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Entry version 156 (13 Nov 2019)
Sequence version 1 (01 Feb 1997)
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Protein

Propionate catabolism operon regulatory protein

Gene

prpR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the transcriptional regulation of the propionate catabolism operon.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi318 – 327ATPPROSITE-ProRule annotation10
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi508 – 527H-T-H motifBy similarityAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:G6195-MONOMER
ECOL316407:JW0322-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Propionate catabolism operon regulatory protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prpR
Synonyms:yahP
Ordered Locus Names:b0330, JW0322
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000813241 – 528Propionate catabolism operon regulatory proteinAdd BLAST528

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P77743

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P77743

PRoteomics IDEntifications database

More...
PRIDEi
P77743

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4259807, 13 interactors

Database of interacting proteins

More...
DIPi
DIP-10582N

Protein interaction database and analysis system

More...
IntActi
P77743, 1 interactor

STRING: functional protein association networks

More...
STRINGi
511145.b0330

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1528
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P77743

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P77743

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini218 – 461Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST244

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108JU7 Bacteria
COG1221 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000058487

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P77743

KEGG Orthology (KO)

More...
KOi
K02688

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P77743

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR009057 Homeobox-like_sf
IPR002197 HTH_Fis
IPR027417 P-loop_NTPase
IPR012704 Sig_transdc_resp-reg_PrpR
IPR010524 Sig_transdc_resp-reg_PrpR_N
IPR002078 Sigma_54_int
IPR025943 Sigma_54_int_dom_ATP-bd_2
IPR025944 Sigma_54_int_dom_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02954 HTH_8, 1 hit
PF06506 PrpR_N, 1 hit
PF00158 Sigma54_activat, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02329 propionate_PrpR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00676 SIGMA54_INTERACT_2, 1 hit
PS00688 SIGMA54_INTERACT_3, 1 hit
PS50045 SIGMA54_INTERACT_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P77743-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHPPRLNDD KPVIWTVSVT RLFELFRDIS LEFDHLANIT PIQLGFEKAV
60 70 80 90 100
TYIRKKLANE RCDAIIAAGS NGAYLKSRLS VPVILIKPSG YDVLQALAKA
110 120 130 140 150
GKLTSSIGVV TYQETIPALV AFQKTFNLRL DQRSYITEED ARGQINELKA
160 170 180 190 200
NGTEAVVGAG LITDLAEEAG MTGIFIYSAA TVRQAFSDAL DMTRMSLRHN
210 220 230 240 250
THDATRNALR TRYVLGDMLG QSPQMEQVRQ TILLYARSSA AVLIEGETGT
260 270 280 290 300
GKELAAQAIH REYFARHDAR QGKKSHPFVA VNCGAIAESL LEAELFGYEE
310 320 330 340 350
GAFTGSRRGG RAGLFEIAHG GTLFLDEIGE MPLPLQTRLL RVLEEKEVTR
360 370 380 390 400
VGGHQPVPVD VRVISATHCN LEEDMQQGRF RRDLFYRLSI LRLQLPPLRE
410 420 430 440 450
RVADILPLAE SFLKVSLAAL SAPFSAALRQ GLQASETVLL HYDWPGNIRE
460 470 480 490 500
LRNMMERLAL FLSVEPTPDL TPQFMQLLLP ELARESAKTP APRLLTPQQA
510 520
LEKFNGDKTA AANYLGISRT TFWRRLKS
Length:528
Mass (Da):58,649
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EAFD1F55D96E8FF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U73857 Genomic DNA Translation: AAB18054.1
U00096 Genomic DNA Translation: AAC73433.1
AP009048 Genomic DNA Translation: BAE76113.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B64760

NCBI Reference Sequences

More...
RefSeqi
NP_414864.1, NC_000913.3
WP_000941041.1, NZ_SSZK01000063.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73433; AAC73433; b0330
BAE76113; BAE76113; BAE76113

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
944987

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0322
eco:b0330

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1946

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA Translation: AAB18054.1
U00096 Genomic DNA Translation: AAC73433.1
AP009048 Genomic DNA Translation: BAE76113.1
PIRiB64760
RefSeqiNP_414864.1, NC_000913.3
WP_000941041.1, NZ_SSZK01000063.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PJUX-ray2.10A/B/C/D2-215[»]
SMRiP77743
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4259807, 13 interactors
DIPiDIP-10582N
IntActiP77743, 1 interactor
STRINGi511145.b0330

Proteomic databases

jPOSTiP77743
PaxDbiP77743
PRIDEiP77743

Genome annotation databases

EnsemblBacteriaiAAC73433; AAC73433; b0330
BAE76113; BAE76113; BAE76113
GeneIDi944987
KEGGiecj:JW0322
eco:b0330
PATRICifig|1411691.4.peg.1946

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3369

Phylogenomic databases

eggNOGiENOG4108JU7 Bacteria
COG1221 LUCA
HOGENOMiHOG000058487
InParanoidiP77743
KOiK02688
PhylomeDBiP77743

Enzyme and pathway databases

BioCyciEcoCyc:G6195-MONOMER
ECOL316407:JW0322-MONOMER

Miscellaneous databases

EvolutionaryTraceiP77743

Protein Ontology

More...
PROi
PR:P77743

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR009057 Homeobox-like_sf
IPR002197 HTH_Fis
IPR027417 P-loop_NTPase
IPR012704 Sig_transdc_resp-reg_PrpR
IPR010524 Sig_transdc_resp-reg_PrpR_N
IPR002078 Sigma_54_int
IPR025943 Sigma_54_int_dom_ATP-bd_2
IPR025944 Sigma_54_int_dom_CS
PfamiView protein in Pfam
PF02954 HTH_8, 1 hit
PF06506 PrpR_N, 1 hit
PF00158 Sigma54_activat, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02329 propionate_PrpR, 1 hit
PROSITEiView protein in PROSITE
PS00676 SIGMA54_INTERACT_2, 1 hit
PS00688 SIGMA54_INTERACT_3, 1 hit
PS50045 SIGMA54_INTERACT_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRPR_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P77743
Secondary accession number(s): Q2MC93
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 13, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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