UniProtKB - P77806 (YBDL_ECOLI)
Protein
Methionine aminotransferase
Gene
ybdL
Organism
Escherichia coli (strain K12)
Status
Functioni
Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine.1 Publication
Catalytic activityi
- a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-α-amino acid1 PublicationEC:2.6.1.881 Publication
Cofactori
GO - Molecular functioni
- kynurenine-oxoglutarate transaminase activity Source: GO_Central
- methionine-oxo-acid transaminase activity Source: EcoCyc
- pyridoxal phosphate binding Source: EcoCyc
GO - Biological processi
- biosynthetic process Source: InterPro
Keywordsi
Molecular function | Aminotransferase, Transferase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BioCyci | EcoCyc:G6329-MONOMER MetaCyc:G6329-MONOMER |
BRENDAi | 2.6.1.88, 2026 |
Names & Taxonomyi
Protein namesi | Recommended name: Methionine aminotransferase (EC:2.6.1.88)Alternative name(s): Methionine-oxo-acid transaminase |
Gene namesi | Name:ybdL Ordered Locus Names:b0600, JW0593 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123925 | 1 – 386 | Methionine aminotransferaseAdd BLAST | 386 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 236 | N6-(pyridoxal phosphate)lysine | 1 |
Proteomic databases
PaxDbi | P77806 |
PRIDEi | P77806 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationBinary interactionsi
Hide detailsP77806
With | #Exp. | IntAct |
---|---|---|
adk [P69441] | 3 | EBI-543661,EBI-543592 |
cyoB [P0ABI8] | 3 | EBI-543661,EBI-2932021 |
dnaE [P10443] | 3 | EBI-543661,EBI-549111 |
fixX [P68646] | 3 | EBI-543661,EBI-1113234 |
Protein-protein interaction databases
BioGRIDi | 4260981, 15 interactors 849596, 9 interactors |
DIPi | DIP-11350N |
IntActi | P77806, 14 interactors |
STRINGi | 511145.b0600 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P77806 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P77806 |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.Curated
Phylogenomic databases
eggNOGi | COG0436, Bacteria |
HOGENOMi | CLU_017584_4_0_6 |
InParanoidi | P77806 |
PhylomeDBi | P77806 |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
i Sequence
Sequence statusi: Complete.
P77806-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNNPLIPQS KLPQLGTTIF TQMSALAQQH QAINLSQGFP DFDGPRYLQE
60 70 80 90 100
RLAHHVAQGA NQYAPMTGVQ ALREAIAQKT ERLYGYQPDA DSDITVTAGA
110 120 130 140 150
TEALYAAITA LVRNGDEVIC FDPSYDSYAP AIALSGGIVK RMALQPPHFR
160 170 180 190 200
VDWQEFAALL SERTRLVILN TPHNPSATVW QQADFAALWQ AIAGHEIFVI
210 220 230 240 250
SDEVYEHINF SQQGHASVLA HPQLRERAVA VSSFGKTYHM TGWKVGYCVA
260 270 280 290 300
PAPISAEIRK VHQYLTFSVN TPAQLALADM LRAEPEHYLA LPDFYRQKRD
310 320 330 340 350
ILVNALNESR LEILPCEGTY FLLVDYSAVS TLDDVEFCQW LTQEHGVAAI
360 370 380
PLSVFCADPF PHKLIRLCFA KKESTLLAAA ERLRQL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82598 Genomic DNA Translation: AAB40801.1 U00096 Genomic DNA Translation: AAC73701.1 AP009048 Genomic DNA Translation: BAA35230.1 |
PIRi | F64793 |
RefSeqi | NP_415133.1, NC_000913.3 WP_000183907.1, NZ_SSZK01000032.1 |
Genome annotation databases
EnsemblBacteriai | AAC73701; AAC73701; b0600 BAA35230; BAA35230; BAA35230 |
GeneIDi | 945211 |
KEGGi | ecj:JW0593 eco:b0600 |
PATRICi | fig|1411691.4.peg.1668 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82598 Genomic DNA Translation: AAB40801.1 U00096 Genomic DNA Translation: AAC73701.1 AP009048 Genomic DNA Translation: BAA35230.1 |
PIRi | F64793 |
RefSeqi | NP_415133.1, NC_000913.3 WP_000183907.1, NZ_SSZK01000032.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1U08 | X-ray | 2.35 | A/B | 1-386 | [»] | |
SMRi | P77806 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260981, 15 interactors 849596, 9 interactors |
DIPi | DIP-11350N |
IntActi | P77806, 14 interactors |
STRINGi | 511145.b0600 |
Proteomic databases
PaxDbi | P77806 |
PRIDEi | P77806 |
Genome annotation databases
EnsemblBacteriai | AAC73701; AAC73701; b0600 BAA35230; BAA35230; BAA35230 |
GeneIDi | 945211 |
KEGGi | ecj:JW0593 eco:b0600 |
PATRICi | fig|1411691.4.peg.1668 |
Organism-specific databases
EchoBASEi | EB3302 |
Phylogenomic databases
eggNOGi | COG0436, Bacteria |
HOGENOMi | CLU_017584_4_0_6 |
InParanoidi | P77806 |
PhylomeDBi | P77806 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6329-MONOMER MetaCyc:G6329-MONOMER |
BRENDAi | 2.6.1.88, 2026 |
Miscellaneous databases
EvolutionaryTracei | P77806 |
PROi | PR:P77806 |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YBDL_ECOLI | |
Accessioni | P77806Primary (citable) accession number: P77806 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families