UniProtKB - P77933 (DPOL_THEKO)

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History
Entry version 158 (23 May 2018)
Sequence version 3 (29 Mar 2005)
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Protein

DNA polymerase

Gene

pol

Organism

Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the "homing site" in gene that lack the intein. PI-PkoI recognizes 5'-GATTTAGATCCCTGTACC-3' and PI-PkoII recognizes 5'-CAGCTACTACGGTTAC-3'.

Catalytic activityⁱ

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Temperature dependenceⁱ

Thermostable.

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-directed DNA polymerase activity Source: UniProtKB-KW
endonuclease activity Source: UniProtKB-KW
nucleotide binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA replication Source: UniProtKB-KW
intein-mediated protein splicing Source: InterPro
intron homing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, DNA-directed DNA polymerase, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological process	DNA replication, Intron homing

Enzyme and pathway databases

BioCycⁱ	TKOD69014:G1G2A-2-MONOMER
BRENDAⁱ	2.7.7.7 5246

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	N10.007
REBASEⁱ	3792 PI-PkoI

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA polymerase (EC:2.7.7.7) Cleaved into the following 2 chains: Endonuclease PI-PkoI (EC:3.1.-.-) Alternative name(s): IVS-A Pko pol-1 intein Endonuclease PI-PkoII (EC:3.1.-.-) Alternative name(s): IVS-B Pko pol-2 intein
Gene namesⁱ	Name:pol Ordered Locus Names:TK0001
Organismⁱ	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifierⁱ	69014 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus › Thermococcus kodakarensis
Proteomesⁱ	UP000000536 Componentⁱ: Chromosome

Pathology & Biotechⁱ

Biotechnological useⁱ

Pyrococcus kodakaraensis enzyme is the fastest thermostable DNA polymerase known today (130 nucleotides/s) and is used in high-performance PCR.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000007325	1 – 406	DNA polymerase, 1st partAdd BLAST	406
ChainⁱPRO_0000007326	407 – 766	Endonuclease PI-PkoIAdd BLAST	360
ChainⁱPRO_0000007327	767 – 851	DNA polymerase, 2nd partAdd BLAST	85
ChainⁱPRO_0000007328	852 – 1388	Endonuclease PI-PkoIIAdd BLAST	537
ChainⁱPRO_0000007329	1389 – 1671	DNA polymerase, 3rd partAdd BLAST	283

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	788 ↔ 802	Combined sources1 Publication
Disulfide bondⁱ	1403 ↔ 1406	Combined sources1 Publication

Post-translational modificationⁱ

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.Curated

Keywords - PTMⁱ

Autocatalytic cleavage, Disulfide bond, Protein splicing

Proteomic databases

PRIDEⁱ	P77933

PRIDEⁱ

P77933

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	69014.TK0001

STRINGⁱ

69014.TK0001

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	2 – 10	Combined sources	9
Beta strandⁱ	13 – 22	Combined sources	10
Beta strandⁱ	25 – 31	Combined sources	7
Beta strandⁱ	37 – 44	Combined sources	8
Helixⁱ	45 – 47	Combined sources	3
Helixⁱ	48 – 51	Combined sources	4
Beta strandⁱ	55 – 58	Combined sources	4
Beta strandⁱ	61 – 64	Combined sources	4
Beta strandⁱ	67 – 75	Combined sources	9
Beta strandⁱ	78 – 86	Combined sources	9
Helixⁱ	92 – 102	Combined sources	11
Beta strandⁱ	106 – 111	Combined sources	6
Helixⁱ	116 – 123	Combined sources	8
Beta strandⁱ	137 – 144	Combined sources	8
Beta strandⁱ	157 – 164	Combined sources	8
Beta strandⁱ	167 – 174	Combined sources	8
Beta strandⁱ	181 – 183	Combined sources	3
Helixⁱ	187 – 201	Combined sources	15
Beta strandⁱ	204 – 210	Combined sources	7
Turnⁱ	211 – 214	Combined sources	4
Helixⁱ	215 – 226	Combined sources	12
Beta strandⁱ	240 – 244	Combined sources	5
Beta strandⁱ	247 – 251	Combined sources	5
Beta strandⁱ	255 – 259	Combined sources	5
Helixⁱ	260 – 267	Combined sources	8
Helixⁱ	275 – 283	Combined sources	9
Helixⁱ	292 – 301	Combined sources	10
Helixⁱ	305 – 337	Combined sources	33
Helixⁱ	341 – 346	Combined sources	6
Helixⁱ	349 – 363	Combined sources	15
Helixⁱ	374 – 379	Combined sources	6
Beta strandⁱ	395 – 406	Combined sources	12
Helixⁱ	768 – 776	Combined sources	9
Turnⁱ	780 – 782	Combined sources	3
Beta strandⁱ	791 – 793	Combined sources	3
Turnⁱ	795 – 797	Combined sources	3
Beta strandⁱ	800 – 802	Combined sources	3
Helixⁱ	810 – 828	Combined sources	19
Helixⁱ	833 – 852	Combined sources	20
Beta strandⁱ	858 – 863	Combined sources	6
Beta strandⁱ	866 – 871	Combined sources	6
Helixⁱ	872 – 881	Combined sources	10
Helixⁱ	884 – 886	Combined sources	3
Beta strandⁱ	888 – 890	Combined sources	3
Beta strandⁱ	893 – 897	Combined sources	5
Beta strandⁱ	900 – 906	Combined sources	7
Turnⁱ	908 – 910	Combined sources	3
Beta strandⁱ	913 – 935	Combined sources	23
Beta strandⁱ	940 – 944	Combined sources	5
Beta strandⁱ	948 – 953	Combined sources	6
Beta strandⁱ	956 – 961	Combined sources	6
Turnⁱ	962 – 964	Combined sources	3
Beta strandⁱ	970 – 975	Combined sources	6
Beta strandⁱ	985 – 987	Combined sources	3
Helixⁱ	988 – 993	Combined sources	6
Helixⁱ	997 – 999	Combined sources	3
Beta strandⁱ	1004 – 1011	Combined sources	8
Helixⁱ	1015 – 1026	Combined sources	12
Helixⁱ	1036 – 1046	Combined sources	11
Beta strandⁱ	1048 – 1051	Combined sources	4
Beta strandⁱ	1053 – 1059	Combined sources	7
Helixⁱ	1061 – 1077	Combined sources	17
Beta strandⁱ	1079 – 1081	Combined sources	3
Turnⁱ	1082 – 1084	Combined sources	3
Beta strandⁱ	1085 – 1088	Combined sources	4
Helixⁱ	1091 – 1094	Combined sources	4
Helixⁱ	1095 – 1098	Combined sources	4
Helixⁱ	1103 – 1106	Combined sources	4
Beta strandⁱ	1110 – 1112	Combined sources	3
Beta strandⁱ	1118 – 1124	Combined sources	7
Helixⁱ	1127 – 1139	Combined sources	13
Beta strandⁱ	1140 – 1145	Combined sources	6
Turnⁱ	1147 – 1150	Combined sources	4
Beta strandⁱ	1153 – 1159	Combined sources	7
Helixⁱ	1163 – 1177	Combined sources	15
Beta strandⁱ	1184 – 1189	Combined sources	6
Helixⁱ	1192 – 1202	Combined sources	11
Helixⁱ	1206 – 1208	Combined sources	3
Helixⁱ	1213 – 1215	Combined sources	3
Helixⁱ	1220 – 1234	Combined sources	15
Beta strandⁱ	1240 – 1248	Combined sources	9
Helixⁱ	1250 – 1262	Combined sources	13
Beta strandⁱ	1268 – 1272	Combined sources	5
Beta strandⁱ	1277 – 1281	Combined sources	5
Turnⁱ	1292 – 1295	Combined sources	4
Helixⁱ	1298 – 1300	Combined sources	3
Helixⁱ	1304 – 1311	Combined sources	8
Helixⁱ	1321 – 1329	Combined sources	9
Helixⁱ	1335 – 1338	Combined sources	4
Helixⁱ	1339 – 1341	Combined sources	3
Helixⁱ	1342 – 1346	Combined sources	5
Beta strandⁱ	1347 – 1371	Combined sources	25
Turnⁱ	1372 – 1374	Combined sources	3
Beta strandⁱ	1376 – 1379	Combined sources	4
Beta strandⁱ	1384 – 1387	Combined sources	4
Helixⁱ	1390 – 1394	Combined sources	5
Helixⁱ	1404 – 1429	Combined sources	26
Beta strandⁱ	1432 – 1437	Combined sources	6
Beta strandⁱ	1440 – 1444	Combined sources	5
Helixⁱ	1450 – 1467	Combined sources	18
Beta strandⁱ	1474 – 1487	Combined sources	14
Beta strandⁱ	1490 – 1494	Combined sources	5
Beta strandⁱ	1500 – 1505	Combined sources	6
Helixⁱ	1506 – 1508	Combined sources	3
Beta strandⁱ	1510 – 1512	Combined sources	3
Helixⁱ	1514 – 1528	Combined sources	15
Helixⁱ	1533 – 1547	Combined sources	15
Turnⁱ	1548 – 1550	Combined sources	3
Helixⁱ	1554 – 1557	Combined sources	4
Beta strandⁱ	1559 – 1562	Combined sources	4
Helixⁱ	1567 – 1569	Combined sources	3
Helixⁱ	1575 – 1585	Combined sources	11
Beta strandⁱ	1595 – 1602	Combined sources	8
Helixⁱ	1608 – 1610	Combined sources	3
Beta strandⁱ	1611 – 1613	Combined sources	3
Helixⁱ	1614 – 1616	Combined sources	3
Turnⁱ	1619 – 1621	Combined sources	3
Helixⁱ	1626 – 1631	Combined sources	6
Helixⁱ	1634 – 1642	Combined sources	9
Helixⁱ	1643 – 1645	Combined sources	3
Helixⁱ	1649 – 1652	Combined sources	4

3D structure databases

ProteinModelPortalⁱ	P77933
SMRⁱ	P77933
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P77933

EvolutionaryTraceⁱ

P77933

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	524 – 665	DOD-type homing endonuclease 1PROSITE-ProRule annotationAdd BLAST		142
Domainⁱ	1132 – 1265	DOD-type homing endonuclease 2PROSITE-ProRule annotationAdd BLAST		134

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	135 – 326	3'-5' exonucleaseCuratedAdd BLAST		192

Sequence similaritiesⁱ

Belongs to the DNA polymerase type-B family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	arCOG00328 Archaea arCOG03145 Archaea COG0417 LUCA
HOGENOMⁱ	HOG000222650
InParanoidⁱ	P77933
KEGG Orthology (KO) More...KOⁱ	K02319
OMAⁱ	YAHNSYY
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z00EA

Family and domain databases

Gene3Dⁱ	3.10.28.10, 2 hits 3.30.420.10, 1 hit 3.90.1600.10, 3 hits
InterProⁱ	View protein in InterPro IPR006172 DNA-dir_DNA_pol_B IPR017964 DNA-dir_DNA_pol_B_CS IPR006133 DNA-dir_DNA_pol_B_exonuc IPR006134 DNA-dir_DNA_pol_B_multi_dom IPR023211 DNA_pol_palm_dom_sf IPR003586 Hint_dom_C IPR003587 Hint_dom_N IPR036844 Hint_dom_sf IPR027434 Homing_endonucl IPR006142 INTEIN IPR030934 Intein_C IPR004042 Intein_endonuc IPR006141 Intein_N IPR004860 LAGLIDADG_2 IPR012337 RNaseH-like_sf IPR036397 RNaseH_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00136 DNA_pol_B, 2 hits PF03104 DNA_pol_B_exo1, 2 hits PF14528 LAGLIDADG_3, 2 hits
PRINTSⁱ	PR00379 INTEIN
SMARTⁱ	View protein in SMART SM00305 HintC, 2 hits SM00306 HintN, 2 hits SM00486 POLBc, 1 hit
SUPFAMⁱ	SSF51294 SSF51294, 4 hits SSF53098 SSF53098, 1 hit SSF55608 SSF55608, 2 hits
TIGRFAMsⁱ	TIGR01443 intein_Cterm, 2 hits TIGR01445 intein_Nterm, 1 hit
PROSITEⁱ	View protein in PROSITE PS00116 DNA_POLYMERASE_B, 1 hit PS50818 INTEIN_C_TER, 2 hits PS50819 INTEIN_ENDONUCLEASE, 2 hits PS50817 INTEIN_N_TER, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P77933-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MILDTDYITE DGKPVIRIFK KENGEFKIEY DRTFEPYFYA LLKDDSAIEE 
        60         70         80         90        100
VKKITAERHG TVVTVKRVEK VQKKFLGRPV EVWKLYFTHP QDVPAIRDKI 
       110        120        130        140        150
REHPAVIDIY EYDIPFAKRY LIDKGLVPME GDEELKMLAF DIETLYHEGE 
       160        170        180        190        200
EFAEGPILMI SYADEEGARV ITWKNVDLPY VDVVSTEREM IKRFLRVVKE 
       210        220        230        240        250
KDPDVLITYN GDNFDFAYLK KRCEKLGINF ALGRDGSEPK IQRMGDRFAV 
       260        270        280        290        300
EVKGRIHFDL YPVIRRTINL PTYTLEAVYE AVFGQPKEKV YAEEITTAWE 
       310        320        330        340        350
TGENLERVAR YSMEDAKVTY ELGKEFLPME AQLSRLIGQS LWDVSRSSTG 
       360        370        380        390        400
NLVEWFLLRK AYERNELAPN KPDEKELARR RQSYEGGYVK EPERGLWENI 
       410        420        430        440        450
VYLDFRCHPA DTKVVVKGKG IINISEVQEG DYVLGIDGWQ RVRKVWEYDY 
       460        470        480        490        500
KGELVNINGL KCTPNHKLPV VTKNERQTRI RDSLAKSFLT KKVKGKIITT 
       510        520        530        540        550
PLFYEIGRAT SENIPEEEVL KGELAGILLA EGTLLRKDVE YFDSSRKKRR 
       560        570        580        590        600
ISHQYRVEIT IGKDEEEFRD RITYIFERLF GITPSISEKK GTNAVTLKVA 
       610        620        630        640        650
KKNVYLKVKE IMDNIESLHA PSVLRGFFEG DGSVNRVRRS IVATQGTKNE 
       660        670        680        690        700
WKIKLVSKLL SQLGIPHQTY TYQYQENGKD RSRYILEITG KDGLILFQTL 
       710        720        730        740        750
IGFISERKNA LLNKAISQRE MNNLENNGFY RLSEFNVSTE YYEGKVYDLT 
       760        770        780        790        800
LEGTPYYFAN GILTHNSLYP SIIITHNVSP DTLNREGCKE YDVAPQVGHR 
       810        820        830        840        850
FCKDFPGFIP SLLGDLLEER QKIKKKMKAT IDPIERKLLD YRQRAIKILA 
       860        870        880        890        900
NSILPEEWLP VLEEGEVHFV RIGELIDRMM EENAGKVKRE GETEVLEVSG 
       910        920        930        940        950
LEVPSFNRRT KKAELKRVKA LIRHDYSGKV YTIRLKSGRR IKITSGHSLF 
       960        970        980        990       1000
SVRNGELVEV TGDELKPGDL VAVPRRLELP ERNHVLNLVE LLLGTPEEET 
      1010       1020       1030       1040       1050
LDIVMTIPVK GKKNFFKGML RTLRWIFGEE KRPRTARRYL RHLEDLGYVR 
      1060       1070       1080       1090       1100
LKKIGYEVLD WDSLKNYRRL YEALVENVRY NGNKREYLVE FNSIRDAVGI 
      1110       1120       1130       1140       1150
MPLKELKEWK IGTLNGFRMS PLIEVDESLA KLLGYYVSEG YARKQRNPKN 
      1160       1170       1180       1190       1200
GWSYSVKLYN EDPEVLDDME RLASRFFGKV RRGRNYVEIP KKIGYLLFEN 
      1210       1220       1230       1240       1250
MCGVLAENKR IPEFVFTSPK GVRLAFLEGY FIGDGDVHPN KRLRLSTKSE 
      1260       1270       1280       1290       1300
LLANQLVLLL NSVGVSAVKL GHDSGVYRVY INEELPFVKL DKKKNAYYSH 
      1310       1320       1330       1340       1350
VIPKEVLSEV FGKVFQKNVS PQTFRKMVED GRLDPEKAQR LSWLIEGDVV 
      1360       1370       1380       1390       1400
LDRVESVDVE DYDGYVYDLS VEDNENFLVG FGLVYAHNSY YGYYGYARAR 
      1410       1420       1430       1440       1450
WYCKECAESV TAWGREYITM TIKEIEEKYG FKVIYSDTDG FFATIPGADA 
      1460       1470       1480       1490       1500
ETVKKKAMEF LKYINAKLPG ALELEYEGFY KRGFFVTKKK YAVIDEEGKI 
      1510       1520       1530       1540       1550
TTRGLEIVRR DWSEIAKETQ ARVLEALLKD GDVEKAVRIV KEVTEKLSKY 
      1560       1570       1580       1590       1600
EVPPEKLVIH EQITRDLKDY KATGPHVAVA KRLAARGVKI RPGTVISYIV 
      1610       1620       1630       1640       1650
LKGSGRIGDR AIPFDEFDPT KHKYDAEYYI ENQVLPAVER ILRAFGYRKE 
      1660       1670 
DLRYQKTRQV GLSAWLKPKG T

Length:1,671

Mass (Da):193,405

Last modified:March 29, 2005 - v3

Checksum:ⁱD9C0029BE7EE2203

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	911	K → N in BAA06142 (PubMed:9361436).Curated		1
Sequence conflictⁱ	1120 – 1121	SP → RK in BAA06142 (PubMed:9361436).Curated		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D29671 Genomic DNA Translation: BAA06142.2 AP006878 Genomic DNA Translation: BAD84190.1
PIRⁱ	S71551
NCBI Reference Sequences More...RefSeqⁱ	WP_011248956.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaⁱ	BAD84190; BAD84190; TK0001
GeneIDⁱ	3233723
KEGGⁱ	tko:TK0001
PATRICⁱ	fig\|69014.16.peg.1

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length
P77933	DNA polymerase		THEG8		1699
PolA		Thermococcus sp. GT		1701
DNA polymerase (Fragment)		THEHY		1668
DNA-directed DNA polymerase		Thermococcus barophilus		2065
DNA polymerase family B		Thermococcus sp. AM4		1699
+6

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WN7	X-ray	2.75	A	1-810	[»]
1WNS	X-ray	3.00	A	1-1671	[»]
2CW7	X-ray	2.70	A	852-1388	[»]
2CW8	X-ray	2.50	A	852-1388	[»]
4K8Z	X-ray	2.29	A	1-1671	[»]
5OMF	X-ray	2.09	A	1-1671	[»]
ProteinModelPortalⁱ	P77933
SMRⁱ	P77933
ModBaseⁱ	Search...
MobiDBⁱ	Search...

STRINGⁱ	69014.TK0001

PRIDEⁱ	P77933

Structural Biology Knowledgebase	Search...

EvolutionaryTraceⁱ	P77933

Entry informationⁱ

Entry nameⁱ	DPOL_THEKO
Accessionⁱ	P77933Primary (citable) accession number: P77933 Secondary accession number(s): Q5JEA7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	March 29, 2005
	Last modified:	May 23, 2018
	This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

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Supporting data

UniProtKB - P77933 (DPOL_THEKO)

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DNA polymerase

pol

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Biotechnological useⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ