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Protein

FeS cluster assembly protein SufD

Gene

sufD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. Required for the stability of the FhuF protein.2 Publications

GO - Biological processi

  • iron-sulfur cluster assembly Source: EcoCyc
  • response to oxidative stress Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G6907-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
FeS cluster assembly protein SufD
Gene namesi
Name:sufD
Synonyms:ynhC
Ordered Locus Names:b1681, JW1671
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13963 sufD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001473751 – 423FeS cluster assembly protein SufDAdd BLAST423

Proteomic databases

PaxDbiP77689
PRIDEiP77689

Interactioni

Subunit structurei

Part of the SufBCD complex that contains SufB, SufC and SufD. Can form homodimers.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4260280, 82 interactors
ComplexPortaliCPX-2123 SufBCD complex
DIPiDIP-10940N
IntActiP77689, 8 interactors
MINTiP77689
STRINGi316385.ECDH10B_1815

Structurei

Secondary structure

1423
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 19Combined sources10
Helixi27 – 39Combined sources13
Beta strandi50 – 52Combined sources3
Helixi55 – 58Combined sources4
Beta strandi59 – 63Combined sources5
Helixi71 – 77Combined sources7
Beta strandi83 – 89Combined sources7
Helixi95 – 97Combined sources3
Turni102 – 105Combined sources4
Beta strandi107 – 112Combined sources6
Helixi125 – 133Combined sources9
Beta strandi137 – 142Combined sources6
Beta strandi152 – 158Combined sources7
Beta strandi162 – 164Combined sources3
Beta strandi166 – 177Combined sources12
Beta strandi182 – 195Combined sources14
Beta strandi197 – 207Combined sources11
Beta strandi212 – 219Combined sources8
Beta strandi226 – 235Combined sources10
Beta strandi240 – 247Combined sources8
Beta strandi251 – 261Combined sources11
Beta strandi263 – 265Combined sources3
Beta strandi267 – 274Combined sources8
Beta strandi281 – 290Combined sources10
Beta strandi292 – 294Combined sources3
Beta strandi296 – 305Combined sources10
Beta strandi310 – 319Combined sources10
Beta strandi326 – 336Combined sources11
Beta strandi338 – 340Combined sources3
Beta strandi342 – 351Combined sources10
Beta strandi354 – 365Combined sources12
Helixi369 – 377Combined sources9
Helixi382 – 398Combined sources17
Helixi399 – 401Combined sources3
Helixi404 – 415Combined sources12
Turni419 – 421Combined sources3

3D structure databases

ProteinModelPortaliP77689
SMRiP77689
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77689

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0051 (ycf24) family.Curated

Phylogenomic databases

eggNOGiENOG4105JRK Bacteria
COG0719 LUCA
HOGENOMiHOG000069113
InParanoidiP77689
KOiK09015
OMAiCSHGCTI
PhylomeDBiP77689

Family and domain databases

InterProiView protein in InterPro
IPR000825 SUF_FeS_clus_asmbl_SufBD
IPR037284 SUF_FeS_clus_asmbl_SufBD_sf
IPR011542 SUF_FeS_clus_asmbl_SufD
PANTHERiPTHR43575 PTHR43575, 1 hit
PfamiView protein in Pfam
PF01458 UPF0051, 1 hit
SUPFAMiSSF101960 SSF101960, 1 hit
TIGRFAMsiTIGR01981 sufD, 1 hit

Sequencei

Sequence statusi: Complete.

P77689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLPNSSNA LQQWHHLFEA EGTKRSPQAQ QHLQQLLRTG LPTRKHENWK
60 70 80 90 100
YTPLEGLINS QFVSIAGEIS PQQRDALALT LDSVRLVFVD GRYVPALSDA
110 120 130 140 150
TEGSGYEVSI NDDRQGLPDA IQAEVFLHLT ESLAQSVTHI AVKRGQRPAK
160 170 180 190 200
PLLLMHITQG VAGEEVNTAH YRHHLDLAEG AEATVIEHFV SLNDARHFTG
210 220 230 240 250
ARFTINVAAN AHLQHIKLAF ENPLSHHFAH NDLLLAEDAT AFSHSFLLGG
260 270 280 290 300
AVLRHNTSTQ LNGENSTLRI NSLAMPVKNE VCDTRTWLEH NKGFCNSRQL
310 320 330 340 350
HKTIVSDKGR AVFNGLINVA QHAIKTDGQM TNNNLLMGKL AEVDTKPQLE
360 370 380 390 400
IYADDVKCSH GATVGRIDDE QIFYLRSRGI NQQDAQQMII YAFAAELTEA
410 420
LRDEGLKQQV LARIGQRLPG GAR
Length:423
Mass (Da):46,823
Last modified:February 1, 1997 - v1
Checksum:i5744291F1E0AE825
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74751.1
AP009048 Genomic DNA Translation: BAA15456.1
PIRiA64926
RefSeqiNP_416196.1, NC_000913.3
WP_000907979.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74751; AAC74751; b1681
BAA15456; BAA15456; BAA15456
GeneIDi944878
KEGGiecj:JW1671
eco:b1681
PATRICifig|1411691.4.peg.577

Similar proteinsi

Entry informationi

Entry nameiSUFD_ECOLI
AccessioniPrimary (citable) accession number: P77689
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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