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Protein

RNA-binding protein 6

Gene

RBM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically binds poly(G) RNA homopolymers in vitro.

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 6
Alternative name(s):
Lung cancer antigen NY-LU-12
Protein G16
RNA-binding motif protein 6
RNA-binding protein DEF-3
Gene namesi
Name:RBM6
Synonyms:DEF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000004534.14
HGNCiHGNC:9903 RBM6
MIMi606886 gene
neXtProtiNX_P78332

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10180
OpenTargetsiENSG00000004534
PharmGKBiPA34268

Polymorphism and mutation databases

BioMutaiRBM6
DMDMi116242749

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817601 – 1123RNA-binding protein 6Add BLAST1123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Cross-linki36Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei240PhosphoserineCombined sources1
Cross-linki331Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei344PhosphothreonineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Cross-linki386Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki453Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki569Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki871Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki887Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei891PhosphoserineCombined sources1
Cross-linki935Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki948Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki991Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1019Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1022PhosphoserineCombined sources1
Modified residuei1025PhosphoserineCombined sources1
Cross-linki1042Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1046Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1066Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP78332
MaxQBiP78332
PaxDbiP78332
PeptideAtlasiP78332
PRIDEiP78332
ProteomicsDBi57570

PTM databases

iPTMnetiP78332
PhosphoSitePlusiP78332

Expressioni

Tissue specificityi

Ubiquitous in adults.

Gene expression databases

BgeeiENSG00000004534 Expressed in 229 organ(s), highest expression level in myometrium
CleanExiHS_RBM6
ExpressionAtlasiP78332 baseline and differential
GenevisibleiP78332 HS

Organism-specific databases

HPAiHPA026272
HPA027164

Interactioni

Subunit structurei

May interact with FAM168B.

Binary interactionsi

WithEntry#Exp.IntActNotes
EEF1GP26641-23EBI-2692323,EBI-10177695

Protein-protein interaction databases

BioGridi115479, 33 interactors
IntActiP78332, 21 interactors
STRINGi9606.ENSP00000266022

Structurei

3D structure databases

ProteinModelPortaliP78332
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini456 – 536RRMPROSITE-ProRule annotationAdd BLAST81
Domaini1051 – 1097G-patchPROSITE-ProRule annotationAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi826 – 829Poly-Glu4
Compositional biasi892 – 895Poly-Pro4
Compositional biasi915 – 921Poly-Glu7

Phylogenomic databases

eggNOGiENOG410IQDR Eukaryota
ENOG4111TS3 LUCA
GeneTreeiENSGT00510000046476
HOGENOMiHOG000133022
HOVERGENiHBG067411
InParanoidiP78332
OMAiSQIFGYG
OrthoDBiEOG091G00Y8
PhylomeDBiP78332
TreeFamiTF315789

Family and domain databases

CDDicd16163 OCRE_RBM6, 1 hit
cd12314 RRM1_RBM6, 1 hit
cd12563 RRM2_RBM6, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR028806 RBM6
IPR035617 RBM6_OCRE
IPR034123 RBM6_RRM1
IPR034125 RBM6_RRM2
IPR000504 RRM_dom
PANTHERiPTHR13948:SF22 PTHR13948:SF22, 1 hit
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit
PS50102 RRM, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P78332-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWGDSRPANR TGPFRGSQEE RFAPGWNRDY PPPPLKSHAQ ERHSGNFPGR
60 70 80 90 100
DSLPFDFQGH SGPPFANVEE HSFSYGARDG PHGDYRGGEG PGHDFRGGDF
110 120 130 140 150
SSSDFQSRDS SQLDFRGRDI HSGDFRDREG PPMDYRGGDG TSMDYRGREA
160 170 180 190 200
PHMNYRDRDA HAVDFRGRDA PPSDFRGRGT YDLDFRGRDG SHADFRGRDL
210 220 230 240 250
SDLDFRAREQ SRSDFRNRDV SDLDFRDKDG TQVDFRGRGS GTTDLDFRDR
260 270 280 290 300
DTPHSDFRGR HRSRTDQDFR GREMGSCMEF KDREMPPVDP NILDYIQPST
310 320 330 340 350
QDREHSGMNV NRREESTHDH TIERPAFGIQ KGEFEHSETR EGETQGVAFE
360 370 380 390 400
HESPADFQNS QSPVQDQDKS QLSGREEQSS DAGLFKEEGG LDFLGRQDTD
410 420 430 440 450
YRSMEYRDVD HRLPGSQMFG YGQSKSFPEG KTARDAQRDL QDQDYRTGPS
460 470 480 490 500
EEKPSRLIRL SGVPEDATKE EILNAFRTPD GMPVKNLQLK EYNTGYDYGY
510 520 530 540 550
VCVEFSLLED AIGCMEANQG TLMIQDKEVT LEYVSSLDFW YCKRCKANIG
560 570 580 590 600
GHRSSCSFCK NPREVTEAKQ ELITYPQPQK TSIPAPLEKQ PNQPLRPADK
610 620 630 640 650
EPEPRKREEG QESRLGHQKR EAERYLPPSR REGPTFRRDR ERESWSGETR
660 670 680 690 700
QDGESKTIML KRIYRSTPPE VIVEVLEPYV RLTTANVRII KNRTGPMGHT
710 720 730 740 750
YGFIDLDSHA EALRVVKILQ NLDPPFSIDG KMVAVNLATG KRRNDSGDHS
760 770 780 790 800
DHMHYYQGKK YFRDRRGGGR NSDWSSDTNR QGQQSSSDCY IYDSATGYYY
810 820 830 840 850
DPLAGTYYDP NTQQEVYVPQ DPGLPEEEEI KEKKPTSQGK SSSKKEMSKR
860 870 880 890 900
DGKEKKDRGV TRFQENASEG KAPAEDVFKK PLPPTVKKEE SPPPPKVVNP
910 920 930 940 950
LIGLLGEYGG DSDYEEEEEE EQTPPPQPRT AQPQKREEQT KKENEEDKLT
960 970 980 990 1000
DWNKLACLLC RRQFPNKEVL IKHQQLSDLH KQNLEIHRKI KQSEQELAYL
1010 1020 1030 1040 1050
ERREREGKFK GRGNDRREKL QSFDSPERKR IKYSRETDSD RKLVDKEDID
1060 1070 1080 1090 1100
TSSKGGCVQQ ATGWRKGTGL GYGHPGLASS EEAEGRMRGP SVGASGRTSK
1110 1120
RQSNETYRDA VRRVMFARYK ELD
Length:1,123
Mass (Da):128,644
Last modified:October 17, 2006 - v5
Checksum:i2952ED1BAA839DE4
GO
Isoform 2 (identifier: P78332-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-522: Missing.

Note: No experimental confirmation available.
Show »
Length:601
Mass (Da):69,179
Checksum:i0A367656D7AB22A3
GO
Isoform 3 (identifier: P78332-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     496-520: YDYGYVCVEFSLLEDAIGCMEANQG → NSNDPGQRSYPGVCIKPGFLVLQTM
     521-1123: Missing.

Note: No experimental confirmation available.
Show »
Length:520
Mass (Da):59,201
Checksum:iDD45F095380D72D4
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGM9E9PGM9_HUMAN
RNA-binding protein 6
RBM6
991Annotation score:
F8WCA5F8WCA5_HUMAN
RNA-binding protein 6
RBM6
697Annotation score:
C9J250C9J250_HUMAN
RNA-binding protein 6
RBM6
119Annotation score:
C9JSL1C9JSL1_HUMAN
RNA-binding protein 6
RBM6
156Annotation score:
C9JMC8C9JMC8_HUMAN
RNA-binding protein 6
RBM6
76Annotation score:
F8WF63F8WF63_HUMAN
RNA-binding protein 6
RBM6
199Annotation score:
C9JII0C9JII0_HUMAN
RNA-binding protein 6
RBM6
120Annotation score:
F8WCT0F8WCT0_HUMAN
RNA-binding protein 6
RBM6
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti642R → K in AAC21578 (PubMed:10352938).Curated1
Sequence conflicti710A → V in AAC05826 (PubMed:9500467).Curated1
Sequence conflicti796T → S in AAC05826 (PubMed:9500467).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014226353S → F in a non-small cell lung cancer cell line. 1 PublicationCorresponds to variant dbSNP:rs61731329Ensembl.1
Natural variantiVAR_052216721N → T. Corresponds to variant dbSNP:rs34707170Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0452021 – 522Missing in isoform 2. 1 PublicationAdd BLAST522
Alternative sequenceiVSP_057401496 – 520YDYGY…EANQG → NSNDPGQRSYPGVCIKPGFL VLQTM in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_057402521 – 1123Missing in isoform 3. 1 PublicationAdd BLAST603

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042857 mRNA Translation: AAC05826.1
AF069517 mRNA Translation: AAC21578.1
AF091264 mRNA Translation: AAD04160.1
U50839 mRNA Translation: AAC35207.1
AK303371 mRNA Translation: BAG64428.1
AC104450 Genomic DNA No translation available.
AC105935 Genomic DNA No translation available.
BC046643 mRNA Translation: AAH46643.1
CCDSiCCDS2809.1 [P78332-1]
CCDS54586.1 [P78332-2]
RefSeqiNP_001161054.1, NM_001167582.1 [P78332-2]
NP_005768.1, NM_005777.2 [P78332-1]
XP_005264843.1, XM_005264786.1
XP_005264844.1, XM_005264787.2
XP_016860988.1, XM_017005499.1
XP_016860989.1, XM_017005500.1 [P78332-2]
XP_016860990.1, XM_017005501.1 [P78332-2]
XP_016860991.1, XM_017005502.1 [P78332-2]
UniGeneiHs.696735

Genome annotation databases

EnsembliENST00000266022; ENSP00000266022; ENSG00000004534 [P78332-1]
ENST00000422955; ENSP00000392939; ENSG00000004534 [P78332-2]
ENST00000425608; ENSP00000408665; ENSG00000004534 [P78332-3]
ENST00000442092; ENSP00000393530; ENSG00000004534 [P78332-2]
GeneIDi10180
KEGGihsa:10180
UCSCiuc003cyc.4 human [P78332-1]
uc062jzu.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042857 mRNA Translation: AAC05826.1
AF069517 mRNA Translation: AAC21578.1
AF091264 mRNA Translation: AAD04160.1
U50839 mRNA Translation: AAC35207.1
AK303371 mRNA Translation: BAG64428.1
AC104450 Genomic DNA No translation available.
AC105935 Genomic DNA No translation available.
BC046643 mRNA Translation: AAH46643.1
CCDSiCCDS2809.1 [P78332-1]
CCDS54586.1 [P78332-2]
RefSeqiNP_001161054.1, NM_001167582.1 [P78332-2]
NP_005768.1, NM_005777.2 [P78332-1]
XP_005264843.1, XM_005264786.1
XP_005264844.1, XM_005264787.2
XP_016860988.1, XM_017005499.1
XP_016860989.1, XM_017005500.1 [P78332-2]
XP_016860990.1, XM_017005501.1 [P78332-2]
XP_016860991.1, XM_017005502.1 [P78332-2]
UniGeneiHs.696735

3D structure databases

ProteinModelPortaliP78332
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115479, 33 interactors
IntActiP78332, 21 interactors
STRINGi9606.ENSP00000266022

PTM databases

iPTMnetiP78332
PhosphoSitePlusiP78332

Polymorphism and mutation databases

BioMutaiRBM6
DMDMi116242749

Proteomic databases

EPDiP78332
MaxQBiP78332
PaxDbiP78332
PeptideAtlasiP78332
PRIDEiP78332
ProteomicsDBi57570

Protocols and materials databases

DNASUi10180
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266022; ENSP00000266022; ENSG00000004534 [P78332-1]
ENST00000422955; ENSP00000392939; ENSG00000004534 [P78332-2]
ENST00000425608; ENSP00000408665; ENSG00000004534 [P78332-3]
ENST00000442092; ENSP00000393530; ENSG00000004534 [P78332-2]
GeneIDi10180
KEGGihsa:10180
UCSCiuc003cyc.4 human [P78332-1]
uc062jzu.1 human

Organism-specific databases

CTDi10180
DisGeNETi10180
EuPathDBiHostDB:ENSG00000004534.14
GeneCardsiRBM6
HGNCiHGNC:9903 RBM6
HPAiHPA026272
HPA027164
MIMi606886 gene
neXtProtiNX_P78332
OpenTargetsiENSG00000004534
PharmGKBiPA34268
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQDR Eukaryota
ENOG4111TS3 LUCA
GeneTreeiENSGT00510000046476
HOGENOMiHOG000133022
HOVERGENiHBG067411
InParanoidiP78332
OMAiSQIFGYG
OrthoDBiEOG091G00Y8
PhylomeDBiP78332
TreeFamiTF315789

Miscellaneous databases

ChiTaRSiRBM6 human
GeneWikiiRBM6
GenomeRNAii10180
PROiPR:P78332
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000004534 Expressed in 229 organ(s), highest expression level in myometrium
CleanExiHS_RBM6
ExpressionAtlasiP78332 baseline and differential
GenevisibleiP78332 HS

Family and domain databases

CDDicd16163 OCRE_RBM6, 1 hit
cd12314 RRM1_RBM6, 1 hit
cd12563 RRM2_RBM6, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR028806 RBM6
IPR035617 RBM6_OCRE
IPR034123 RBM6_RRM1
IPR034125 RBM6_RRM2
IPR000504 RRM_dom
PANTHERiPTHR13948:SF22 PTHR13948:SF22, 1 hit
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBM6_HUMAN
AccessioniPrimary (citable) accession number: P78332
Secondary accession number(s): B4E0G6
, O60549, O75524, Q86SS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 172 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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