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UniProtKB - P78330 (SERB_HUMAN)

Entry version 193 (23 Feb 2022)
Sequence version 2 (26 Apr 2005)
Previous versions | rss
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Protein

Phosphoserine phosphatase

Gene

PSPH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine (PubMed:12213811, PubMed:15291819, PubMed:9222972, PubMed:14673469, PubMed:25080166).

L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator (PubMed:14673469).

May also act on O-phospho-D-serine (Probable).

1 Publication1 Publication5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+2 PublicationsNote: Binds 1 Mg2+ ion per subunit.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by calcium ions.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-serine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.3 Publications This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei20NucleophileCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi20MagnesiumCombined sources1 Publication1
Active sitei22Proton donorCombined sources1 Publication1
Metal bindingi22Magnesium; via carbonyl oxygenCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei52O-phospho-L-serineCombined sources1 Publication1
Binding sitei53Phosphate; via amide nitrogenCombined sources1 Publication1
Binding sitei158L-serineCombined sources1 Publication1
Binding sitei158O-phospho-L-serineCombined sources1 Publication1
Metal bindingi179MagnesiumCombined sources1 Publication1
Binding sitei182O-phospho-L-serineCombined sources1 Publication1
Binding sitei182PhosphateCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processAmino-acid biosynthesis, Serine biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.3, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P78330

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-977347, Serine biosynthesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P78330

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00135;UER00198

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoserine phosphatase1 Publication (EC:3.1.3.36 Publications)
Short name:
PSP1 Publication
Short name:
PSPase
Alternative name(s):
L-3-phosphoserine phosphatase1 Publication
O-phosphoserine phosphohydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSPHImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9577, PSPH

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		172480, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P78330

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000146733

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Phosphoserine phosphatase deficiency (PSPHD)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02237832D → N in PSPHD; decreased L-phosphoserine phosphatase activity. 1 PublicationCorresponds to variant dbSNP:rs104894035EnsemblClinVar.1
Natural variantiVAR_08450835A → T in PSPHD; decreased L-phosphoserine phosphatase activity. 1 Publication1
Natural variantiVAR_02237952M → T in PSPHD; decreased L-phosphoserine phosphatase activity. 1 PublicationCorresponds to variant dbSNP:rs104894036EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi23S → A: Reduces L-phosphoserine phosphatase activity by about 50%. 1 Publication1
Mutagenesisi23S → T: Reduces L-phosphoserine phosphatase activity by about 80%. 1 Publication1
Mutagenesisi29E → D: Reduces L-phosphoserine phosphatase activity by about 95%. 1 Publication1
Mutagenesisi29E → Q: Loss of L-phosphoserine phosphatase activity. 1 Publication1
Mutagenesisi65R → A or K: Loss of L-phosphoserine phosphatase activity. 1 Publication1
Mutagenesisi133N → A: Reduces L-phosphoserine phosphatase activity by about 75%. 1 Publication1
Mutagenesisi182T → S: Reduces L-phosphoserine phosphatase activity by about 99%. 1 Publication1
Mutagenesisi182T → V: Reduces L-phosphoserine phosphatase activity by about 25%. 1 Publication1
Mutagenesisi202R → A: Reduces L-phosphoserine phosphatase activity by about 99%. 1 Publication1
Mutagenesisi202R → K: Reduces L-phosphoserine phosphatase activity by about 95%. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		5723

MalaCards human disease database

More...MalaCardsi		PSPH
MIMi614023, phenotype

Open Targets

More...OpenTargetsi		ENSG00000146733

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		79350, 3-phosphoserine phosphatase deficiency, infantile/juvenile form

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33928

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P78330, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB03292, 3-Phosphono-D-alanine
DB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PSPH

Domain mapping of disease mutations (DMDM)

More...DMDMi		62906870

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001568791 – 225Phosphoserine phosphataseAdd BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P78330

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P78330

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P78330

MaxQB - The MaxQuant DataBase

More...MaxQBi		P78330

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P78330

PeptideAtlas

More...PeptideAtlasi		P78330

PRoteomics IDEntifications database

More...PRIDEi		P78330

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57569

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		PSPH

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P78330, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P78330

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P78330

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P78330

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000146733, Expressed in C1 segment of cervical spinal cord and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P78330, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P78330, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000146733, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P78330
With#Exp.IntAct
itself3EBI-1042956,EBI-1042956

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111695, 22 interactors

Protein interaction database and analysis system

More...IntActi		P78330, 5 interactors

Molecular INTeraction database

More...MINTi		P78330

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000378854

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P78330, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P78330

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P78330

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 22L-serine bindingCombined sources1 Publication3
Regioni109 – 111L-serine bindingCombined sources1 Publication3
Regioni109 – 111O-phospho-L-serine bindingCombined sources1 Publication3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. SerB family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1615, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003115

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_036368_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P78330

Identification of Orthologs from Complete Genome Data

More...OMAi		RAQYYVT

Database of Orthologous Groups

More...OrthoDBi		1009123at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P78330

TreeFam database of animal gene trees

More...TreeFami		TF315024

Family and domain databases

Database of protein disorder

More...DisProti		DP02639

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1000, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR004469, PSP

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56784, SSF56784, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00338, serB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P78330-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSHSELRKL FYSADAVCFD VDSTVIREEG IDELAKICGV EDAVSEMTRR 
        60         70         80         90        100
AMGGAVPFKA ALTERLALIQ PSREQVQRLI AEQPPHLTPG IRELVSRLQE 
       110        120        130        140        150
RNVQVFLISG GFRSIVEHVA SKLNIPATNV FANRLKFYFN GEYAGFDETQ 
       160        170        180        190        200
PTAESGGKGK VIKLLKEKFH FKKIIMIGDG ATDMEACPPA DAFIGFGGNV 
       210        220 
IRQQVKDNAK WYITDFVELL GELEE
Length:225
Mass (Da):25,008
Last modified:April 26, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD5D72697747FA30
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JBI3C9JBI3_HUMAN
O-phosphoserine phosphohydrolase
PSPH
187Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD74F8WD74_HUMAN
Phosphoserine phosphatase
PSPH
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEJ7C9JEJ7_HUMAN
Phosphoserine phosphatase
PSPH
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMN5A0A1D5RMN5_HUMAN
Phosphoserine phosphatase
PSPH
10Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2V → I in CAA71318 (PubMed:9188776).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02237832D → N in PSPHD; decreased L-phosphoserine phosphatase activity. 1 PublicationCorresponds to variant dbSNP:rs104894035EnsemblClinVar.1
Natural variantiVAR_08450835A → T in PSPHD; decreased L-phosphoserine phosphatase activity. 1 Publication1
Natural variantiVAR_02237952M → T in PSPHD; decreased L-phosphoserine phosphatase activity. 1 PublicationCorresponds to variant dbSNP:rs104894036EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y10275 mRNA Translation: CAA71318.1
AK315235 mRNA Translation: BAG37662.1
BX537439 mRNA Translation: CAD97681.1
CH471140 Genomic DNA Translation: EAX07968.1
BC063614 mRNA Translation: AAH63614.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5522.1

NCBI Reference Sequences

More...RefSeqi		NP_004568.2, NM_004577.3
XP_005271830.1, XM_005271773.1
XP_005271831.1, XM_005271774.1
XP_005271832.1, XM_005271775.1
XP_005271833.1, XM_005271776.1
XP_006715823.1, XM_006715760.1
XP_011513763.1, XM_011515461.1
XP_016867955.1, XM_017012466.1
XP_016867956.1, XM_017012467.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000275605; ENSP00000275605; ENSG00000146733
ENST00000395471; ENSP00000378854; ENSG00000146733
ENST00000437355; ENSP00000401639; ENSG00000146733

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5723

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5723

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000275605.8; ENSP00000275605.3; NM_004577.4; NP_004568.2

UCSC genome browser

More...UCSCi		uc003trh.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10275 mRNA Translation: CAA71318.1
AK315235 mRNA Translation: BAG37662.1
BX537439 mRNA Translation: CAD97681.1
CH471140 Genomic DNA Translation: EAX07968.1
BC063614 mRNA Translation: AAH63614.1
CCDSiCCDS5522.1
RefSeqiNP_004568.2, NM_004577.3
XP_005271830.1, XM_005271773.1
XP_005271831.1, XM_005271774.1
XP_005271832.1, XM_005271775.1
XP_005271833.1, XM_005271776.1
XP_006715823.1, XM_006715760.1
XP_011513763.1, XM_011515461.1
XP_016867955.1, XM_017012466.1
XP_016867956.1, XM_017012467.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L8LX-ray2.51A/B1-225[»]
1L8OX-ray2.80A/B1-225[»]
1NNLX-ray1.53A/B1-225[»]
6HYJX-ray1.93A/B3-224[»]
6HYYX-ray1.57A/B5-225[»]
6Q6JX-ray1.99A/B5-224[»]
SMRiP78330
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111695, 22 interactors
IntActiP78330, 5 interactors
MINTiP78330
STRINGi9606.ENSP00000378854

Chemistry databases

DrugBankiDB03292, 3-Phosphono-D-alanine
DB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

PTM databases

DEPODiPSPH
GlyGeniP78330, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP78330
MetOSiteiP78330
PhosphoSitePlusiP78330

Genetic variation databases

BioMutaiPSPH
DMDMi62906870

Proteomic databases

EPDiP78330
jPOSTiP78330
MassIVEiP78330
MaxQBiP78330
PaxDbiP78330
PeptideAtlasiP78330
PRIDEiP78330
ProteomicsDBi57569

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13863, 345 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		5723

Genome annotation databases

EnsembliENST00000275605; ENSP00000275605; ENSG00000146733
ENST00000395471; ENSP00000378854; ENSG00000146733
ENST00000437355; ENSP00000401639; ENSG00000146733
GeneIDi5723
KEGGihsa:5723
MANE-SelectiENST00000275605.8; ENSP00000275605.3; NM_004577.4; NP_004568.2
UCSCiuc003trh.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5723
DisGeNETi5723

GeneCards: human genes, protein and diseases

More...GeneCardsi		PSPH
HGNCiHGNC:9577, PSPH
HPAiENSG00000146733, Low tissue specificity
MalaCardsiPSPH
MIMi172480, gene
614023, phenotype
neXtProtiNX_P78330
OpenTargetsiENSG00000146733
Orphaneti79350, 3-phosphoserine phosphatase deficiency, infantile/juvenile form
PharmGKBiPA33928
VEuPathDBiHostDB:ENSG00000146733

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1615, Eukaryota
GeneTreeiENSGT00390000003115
HOGENOMiCLU_036368_2_1_1
InParanoidiP78330
OMAiRAQYYVT
OrthoDBi1009123at2759
PhylomeDBiP78330
TreeFamiTF315024

Enzyme and pathway databases

UniPathwayiUPA00135;UER00198
BRENDAi3.1.3.3, 2681
PathwayCommonsiP78330
ReactomeiR-HSA-977347, Serine biosynthesis
SignaLinkiP78330

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5723, 12 hits in 1054 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PSPH, human
EvolutionaryTraceiP78330

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PSPH

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5723
PharosiP78330, Tbio

Protein Ontology

More...PROi		PR:P78330
RNActiP78330, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000146733, Expressed in C1 segment of cervical spinal cord and 224 other tissues
ExpressionAtlasiP78330, baseline and differential
GenevisibleiP78330, HS

Family and domain databases

DisProtiDP02639
Gene3Di3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR004469, PSP
SUPFAMiSSF56784, SSF56784, 1 hit
TIGRFAMsiTIGR00338, serB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSERB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78330
Secondary accession number(s): B2RCR5, Q7Z3S5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 26, 2005
Last modified: February 23, 2022
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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