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Entry version 175 (13 Feb 2019)
Sequence version 2 (15 Jul 1998)
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Protein

SH3 domain-binding protein 2

Gene

SH3BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phosphotyrosine residue binding Source: CAFA
  • SH3/SH2 adaptor activity Source: ProtInc
  • SH3 domain binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P78314

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P78314

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 domain-binding protein 2
Short name:
3BP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3BP2
Synonyms:3BP2
ORF Names:RES4-23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000087266.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10825 SH3BP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602104 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P78314

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cherubism (CRBM)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.
See also OMIM:118400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013257415R → P in CRBM. 1 PublicationCorresponds to variant dbSNP:rs121909149EnsemblClinVar.1
Natural variantiVAR_013258415R → Q in CRBM. 1 PublicationCorresponds to variant dbSNP:rs121909149EnsemblClinVar.1
Natural variantiVAR_013259418P → H in CRBM. 1 PublicationCorresponds to variant dbSNP:rs121909146EnsemblClinVar.1
Natural variantiVAR_013260418P → L in CRBM. 1 PublicationCorresponds to variant dbSNP:rs121909146EnsemblClinVar.1
Natural variantiVAR_013261418P → R in CRBM. 2 PublicationsCorresponds to variant dbSNP:rs121909146EnsemblClinVar.1
Natural variantiVAR_013262420G → E in CRBM. 1 PublicationCorresponds to variant dbSNP:rs28938171EnsemblClinVar.1
Natural variantiVAR_013263420G → R in CRBM. 2 PublicationsCorresponds to variant dbSNP:rs28938170EnsemblClinVar.1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6452

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SH3BP2

MalaCards human disease database

More...
MalaCardsi
SH3BP2
MIMi118400 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000087266

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
184 Cherubism

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35733

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SH3BP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3023207

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000643651 – 561SH3 domain-binding protein 2Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei174Phosphotyrosine; by SYKBy similarity1
Modified residuei183Phosphotyrosine; by SYKBy similarity1
Modified residuei278PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1
Modified residuei448Phosphotyrosine; by SYKBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation at Tyr-448 may stimulate the activity of the LYN kinase (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P78314

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P78314

MaxQB - The MaxQuant DataBase

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MaxQBi
P78314

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P78314

PeptideAtlas

More...
PeptideAtlasi
P78314

PRoteomics IDEntifications database

More...
PRIDEi
P78314

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57557
57558 [P78314-2]
57559 [P78314-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P78314

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P78314

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000087266 Expressed in 174 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P78314 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P78314 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036790

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112350, 22 interactors

Protein interaction database and analysis system

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IntActi
P78314, 25 interactors

Molecular INTeraction database

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MINTi
P78314

STRING: functional protein association networks

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STRINGi
9606.ENSP00000422168

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1561
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CR4NMR-A446-558[»]
3TWRX-ray1.55E/F/G/H410-425[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P78314

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P78314

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P78314

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 130PHPROSITE-ProRule annotationAdd BLAST105
Domaini457 – 555SH2PROSITE-ProRule annotationAdd BLAST99

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi201 – 210SH3-binding10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi205 – 212Poly-Pro8
Compositional biasi236 – 240Poly-Pro5

Keywords - Domaini

SH2 domain, SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGI1 Eukaryota
ENOG4111SD6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000002216

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000190359

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000016

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P78314

KEGG Orthology (KO)

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KOi
K07984

Identification of Orthologs from Complete Genome Data

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OMAi
HHGSLCL

Database of Orthologous Groups

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OrthoDBi
1189650at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P78314

TreeFam database of animal gene trees

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TreeFami
TF333342

Family and domain databases

Conserved Domains Database

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CDDi
cd10359 SH2_SH3BP2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035848 SH3BP2
IPR035847 SH3BP2_SH2

The PANTHER Classification System

More...
PANTHERi
PTHR15126 PTHR15126, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00169 PH, 1 hit
PF00017 SH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00252 SH2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P78314-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEEMHWPV PMKAIGAQNL LTMPGGVAKA GYLHKKGGTQ LQLLKWPLRF
60 70 80 90 100
VIIHKRCVYY FKSSTSASPQ GAFSLSGYNR VMRAAEETTS NNVFPFKIIH
110 120 130 140 150
ISKKHRTWFF SASSEEERKS WMALLRREIG HFHEKKDLPL DTSDSSSDTD
160 170 180 190 200
SFYGAVERPV DISLSPYPTD NEDYEHDDED DSYLEPDSPE PGRLEDALMH
210 220 230 240 250
PPAYPPPPVP TPRKPAFSDM PRAHSFTSKG PGPLLPPPPP KHGLPDVGLA
260 270 280 290 300
AEDSKRDPLC PRRAEPCPRV PATPRRMSDP PLSTMPTAPG LRKPPCFRES
310 320 330 340 350
ASPSPEPWTP GHGACSTSSA AIMATATSRN CDKLKSFHLS PRGPPTSEPP
360 370 380 390 400
PVPANKPKFL KIAEEDPPRE AAMPGLFVPP VAPRPPALKL PVPEAMARPA
410 420 430 440 450
VLPRPEKPQL PHLQRSPPDG QSFRSFSFEK PRQPSQADTG GDDSDEDYEK
460 470 480 490 500
VPLPNSVFVN TTESCEVERL FKATSPRGEP QDGLYCIRNS STKSGKVLVV
510 520 530 540 550
WDETSNKVRN YRIFEKDSKF YLEGEVLFVS VGSMVEHYHT HVLPSHQSLL
560
LRHPYGYTGP R
Length:561
Mass (Da):62,244
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69E6846A4F6D8F15
GO
Isoform 2 (identifier: P78314-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     81-97: VMRAAEETTSNNVFPFK → QPRPQPAQALSQTEAGP
     98-561: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:97
Mass (Da):10,624
Checksum:i58CB0FBE9EB3A7FF
GO
Isoform 3 (identifier: P78314-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MASLGPRTPAPSRSRGRRAMCWVSTISFM

Note: No experimental confirmation available.
Show »
Length:589
Mass (Da):65,305
Checksum:iB41A1B1688245A77
GO
Isoform 4 (identifier: P78314-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGSGPRPRSWGRREAGARDEAAAAGGRGPGPCRCSQGRRAWIAPGKPAMPAAWTPFM

Note: No experimental confirmation available.
Show »
Length:618
Mass (Da):68,129
Checksum:i4A1A055BBB057AD9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RER9D6RER9_HUMAN
SH3 domain-binding protein 2
SH3BP2
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBL6D6RBL6_HUMAN
SH3 domain-binding protein 2
SH3BP2
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R995D6R995_HUMAN
SH3 domain-binding protein 2
SH3BP2
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC64D6RC64_HUMAN
SH3 domain-binding protein 2
SH3BP2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAB4D6RAB4_HUMAN
SH3 domain-binding protein 2
SH3BP2
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAD9H0YAD9_HUMAN
SH3 domain-binding protein 2
SH3BP2
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27V → L in AAB59973 (PubMed:9734812).Curated1
Sequence conflicti224H → N in AAB59973 (PubMed:9734812).Curated1
Sequence conflicti249L → R in AAB59973 (PubMed:9734812).Curated1
Sequence conflicti251A → P in AAB59973 (PubMed:9734812).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013257415R → P in CRBM. 1 PublicationCorresponds to variant dbSNP:rs121909149EnsemblClinVar.1
Natural variantiVAR_013258415R → Q in CRBM. 1 PublicationCorresponds to variant dbSNP:rs121909149EnsemblClinVar.1
Natural variantiVAR_013259418P → H in CRBM. 1 PublicationCorresponds to variant dbSNP:rs121909146EnsemblClinVar.1
Natural variantiVAR_013260418P → L in CRBM. 1 PublicationCorresponds to variant dbSNP:rs121909146EnsemblClinVar.1
Natural variantiVAR_013261418P → R in CRBM. 2 PublicationsCorresponds to variant dbSNP:rs121909146EnsemblClinVar.1
Natural variantiVAR_013262420G → E in CRBM. 1 PublicationCorresponds to variant dbSNP:rs28938171EnsemblClinVar.1
Natural variantiVAR_013263420G → R in CRBM. 2 PublicationsCorresponds to variant dbSNP:rs28938170EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0436361M → MASLGPRTPAPSRSRGRRAM CWVSTISFM in isoform 3. 1 Publication1
Alternative sequenceiVSP_0550461M → MAGSGPRPRSWGRREAGARD EAAAAGGRGPGPCRCSQGRR AWIAPGKPAMPAAWTPFM in isoform 4. Curated1
Alternative sequenceiVSP_00408581 – 97VMRAA…VFPFK → QPRPQPAQALSQTEAGP in isoform 2. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_00408698 – 561Missing in isoform 2. 2 PublicationsAdd BLAST464

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF000936 mRNA Translation: AAB59973.1
U56386 mRNA Translation: AAB72034.1
AB000462 mRNA Translation: BAA19119.1
AB000463 mRNA Translation: BAA19120.1
AK299996 mRNA Translation: BAG61816.1
AK312286 mRNA Translation: BAG35213.1
AL121750 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82509.1
CH471131 Genomic DNA Translation: EAW82510.1
CH471131 Genomic DNA Translation: EAW82511.1
CH471131 Genomic DNA Translation: EAW82512.1
BC022996 mRNA Translation: AAH22996.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33944.1 [P78314-1]
CCDS54715.1 [P78314-3]
CCDS54716.1 [P78314-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001116153.1, NM_001122681.1 [P78314-1]
NP_001139327.1, NM_001145855.1 [P78314-3]
NP_001139328.1, NM_001145856.1 [P78314-4]
NP_003014.3, NM_003023.4 [P78314-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.167679

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356331; ENSP00000348685; ENSG00000087266 [P78314-1]
ENST00000435136; ENSP00000403231; ENSG00000087266 [P78314-1]
ENST00000442312; ENSP00000388152; ENSG00000087266 [P78314-3]
ENST00000452765; ENSP00000409746; ENSG00000087266 [P78314-1]
ENST00000503393; ENSP00000422168; ENSG00000087266 [P78314-4]
ENST00000511747; ENSP00000424846; ENSG00000087266 [P78314-1]
ENST00000513020; ENSP00000424072; ENSG00000087266 [P78314-2]
ENST00000515737; ENSP00000422605; ENSG00000087266 [P78314-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6452

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6452

UCSC genome browser

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UCSCi
uc003gfi.5 human [P78314-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000936 mRNA Translation: AAB59973.1
U56386 mRNA Translation: AAB72034.1
AB000462 mRNA Translation: BAA19119.1
AB000463 mRNA Translation: BAA19120.1
AK299996 mRNA Translation: BAG61816.1
AK312286 mRNA Translation: BAG35213.1
AL121750 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82509.1
CH471131 Genomic DNA Translation: EAW82510.1
CH471131 Genomic DNA Translation: EAW82511.1
CH471131 Genomic DNA Translation: EAW82512.1
BC022996 mRNA Translation: AAH22996.1
CCDSiCCDS33944.1 [P78314-1]
CCDS54715.1 [P78314-3]
CCDS54716.1 [P78314-4]
RefSeqiNP_001116153.1, NM_001122681.1 [P78314-1]
NP_001139327.1, NM_001145855.1 [P78314-3]
NP_001139328.1, NM_001145856.1 [P78314-4]
NP_003014.3, NM_003023.4 [P78314-1]
UniGeneiHs.167679

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CR4NMR-A446-558[»]
3TWRX-ray1.55E/F/G/H410-425[»]
ProteinModelPortaliP78314
SMRiP78314
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112350, 22 interactors
IntActiP78314, 25 interactors
MINTiP78314
STRINGi9606.ENSP00000422168

PTM databases

iPTMnetiP78314
PhosphoSitePlusiP78314

Polymorphism and mutation databases

BioMutaiSH3BP2
DMDMi3023207

Proteomic databases

EPDiP78314
jPOSTiP78314
MaxQBiP78314
PaxDbiP78314
PeptideAtlasiP78314
PRIDEiP78314
ProteomicsDBi57557
57558 [P78314-2]
57559 [P78314-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356331; ENSP00000348685; ENSG00000087266 [P78314-1]
ENST00000435136; ENSP00000403231; ENSG00000087266 [P78314-1]
ENST00000442312; ENSP00000388152; ENSG00000087266 [P78314-3]
ENST00000452765; ENSP00000409746; ENSG00000087266 [P78314-1]
ENST00000503393; ENSP00000422168; ENSG00000087266 [P78314-4]
ENST00000511747; ENSP00000424846; ENSG00000087266 [P78314-1]
ENST00000513020; ENSP00000424072; ENSG00000087266 [P78314-2]
ENST00000515737; ENSP00000422605; ENSG00000087266 [P78314-2]
GeneIDi6452
KEGGihsa:6452
UCSCiuc003gfi.5 human [P78314-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6452
DisGeNETi6452
EuPathDBiHostDB:ENSG00000087266.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SH3BP2
GeneReviewsiSH3BP2
HGNCiHGNC:10825 SH3BP2
HPAiHPA036790
MalaCardsiSH3BP2
MIMi118400 phenotype
602104 gene
neXtProtiNX_P78314
OpenTargetsiENSG00000087266
Orphaneti184 Cherubism
PharmGKBiPA35733

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGI1 Eukaryota
ENOG4111SD6 LUCA
GeneTreeiENSGT00390000002216
HOGENOMiHOG000190359
HOVERGENiHBG000016
InParanoidiP78314
KOiK07984
OMAiHHGSLCL
OrthoDBi1189650at2759
PhylomeDBiP78314
TreeFamiTF333342

Enzyme and pathway databases

SignaLinkiP78314
SIGNORiP78314

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SH3BP2 human
EvolutionaryTraceiP78314

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6452

Protein Ontology

More...
PROi
PR:P78314

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000087266 Expressed in 174 organ(s), highest expression level in blood
ExpressionAtlasiP78314 baseline and differential
GenevisibleiP78314 HS

Family and domain databases

CDDicd10359 SH2_SH3BP2, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035848 SH3BP2
IPR035847 SH3BP2_SH2
PANTHERiPTHR15126 PTHR15126, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei3BP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78314
Secondary accession number(s): A6NNC2
, B2R5R6, B4DT04, D3DVR0, D6R919, O00500, O15373, P78315
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 13, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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