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Protein

Methionine aminotransferase

Gene

ybdL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine.1 Publication

Catalytic activityi

L-methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an L-amino acid.1 Publication

Cofactori

GO - Molecular functioni

  • methionine-oxo-acid transaminase activity Source: EcoCyc
  • pyridoxal phosphate binding Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciEcoCyc:G6329-MONOMER
MetaCyc:G6329-MONOMER
BRENDAi2.6.1.88 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminotransferase (EC:2.6.1.88)
Alternative name(s):
Methionine-oxo-acid transaminase
Gene namesi
Name:ybdL
Ordered Locus Names:b0600, JW0593
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13531 ybdL

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239251 – 386Methionine aminotransferaseAdd BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236N6-(pyridoxal phosphate)lysine1

Proteomic databases

PaxDbiP77806
PRIDEiP77806

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi4260981, 15 interactors
DIPiDIP-11350N
IntActiP77806, 14 interactors
STRINGi316385.ECDH10B_0669

Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP77806
SMRiP77806
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77806

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHM Bacteria
COG0436 LUCA
HOGENOMiHOG000223045
InParanoidiP77806
KOiK14287
PhylomeDBiP77806

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

P77806-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNNPLIPQS KLPQLGTTIF TQMSALAQQH QAINLSQGFP DFDGPRYLQE
60 70 80 90 100
RLAHHVAQGA NQYAPMTGVQ ALREAIAQKT ERLYGYQPDA DSDITVTAGA
110 120 130 140 150
TEALYAAITA LVRNGDEVIC FDPSYDSYAP AIALSGGIVK RMALQPPHFR
160 170 180 190 200
VDWQEFAALL SERTRLVILN TPHNPSATVW QQADFAALWQ AIAGHEIFVI
210 220 230 240 250
SDEVYEHINF SQQGHASVLA HPQLRERAVA VSSFGKTYHM TGWKVGYCVA
260 270 280 290 300
PAPISAEIRK VHQYLTFSVN TPAQLALADM LRAEPEHYLA LPDFYRQKRD
310 320 330 340 350
ILVNALNESR LEILPCEGTY FLLVDYSAVS TLDDVEFCQW LTQEHGVAAI
360 370 380
PLSVFCADPF PHKLIRLCFA KKESTLLAAA ERLRQL
Length:386
Mass (Da):42,963
Last modified:February 1, 1997 - v1
Checksum:iA95A782EA910B13F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA Translation: AAB40801.1
U00096 Genomic DNA Translation: AAC73701.1
AP009048 Genomic DNA Translation: BAA35230.1
PIRiF64793
RefSeqiNP_415133.1, NC_000913.3
WP_000183907.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73701; AAC73701; b0600
BAA35230; BAA35230; BAA35230
GeneIDi945211
KEGGiecj:JW0593
eco:b0600
PATRICifig|1411691.4.peg.1668

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA Translation: AAB40801.1
U00096 Genomic DNA Translation: AAC73701.1
AP009048 Genomic DNA Translation: BAA35230.1
PIRiF64793
RefSeqiNP_415133.1, NC_000913.3
WP_000183907.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U08X-ray2.35A/B1-386[»]
ProteinModelPortaliP77806
SMRiP77806
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260981, 15 interactors
DIPiDIP-11350N
IntActiP77806, 14 interactors
STRINGi316385.ECDH10B_0669

Proteomic databases

PaxDbiP77806
PRIDEiP77806

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73701; AAC73701; b0600
BAA35230; BAA35230; BAA35230
GeneIDi945211
KEGGiecj:JW0593
eco:b0600
PATRICifig|1411691.4.peg.1668

Organism-specific databases

EchoBASEiEB3302
EcoGeneiEG13531 ybdL

Phylogenomic databases

eggNOGiENOG4105CHM Bacteria
COG0436 LUCA
HOGENOMiHOG000223045
InParanoidiP77806
KOiK14287
PhylomeDBiP77806

Enzyme and pathway databases

BioCyciEcoCyc:G6329-MONOMER
MetaCyc:G6329-MONOMER
BRENDAi2.6.1.88 2026

Miscellaneous databases

EvolutionaryTraceiP77806
PROiPR:P77806

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYBDL_ECOLI
AccessioniPrimary (citable) accession number: P77806
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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