UniProtKB - P77756 (QUEC_ECOLI)
Protein
7-cyano-7-deazaguanine synthase
Gene
queC
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).By similarity1 Publication
Catalytic activityi
- EC:6.3.4.20
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
: 7-cyano-7-deazaguanine biosynthesis Pathwayi
This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 188 | ZincBy similarity | 1 | |
Metal bindingi | 197 | ZincBy similarity | 1 | |
Metal bindingi | 200 | ZincBy similarity | 1 | |
Metal bindingi | 203 | ZincBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 8 – 18 | ATPBy similarityAdd BLAST | 11 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- ligase activity, forming carbon-nitrogen bonds Source: UniProtKB-UniRule
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- queuosine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Ligase |
Biological process | Queuosine biosynthesis |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BioCyci | EcoCyc:G6245-MONOMER MetaCyc:G6245-MONOMER |
UniPathwayi | UPA00391 |
Names & Taxonomyi
Protein namesi | Recommended name: 7-cyano-7-deazaguanine synthase (EC:6.3.4.20)Alternative name(s): 7-cyano-7-carbaguanine synthase PreQ(0) synthase Queuosine biosynthesis protein QueC |
Gene namesi | Name:queC Synonyms:ybaX Ordered Locus Names:b0444, JW0434 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168631 | 1 – 231 | 7-cyano-7-deazaguanine synthaseAdd BLAST | 231 |
Proteomic databases
jPOSTi | P77756 |
PaxDbi | P77756 |
PRIDEi | P77756 |
Interactioni
Binary interactionsi
P77756
With | #Exp. | IntAct |
---|---|---|
tufA [P0CE47] | 3 | EBI-560024,EBI-301077 |
Protein-protein interaction databases
BioGRIDi | 4262187, 62 interactors |
DIPi | DIP-11311N |
IntActi | P77756, 14 interactors |
STRINGi | 511145.b0444 |
Family & Domainsi
Sequence similaritiesi
Belongs to the QueC family.Curated
Phylogenomic databases
eggNOGi | COG0603, Bacteria |
HOGENOMi | CLU_081854_0_0_6 |
InParanoidi | P77756 |
PhylomeDBi | P77756 |
Family and domain databases
CDDi | cd01995, ExsB, 1 hit |
Gene3Di | 3.40.50.620, 1 hit |
HAMAPi | MF_01633, QueC, 1 hit |
InterProi | View protein in InterPro IPR018317, QueC IPR014729, Rossmann-like_a/b/a_fold |
PANTHERi | PTHR42914, PTHR42914, 1 hit |
Pfami | View protein in Pfam PF06508, QueC, 1 hit |
PIRSFi | PIRSF006293, ExsB, 1 hit |
TIGRFAMsi | TIGR00364, TIGR00364, 1 hit |
i Sequence
Sequence statusi: Complete.
P77756-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRAVVVFSG GQDSTTCLVQ ALQQYDEVHC VTFDYGQRHR AEIDVARELA
60 70 80 90 100
LKLGARAHKV LDVTLLNELA VSSLTRDSIP VPDYEPEADG IPNTFVPGRN
110 120 130 140 150
ILFLTLAAIY AYQVKAEAVI TGVCETDFSG YPDCRDEFVK ALNHAVSLGM
160 170 180 190 200
AKDIRFETPL MWIDKAETWA LADYYGKLDL VRNETLTCYN GFKGDGCGHC
210 220 230
AACNLRANGL NHYLADKPTV MAAMKQKTGL R
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D82943 Genomic DNA Translation: BAA11648.1 U82664 Genomic DNA Translation: AAB40200.1 U00096 Genomic DNA Translation: AAC73547.1 AP009048 Genomic DNA Translation: BAE76224.1 |
PIRi | D64774 |
RefSeqi | NP_414978.1, NC_000913.3 WP_000817220.1, NZ_SSZK01000009.1 |
Genome annotation databases
EnsemblBacteriai | AAC73547; AAC73547; b0444 BAE76224; BAE76224; BAE76224 |
GeneIDi | 947034 |
KEGGi | ecj:JW0434 eco:b0444 |
PATRICi | fig|1411691.4.peg.1832 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D82943 Genomic DNA Translation: BAA11648.1 U82664 Genomic DNA Translation: AAB40200.1 U00096 Genomic DNA Translation: AAC73547.1 AP009048 Genomic DNA Translation: BAE76224.1 |
PIRi | D64774 |
RefSeqi | NP_414978.1, NC_000913.3 WP_000817220.1, NZ_SSZK01000009.1 |
3D structure databases
SMRi | P77756 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262187, 62 interactors |
DIPi | DIP-11311N |
IntActi | P77756, 14 interactors |
STRINGi | 511145.b0444 |
Proteomic databases
jPOSTi | P77756 |
PaxDbi | P77756 |
PRIDEi | P77756 |
Genome annotation databases
EnsemblBacteriai | AAC73547; AAC73547; b0444 BAE76224; BAE76224; BAE76224 |
GeneIDi | 947034 |
KEGGi | ecj:JW0434 eco:b0444 |
PATRICi | fig|1411691.4.peg.1832 |
Organism-specific databases
EchoBASEi | EB3041 |
Phylogenomic databases
eggNOGi | COG0603, Bacteria |
HOGENOMi | CLU_081854_0_0_6 |
InParanoidi | P77756 |
PhylomeDBi | P77756 |
Enzyme and pathway databases
UniPathwayi | UPA00391 |
BioCyci | EcoCyc:G6245-MONOMER MetaCyc:G6245-MONOMER |
Miscellaneous databases
PROi | PR:P77756 |
Family and domain databases
CDDi | cd01995, ExsB, 1 hit |
Gene3Di | 3.40.50.620, 1 hit |
HAMAPi | MF_01633, QueC, 1 hit |
InterProi | View protein in InterPro IPR018317, QueC IPR014729, Rossmann-like_a/b/a_fold |
PANTHERi | PTHR42914, PTHR42914, 1 hit |
Pfami | View protein in Pfam PF06508, QueC, 1 hit |
PIRSFi | PIRSF006293, ExsB, 1 hit |
TIGRFAMsi | TIGR00364, TIGR00364, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | QUEC_ECOLI | |
Accessioni | P77756Primary (citable) accession number: P77756 Secondary accession number(s): Q2MBY2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families