UniProtKB - P78310 (CXAR_HUMAN)
Coxsackievirus and adenovirus receptor
CXADR
Functioni
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
- cell adhesion molecule binding Source: UniProtKB
- cell adhesive protein binding involved in AV node cell-bundle of His cell communication Source: BHF-UCL
- connexin binding Source: UniProtKB
- identical protein binding Source: UniProtKB
- integrin binding Source: UniProtKB
- PDZ domain binding Source: UniProtKB
- signaling receptor binding Source: UniProtKB
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- actin cytoskeleton reorganization Source: UniProtKB
- AV node cell-bundle of His cell adhesion involved in cell communication Source: BHF-UCL
- AV node cell to bundle of His cell communication Source: UniProtKB
- cardiac muscle fiber development Source: UniProtKB
- cell-cell junction organization Source: UniProtKB
- defense response to virus Source: UniProtKB
- epithelial structure maintenance Source: UniProtKB
- gamma-delta T cell activation Source: UniProtKB
- germ cell migration Source: UniProtKB
- heart development Source: UniProtKB
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
- homotypic cell-cell adhesion Source: UniProtKB
- leukocyte migration Source: Reactome
- mitochondrion organization Source: UniProtKB
- negative regulation of cardiac muscle cell proliferation Source: Ensembl
- neutrophil chemotaxis Source: UniProtKB
- regulation of AV node cell action potential Source: BHF-UCL
- regulation of immune response Source: Reactome
- transepithelial transport Source: UniProtKB
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor |
Biological process | Cell adhesion, Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P78310 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733, Cell surface interactions at the vascular wall |
Protein family/group databases
TCDBi | 8.A.23.1.14, the basigin (basigin) family |
UniLectini | P78310 |
Names & Taxonomyi
Protein namesi | Recommended name: Coxsackievirus and adenovirus receptorShort name: CAR Short name: hCAR Alternative name(s): CVB3-binding protein Coxsackievirus B-adenovirus receptor HCVADR |
Gene namesi | Name:CXADR Synonyms:CAR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2559, CXADR |
MIMi | 602621, gene |
neXtProti | NX_P78310 |
VEuPathDBi | HostDB:ENSG00000154639.18 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
- Basolateral cell membrane 4 Publications; Single-pass type I membrane protein Sequence analysis
Other locations
- tight junction 2 Publications
- adherens junction 1 Publication
Note: In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797).2 Publications
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
- extracellular space Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- apicolateral plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- acrosomal vesicle Source: UniProtKB
- adherens junction Source: UniProtKB
- bicellular tight junction Source: UniProtKB
- cell body Source: UniProtKB
- cell junction Source: HPA
- cell-cell junction Source: UniProtKB
- cytoplasm Source: CACAO
- filopodium Source: UniProtKB
- growth cone Source: UniProtKB
- intercalated disc Source: UniProtKB
- membrane raft Source: UniProtKB
- neuromuscular junction Source: UniProtKB
- neuron projection Source: UniProtKB
- protein-containing complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 237 | ExtracellularSequence analysisAdd BLAST | 218 | |
Transmembranei | 238 – 258 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 365 | CytoplasmicSequence analysisAdd BLAST | 107 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Secreted, Tight junctionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 70 – 72 | VII → AID: Abolishes binding to adenovirus type 5. 1 Publication | 3 | |
Mutagenesisi | 259 – 260 | CC → AA: Loss of palmitoylation and altered localization. 1 Publication | 2 | |
Mutagenesisi | 318 | Y → A: Affects basolateral localization in airway epithelial cells. 1 Publication | 1 | |
Mutagenesisi | 345 – 348 | LSRM → AAAA: Affects basolateral localization in airway epithelial cells. 1 Publication | 4 |
Organism-specific databases
DisGeNETi | 1525 |
OpenTargetsi | ENSG00000154639 |
PharmGKBi | PA27055 |
Miscellaneous databases
Pharosi | P78310, Tbio |
Genetic variation databases
BioMutai | CXADR |
DMDMi | 6685351 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000014739 | 20 – 365 | Coxsackievirus and adenovirus receptorAdd BLAST | 346 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 41 ↔ 120 | 3 Publications | ||
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 162 ↔ 212 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 201 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 259 | S-palmitoyl cysteine1 Publication | 1 | |
Lipidationi | 260 | S-palmitoyl cysteine1 Publication | 1 | |
Modified residuei | 297 | PhosphoserineBy similarity | 1 | |
Modified residuei | 304 | PhosphoserineBy similarity | 1 | |
Modified residuei | 306 | PhosphoserineCombined sources | 1 | |
Modified residuei | 323 | PhosphoserineCombined sources | 1 | |
Modified residuei | 332 | PhosphoserineCombined sources | 1 | |
Modified residuei | 363 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
EPDi | P78310 |
jPOSTi | P78310 |
MassIVEi | P78310 |
MaxQBi | P78310 |
PaxDbi | P78310 |
PeptideAtlasi | P78310 |
PRIDEi | P78310 |
ProteomicsDBi | 12784 57548 [P78310-1] 57549 [P78310-2] 57550 [P78310-3] 57551 [P78310-4] 57552 [P78310-5] 6303 |
PTM databases
GlyConnecti | 1159, 1 N-Linked glycan (1 site) |
GlyGeni | P78310, 3 sites |
iPTMneti | P78310 |
PhosphoSitePlusi | P78310 |
SwissPalmi | P78310 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000154639, Expressed in neocortex and 232 other tissues |
Genevisiblei | P78310, HS |
Organism-specific databases
HPAi | ENSG00000154639, Tissue enhanced (intestine) |
Interactioni
Subunit structurei
Monomer. May form homodimer.
Interacts with LNX, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1.
Interacts with MPDZ; recruits MPDZ to intercellular contact sites.
Interacts with JAML (homodimeric form). Secreted isoform 3, isoform 4 and isoform 5 can interact with the extracellular domain of the receptor.
6 PublicationsBinary interactionsi
Hide detailsP78310
With | #Exp. | IntAct |
---|---|---|
ANKRD46 - isoform 1 [Q86W74-2] | 3 | EBI-747931,EBI-12109402 |
FAM3C [Q92520] | 3 | EBI-747931,EBI-2876774 |
MAL [P21145] | 3 | EBI-747931,EBI-3932027 |
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
- cell adhesion molecule binding Source: UniProtKB
- cell adhesive protein binding involved in AV node cell-bundle of His cell communication Source: BHF-UCL
- connexin binding Source: UniProtKB
- identical protein binding Source: UniProtKB
- integrin binding Source: UniProtKB
- PDZ domain binding Source: UniProtKB
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107905, 37 interactors |
IntActi | P78310, 14 interactors |
MINTi | P78310 |
STRINGi | 9606.ENSP00000284878 |
Miscellaneous databases
RNActi | P78310, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P78310 |
SMRi | P78310 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P78310 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 134 | Ig-like C2-type 1Add BLAST | 115 | |
Domaini | 141 – 228 | Ig-like C2-type 2Add BLAST | 88 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 360 – 365 | PDZ-binding | 6 |
Domaini
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSG0, Eukaryota |
GeneTreei | ENSGT00940000154829 |
HOGENOMi | CLU_040549_0_0_1 |
InParanoidi | P78310 |
OMAi | ICNEIRE |
OrthoDBi | 896005at2759 |
PhylomeDBi | P78310 |
TreeFami | TF330875 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
s (7)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALLLCFVLL CGVVDFARSL SITTPEEMIE KAKGETAYLP CKFTLSPEDQ
60 70 80 90 100
GPLDIEWLIS PADNQKVDQV IILYSGDKIY DDYYPDLKGR VHFTSNDLKS
110 120 130 140 150
GDASINVTNL QLSDIGTYQC KVKKAPGVAN KKIHLVVLVK PSGARCYVDG
160 170 180 190 200
SEEIGSDFKI KCEPKEGSLP LQYEWQKLSD SQKMPTSWLA EMTSSVISVK
210 220 230 240 250
NASSEYSGTY SCTVRNRVGS DQCLLRLNVV PPSNKAGLIA GAIIGTLLAL
260 270 280 290 300
ALIGLIIFCC RKKRREEKYE KEVHHDIRED VPPPKSRTST ARSYIGSNHS
310 320 330 340 350
SLGSMSPSNM EGYSKTQYNQ VPSEDFERTP QSPTLPPAKV AAPNLSRMGA
360
IPVMIPAQSK DGSIV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: P78310-2) | |||||
Sequence conflicti | 343 | P → A in AAD31772 (PubMed:10490761).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049871 | 323 | S → R. Corresponds to variant dbSNP:rs34727960Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014819 | 71 – 89 | IILYS…PDLKG → GRCATSKEPYVHCQKLHRQ in isoform 3. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_014820 | 90 – 365 | Missing in isoform 3. 1 PublicationAdd BLAST | 276 | |
Alternative sequenceiVSP_014821 | 139 | V → GKMCHLQRAVRPLPEATSAV IIHPWGPCLLPTWKDIPRLS ITKYQVKTLNALLRVRLSHL LR in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_014822 | 140 – 365 | Missing in isoform 4. 1 PublicationAdd BLAST | 226 | |
Alternative sequenceiVSP_047729 | 191 – 232 | EMTSS…NVVPP → A in isoform 7. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_014823 | 191 | E → GKMCHLQRAVRPLPEATSAV IIHPWGPCLLPTWKDIPRLS ITKYQVKTLNALLRVRLSHL LR in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_014824 | 192 – 365 | Missing in isoform 5. 1 PublicationAdd BLAST | 174 | |
Alternative sequenceiVSP_047357 | 340 – 365 | VAAPN…DGSIV → FKYPYKTDGITVV in isoform 6. CuratedAdd BLAST | 26 | |
Alternative sequenceiVSP_014825 | 340 – 345 | VAAPNL → FKYPY in isoform 2. 1 Publication | 6 | |
Alternative sequenceiVSP_014826 | 346 – 365 | Missing in isoform 2. 1 PublicationAdd BLAST | 20 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000284878; ENSP00000284878; ENSG00000154639 [P78310-1] ENST00000356275; ENSP00000348620; ENSG00000154639 [P78310-3] ENST00000400165; ENSP00000383029; ENSG00000154639 [P78310-4] ENST00000400166; ENSP00000383030; ENSG00000154639 [P78310-5] ENST00000400169; ENSP00000383033; ENSG00000154639 [P78310-6] |
GeneIDi | 1525 |
KEGGi | hsa:1525 |
UCSCi | uc002ykh.3, human [P78310-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EAJ | X-ray | 1.35 | A/B | 15-140 | [»] | |
1F5W | X-ray | 1.70 | A/B | 15-140 | [»] | |
1JEW | electron microscopy | 22.00 | R | 21-140 | [»] | |
1KAC | X-ray | 2.60 | B | 22-144 | [»] | |
1P69 | X-ray | 3.10 | B | 22-144 | [»] | |
1P6A | X-ray | 2.90 | B | 22-144 | [»] | |
1RSF | NMR | - | A | 21-144 | [»] | |
2J12 | X-ray | 1.50 | B | 15-140 | [»] | |
2J1K | X-ray | 2.30 | A/B/G/J/K/O/P/T/V/X/Y/Z | 15-140 | [»] | |
2NPL | NMR | - | X | 142-235 | [»] | |
2W9L | X-ray | 2.91 | A/B/G/J/K/O/P/T/V/X/Y/Z | 16-139 | [»] | |
2WBW | X-ray | 1.55 | B | 15-138 | [»] | |
3J6L | electron microscopy | 9.00 | B | 15-140 | [»] | |
3J6M | electron microscopy | 9.00 | B | 22-144 | [»] | |
3J6N | electron microscopy | 9.00 | K | 20-233 | [»] | |
3J6O | electron microscopy | 9.00 | S | 20-236 | [»] | |
BMRBi | P78310 | |||||
SMRi | P78310 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107905, 37 interactors |
IntActi | P78310, 14 interactors |
MINTi | P78310 |
STRINGi | 9606.ENSP00000284878 |
Protein family/group databases
TCDBi | 8.A.23.1.14, the basigin (basigin) family |
UniLectini | P78310 |
PTM databases
GlyConnecti | 1159, 1 N-Linked glycan (1 site) |
GlyGeni | P78310, 3 sites |
iPTMneti | P78310 |
PhosphoSitePlusi | P78310 |
SwissPalmi | P78310 |
Genetic variation databases
BioMutai | CXADR |
DMDMi | 6685351 |
Proteomic databases
EPDi | P78310 |
jPOSTi | P78310 |
MassIVEi | P78310 |
MaxQBi | P78310 |
PaxDbi | P78310 |
PeptideAtlasi | P78310 |
PRIDEi | P78310 |
ProteomicsDBi | 12784 57548 [P78310-1] 57549 [P78310-2] 57550 [P78310-3] 57551 [P78310-4] 57552 [P78310-5] 6303 |
Protocols and materials databases
Antibodypediai | 1120, 455 antibodies |
DNASUi | 1525 |
Genome annotation databases
Ensembli | ENST00000284878; ENSP00000284878; ENSG00000154639 [P78310-1] ENST00000356275; ENSP00000348620; ENSG00000154639 [P78310-3] ENST00000400165; ENSP00000383029; ENSG00000154639 [P78310-4] ENST00000400166; ENSP00000383030; ENSG00000154639 [P78310-5] ENST00000400169; ENSP00000383033; ENSG00000154639 [P78310-6] |
GeneIDi | 1525 |
KEGGi | hsa:1525 |
UCSCi | uc002ykh.3, human [P78310-1] |
Organism-specific databases
CTDi | 1525 |
DisGeNETi | 1525 |
GeneCardsi | CXADR |
HGNCi | HGNC:2559, CXADR |
HPAi | ENSG00000154639, Tissue enhanced (intestine) |
MIMi | 602621, gene |
neXtProti | NX_P78310 |
OpenTargetsi | ENSG00000154639 |
PharmGKBi | PA27055 |
VEuPathDBi | HostDB:ENSG00000154639.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSG0, Eukaryota |
GeneTreei | ENSGT00940000154829 |
HOGENOMi | CLU_040549_0_0_1 |
InParanoidi | P78310 |
OMAi | ICNEIRE |
OrthoDBi | 896005at2759 |
PhylomeDBi | P78310 |
TreeFami | TF330875 |
Enzyme and pathway databases
PathwayCommonsi | P78310 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733, Cell surface interactions at the vascular wall |
Miscellaneous databases
BioGRID-ORCSi | 1525, 33 hits in 882 CRISPR screens |
ChiTaRSi | CXADR, human |
EvolutionaryTracei | P78310 |
GeneWikii | Coxsackie_virus_and_adenovirus_receptor |
GenomeRNAii | 1525 |
Pharosi | P78310, Tbio |
PROi | PR:P78310 |
RNActi | P78310, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154639, Expressed in neocortex and 232 other tissues |
Genevisiblei | P78310, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXAR_HUMAN | |
Accessioni | P78310Primary (citable) accession number: P78310 Secondary accession number(s): B2R8V8 Q9UKV4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 207 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references