide detailsP78332
With | #Exp. | IntAct |
---|---|---|
EEF1G - isoform 2 [P26641-2] | 3 | EBI-2692323,EBI-10177695 |
Isoform 2 [P78332-2]
With | #Exp. | IntAct |
---|---|---|
MAPRE2 [Q15555] | 3 | EBI-14150298,EBI-739717 |
Protein-protein interaction databases
BioGRIDi | 115479, 43 interactors |
IntActi | P78332, 32 interactors |
STRINGi | 9606.ENSP00000266022 |
Miscellaneous databases
RNActi | P78332, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 456 – 536 | RRMPROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 1051 – 1097 | G-patchPROSITE-ProRule annotationAdd BLAST | 47 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 826 – 829 | Poly-Glu | 4 | |
Compositional biasi | 892 – 895 | Poly-Pro | 4 | |
Compositional biasi | 915 – 921 | Poly-Glu | 7 |
Phylogenomic databases
eggNOGi | KOG0154, Eukaryota |
GeneTreei | ENSGT00940000157976 |
HOGENOMi | CLU_010527_0_0_1 |
InParanoidi | P78332 |
OMAi | SQMDFRG |
PhylomeDBi | P78332 |
TreeFami | TF315789 |
Family and domain databases
CDDi | cd16163, OCRE_RBM6, 1 hit cd12314, RRM1_RBM6, 1 hit cd12563, RRM2_RBM6, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR000467, G_patch_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR041591, OCRE IPR035979, RBD_domain_sf IPR028806, RBM6 IPR035617, RBM6_OCRE IPR034123, RBM6_RRM1 IPR034125, RBM6_RRM2 IPR000504, RRM_dom |
PANTHERi | PTHR13948:SF22, PTHR13948:SF22, 3 hits |
Pfami | View protein in Pfam PF01585, G-patch, 1 hit PF17780, OCRE, 1 hit |
SMARTi | View protein in SMART SM00443, G_patch, 1 hit SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50174, G_PATCH, 1 hit PS50102, RRM, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P78332-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWGDSRPANR TGPFRGSQEE RFAPGWNRDY PPPPLKSHAQ ERHSGNFPGR
60 70 80 90 100
DSLPFDFQGH SGPPFANVEE HSFSYGARDG PHGDYRGGEG PGHDFRGGDF
110 120 130 140 150
SSSDFQSRDS SQLDFRGRDI HSGDFRDREG PPMDYRGGDG TSMDYRGREA
160 170 180 190 200
PHMNYRDRDA HAVDFRGRDA PPSDFRGRGT YDLDFRGRDG SHADFRGRDL
210 220 230 240 250
SDLDFRAREQ SRSDFRNRDV SDLDFRDKDG TQVDFRGRGS GTTDLDFRDR
260 270 280 290 300
DTPHSDFRGR HRSRTDQDFR GREMGSCMEF KDREMPPVDP NILDYIQPST
310 320 330 340 350
QDREHSGMNV NRREESTHDH TIERPAFGIQ KGEFEHSETR EGETQGVAFE
360 370 380 390 400
HESPADFQNS QSPVQDQDKS QLSGREEQSS DAGLFKEEGG LDFLGRQDTD
410 420 430 440 450
YRSMEYRDVD HRLPGSQMFG YGQSKSFPEG KTARDAQRDL QDQDYRTGPS
460 470 480 490 500
EEKPSRLIRL SGVPEDATKE EILNAFRTPD GMPVKNLQLK EYNTGYDYGY
510 520 530 540 550
VCVEFSLLED AIGCMEANQG TLMIQDKEVT LEYVSSLDFW YCKRCKANIG
560 570 580 590 600
GHRSSCSFCK NPREVTEAKQ ELITYPQPQK TSIPAPLEKQ PNQPLRPADK
610 620 630 640 650
EPEPRKREEG QESRLGHQKR EAERYLPPSR REGPTFRRDR ERESWSGETR
660 670 680 690 700
QDGESKTIML KRIYRSTPPE VIVEVLEPYV RLTTANVRII KNRTGPMGHT
710 720 730 740 750
YGFIDLDSHA EALRVVKILQ NLDPPFSIDG KMVAVNLATG KRRNDSGDHS
760 770 780 790 800
DHMHYYQGKK YFRDRRGGGR NSDWSSDTNR QGQQSSSDCY IYDSATGYYY
810 820 830 840 850
DPLAGTYYDP NTQQEVYVPQ DPGLPEEEEI KEKKPTSQGK SSSKKEMSKR
860 870 880 890 900
DGKEKKDRGV TRFQENASEG KAPAEDVFKK PLPPTVKKEE SPPPPKVVNP
910 920 930 940 950
LIGLLGEYGG DSDYEEEEEE EQTPPPQPRT AQPQKREEQT KKENEEDKLT
960 970 980 990 1000
DWNKLACLLC RRQFPNKEVL IKHQQLSDLH KQNLEIHRKI KQSEQELAYL
1010 1020 1030 1040 1050
ERREREGKFK GRGNDRREKL QSFDSPERKR IKYSRETDSD RKLVDKEDID
1060 1070 1080 1090 1100
TSSKGGCVQQ ATGWRKGTGL GYGHPGLASS EEAEGRMRGP SVGASGRTSK
1110 1120
RQSNETYRDA VRRVMFARYK ELD
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PGM9 | E9PGM9_HUMAN | RNA-binding protein 6 | RBM6 | 991 | Annotation score: | ||
F8WCA5 | F8WCA5_HUMAN | RNA-binding protein 6 | RBM6 | 697 | Annotation score: | ||
C9J250 | C9J250_HUMAN | RNA-binding protein 6 | RBM6 | 119 | Annotation score: | ||
C9JII0 | C9JII0_HUMAN | RNA-binding protein 6 | RBM6 | 120 | Annotation score: | ||
F8WF63 | F8WF63_HUMAN | RNA-binding protein 6 | RBM6 | 199 | Annotation score: | ||
C9JSL1 | C9JSL1_HUMAN | RNA-binding protein 6 | RBM6 | 156 | Annotation score: | ||
C9JMC8 | C9JMC8_HUMAN | RNA-binding protein 6 | RBM6 | 76 | Annotation score: | ||
F8WCT0 | F8WCT0_HUMAN | RNA-binding protein 6 | RBM6 | 35 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 642 | R → K in AAC21578 (PubMed:10352938).Curated | 1 | |
Sequence conflicti | 710 | A → V in AAC05826 (PubMed:9500467).Curated | 1 | |
Sequence conflicti | 796 | T → S in AAC05826 (PubMed:9500467).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014226 | 353 | S → F in a non-small cell lung cancer cell line. 1 PublicationCorresponds to variant dbSNP:rs61731329Ensembl. | 1 | |
Natural variantiVAR_052216 | 721 | N → T. Corresponds to variant dbSNP:rs34707170Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045202 | 1 – 522 | Missing in isoform 2. 1 PublicationAdd BLAST | 522 | |
Alternative sequenceiVSP_057401 | 496 – 520 | YDYGY…EANQG → NSNDPGQRSYPGVCIKPGFL VLQTM in isoform 3. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_057402 | 521 – 1123 | Missing in isoform 3. 1 PublicationAdd BLAST | 603 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF042857 mRNA Translation: AAC05826.1 AF069517 mRNA Translation: AAC21578.1 AF091264 mRNA Translation: AAD04160.1 U50839 mRNA Translation: AAC35207.1 AK303371 mRNA Translation: BAG64428.1 AC104450 Genomic DNA No translation available. AC105935 Genomic DNA No translation available. BC046643 mRNA Translation: AAH46643.1 |
CCDSi | CCDS2809.1 [P78332-1] CCDS54586.1 [P78332-2] |
RefSeqi | NP_001161054.1, NM_001167582.1 [P78332-2] NP_005768.1, NM_005777.2 [P78332-1] XP_005264843.1, XM_005264786.1 XP_005264844.1, XM_005264787.2 XP_016860988.1, XM_017005499.1 XP_016860989.1, XM_017005500.1 [P78332-2] XP_016860990.1, XM_017005501.1 [P78332-2] XP_016860991.1, XM_017005502.1 [P78332-2] |
Genome annotation databases
Ensembli | ENST00000266022; ENSP00000266022; ENSG00000004534 [P78332-1] ENST00000422955; ENSP00000392939; ENSG00000004534 [P78332-2] ENST00000425608; ENSP00000408665; ENSG00000004534 [P78332-3] ENST00000442092; ENSP00000393530; ENSG00000004534 [P78332-2] |
GeneIDi | 10180 |
KEGGi | hsa:10180 |
UCSCi | uc003cyc.4, human [P78332-1] uc062jzu.1, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF042857 mRNA Translation: AAC05826.1 AF069517 mRNA Translation: AAC21578.1 AF091264 mRNA Translation: AAD04160.1 U50839 mRNA Translation: AAC35207.1 AK303371 mRNA Translation: BAG64428.1 AC104450 Genomic DNA No translation available. AC105935 Genomic DNA No translation available. BC046643 mRNA Translation: AAH46643.1 |
CCDSi | CCDS2809.1 [P78332-1] CCDS54586.1 [P78332-2] |
RefSeqi | NP_001161054.1, NM_001167582.1 [P78332-2] NP_005768.1, NM_005777.2 [P78332-1] XP_005264843.1, XM_005264786.1 XP_005264844.1, XM_005264787.2 XP_016860988.1, XM_017005499.1 XP_016860989.1, XM_017005500.1 [P78332-2] XP_016860990.1, XM_017005501.1 [P78332-2] XP_016860991.1, XM_017005502.1 [P78332-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 115479, 43 interactors |
IntActi | P78332, 32 interactors |
STRINGi | 9606.ENSP00000266022 |
PTM databases
iPTMneti | P78332 |
PhosphoSitePlusi | P78332 |
Genetic variation databases
BioMutai | RBM6 |
DMDMi | 116242749 |
Proteomic databases
EPDi | P78332 |
jPOSTi | P78332 |
MassIVEi | P78332 |
MaxQBi | P78332 |
PaxDbi | P78332 |
PeptideAtlasi | P78332 |
PRIDEi | P78332 |
ProteomicsDBi | 5671 57570 [P78332-1] 69630 |
Protocols and materials databases
Antibodypediai | 13824, 174 antibodies |
DNASUi | 10180 |
Genome annotation databases
Ensembli | ENST00000266022; ENSP00000266022; ENSG00000004534 [P78332-1] ENST00000422955; ENSP00000392939; ENSG00000004534 [P78332-2] ENST00000425608; ENSP00000408665; ENSG00000004534 [P78332-3] ENST00000442092; ENSP00000393530; ENSG00000004534 [P78332-2] |
GeneIDi | 10180 |
KEGGi | hsa:10180 |
UCSCi | uc003cyc.4, human [P78332-1] uc062jzu.1, human |
Organism-specific databases
CTDi | 10180 |
DisGeNETi | 10180 |
GeneCardsi | RBM6 |
HGNCi | HGNC:9903, RBM6 |
HPAi | ENSG00000004534, Low tissue specificity |
MIMi | 606886, gene |
neXtProti | NX_P78332 |
OpenTargetsi | ENSG00000004534 |
PharmGKBi | PA34268 |
VEuPathDBi | HostDB:ENSG00000004534.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0154, Eukaryota |
GeneTreei | ENSGT00940000157976 |
HOGENOMi | CLU_010527_0_0_1 |
InParanoidi | P78332 |
OMAi | SQMDFRG |
PhylomeDBi | P78332 |
TreeFami | TF315789 |
Enzyme and pathway databases
PathwayCommonsi | P78332 |
Miscellaneous databases
BioGRID-ORCSi | 10180, 10 hits in 886 CRISPR screens |
ChiTaRSi | RBM6, human |
GeneWikii | RBM6 |
GenomeRNAii | 10180 |
Pharosi | P78332, Tbio |
PROi | PR:P78332 |
RNActi | P78332, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000004534, Expressed in endocervix and 240 other tissues |
ExpressionAtlasi | P78332, baseline and differential |
Genevisiblei | P78332, HS |
Family and domain databases
CDDi | cd16163, OCRE_RBM6, 1 hit cd12314, RRM1_RBM6, 1 hit cd12563, RRM2_RBM6, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR000467, G_patch_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR041591, OCRE IPR035979, RBD_domain_sf IPR028806, RBM6 IPR035617, RBM6_OCRE IPR034123, RBM6_RRM1 IPR034125, RBM6_RRM2 IPR000504, RRM_dom |
PANTHERi | PTHR13948:SF22, PTHR13948:SF22, 3 hits |
Pfami | View protein in Pfam PF01585, G-patch, 1 hit PF17780, OCRE, 1 hit |
SMARTi | View protein in SMART SM00443, G_patch, 1 hit SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50174, G_PATCH, 1 hit PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBM6_HUMAN | |
Accessioni | P78332Primary (citable) accession number: P78332 Secondary accession number(s): B4E0G6 Q86SS3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 188 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot