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UniProtKB - P77851 (HBD_THETC)
Protein
3-hydroxybutyryl-CoA dehydrogenase
Gene
hbd
Organism
Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032) (Clostridium thermosaccharolyticum)
Status
Functioni
Catalytic activityi
- EC:1.1.1.157
: butanoate metabolism Pathwayi
This protein is involved in the pathway butanoate metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway butanoate metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 138 | Important for catalytic activityBy similarity | 1 |
GO - Molecular functioni
- 3-hydroxybutyryl-CoA dehydrogenase activity Source: UniProtKB-EC
- NAD+ binding Source: InterPro
GO - Biological processi
- butyrate metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | NADP |
Enzyme and pathway databases
UniPathwayi | UPA00863 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-hydroxybutyryl-CoA dehydrogenase (EC:1.1.1.157)Alternative name(s): Beta-hydroxybutyryl-CoA dehydrogenase Short name: BHBD |
Gene namesi | Name:hbd Ordered Locus Names:Tthe_1657 |
Organismi | Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032) (Clostridium thermosaccharolyticum) |
Taxonomic identifieri | 580327 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Thermoanaerobacterium › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000109260 | 1 – 281 | 3-hydroxybutyryl-CoA dehydrogenaseAdd BLAST | 281 |
Proteomic databases
PRIDEi | P77851 |
Family & Domainsi
Sequence similaritiesi
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | COG1250, Bacteria |
HOGENOMi | CLU_009834_2_0_9 |
OMAi | SVMEVFY |
OrthoDBi | 862072at2 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR022694, 3-OHacyl-CoA_DH IPR006180, 3-OHacyl-CoA_DH_CS IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 1 hit PF02737, 3HCDH_N, 1 hit |
PIRSFi | PIRSF000105, HCDH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00067, 3HCDH, 1 hit |
i Sequence
Sequence statusi: Complete.
P77851-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQKICVIGAG TMGSGIAQVF AQNGFEVILR DIDMKFVEKG FGTIEKNLQR
60 70 80 90 100
NVDKGKITAD EKNEILSRIR GTTNLEDAKE ADFVVEAAIE NMDLKKQIFK
110 120 130 140 150
ELDEICKMET ILASNTSSLS ITEIASATKR PEKVIGMHFF NPVPVMKLVE
160 170 180 190 200
VIKGLKTSEQ TFNVVRELAL KVDKTPIEVK EAPGFVVNRI LIPMINEAIG
210 220 230 240 250
ILADGVATAE DIDEAMKLGA NHPIGPLALS DLIGNDVVLA IMNVLYEEYG
260 270 280
DSKYRPHPLL KKMVRGGLLG RKTGKGFFEY K
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 – 53 | NLQRNVD → IYKEMLT in CAB04792 (Ref. 1) Curated | 7 | |
Sequence conflicti | 47 – 53 | NLQRNVD → IYKEMLT in CAB07499 (Ref. 1) Curated | 7 | |
Sequence conflicti | 57 – 64 | ITADEKNE → LQQMRKR in CAB04792 (Ref. 1) Curated | 8 | |
Sequence conflicti | 57 – 64 | ITADEKNE → LQQMRKR in CAB07499 (Ref. 1) Curated | 8 | |
Sequence conflicti | 204 – 211 | DGVATAED → VVLATDKS in CAB04792 (Ref. 1) Curated | 8 | |
Sequence conflicti | 204 – 211 | DGVATAED → VVLATDKS in CAB07499 (Ref. 1) Curated | 8 | |
Sequence conflicti | 231 | D → S in CAB04792 (Ref. 1) Curated | 1 | |
Sequence conflicti | 231 | D → S in CAB07499 (Ref. 1) Curated | 1 | |
Sequence conflicti | 263 | M → V in CAB04792 (Ref. 1) Curated | 1 | |
Sequence conflicti | 263 | M → V in CAB07499 (Ref. 1) Curated | 1 | |
Sequence conflicti | 281 | K → KINLLRRRIS in CAB04792 (Ref. 1) Curated | 1 | |
Sequence conflicti | 281 | K → KINLLRRRIS in CAB07499 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z82038 Genomic DNA Translation: CAB04792.1 Z92974 Genomic DNA Translation: CAB07499.1 CP002171 Genomic DNA Translation: ADL69166.1 |
PIRi | T45289 |
RefSeqi | WP_013298133.1, NC_014410.1 |
Genome annotation databases
EnsemblBacteriai | ADL69166; ADL69166; Tthe_1657 |
KEGGi | ttm:Tthe_1657 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z82038 Genomic DNA Translation: CAB04792.1 Z92974 Genomic DNA Translation: CAB07499.1 CP002171 Genomic DNA Translation: ADL69166.1 |
PIRi | T45289 |
RefSeqi | WP_013298133.1, NC_014410.1 |
3D structure databases
AlphaFoldDBi | P77851 |
SMRi | P77851 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 580327.Tthe_1657 |
Proteomic databases
PRIDEi | P77851 |
Genome annotation databases
EnsemblBacteriai | ADL69166; ADL69166; Tthe_1657 |
KEGGi | ttm:Tthe_1657 |
Phylogenomic databases
eggNOGi | COG1250, Bacteria |
HOGENOMi | CLU_009834_2_0_9 |
OMAi | SVMEVFY |
OrthoDBi | 862072at2 |
Enzyme and pathway databases
UniPathwayi | UPA00863 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR022694, 3-OHacyl-CoA_DH IPR006180, 3-OHacyl-CoA_DH_CS IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 1 hit PF02737, 3HCDH_N, 1 hit |
PIRSFi | PIRSF000105, HCDH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00067, 3HCDH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HBD_THETC | |
Accessioni | P77851Primary (citable) accession number: P77851 Secondary accession number(s): D9TPZ7, O08502 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 30, 2010 | |
Last modified: | May 25, 2022 | |
This is version 123 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families