ackA

Functionⁱ

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityⁱ

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactorⁱ

Mg²⁺UniRule annotation, Mn²⁺UniRule annotationNote: Mg²⁺. Can also accept Mn²⁺.UniRule annotation

Pathwayⁱ: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Acetate kinase (ackA)
Phosphate acetyltransferase (pta)

This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	8	MagnesiumUniRule annotation	1
Binding siteⁱ	15	ATPUniRule annotation	1
Binding siteⁱ	92	SubstrateUniRule annotation	1
Active siteⁱ	149	Proton donor/acceptorUniRule annotation	1
Siteⁱ	181	Transition state stabilizerUniRule annotation	1
Siteⁱ	242	Transition state stabilizerUniRule annotation	1
Metal bindingⁱ	385	MagnesiumUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	209 – 213	ATPUniRule annotation	5
Nucleotide bindingⁱ	283 – 285	ATPUniRule annotation	3
Nucleotide bindingⁱ	331 – 335	ATPUniRule annotation	5

GO - Molecular functionⁱ

acetate kinase activity Source: UniProtKB-EC
ATP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
organic acid metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	CORYNE:G18NG-12369-MONOMER
UniPathwayⁱ	UPA00340;UER00458

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation) Alternative name(s): AcetokinaseUniRule annotation
Gene namesⁱ	Name:ackAUniRule annotation Synonyms:ack Ordered Locus Names:Cgl2752, cg3047
Organismⁱ	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifierⁱ	196627 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Corynebacteriales › Corynebacteriaceae › Corynebacterium › Corynebacterium glutamicum
Proteomesⁱ	UP000000582 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000107553	1 – 397	Acetate kinaseAdd BLAST		397

2D gel databases

The World-2DPAGE database More...World-2DPAGEⁱ	0001:P77845

World-2DPAGEⁱ

0001:P77845

Expressionⁱ

Inductionⁱ

Activated by RamA and repressed by RamB and GlxR.3 Publications

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	196627.cg3047

STRINGⁱ

196627.cg3047

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P77845
SMRⁱ	P77845
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105C6H Bacteria COG0282 LUCA
HOGENOMⁱ	HOG000288398
KEGG Orthology (KO) More...KOⁱ	K00925
OMAⁱ	WKALTGT

Family and domain databases

HAMAPⁱ	MF_00020 Acetate_kinase, 1 hit
InterProⁱ	View protein in InterPro IPR004372 Ac/propionate_kinase IPR000890 Aliphatic_acid_kin_short-chain IPR023865 Aliphatic_acid_kinase_CS
PANTHERⁱ	PTHR21060 PTHR21060, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00871 Acetate_kinase, 1 hit
PIRSFⁱ	PIRSF000722 Acetate_prop_kin, 1 hit
PRINTSⁱ	PR00471 ACETATEKNASE
TIGRFAMsⁱ	TIGR00016 ackA, 1 hit
PROSITEⁱ	View protein in PROSITE PS01075 ACETATE_KINASE_1, 1 hit PS01076 ACETATE_KINASE_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P77845-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALALVLNSG SSSIKFQLVN PENSAIDEPY VSGLVEQIGE PNGRIVLKIE 
        60         70         80         90        100
GEKYTLETPI ADHSEGLNLA FDLMDQHNCG PSQLEITAVG HRVVHGGILF 
       110        120        130        140        150
SAPELITDEI VEMIRDLIPL APLHNPANVD GIDVARKILP DVPHVAVFDT 
       160        170        180        190        200
GFFHSLPPAA ALYAINKDVA AEHGIRRYGF HGTSHEFVSK RVVEILEKPT 
       210        220        230        240        250
EDINTITFHL GNGASMAAVQ GGRAVDTSMG MTPLAGLVMG TRSGDIDPGI 
       260        270        280        290        300
VFHLSRTAGM SIDEIDNLLN KKSGVKGLSG VNDFRELREM IDNNDQDAWS 
       310        320        330        340        350
AYNIYIHQLR RYLGSYMVAL GRVDTIVFTA GVGENAQFVR EDALAGLEMY 
       360        370        380        390 
GIEIDPERNA LPNDGPRLIS TDASKVKVFV IPTNEELAIA RYAVKFA

Length:397

Mass (Da):43,092

Last modified:February 1, 1997 - v1

Checksum:ⁱ248FF97A3C52B0E4

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X89084 Genomic DNA Translation: CAA61456.1 BA000036 Genomic DNA Translation: BAC00146.1 BX927156 Genomic DNA Translation: CAF20774.1
NCBI Reference Sequences More...RefSeqⁱ	NP_601947.1, NC_003450.3 WP_003862874.1, NC_006958.1

Genome annotation databases

EnsemblBacteriaⁱ	BAC00146; BAC00146; BAC00146 CAF20774; CAF20774; cg3047
GeneIDⁱ	1020697
KEGGⁱ	cgb:cg3047 cgl:NCgl2656
PATRICⁱ	fig\|196627.13.peg.2683

Protein	Similar proteins		Species	Score	Length	Source
P77845	Acetate kinase		[Brevibacterium] flavum		397	UniRef100_P77845
Acetate kinase		Corynebacterium glutamicum ATCC 14067		397

Protein	Similar proteins		Species	Score	Length	Source
P77845	Acetate kinase		CORGB		397	UniRef90_P77845
Acetate kinase		[Brevibacterium] flavum		397
Acetate kinase		Corynebacterium glutamicum ATCC 14067		397
Acetate kinase		Corynebacterium crenatum MT		397
Acetate kinase		Corynebacterium crudilactis		397
+12

Protein	Similar proteins		Species	Score	Length	Source
P77845	Acetate kinase		CORGB		397	UniRef50_P77845
Acetate kinase		NOCFA		402
Acetate kinase		CORJK		403
Acetate kinase		MYCGI		386
Acetate kinase		LEIXX		397
+1654

Entry informationⁱ

Entry nameⁱ	ACKA_CORGL
Accessionⁱ	P77845Primary (citable) accession number: P77845
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	February 1, 1997
	Last modified:	May 23, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P77845 (ACKA_CORGL)

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Acetate kinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: acetyl-CoA biosynthesis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

2D gel databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Pathwayⁱ: acetyl-CoA biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ