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Protein

FeS cluster assembly protein SufD

Gene

sufD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. Required for the stability of the FhuF protein.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • iron-sulfur cluster assembly Source: EcoCyc
  • response to oxidative stress Source: EcoCyc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
EcoCyc:G6907-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FeS cluster assembly protein SufD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sufD
Synonyms:ynhC
Ordered Locus Names:b1681, JW1671
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

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EcoGenei
EG13963 sufD

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001473751 – 423FeS cluster assembly protein SufDAdd BLAST423

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P77689

PRoteomics IDEntifications database

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PRIDEi
P77689

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the SufBCD complex that contains SufB, SufC and SufD. Can form homodimers.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
4260280, 82 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-2123 SufBCD complex

Database of interacting proteins

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DIPi
DIP-10940N

Protein interaction database and analysis system

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IntActi
P77689, 8 interactors

Molecular INTeraction database

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MINTi
P77689

STRING: functional protein association networks

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STRINGi
316385.ECDH10B_1815

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1423
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P77689

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P77689

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P77689

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0051 (ycf24) family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4105JRK Bacteria
COG0719 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000069113

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P77689

KEGG Orthology (KO)

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KOi
K09015

Database for complete collections of gene phylogenies

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PhylomeDBi
P77689

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000825 SUF_FeS_clus_asmbl_SufBD
IPR037284 SUF_FeS_clus_asmbl_SufBD_sf
IPR011542 SUF_FeS_clus_asmbl_SufD

The PANTHER Classification System

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PANTHERi
PTHR43575 PTHR43575, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01458 UPF0051, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF101960 SSF101960, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01981 sufD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P77689-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGLPNSSNA LQQWHHLFEA EGTKRSPQAQ QHLQQLLRTG LPTRKHENWK
60 70 80 90 100
YTPLEGLINS QFVSIAGEIS PQQRDALALT LDSVRLVFVD GRYVPALSDA
110 120 130 140 150
TEGSGYEVSI NDDRQGLPDA IQAEVFLHLT ESLAQSVTHI AVKRGQRPAK
160 170 180 190 200
PLLLMHITQG VAGEEVNTAH YRHHLDLAEG AEATVIEHFV SLNDARHFTG
210 220 230 240 250
ARFTINVAAN AHLQHIKLAF ENPLSHHFAH NDLLLAEDAT AFSHSFLLGG
260 270 280 290 300
AVLRHNTSTQ LNGENSTLRI NSLAMPVKNE VCDTRTWLEH NKGFCNSRQL
310 320 330 340 350
HKTIVSDKGR AVFNGLINVA QHAIKTDGQM TNNNLLMGKL AEVDTKPQLE
360 370 380 390 400
IYADDVKCSH GATVGRIDDE QIFYLRSRGI NQQDAQQMII YAFAAELTEA
410 420
LRDEGLKQQV LARIGQRLPG GAR
Length:423
Mass (Da):46,823
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5744291F1E0AE825
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74751.1
AP009048 Genomic DNA Translation: BAA15456.1

Protein sequence database of the Protein Information Resource

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PIRi
A64926

NCBI Reference Sequences

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RefSeqi
NP_416196.1, NC_000913.3
WP_000907979.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

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EnsemblBacteriai
AAC74751; AAC74751; b1681
BAA15456; BAA15456; BAA15456

Database of genes from NCBI RefSeq genomes

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GeneIDi
944878

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ecj:JW1671
eco:b1681

Pathosystems Resource Integration Center (PATRIC)

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PATRICi
fig|1411691.4.peg.577

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74751.1
AP009048 Genomic DNA Translation: BAA15456.1
PIRiA64926
RefSeqiNP_416196.1, NC_000913.3
WP_000907979.1, NZ_LN832404.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VH4X-ray1.75A/B1-423[»]
2ZU0X-ray2.20A/B1-423[»]
5AWFX-ray2.96B/F1-423[»]
5AWGX-ray4.28B/F1-423[»]
ProteinModelPortaliP77689
SMRiP77689
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260280, 82 interactors
ComplexPortaliCPX-2123 SufBCD complex
DIPiDIP-10940N
IntActiP77689, 8 interactors
MINTiP77689
STRINGi316385.ECDH10B_1815

Proteomic databases

PaxDbiP77689
PRIDEiP77689

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74751; AAC74751; b1681
BAA15456; BAA15456; BAA15456
GeneIDi944878
KEGGiecj:JW1671
eco:b1681
PATRICifig|1411691.4.peg.577

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3721
EcoGeneiEG13963 sufD

Phylogenomic databases

eggNOGiENOG4105JRK Bacteria
COG0719 LUCA
HOGENOMiHOG000069113
InParanoidiP77689
KOiK09015
PhylomeDBiP77689

Enzyme and pathway databases

BioCyciEcoCyc:G6907-MONOMER

Miscellaneous databases

EvolutionaryTraceiP77689

Protein Ontology

More...
PROi
PR:P77689

Family and domain databases

InterProiView protein in InterPro
IPR000825 SUF_FeS_clus_asmbl_SufBD
IPR037284 SUF_FeS_clus_asmbl_SufBD_sf
IPR011542 SUF_FeS_clus_asmbl_SufD
PANTHERiPTHR43575 PTHR43575, 1 hit
PfamiView protein in Pfam
PF01458 UPF0051, 1 hit
SUPFAMiSSF101960 SSF101960, 1 hit
TIGRFAMsiTIGR01981 sufD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUFD_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P77689
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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