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UniProtKB - P77845 (ACKA_CORGL)
Protein
Acetate kinase
Gene
ackA
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Functioni
Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
UniRule annotationCatalytic activityi
- EC:2.7.2.1UniRule annotation
Cofactori
: acetyl-CoA biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 8 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 15 | ATPUniRule annotation | 1 | |
Binding sitei | 92 | SubstrateUniRule annotation | 1 | |
Active sitei | 149 | Proton donor/acceptorUniRule annotation | 1 | |
Sitei | 181 | Transition state stabilizerUniRule annotation | 1 | |
Sitei | 242 | Transition state stabilizerUniRule annotation | 1 | |
Metal bindingi | 385 | MagnesiumUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 209 – 213 | ATPUniRule annotation | 5 | |
Nucleotide bindingi | 283 – 285 | ATPUniRule annotation | 3 | |
Nucleotide bindingi | 331 – 335 | ATPUniRule annotation | 5 |
GO - Molecular functioni
- acetate kinase activity Source: UniProtKB-UniRule
- ATP binding Source: UniProtKB-KW
- magnesium ion binding Source: UniProtKB-UniRule
GO - Biological processi
- acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
- organic acid metabolic process Source: InterPro
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | CORYNE:G18NG-12369-MONOMER |
UniPathwayi | UPA00340;UER00458 |
Names & Taxonomyi
Protein namesi | Recommended name: Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)Alternative name(s): AcetokinaseUniRule annotation |
Gene namesi | Name:ackAUniRule annotation Synonyms:ack Ordered Locus Names:Cgl2752, cg3047 |
Organismi | Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) |
Taxonomic identifieri | 196627 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Corynebacteriaceae › Corynebacterium › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000107553 | 1 – 397 | Acetate kinaseAdd BLAST | 397 |
2D gel databases
World-2DPAGEi | 0001:P77845 |
Expressioni
Inductioni
Activated by RamA and repressed by RamB and GlxR.3 Publications
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 196627.cg3047 |
Family & Domainsi
Sequence similaritiesi
Belongs to the acetokinase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0282, Bacteria |
HOGENOMi | CLU_020352_0_1_11 |
OMAi | KIITCHI |
Family and domain databases
HAMAPi | MF_00020, Acetate_kinase, 1 hit |
InterProi | View protein in InterPro IPR004372, Ac/propionate_kinase IPR000890, Aliphatic_acid_kin_short-chain IPR023865, Aliphatic_acid_kinase_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR21060, PTHR21060, 1 hit |
Pfami | View protein in Pfam PF00871, Acetate_kinase, 1 hit |
PIRSFi | PIRSF000722, Acetate_prop_kin, 1 hit |
PRINTSi | PR00471, ACETATEKNASE |
SUPFAMi | SSF53067, SSF53067, 2 hits |
TIGRFAMsi | TIGR00016, ackA, 1 hit |
PROSITEi | View protein in PROSITE PS01075, ACETATE_KINASE_1, 1 hit PS01076, ACETATE_KINASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P77845-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALALVLNSG SSSIKFQLVN PENSAIDEPY VSGLVEQIGE PNGRIVLKIE
60 70 80 90 100
GEKYTLETPI ADHSEGLNLA FDLMDQHNCG PSQLEITAVG HRVVHGGILF
110 120 130 140 150
SAPELITDEI VEMIRDLIPL APLHNPANVD GIDVARKILP DVPHVAVFDT
160 170 180 190 200
GFFHSLPPAA ALYAINKDVA AEHGIRRYGF HGTSHEFVSK RVVEILEKPT
210 220 230 240 250
EDINTITFHL GNGASMAAVQ GGRAVDTSMG MTPLAGLVMG TRSGDIDPGI
260 270 280 290 300
VFHLSRTAGM SIDEIDNLLN KKSGVKGLSG VNDFRELREM IDNNDQDAWS
310 320 330 340 350
AYNIYIHQLR RYLGSYMVAL GRVDTIVFTA GVGENAQFVR EDALAGLEMY
360 370 380 390
GIEIDPERNA LPNDGPRLIS TDASKVKVFV IPTNEELAIA RYAVKFA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X89084 Genomic DNA Translation: CAA61456.1 BA000036 Genomic DNA Translation: BAC00146.1 BX927156 Genomic DNA Translation: CAF20774.1 |
RefSeqi | NP_601947.1, NC_003450.3 WP_003862874.1, NC_006958.1 |
Genome annotation databases
EnsemblBacteriai | BAC00146; BAC00146; BAC00146 |
KEGGi | cgb:cg3047 cgl:NCgl2656 |
PATRICi | fig|196627.13.peg.2683 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X89084 Genomic DNA Translation: CAA61456.1 BA000036 Genomic DNA Translation: BAC00146.1 BX927156 Genomic DNA Translation: CAF20774.1 |
RefSeqi | NP_601947.1, NC_003450.3 WP_003862874.1, NC_006958.1 |
3D structure databases
SMRi | P77845 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 196627.cg3047 |
2D gel databases
World-2DPAGEi | 0001:P77845 |
Genome annotation databases
EnsemblBacteriai | BAC00146; BAC00146; BAC00146 |
KEGGi | cgb:cg3047 cgl:NCgl2656 |
PATRICi | fig|196627.13.peg.2683 |
Phylogenomic databases
eggNOGi | COG0282, Bacteria |
HOGENOMi | CLU_020352_0_1_11 |
OMAi | KIITCHI |
Enzyme and pathway databases
UniPathwayi | UPA00340;UER00458 |
BioCyci | CORYNE:G18NG-12369-MONOMER |
Family and domain databases
HAMAPi | MF_00020, Acetate_kinase, 1 hit |
InterProi | View protein in InterPro IPR004372, Ac/propionate_kinase IPR000890, Aliphatic_acid_kin_short-chain IPR023865, Aliphatic_acid_kinase_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR21060, PTHR21060, 1 hit |
Pfami | View protein in Pfam PF00871, Acetate_kinase, 1 hit |
PIRSFi | PIRSF000722, Acetate_prop_kin, 1 hit |
PRINTSi | PR00471, ACETATEKNASE |
SUPFAMi | SSF53067, SSF53067, 2 hits |
TIGRFAMsi | TIGR00016, ackA, 1 hit |
PROSITEi | View protein in PROSITE PS01075, ACETATE_KINASE_1, 1 hit PS01076, ACETATE_KINASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACKA_CORGL | |
Accessioni | P77845Primary (citable) accession number: P77845 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- UniProtKB entry view manual
User manual for the UniProtKB entry view - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families