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Protein

Argininosuccinate synthase

Gene

argG

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei89CitrullineUniRule annotation1
Binding sitei119ATP; via amide nitrogenUniRule annotation1
Binding sitei121AspartateUniRule annotation1
Binding sitei125AspartateUniRule annotation1
Binding sitei125CitrullineUniRule annotation1
Binding sitei126AspartateUniRule annotation1
Binding sitei129CitrullineUniRule annotation1
Binding sitei177CitrullineUniRule annotation1
Binding sitei186CitrullineUniRule annotation1
Binding sitei262CitrullineUniRule annotation1
Binding sitei274CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPUniRule annotation9

GO - Molecular functioni

  • argininosuccinate synthase activity Source: GO_Central
  • ATP binding Source: UniProtKB-UniRule

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:slr0585
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001486551 – 400Argininosuccinate synthaseAdd BLAST400

Proteomic databases

PaxDbiP77973
PRIDEiP77973

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
trxAP522312EBI-862317,EBI-862916

Protein-protein interaction databases

IntActiP77973, 7 interactors
STRINGi1148.SYNGTS_3135

Structurei

3D structure databases

ProteinModelPortaliP77973
SMRiP77973
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230093
InParanoidiP77973
KOiK01940
OMAiPAREWGM
PhylomeDBiP77973

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P77973-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRAKKVVLA YSGGVDTSVC IPYLMHEWGV EEVITLAADL GQGDELGPIQ
60 70 80 90 100
EKALRCGAVE SLVIDGKEEF VKEYAFRSIQ ANALYENRYP LSTALARPLI
110 120 130 140 150
AKMLVEAAEK YGADAVAHGC TGKGNDQVRF DISIMALNPN LKVLAPAREW
160 170 180 190 200
KMSREETIAY GERYGVESPV KKSSPYSIDR NILGRSIEAG PLEDPMTEPT
210 220 230 240 250
EEIYLMTKAI ADTPDEPEYV DIGFEKGIPV SLNGVMLDPV TLVERLNEIA
260 270 280 290 300
GNHGVGRLDM VENRVVGIKS REIYEAPALL VLIDAHRDLE SLTQTADVTH
310 320 330 340 350
YKNTVEEIYS QLIYRGLWYS PLKEALDAFI VKTQERVTGM VRVKFFKGNA
360 370 380 390 400
NVAGRKSDYS IYDAELATYG MEDQFDHKAA EGFIYIWGLP TKVWAQKMRG
Length:400
Mass (Da):44,485
Last modified:February 1, 1997 - v1
Checksum:i37BDB758CBB82C05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA18841.1
PIRiS76929

Genome annotation databases

EnsemblBacteriaiBAA18841; BAA18841; BAA18841
KEGGisyn:slr0585

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA18841.1
PIRiS76929

3D structure databases

ProteinModelPortaliP77973
SMRiP77973
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP77973, 7 interactors
STRINGi1148.SYNGTS_3135

Proteomic databases

PaxDbiP77973
PRIDEiP77973

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18841; BAA18841; BAA18841
KEGGisyn:slr0585

Phylogenomic databases

HOGENOMiHOG000230093
InParanoidiP77973
KOiK01940
OMAiPAREWGM
PhylomeDBiP77973

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00113

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASSY_SYNY3
AccessioniPrimary (citable) accession number: P77973
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names
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Main funding by: National Institutes of Health

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