UniProtKB - P77569 (MHPR_ECOLI)
Protein
DNA-binding transcriptional activator MhpR
Gene
mhpR
Organism
Escherichia coli (strain K12)
Status
Functioni
Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 34 – 53 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: GO_Central
- DNA-binding transcription factor activity Source: GO_Central
GO - Biological processi
- aromatic compound catabolic process Source: UniProtKB-KW
- negative regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Aromatic hydrocarbons catabolism, Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:G6201-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-binding transcriptional activator MhpRCuratedAlternative name(s): mhp operon transcriptional activator |
Gene namesi | Name:mhpR Ordered Locus Names:b0346, JW0337 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201763 | 1 – 277 | DNA-binding transcriptional activator MhpRAdd BLAST | 277 |
Proteomic databases
jPOSTi | P77569 |
PaxDbi | P77569 |
PRIDEi | P77569 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260667, 12 interactors |
DIPi | DIP-10211N |
IntActi | P77569, 4 interactors |
STRINGi | 511145.b0346 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 74 | HTH iclR-typePROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 89 – 262 | IclR-EDPROSITE-ProRule annotationAdd BLAST | 174 |
Phylogenomic databases
eggNOGi | COG1414, Bacteria |
HOGENOMi | CLU_062618_1_0_6 |
InParanoidi | P77569 |
PhylomeDBi | P77569 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.450.40, 1 hit |
InterProi | View protein in InterPro IPR029016, GAF-like_dom_sf IPR014757, Tscrpt_reg_IclR_C IPR005471, Tscrpt_reg_IclR_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF09339, HTH_IclR, 1 hit PF01614, IclR, 1 hit |
SMARTi | View protein in SMART SM00346, HTH_ICLR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51077, HTH_ICLR, 1 hit PS51078, ICLR_ED, 1 hit |
i Sequence
Sequence statusi: Complete.
P77569-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQNNEQTEYK TVRGLTRGLM LLNMLNKLDG GASVGLLAEL SGLHRTTVRR
60 70 80 90 100
LLETLQEEGY VRRSPSDDSF RLTIKVRQLS EGFRDEQWIS ALAAPLLGDL
110 120 130 140 150
LREVVWPTDV STLDVDAMVV RETTHRFSRL SFHRAMVGRR LPLLKTASGL
160 170 180 190 200
TWLAFCPEQD RKELIEMLAS RPGDDYQLAR EPLKLEAILA RARKEGYGQN
210 220 230 240 250
YRGWDQEEKI ASIAVPLRSE QRVIGCLNLV YMASAMTIEQ AAEKHLPALQ
260 270
RVAKQIEEGV ESQAILVAGR RSGMHLR
Sequence cautioni
The sequence AAB18070 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA13051 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAE76128 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA70746 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 249 | L → Q in BAA13051 (Ref. 2) Curated | 1 | |
Sequence conflicti | 256 – 277 | IEEGV…GMHLR → NRRRG in BAA13051 (Ref. 2) CuratedAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09555 Genomic DNA Translation: CAA70746.1 Different initiation. D86239 Genomic DNA Translation: BAA13051.1 Different initiation. U73857 Genomic DNA Translation: AAB18070.1 Different initiation. U00096 Genomic DNA Translation: AAC73449.2 AP009048 Genomic DNA Translation: BAE76128.1 Different initiation. |
PIRi | B64762 |
RefSeqi | NP_414880.2, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAC73449; AAC73449; b0346 BAE76128; BAE76128; BAE76128 |
GeneIDi | 945938 |
KEGGi | ecj:JW0337 eco:b0346 |
PATRICi | fig|1411691.4.peg.1932 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09555 Genomic DNA Translation: CAA70746.1 Different initiation. D86239 Genomic DNA Translation: BAA13051.1 Different initiation. U73857 Genomic DNA Translation: AAB18070.1 Different initiation. U00096 Genomic DNA Translation: AAC73449.2 AP009048 Genomic DNA Translation: BAE76128.1 Different initiation. |
PIRi | B64762 |
RefSeqi | NP_414880.2, NC_000913.3 |
3D structure databases
SMRi | P77569 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260667, 12 interactors |
DIPi | DIP-10211N |
IntActi | P77569, 4 interactors |
STRINGi | 511145.b0346 |
Proteomic databases
jPOSTi | P77569 |
PaxDbi | P77569 |
PRIDEi | P77569 |
Protocols and materials databases
DNASUi | 945938 |
Genome annotation databases
EnsemblBacteriai | AAC73449; AAC73449; b0346 BAE76128; BAE76128; BAE76128 |
GeneIDi | 945938 |
KEGGi | ecj:JW0337 eco:b0346 |
PATRICi | fig|1411691.4.peg.1932 |
Organism-specific databases
EchoBASEi | EB4169 |
Phylogenomic databases
eggNOGi | COG1414, Bacteria |
HOGENOMi | CLU_062618_1_0_6 |
InParanoidi | P77569 |
PhylomeDBi | P77569 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6201-MONOMER |
Miscellaneous databases
PROi | PR:P77569 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.450.40, 1 hit |
InterProi | View protein in InterPro IPR029016, GAF-like_dom_sf IPR014757, Tscrpt_reg_IclR_C IPR005471, Tscrpt_reg_IclR_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF09339, HTH_IclR, 1 hit PF01614, IclR, 1 hit |
SMARTi | View protein in SMART SM00346, HTH_ICLR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51077, HTH_ICLR, 1 hit PS51078, ICLR_ED, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MHPR_ECOLI | |
Accessioni | P77569Primary (citable) accession number: P77569 Secondary accession number(s): P71202, Q2MC78 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | June 26, 2007 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |