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Entry version 125 (13 Feb 2019)
Sequence version 2 (19 Jul 2005)
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Protein

Protein FAM193A

Gene

FAM193A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM193A
Alternative name(s):
Protein IT14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM193A
Synonyms:C4orf8
ORF Names:RES4-22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000125386.14

Human Gene Nomenclature Database

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HGNCi
HGNC:16822 FAM193A

neXtProt; the human protein knowledge platform

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neXtProti
NX_P78312

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8603

Open Targets

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OpenTargetsi
ENSG00000125386

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA165663979

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FAM193A

Domain mapping of disease mutations (DMDM)

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DMDMi
71152365

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894301 – 1265Protein FAM193AAdd BLAST1265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei293PhosphoserineBy similarity1
Modified residuei383PhosphoserineCombined sources1
Modified residuei642PhosphoserineCombined sources1
Modified residuei1129PhosphoserineCombined sources1
Modified residuei1144PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P78312

MaxQB - The MaxQuant DataBase

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MaxQBi
P78312

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P78312

PeptideAtlas

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PeptideAtlasi
P78312

PRoteomics IDEntifications database

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PRIDEi
P78312

ProteomicsDB human proteome resource

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ProteomicsDBi
57553
57554 [P78312-2]
57555 [P78312-3]
57556 [P78312-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P78312

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P78312

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000125386 Expressed in 211 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P78312 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P78312 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043116

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114163, 6 interactors

Protein interaction database and analysis system

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IntActi
P78312, 5 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P78312

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P78312

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili107 – 142Sequence analysisAdd BLAST36
Coiled coili873 – 932Sequence analysisAdd BLAST60
Coiled coili1093 – 1118Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi347 – 354Poly-Ser8
Compositional biasi880 – 920Glu-richAdd BLAST41
Compositional biasi934 – 938Poly-Lys5
Compositional biasi1148 – 1158Poly-LysAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM193 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEE8 Eukaryota
ENOG410ZQD4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000000973

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000090198

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081059

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P78312

Database of Orthologous Groups

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OrthoDBi
171147at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P78312

TreeFam database of animal gene trees

More...
TreeFami
TF330223

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029717 FAM193
IPR031802 FAM193_C
IPR029719 FAM193A

The PANTHER Classification System

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PANTHERi
PTHR15109 PTHR15109, 1 hit
PTHR15109:SF2 PTHR15109:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15914 FAM193_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P78312-1) [UniParc]FASTAAdd to basket
Also known as: RES4-22B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVRLLRQLS AAAKVKAPSG LQGPPQAHQF ISLLLEEYGA LCQAARSIST
60 70 80 90 100
FLGTLENEHL KKFQVTWELH NKHLFENLVF SEPLLQSNLP ALVSQIRLGT
110 120 130 140 150
TTHDTCSEDT YSTLLQRYQR SEEELRRVAE EWLECQKRID AYVDEQMTMK
160 170 180 190 200
TKQRMLTEDW ELFKQRRFIE EQLTNKKAVT GENNFTDTMR HMLSSRLSMP
210 220 230 240 250
DCPNCNYRRR CACDDCSLSH ILTCGIMDPP VTDDIHIHQL PLQVDPAPDY
260 270 280 290 300
LAERSPPSVS SASSGSGSSS PITIQQHPRL ILTDSGSAPT FCSDDEDVAP
310 320 330 340 350
LSAKFADIYP LSNYDDTEVV ANMNGIHSEL NGGGENMALK DESPQISSTS
360 370 380 390 400
SSSSEADDEE ADGESSGEPP GAPKEDGVLG SRSPRTEESK ADSPPPSYPT
410 420 430 440 450
QQAEQAPNTC ECHVCKQEAS GLTPSAMTAG ALPPGHQFLS PEKPTHPALH
460 470 480 490 500
LYPHIHGHVP LHTVPHLPRP LIHPTLYATP PFTHSKALPP APVQNHTNKH
510 520 530 540 550
QVFNASLQDH IYPSCFGNTP EWNSSKFISL WGSEVMNDKN WNPGTFLPDT
560 570 580 590 600
ISGSEILGPT LSETRPEALP PPSSNETPAV SDSKEKKNAA KKKCLYNFQD
610 620 630 640 650
AFMEANKVVM ATSSATSSVS CTATTVQSSN SQFRVSSKRP PSVGDVFHGI
660 670 680 690 700
SKEDHRHSAP AAPRNSPTGL APLPALSPAA LSPAALSPAS TPHLANLAAP
710 720 730 740 750
SFPKTATTTP GFVDTRKSFC PAPLPPATDG SISAPPSVCS DPDCEGHRCE
760 770 780 790 800
NGVYDPQQDD GDESADEDSC SEHSSSTSTS TNQKEGKYCD CCYCEFFGHG
810 820 830 840 850
GPPAAPTSRN YAEMREKLRL RLTKRKEEQP KKMDQISERE SVVDHRRVED
860 870 880 890 900
LLQFINSSET KPVSSTRAAK RARHKQRKLE EKARLEAEAR AREHLHLQEE
910 920 930 940 950
QRRREEEEDE EEEEDRFKEE FQRLQELQKL RAVKKKKKER PSKDCPKLDM
960 970 980 990 1000
LTRNFQAATE SVPNSGNIHN GSLEQTEEPE TSSHSPSRHM NHSEPRPGLG
1010 1020 1030 1040 1050
ADGDAADPVD TRDSKFLLPK EVNGKQHEPL SFFFDIMQHH KEGNGKQKLR
1060 1070 1080 1090 1100
QTSKASSEPA RRPTEPPKAT EGQSKPRAQT ESKAKVVDLM SITEQKREER
1110 1120 1130 1140 1150
KVNSNNNNKK QLNHIKDEKS NPTPMEPTSP GEHQQNSKLV LAESPQPKGK
1160 1170 1180 1190 1200
NKKNKKKKGD RVNNSIDGVS LLLPSLGYNG AILAHCNLRL PGSSDCAASA
1210 1220 1230 1240 1250
SQVVGITDDV FLPKDIDLDS VDMDETEREV EYFKRFCLDS ARQTRQRLSI
1260
NWSNFSLKKA TFAAH
Length:1,265
Mass (Da):139,988
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B4EDD55B49AC9EE
GO
Isoform 2 (identifier: P78312-2) [UniParc]FASTAAdd to basket
Also known as: RES4-22A

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1207: Missing.

Show »
Length:1,224
Mass (Da):135,964
Checksum:i19D359B7F14E9C55
GO
Isoform 3 (identifier: P78312-3) [UniParc]FASTAAdd to basket
Also known as: RES4-22C

The sequence of this isoform differs from the canonical sequence as follows:
     786-792: GKYCDCC → ASSCTNK
     793-1265: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:792
Mass (Da):85,882
Checksum:iFA793B32D2EAE871
GO
Isoform 4 (identifier: P78312-4) [UniParc]FASTAAdd to basket
Also known as: RES4-22D

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Show »
Length:1,119
Mass (Da):123,237
Checksum:i842B5165FB165C19
GO
Isoform 5 (identifier: P78312-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-146: Q → QDLQTSVNKSIDTGTLVQSWLRGAA
     292-293: Missing.
     1167-1207: Missing.

Note: No experimental confirmation available.
Show »
Length:1,246
Mass (Da):138,317
Checksum:iDBB79CF295CF8217
GO
Isoform 6 (identifier: P78312-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1207: Missing.
     1236-1265: FCLDSARQTRQRLSINWSNFSLKKATFAAH → DGVSPHCPGWSRTPGLK

Show »
Length:1,211
Mass (Da):134,260
Checksum:iA1F5AD29AC439C0D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFZ4D6RFZ4_HUMAN
Protein FAM193A
FAM193A
804Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUR8E7EUR8_HUMAN
Protein FAM193A
FAM193A
1,006Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVL4A0A1B0GVL4_HUMAN
Protein FAM193A
FAM193A
1,515Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022863192M → V1 PublicationCorresponds to variant dbSNP:rs17164077Ensembl.1
Natural variantiVAR_0567831115I → V1 PublicationCorresponds to variant dbSNP:rs17681870Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0146141 – 146Missing in isoform 4. 2 PublicationsAdd BLAST146
Alternative sequenceiVSP_045574146Q → QDLQTSVNKSIDTGTLVQSW LRGAA in isoform 5. 1 Publication1
Alternative sequenceiVSP_045575292 – 293Missing in isoform 5. 1 Publication2
Alternative sequenceiVSP_014616786 – 792GKYCDCC → ASSCTNK in isoform 3. 1 Publication7
Alternative sequenceiVSP_014617793 – 1265Missing in isoform 3. 1 PublicationAdd BLAST473
Alternative sequenceiVSP_0146151167 – 1207Missing in isoform 2, isoform 5 and isoform 6. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_0471631236 – 1265FCLDS…TFAAH → DGVSPHCPGWSRTPGLK in isoform 6. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB000459 mRNA Translation: BAA19116.1
AB000460 mRNA Translation: BAA19117.1
AB000461 mRNA Translation: BAA19118.1 Sequence problems.
AB001563 mRNA Translation: BAA31858.1
AL110117 Genomic DNA No translation available.
BC136646 mRNA Translation: AAI36647.1
BC144340 mRNA Translation: AAI44341.1
AF040966 mRNA Translation: AAB97012.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33943.1 [P78312-2]
CCDS58874.1 [P78312-5]
CCDS58875.1 [P78312-1]
CCDS58876.1 [P78312-6]

NCBI Reference Sequences

More...
RefSeqi
NP_001243595.1, NM_001256666.1 [P78312-1]
NP_001243596.1, NM_001256667.1 [P78312-5]
NP_001243597.1, NM_001256668.1 [P78312-6]
NP_003695.3, NM_003704.3 [P78312-2]
XP_006713993.2, XM_006713930.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.652364

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324666; ENSP00000324587; ENSG00000125386 [P78312-1]
ENST00000382839; ENSP00000372290; ENSG00000125386 [P78312-2]
ENST00000502458; ENSP00000427505; ENSG00000125386 [P78312-5]
ENST00000505311; ENSP00000421200; ENSG00000125386 [P78312-6]
ENST00000512465; ENSP00000423852; ENSG00000125386 [P78312-3]
ENST00000545951; ENSP00000443617; ENSG00000125386 [P78312-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8603

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8603

UCSC genome browser

More...
UCSCi
uc003gfd.4 human [P78312-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000459 mRNA Translation: BAA19116.1
AB000460 mRNA Translation: BAA19117.1
AB000461 mRNA Translation: BAA19118.1 Sequence problems.
AB001563 mRNA Translation: BAA31858.1
AL110117 Genomic DNA No translation available.
BC136646 mRNA Translation: AAI36647.1
BC144340 mRNA Translation: AAI44341.1
AF040966 mRNA Translation: AAB97012.1
CCDSiCCDS33943.1 [P78312-2]
CCDS58874.1 [P78312-5]
CCDS58875.1 [P78312-1]
CCDS58876.1 [P78312-6]
RefSeqiNP_001243595.1, NM_001256666.1 [P78312-1]
NP_001243596.1, NM_001256667.1 [P78312-5]
NP_001243597.1, NM_001256668.1 [P78312-6]
NP_003695.3, NM_003704.3 [P78312-2]
XP_006713993.2, XM_006713930.2
UniGeneiHs.652364

3D structure databases

ProteinModelPortaliP78312
SMRiP78312
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114163, 6 interactors
IntActiP78312, 5 interactors

PTM databases

iPTMnetiP78312
PhosphoSitePlusiP78312

Polymorphism and mutation databases

BioMutaiFAM193A
DMDMi71152365

Proteomic databases

jPOSTiP78312
MaxQBiP78312
PaxDbiP78312
PeptideAtlasiP78312
PRIDEiP78312
ProteomicsDBi57553
57554 [P78312-2]
57555 [P78312-3]
57556 [P78312-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324666; ENSP00000324587; ENSG00000125386 [P78312-1]
ENST00000382839; ENSP00000372290; ENSG00000125386 [P78312-2]
ENST00000502458; ENSP00000427505; ENSG00000125386 [P78312-5]
ENST00000505311; ENSP00000421200; ENSG00000125386 [P78312-6]
ENST00000512465; ENSP00000423852; ENSG00000125386 [P78312-3]
ENST00000545951; ENSP00000443617; ENSG00000125386 [P78312-6]
GeneIDi8603
KEGGihsa:8603
UCSCiuc003gfd.4 human [P78312-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8603
DisGeNETi8603
EuPathDBiHostDB:ENSG00000125386.14

GeneCards: human genes, protein and diseases

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GeneCardsi
FAM193A
HGNCiHGNC:16822 FAM193A
HPAiHPA043116
neXtProtiNX_P78312
OpenTargetsiENSG00000125386
PharmGKBiPA165663979

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEE8 Eukaryota
ENOG410ZQD4 LUCA
GeneTreeiENSGT00390000000973
HOGENOMiHOG000090198
HOVERGENiHBG081059
InParanoidiP78312
OrthoDBi171147at2759
PhylomeDBiP78312
TreeFamiTF330223

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAM193A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FAM193A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8603

Protein Ontology

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PROi
PR:P78312

Gene expression databases

BgeeiENSG00000125386 Expressed in 211 organ(s), highest expression level in testis
ExpressionAtlasiP78312 baseline and differential
GenevisibleiP78312 HS

Family and domain databases

InterProiView protein in InterPro
IPR029717 FAM193
IPR031802 FAM193_C
IPR029719 FAM193A
PANTHERiPTHR15109 PTHR15109, 1 hit
PTHR15109:SF2 PTHR15109:SF2, 1 hit
PfamiView protein in Pfam
PF15914 FAM193_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF193A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P78312
Secondary accession number(s): B7ZM85
, B9EGR0, E9PFA1, O43607, P78311, P78313, Q9UEG8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: February 13, 2019
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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