UniProtKB - P77596 (YAGF_ECOLI)
Protein
D-xylonate dehydratase YagF
Gene
yagF
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the dehydration of D-xylonic acid to form 2-dehydro-3-deoxy-D-pentonate.1 Publication
Catalytic activityi
- EC:4.2.1.821 Publication
GO - Molecular functioni
- hydro-lyase activity Source: GO_Central
- xylonate dehydratase activity Source: EcoCyc
GO - Biological processi
- aldonic acid catabolic process Source: EcoCyc
Keywordsi
Molecular function | Lyase |
Enzyme and pathway databases
BioCyci | EcoCyc:G6141-MONOMER MetaCyc:G6141-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:yagF Ordered Locus Names:b0269, JW0262 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Disruption mutant has reduced ability to catabolize D-xylonic acid. YjhG-yagF double mutant cannot use D-xylonate as the sole source of carbon.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000103560 | 1 – 655 | D-xylonate dehydratase YagFAdd BLAST | 655 |
Proteomic databases
PaxDbi | P77596 |
PRIDEi | P77596 |
Expressioni
Inductioni
Expression is repressed by the transcriptional regulator XynR.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261825, 9 interactors |
STRINGi | 511145.b0269 |
Family & Domainsi
Sequence similaritiesi
Belongs to the IlvD/Edd family.Curated
Phylogenomic databases
eggNOGi | COG0129, Bacteria |
HOGENOMi | CLU_014271_5_0_6 |
PhylomeDBi | P77596 |
Family and domain databases
Gene3Di | 3.50.30.80, 1 hit |
InterProi | View protein in InterPro IPR017798, Dehydratase_YjhG/YagF IPR042096, Dihydro-acid_dehy_C IPR000581, DiOHA_6PGluconate_deHydtase IPR020558, DiOHA_6PGluconate_deHydtase_CS IPR037237, IlvD/EDD_N |
Pfami | View protein in Pfam PF00920, ILVD_EDD, 1 hit |
SUPFAMi | SSF143975, SSF143975, 1 hit |
TIGRFAMsi | TIGR03432, yjhG_yagF, 1 hit |
PROSITEi | View protein in PROSITE PS00886, ILVD_EDD_1, 1 hit PS00887, ILVD_EDD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P77596-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTIEKIFTPQ DDAFYAVITH AAGPQGALPL TPQMLMESPS GNLFGMTQNA
60 70 80 90 100
GMGWDANKLT GKEVLIIGTQ GGIRAGDGRP IALGYHTGHW EIGMQMQAAA
110 120 130 140 150
KEITRNGGIP FAAFVSDPCD GRSQGTHGMF DSLPYRNDAA IVFRRLIRSL
160 170 180 190 200
PTRRAVIGVA TCDKGLPATM IALAAMHDLP TILVPGGATL PPTVGEDAGK
210 220 230 240 250
VQTIGARFAN HELSLQEAAE LGCRACASPG GGCQFLGTAG TSQVVAEALG
260 270 280 290 300
LALPHSALAP SGQAVWLEIA RQSARAVSEL DSRGITTRDI LSDKAIENAM
310 320 330 340 350
VIHAAFGGST NLLLHIPAIA HAAGCTIPDV EHWTRINRKV PRLVSVLPNG
360 370 380 390 400
PDYHPTVRAF LAGGVPEVML HLRDLGLLHL DAMTVTGQTV GENLEWWQAS
410 420 430 440 450
ERRARFRQCL REQDGVEPDD VILPPEKAKA KGLTSTVCFP TGNIAPEGSV
460 470 480 490 500
IKATAIDPSV VGEDGVYHHT GRVRVFVSEA QAIKAIKREE IVQGDIMVVI
510 520 530 540 550
GGGPSGTGME ETYQLTSALK HISWGKTVSL ITDARFSGVS TGACFGHVSP
560 570 580 590 600
EALAGGPIGK LRDNDIIEIA VDRLTLTGSV NFIGTADNPL TPEEGARELA
610 620 630 640 650
RRQTHPDLHA HDFLPDDTRL WAALQSVSGG TWKGCIYDTD KIIEVINAGK
KALGI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70214 Genomic DNA Translation: AAB08690.1 U00096 Genomic DNA Translation: AAC73372.1 AP009048 Genomic DNA Translation: BAE76053.1 |
PIRi | E64752 |
RefSeqi | NP_414803.1, NC_000913.3 WP_000151261.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC73372; AAC73372; b0269 BAE76053; BAE76053; BAE76053 |
GeneIDi | 944928 |
KEGGi | ecj:JW0262 eco:b0269 |
PATRICi | fig|511145.12.peg.273 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70214 Genomic DNA Translation: AAB08690.1 U00096 Genomic DNA Translation: AAC73372.1 AP009048 Genomic DNA Translation: BAE76053.1 |
PIRi | E64752 |
RefSeqi | NP_414803.1, NC_000913.3 WP_000151261.1, NZ_LN832404.1 |
3D structure databases
SMRi | P77596 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261825, 9 interactors |
STRINGi | 511145.b0269 |
Proteomic databases
PaxDbi | P77596 |
PRIDEi | P77596 |
Genome annotation databases
EnsemblBacteriai | AAC73372; AAC73372; b0269 BAE76053; BAE76053; BAE76053 |
GeneIDi | 944928 |
KEGGi | ecj:JW0262 eco:b0269 |
PATRICi | fig|511145.12.peg.273 |
Organism-specific databases
EchoBASEi | EB3129 |
Phylogenomic databases
eggNOGi | COG0129, Bacteria |
HOGENOMi | CLU_014271_5_0_6 |
PhylomeDBi | P77596 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6141-MONOMER MetaCyc:G6141-MONOMER |
Miscellaneous databases
PROi | PR:P77596 |
Family and domain databases
Gene3Di | 3.50.30.80, 1 hit |
InterProi | View protein in InterPro IPR017798, Dehydratase_YjhG/YagF IPR042096, Dihydro-acid_dehy_C IPR000581, DiOHA_6PGluconate_deHydtase IPR020558, DiOHA_6PGluconate_deHydtase_CS IPR037237, IlvD/EDD_N |
Pfami | View protein in Pfam PF00920, ILVD_EDD, 1 hit |
SUPFAMi | SSF143975, SSF143975, 1 hit |
TIGRFAMsi | TIGR03432, yjhG_yagF, 1 hit |
PROSITEi | View protein in PROSITE PS00886, ILVD_EDD_1, 1 hit PS00887, ILVD_EDD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YAGF_ECOLI | |
Accessioni | P77596Primary (citable) accession number: P77596 Secondary accession number(s): Q2MCF3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families