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UniProtKB - P77783 (YNFF_ECOLI)

Entry version 175 (10 Feb 2021)
Sequence version 4 (22 Jul 2008)
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Protein

Probable dimethyl sulfoxide reductase chain YnfF

Gene

ynfF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi59Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi63Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi67Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi99Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi195MolybdenumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:G6846-MONOMER
MetaCyc:G6846-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		5.A.3.3.1, the prokaryotic molybdopterin-containing oxidoreductase (pmo) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable dimethyl sulfoxide reductase chain YnfF (EC:1.8.99.-)
Short name:
DMSO reductase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ynfF
Ordered Locus Names:b1588, JW5260
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 45Tat-type signalPROSITE-ProRule annotationAdd BLAST45
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001914846 – 807Probable dimethyl sulfoxide reductase chain YnfFAdd BLAST762

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Can also be exported by the Sec system.

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P77783

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P77783

PRoteomics IDEntifications database

More...PRIDEi		P77783

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The complex consists of three subunits: YnfF, the reductase; YnfG, an electron transfer protein, and YnfH, a membrane anchor protein.

Curated

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4259130, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6019, Putative dimethyl sulfoxide reductase

Database of interacting proteins

More...DIPi		DIP-12766N

Protein interaction database and analysis system

More...IntActi		P77783, 2 interactors

STRING: functional protein association networks

More...STRINGi		511145.b1588

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P77783

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 1134Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST62

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0243, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000422_13_3_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P77783

Database for complete collections of gene phylogenies

More...PhylomeDBi		P77783

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011888, Anaer_DMSO_reductase
IPR009010, Asp_de-COase-like_dom_sf
IPR006657, MoPterin_dinucl-bd_dom
IPR006656, Mopterin_OxRdtase
IPR006963, Mopterin_OxRdtase_4Fe-4S_dom
IPR006655, Mopterin_OxRdtase_prok_CS
IPR027467, MopterinOxRdtase_cofactor_BS
IPR006311, TAT_signal

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04879, Molybdop_Fe4S4, 1 hit
PF00384, Molybdopterin, 1 hit
PF01568, Molydop_binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00926, Molybdop_Fe4S4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50692, SSF50692, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02166, dmsA_ynfE, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51669, 4FE4S_MOW_BIS_MGD, 1 hit
PS00551, MOLYBDOPTERIN_PROK_1, 1 hit
PS00932, MOLYBDOPTERIN_PROK_3, 1 hit
PS51318, TAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P77783-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIHTTEALM KAEISRRSLM KTSALGSLAL ASSAFTLPFS QMVRAAEAPV 
        60         70         80         90        100
EEKAVWSSCT VNCGSRCLLR LHVKDDTVYW VESDTTGDDV YGNHQVRACL 
       110        120        130        140        150
RGRSIRRRMN HPDRLKYPMK RVGKRGEGKF ERISWDEALD TISDNLRRIL 
       160        170        180        190        200
KDYGNEAVHV LYGTGVDGGN ITNSNVPYRL MNSCGGFLSR YGSYSTAQIS 
       210        220        230        240        250
AAMSYMFGAN DGNSPDDIAN TKLVVMFGNN PAETRMSGGG VTYYVEQARE 
       260        270        280        290        300
RSNARMIVID PRYNDTAAGR EDEWLPIRPG TDGALACAIA WVLITENMVD 
       310        320        330        340        350
QPFLDKYCVG YDEKTLPANA PRNAHYKAYI LGEGPDGIAK TPEWAAKITS 
       360        370        380        390        400
IPAEKIIQLA REIGSAKPAY ICQGWGPQRH SNGEQTSRAI AMLSVLTGNV 
       410        420        430        440        450
GINGGNSGVR EGSWDLGVEW FPMLENPVKT QISVFTWTDA IDHGTEMTAT 
       460        470        480        490        500
RDGVRGKEKL DVPIKFLWCY ASNTLINQHG DINHTHEVLQ DDSKCEMIVG 
       510        520        530        540        550
IDHFMTASAK YCDILLPDLM PTEQEDLISH ESAGNMGYVI LAQPATSAKF 
       560        570        580        590        600
ERKPIYWMLS EVAKRLGPDV YQTFTEGRSQ HEWIKYLHAK TKERNPEMPD 
       610        620        630        640        650
YEEMKTTGIF KKKCPEEHYV AFRAFREDPQ ANPLKTPSGK IEIYSERLAK 
       660        670        680        690        700
IADTWELKKD EIIHPLPAYT PGFDGWDDPL RKTYPLQLTG FHYKARTHSS 
       710        720        730        740        750
YGNIDVLQQA CPQEVWINPI DAQARGIRHG DTVRVFNNNG EMLIAAKVTP 
       760        770        780        790        800
RILPGVTAIG QGAWLKADMF GDRVDHGGSI NILTSHRPSP LAKGNPSHSN 

LVQIEKV
Length:807
Mass (Da):89,987
Last modified:July 22, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8120594A8C5816C5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74660.4
AP009048 Genomic DNA Translation: BAA15312.2

Protein sequence database of the Protein Information Resource

More...PIRi		F64914

NCBI Reference Sequences

More...RefSeqi		NP_416105.4, NC_000913.3
WP_001340362.1, NZ_SSZK01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74660; AAC74660; b1588
BAA15312; BAA15312; BAA15312

Database of genes from NCBI RefSeq genomes

More...GeneIDi		945268

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW5260
eco:b1588

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|511145.12.peg.1659

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74660.4
AP009048 Genomic DNA Translation: BAA15312.2
PIRiF64914
RefSeqiNP_416105.4, NC_000913.3
WP_001340362.1, NZ_SSZK01000001.1

3D structure databases

SMRiP77783
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4259130, 9 interactors
ComplexPortaliCPX-6019, Putative dimethyl sulfoxide reductase
DIPiDIP-12766N
IntActiP77783, 2 interactors
STRINGi511145.b1588

Protein family/group databases

TCDBi5.A.3.3.1, the prokaryotic molybdopterin-containing oxidoreductase (pmo) family

Proteomic databases

jPOSTiP77783
PaxDbiP77783
PRIDEiP77783

Genome annotation databases

EnsemblBacteriaiAAC74660; AAC74660; b1588
BAA15312; BAA15312; BAA15312
GeneIDi945268
KEGGiecj:JW5260
eco:b1588
PATRICifig|511145.12.peg.1659

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB3605

Phylogenomic databases

eggNOGiCOG0243, Bacteria
HOGENOMiCLU_000422_13_3_6
InParanoidiP77783
PhylomeDBiP77783

Enzyme and pathway databases

BioCyciEcoCyc:G6846-MONOMER
MetaCyc:G6846-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P77783

Family and domain databases

InterProiView protein in InterPro
IPR011888, Anaer_DMSO_reductase
IPR009010, Asp_de-COase-like_dom_sf
IPR006657, MoPterin_dinucl-bd_dom
IPR006656, Mopterin_OxRdtase
IPR006963, Mopterin_OxRdtase_4Fe-4S_dom
IPR006655, Mopterin_OxRdtase_prok_CS
IPR027467, MopterinOxRdtase_cofactor_BS
IPR006311, TAT_signal
PfamiView protein in Pfam
PF04879, Molybdop_Fe4S4, 1 hit
PF00384, Molybdopterin, 1 hit
PF01568, Molydop_binding, 1 hit
SMARTiView protein in SMART
SM00926, Molybdop_Fe4S4, 1 hit
SUPFAMiSSF50692, SSF50692, 1 hit
TIGRFAMsiTIGR02166, dmsA_ynfE, 1 hit
PROSITEiView protein in PROSITE
PS51669, 4FE4S_MOW_BIS_MGD, 1 hit
PS00551, MOLYBDOPTERIN_PROK_1, 1 hit
PS00932, MOLYBDOPTERIN_PROK_3, 1 hit
PS51318, TAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYNFF_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P77783
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 22, 2008
Last modified: February 10, 2021
This is version 175 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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